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VC ethyl ether 86404-04-8 3-O-Ethyl-L-ascorbic acid
Molecular Formula | C8H12O6 |
Molar Mass | 204.18 |
Density | 1.46g/cm3 |
Melting Point | 112.0 to 116.0 °C |
Boling Point | 551.5°C at 760 mmHg |
Flash Point | 228.5°C |
Vapor Presure | 1.84E-14mmHg at 25°C |
Storage Condition | 2-8℃ |
Refractive Index | 1.555 |
MDL | MFCD09261382 |
Use | Vitamin C ethyl ether (VC ethyl ether) is a kind of lipophilic and hydrophilic Amphoteric vitamin C derivatives, not only retains the oxidation-reduction effect of vitamin C and is very stable, is not discolored vitamin C derivatives, and it is a lipophilic hydrophilic amphoteric substance, which not only makes it extremely convenient to use in the formula, but also makes it easy to penetrate the stratum corneum into the dermis, after entering the skin, it is easily decomposed by biological enzymes to play the role of vitamin C, thereby improving its bioavailability. |
Vitamin C ethyl ether is a very useful vitamin C derivative. It is not only very stable in chemical substances, it is a non-discolored vitamin C derivative, but also an oleophilic hydrophilic amphoteric substance, which greatly expands his scope of application, especially in daily chemistry. 3-O-ethyl ascorbic acid ether is easy to enter the dermis through the stratum corneum. After it enters the body, it is very easy to decompose the biological enzymes in the body to exert the biological effects of vitamin C.
3-O-ethyl ascorbic acid ether is also called vitamin C ethyl ether. Vitamin C has 4 hydroxyl groups in its structure, which cannot be directly absorbed by the skin, and is easily oxidized to cause discoloration. As a whitening agent, it is restricted in the use of cosmetics. The vitamin C ethyl ether prepared after 3-position hydroxyl alkylation is a vitamin C derivative that does not change color and does not affect its biological activity, thus filling the gap of similar products in the market. Studies have shown that vitamin C ethyl ether is easily decomposed by enzymes after entering the skin to play the role of vitamin C.
Last Update:2024-03-19 21:20:20
mechanism of action
VC ethyl ether through the stratum corneum to the basal layer of melanocytes, inhibit tyrosinase activity, inhibit the formation of melanin, reduce melanin to colorless, thus effectively whitening skin. And VC ethyl ether can directly participate in the synthesis of collagen to repair the activity of skin cells after entering the dermis, so that collagen increases, so that the skin becomes full of elasticity, and the skin is delicate and smooth. 3-O-ethyl-L-ascorbic acid may be a useful stabilizer for p-hydroxyacetophenone solutions.
application
3-O-ethylascorbic acid ether (vitamin C ethyl ether) is an oil-water two-soluble substance, which allows the formulator to add it to the oil phase or water phase, or it can be added at high or low temperature. It is convenient to use. More importantly, this two-soluble property makes it easier to penetrate the stratum corneum and enter the dermis to exert its biological effects, this is not available in other vitamin C derivatives. It can block the formation of melanin by inhibiting the activity of tyrosinase; it has whitening and freckle removal effects (when 2% is added); it can resist inflammation caused by sunlight and has a strong antibacterial and anti-inflammatory effect; at the same time, it can improve the dull skin, Give skin luster and elasticity, repair skin cell activity, and promote collagen production.
application
1. Inhibit its activity by Cu2 + acting on tyrosinase and block melanin formation;
2. Very effective whitening and freckle removal (when added 2%);
3. Anti-inflammation caused by sunlight, with strong antibacterial and anti-inflammatory effects;
4. Improve dull skin and give skin elasticity;
5. Repair skin cell activity and promote collagen production.
CAS:
86404-04-8
MF:
C8H12O6
MW:
204.18
EINECS:
617-849-3
MDL No.:
MFCD09261382
Melting point:
112.0 to 116.0 °C
Boiling point:
551.5±50.0 °C(Predicted)
Density
1.46±0.1 g/cm3(Predicted)
vapor pressure
0-0Pa at 20-25℃
storage temp.
Sealed in dry,2-8°C
solubility
Methanol (Slightly), Water (Slightly)
form
Solid
pka
8.89±0.40(Predicted)
color
White to Off-White
InChI
InChI=1S/C8H12O6/c1-2-13-7-5(11)8(12)14-6(7)4(10)3-9/h4,6,9-11H,2-3H2,1H3/t4-,6+/m0/s1
InChIKey
ZGSCRDSBTNQPMS-UJURSFKZSA-N
SMILES
O(CC)C1=C(O)C(=O)O[C@@H]1[C@H](CO)O
LogP
-0.8--0.64 at 20-25℃ and pH7
Surface tension
69-72.4mN/m at 1g/L and 20℃
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