Factory high qualit...

Factory high quality bromohexine hydrochloride
Factory high quality bromohexine hydrochloride

Factory high quality bromohexine hydrochloride

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1 Gram

FOB Price:USD 5.0000 -7.0000
  • Min.Order :1 Gram
  • Purity: purity 98%-101%
  • Payment Terms : L/C,T/T,Other

Keywords

bromohexine hydrochloride 611-75-6 bromohexine

Quick Details

  • Appearance:white powder
  • Application:Dietary supplements;Food;Additives;Pharmaceuticals;medicines;cosmetics Heart protection
  • PackAge:1kg/bag,5kg/bag,25kg/drum
  • ProductionCapacity:1|Metric Ton|Day
  • Storage:20°
  • Transportation:20

Superiority:

bromohexine hydrochloride

CAS: 611-75-6

Molecular Formula: C14H21Br2ClN2

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611-75-6 - Names and Identifiers

Name bromohexine hydrochloride
Synonyms bisolvon
bromessina
BROMHEXINE HCL
bisolvonhydrochloride
BROMHEXINE HYDROCHLORIDE
bromohexine hydrochloride
2-amino-n-cyclohexyl-3,5-dibromo-n-methyl-benzylaminhydrochloride
2-amino-n-cyclohexyl-3,5-dibromo-n-methylbenzylaminehydrochloride
2-Amino-3,5-dibromo-N-cyclohexyl-N-methylbenzylamine hydrochloride
2-AMINO-3,5-DIBROMO-N-CYCLOHEXYL-N-METHYLBENZY-LAMINE HYDROCHLORIDE
N-(2-Amino-3,5-dibromobenzyl)-N-methylcyclohexylamine hydrochloride
n-(2-amino-3,5-dibromobenzyl)-n-methylcyclohexylamine hydrochloride
2,4-dibromo-6-{[cyclohexyl(methyl)amino]methyl}aniline hydrochloride
2-amino-3,5-dibromo-n-cyclohexyl-n-methyl-benzenemethanaminmonohydrochlo
CAS 611-75-6
EINECS 210-280-8
InChI InChI=1/C14H20Br2N2.ClH/c1-18(12-5-3-2-4-6-12)9-10-7-11(15)8-13(16)14(10)17;/h7-8,12H,2-6,9,17H2,1H3;1H
InChIKey UCDKONUHZNTQPY-UHFFFAOYSA-N

611-75-6 - Physico-chemical Properties

Molecular Formula C14H21Br2ClN2
Molar Mass 412.59
Melting Point 240-244°C
Boling Point 441.5°C at 760 mmHg
Flash Point 220.8°C
Solubility Soluble in water (<1 mg/ml at 25 °C), ethanol (5 mg/ml at 25 °C), methanol (1:50), a
Vapor Presure 3.37E-08mmHg at 25°C
Appearance powder
Color White to Light Beige
Maximum wavelength(λmax) ['307nm(Decane)(lit.)']
Merck 14,1391
BRN 4848376
Storage Condition Sealed in dry,Room Temperature
Sensitive Sensitive to light
MDL MFCD00056626
Physical and Chemical Properties
melting point 240-244°C
Use Used as an expectorant

611-75-6 - Risk and Safety

Hazard Symbols Xn - Harmful
Harmful
Risk Codes R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed.
R36/37/38 - Irritating to eyes, respiratory system and skin.
Safety Description S22 - Do not breathe dust.
S24/25 - Avoid contact with skin and eyes.
S36 - Wear suitable protective clothing.
S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
WGK Germany 2
RTECS XS9950000
HS Code 29215990

611-75-6 - Reference Information

Introduction Bromhexine hydrochloride is a mucolytic agent, which can directly act on the bronchial glands and promote the release of lysosomes of mucus secreting cells, the differentiation and lysis of mucopolysaccharide fibers in sputum, sputum dilution, easy to cough. Clinically, it is mainly used for acute and chronic bronchitis, asthma, bronchiectasis, emphysema, especially for white sputum expectoration difficulties and critical emergencies caused by sputum extensive obstruction of small bronchi. Bromhexine hydrochloride tablets, solutions, aerosols, injection, freeze-dried powder injection, infusion and other dosage forms.
preparation 2.0g of 2-amino -3, 5-dibromobenzaldehyde, 1.2g of N-methyl
cyclohexylamine is dissolved in 20ml of methanol, and 4g of tetraisopropyl titanate is slowly dropped into the reaction solution under stirring at room temperature, and after adding, the reaction is continued at room temperature for 5 hours; 0.3g of sodium borohydride was added to the reaction solution in portions, and the reaction was stirred at room temperature for 2H. The reaction was complete by TLC. After the reaction, add 20ml of water to the reaction solution to quench the reaction, precipitate a large number of solids, filter, filter cake washed with ethyl acetate for 3 times, combine filtrate and wash, extract with ethyl acetate to obtain organic phase, the organic phase was washed sequentially with sodium carbonate solution and saturated brine. 5ml of 6N hydrochloric acid was added dropwise to the organic phase at room temperature under stirring, and the mixture was stirred for 3H for crystallization. A white solid was obtained by filtration, recrystallized from ethanol and dried to obtain 2.3g of Bromhexine hydrochloride. Yield: 78%.
biological activity Bromhexine HCl is a drug that treats Cough of hard sputum by dissolving it.
Use this strain is based on the active ingredient proposed in the medicinal plant duckbill flower (hyonidine) the structure of the synthesis of a new type of mucus soluble expectorant, has a strong role in dissolving phlegm. Can make sputum mucopolysaccharide fiber differentiation and lysis, can also inhibit the synthesis of mucopolysaccharides, so that sputum sialic acid (one of the acidic mucopolysaccharides) content reduced, thereby reducing the viscosity of sputum, there are Nausea of the expectorant effect after oral administration, so that sputum is easy to cough, so that the respiratory tract is smooth. It is clinically used for the treatment of acute and chronic bronchitis, asthma, bronchiectasis and emphysema, especially for the difficulty of expectoration of white phlegm, and the shortness of breath caused by extensive obstruction of small bronchi by sputum. Adverse Reactions: taking this product occasionally Nausea, stomach discomfort, reduction or discontinuation can disappear. A small number of patients with temporary elevated serum transaminase. Patients with gastric ulcer should be used with caution. The toxicity of this product is very small.
used as expectorant
This product is a new type of mucolytic expectorant, which can differentiate and split the mucopolysaccharide fibers in sputum, reduce the viscosity of sputum and increase the secretion, thus thinning the sputum, easy to cough, make respiratory tract unobstructed, relieve symptoms
production method There are a variety of process routes. One of them is o-toluidine as raw material, first bromination to produce 2, 4-dibromo-6-toluidine, and acetic anhydride reaction to acetylated amino to produce N,N-diacetyl-2, 4-dibromo-6-methylaniline; The amino group is protected and then brominated again to form N, n-diacetyl-2, 4-dibromo-6-bromomethylaniline; condensation with N-methylcyclohexylamine to N, n-diacetyl-2, 4-dibromo-6-(N-methyl) cyclohexylamine methylaniline. Finally, hydrochloric acid is used to hydrolyze the acetyl group and salt to obtain the finished product.
category toxic substances
toxicity grade poisoning
Acute toxicity oral-rat LD50: 6000 mg/kg; Oral-mouse LD50: 4800 mg/kg
flammability hazard characteristics toxic nitrogen oxides, bromide and hydrochloric acid fumes emitted by thermal decomposition
storage and transportation characteristics warehouse ventilation and low temperature drying
fire extinguishing agent water, foam, sand, carbon dioxide, dry powder

Details:

Bromhexine hydrochloride

Mol Download Chemical properties

CAS:

611-75-6

MF:

C14H21Br2ClN2

MW:

412.59

EINECS:

210-280-8

MDL No.:

MFCD00056626

Properties

Melting point:

240-244 °C

storage temp. 

Sealed in dry,Room Temperature

solubility 

Very slightly soluble in water, slightly soluble in alcohol and in methylene chloride.

form 

powder

color 

White to Light Beige

λmax

307nm(Decane)(lit.)

Merck 

14,1391

BRN 

4848376

InChIKey

UCDKONUHZNTQPY-UHFFFAOYSA-N

LogP

5.081 (est)

Xi'an Eastling biotech Co., Ltd. is dedicated to the research and development, production, and sales of natural plant extracts; With nearly 15 years of experience in identifying, researching, developing, and producing active ingredients for medicinal plants, we focus on providing innovative products and services to customers in industries such as pharmaceuticals, health food, and cosmetics.

 

Eastling Biotechnology has established a global direct harvesting system for plant raw materials, ensuring the high quality and authenticity of raw materials, while also protecting the continuity and diversity of plants; Having strong research and development capabilities, we can develop more effective and specialized plant active ingredients for the pharmaceutical, health food, and cosmetics industries; We have established an advanced quality control system, and the quality control of our products depends on advanced testing instruments and high-level technical experts. The effective combination of the two forms Eastling's ability to quickly and rigorously control product quality.

 

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