Factory high quality Clobetasol propionate

Superiority:

clobetasol propionate

CAS: 25122-46-7

Molecular Formula: C25H32ClFO5

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25122-46-7 - Names and Identifiers

25122-46-7 - Physico-chemical Properties

This product contains clobetasol propionate (C25H32CIFO5) should be 90.0% ~ 110.0% of the label amount.

trait

This product is white cream.

identification

In the chromatogram recorded under the content determination item, the retention time of the main peak of the test solution should be consistent with the retention time of the main peak of the control solution.

examination

should comply with the relevant provisions under Cream (General rule 0109).

Content determination

• measured by high performance liquid chromatography (General 0512).
• chromatographic conditions and system suitability test using eighteen alkyl silane bonded silica gel as filler; Methanol-water (65:35) as mobile phase; The detection wavelength was 240nm. The number of theoretical plates shall not be less than 2000 based on clobetasol propionate peak. The separation degree between the peak of Clobetasol propionate and the peak of internal standard substance shall meet the requirements. Preparation of internal standard solution fluorine acetate was easily taken, dissolved in methanol and diluted to prepare a solution containing about 0.15mg per 1ml.
• determination: take an appropriate amount of this product (about 1 mg equivalent to clobetasol propionate), weigh it accurately, put it in a 50ml measuring flask, add 5ml of internal standard solution accurately, and add about 30ml of methanol, heat in a 60°C water bath for 5 minutes, carefully shake to dissolve clobetasol propionate, let it cool, dilute with methanol to the scale, shake well, cool in an ice bath for more than 2 hours, take it out and quickly filter, the filtrate was taken to room temperature as a test solution, and 20u1 was injected into the liquid chromatograph to record the chromatogram, add methanol to dissolve and dilute quantitatively to make a solution containing about 0.2mg per 1ml. Take 5ml of the solution and 5ml of the internal standard solution precisely, put them in a 50ml measuring flask, and dilute to the mark with methanol, shake well, take a liquid chromatograph and record the chromatogram. According to the internal standard method to calculate the peak area, that is.

• overview	clobetasol propionate is a dermatological drug. External use is suitable for chronic eczema, neurodermatitis, psoriasis, palmoplantar pustulosis, lichen planus, discoid lupus erythematosus and other glucocorticoids for external use to treat effective pruritic and non-infectious inflammatory skin diseases.
  pharmacology and toxicology	this product has rapid action and is one of the highly effective topical corticosteroids currently used clinically. It has a strong capillary contraction effect, and its anti-inflammatory effect is 112.5 times that of hydrocortisone, 2.3 times that of betamethasone sodium phosphate, and 18.7 times that of fluocinolone. The systemic adverse reactions are 3 times that of fluocinolone, anhydrous sodium retention, and it has a certain effect of promoting sodium and potassium excretion.
  biological activity	Clobetasol propionate (CGP9555, CCl 4725) is an anti-inflammatory corticosteroid used to treat various skin diseases.
  Target	Value
  use	clobetasol propionate is a synthetic and efficient topical glucocorticoid drug. It has strong anti-inflammatory, anti-pruritic and capillary contraction effects It is a drug of adrenocorticotropic hormone and adrenocorticotropic hormone. Clobetasol propionate is a synthetic and efficient topical glucocorticoid drug. It has strong anti-inflammatory, anti-pruritic and capillary contraction effects
  category	toxic substances
  toxicity classification	poisoning
  acute toxicity	oral-rat LD50: >3000 mg/kg; Oral-mouse LD50; >3000 mg/kg
  flammability hazard characteristics	combustible; combustion produces toxic chloride and fluoride smoke
  storage and transportation characteristics	warehouse ventilation and low temperature drying
  fire extinguishing agent	dry powder, foam, sand, carbon dioxide, mist water