Factory high quality Dipyridamole

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Dipyridamole

CAS: 58-32-2

Molecular Formula: C24H40N8O4

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58-32-2 - Names and Identifiers

58-32-2 - Physico-chemical Properties

chlorine-containing compounds

take about 20mg of this product, according to the oxygen flask combustion method (General rule 0703) for organic damage, 0.4% sodium hydroxide solution 20ml as the absorption liquid, once the combustion is completed, strong shaking for 15 minutes, add 10ml of dilute nitric acid, move to 50ml Nessler's colorimetric tube, check according to the chloride inspection method (General 0801), and operate with the control solution (the same method as the test sample), however, the test article is not contained in the filter paper during combustion, and 4.0 of standard sodium chloride solution is added), and it should not be more concentrated (0.20%).

Related substances

take this product, add methanol to dissolve and dilute to make 1.0 mg of the solution was used as a test solution, and an appropriate amount was quantitatively diluted with methanol to prepare a solution containing 10ug per 1 ml as a control solution. According to the high performance liquid chromatography (General rule 0512) test, with eighteen alkyl silane bonded silica gel as filler; Disodium hydrogen phosphate solution [take disodium hydrogen phosphate 250mg, add water 250ml, dissolve, Dropwise add phosphoric acid solution (1-3) the pH value was adjusted to 4.6]-methanol (25:75) as the mobile phase; The detection wavelength was 288nm, and the number of theoretical plates was not less than 600 based on the dipyridamole peak. The LOLs of the test solution and the control solution were respectively injected into the human liquid chromatograph, and the chromatogram was recorded to 2 times of the retention time of the main component peak. If there are impurity peaks in the chromatogram of the test solution, the sum of each impurity peak area shall not be greater than the main peak area of the control solution (1.0%).

residual solvent

take about 0.1g of this product, precision weighing, in the top empty bottle, Precision Add 5ml of N,IV-dimethylformamide to dissolve, seal, as a test solution; Separately take methanol, appropriate amount of acetone and ethyl acetate, precision weighing, quantitative dilution with N,N-dimethylformamide to make solution containing about 50ug in each lml, precision measuring 5ml, in the empty bottle, sealed, as a control solution. Test as residual solvent assay (General 0861 second method). With 6% cyanopropylphenyl-94% dimethylpolysiloxane (or polar similar) as the stationary liquid; The initial temperature is 50°C, maintained for 3 minutes, and the temperature is raised to 160°C at a rate of 40°C per minute, maintained for 3 minutes; the inlet temperature was 200°C; The detector temperature was 250°C; The headspace bottle equilibrium temperature was 80°C and the equilibrium time was 30 minutes. Take the reference solution into the headspace, the separation degree between the peaks of each component shall meet the requirements. Then the sample solution and the reference solution were injected with headspace, and the chromatogram was recorded. According to the external standard method to calculate the peak area, methanol, acetone and ethyl acetate residues should be in accordance with the provisions.

loss on drying

take this product, dry to constant weight at 105°C, weight loss shall not exceed 0.5% (General rule 0831).

ignition residue

take l.Og of this product and check it according to law (General rule 0841). The residue left shall not exceed 0.1%.

Heavy metals

The residue left under the item of taking the ignition residue shall not contain more than 10 parts per million of heavy metal when examined by law (General Principles 0821, Law II).