Factory high quality Triamcinolone acetonide

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1 Gram	FOB Price:USD 5.0000 -6.0000

1 Gram

FOB Price:USD 5.0000 -6.0000

Min.Order :1 Gram
Purity: purity 98%-101%
Payment Terms : L/C,T/T,Other

Keywords

Triamcinolone acetonide 76-25-5 Triamcinolone acetonide powder

Quick Details

Appearance:white powder
Application:Dietary supplements;Food;Additives;Pharmaceuticals;medicines;cosmetics Heart protection
PackAge:1kg/bag,5kg/bag,25kg/drum
ProductionCapacity:1|Metric Ton|Day
Storage:20°
Transportation:20

Superiority:

76-25-5 - Physico-chemical Properties

Molecular Formula	C24H31FO6
Molar Mass	434.5
Density	1.1517 (estimate)
Melting Point	274-278°C (dec.)
Boling Point	576.9±50.0 °C(Predicted)
Specific Rotation(α)	D23 +109° (c = 0.75 in chloroform)
Flash Point	302.7°C
Water Solubility	Soluble in DMSO or ethanol. Slightly soluble in water.
Solubility	Very slightly soluble in water, slightly soluble in ethanol, soluble in chloroform, slightly soluble in acetone.
Vapor Presure	1.04E-15mmHg at 25°C
Appearance	White to off-white crystalline powder
Color	White to Off-White
Merck	9596
pKa	12.87±0.10(Predicted)
Storage Condition	Refrigerator
Stability	Combustible. Incompatible with strong oxidizing agents.
Refractive Index	1.5980 (estimate)
MDL	MFCD00056834
Use	For the adrenal cortex hormone drugs, for neurodermatitis, eczema, psoriasis, Arthralgia, bronchial asthma and other diseases

Introduction	triamcinolone acetonide is a hormone drug that can be used in some immune diseases, but it also has great side effects on the human body. It is a short-acting hormonal drug. This drug can not be used for a long time, must be used under the guidance of a doctor, if there are other diseases, we must pay attention to the side effects of the drug, in the course of medication should pay attention to the monitoring of liver and kidney function, in order to avoid drug phase.
glucocorticoid drugs	triamcinolone acetonide is a kind of long-acting glucocorticoid drugs which is widely used in clinical Dermatology in China, also known as Qu anshusong, de yanshusong, Kang ningke Tong, conorle cream, conak-A, belong to adrenocortical hormone drugs, is A derivative of triamcinolone (de Yansong), similar to Triamcinolone, with anti-inflammatory, anti-allergic, anti-itching and contraction of the role of capillary, its water and sodium retention weak, and anti-inflammatory, anti-allergic effects than hydrocortisone (10~30 times) prednisone was strong and lasting. Aerosol inhalation for bronchial asthma was effective and lasting. The local effect was better than that of quansilong.
Clinical application	clinically triamcinolone acetonide is mainly used to treat various skin diseases such as allergic dermatitis, contact dermatitis, seborrheic dermatitis, neurodermatitis, eczema, psoriasis, psoriasis, lichen planus and other skin diseases and skin pruritus, as well as bronchial asthma, rheumatoid arthritis, acute sprain, chronic low back pain, scapulohumeral periarthritis, tenosynovitis, Ophthalmic Inflammation, oral mucosal congestion, erosion, ulcers, granulomatous cheilitis, chronic infectious diseases of oral mucosa can also be used for local injection of small area lesions such as keloid, cystic acne, discoid lupus erythematosus and alopecia areata. Triamcinolone acetonide acetate nasal spray can be used for the prevention and treatment of perennial, seasonal allergic rhinitis and vasomotor rhinitis. Intra-articular injections eliminate inflammation and relieve pain, swelling, or stiff sensations.
pharmacological action	1. Anti-inflammatory effect The anti-inflammatory and anti-allergic effects of triamcinolone acetonide are strong and lasting, and can be used for local administration. The pharmacodynamic value was equivalent to prednisolone and hydrocortisone. Can reduce congestion, reduce the permeability of capillaries; Inhibit the migration of granulocytes, lymphocytes and macrophages to inflammatory sites; Prevent the release of inflammatory mediators such as kinins, histamine and slow reaction substances; inhibits phagocyte function, stabilizes the lysosomal membrane; Prevents complement from participating in the inflammatory response. So as to reduce the symptoms of acute inflammation and inhibit the repair of tissue damage after inflammation, prevent scar formation. Immunosuppressive effect The drug can reduce the body's own immunity, lyse and deplete the lymph nodes, spleen and thymus lymphocytes, especially the 9 lymphocytes. Inhibits phagocytosis and processing of antigen by macrophages. Reduces the effect of the reticuloendothelial system on the elimination of granular anti-or degenerative cells. 3. Antitoxin effect triamcinolone acetonide can non-specifically improve the stress ability of the body, resist harmful stimulation, reduce the damage of bacterial endotoxin to the body, relieve the symptoms of toxemia, reduce the release of endogenous pyrogen, it has antipyretic effect on toxemia. Triamcinolone acetonide can increase the content of red blood cells and hemoglobin, increase the number of platelets and increase the concentration of fibrinogen, shorten the clotting time, reduce blood eosinophil and lymphocyte count. 4. Effect on metabolism The drug has the effect of glucocorticoid, which can increase blood sugar and promote protein decomposition. However, mineralocorticoid activity is low, and has little effect on water-electrolyte balance. Its potassium excretion, sodium retention and water storage effects are obviously weaker than those of hydrocortisone.
indication	triamcinolone acetonide is a kind of adrenal cortex hormone, which has anti-inflammatory, anti-allergic and antipruritic effects, can eliminate local non-infectious inflammation caused by Fever, redness and swelling. Long-term use can cause local skin atrophy, telangiectasia, pigmentation and infection. Use during pregnancy increases placental insufficiency and cleft lip and palate in the fetus by Incidence Rate.
pharmacokinetics	oral absorption. Oral administration of 5mg, bioavailability of about 23%,1 hour peak plasma concentration of 105ng/ml, half-life of 2 hours; Intramuscular injection of slow absorption, a few hours, 1~2 days to the maximum effect, the effect can be maintained for 2~3 weeks; Intradermal, intra-articular local injection of the chemical book Drug absorption is slow, lasting effect, general injection of a curative effect can be maintained for more than 1 to 2 weeks. The drug is less combined with plasma albumin, after absorption in the liver, kidney and tissue metabolism to inactive metabolites, excreted by the kidney. Local injection can also show a lasting effect, topical ointment can also produce good curative effect.
appearance	acetate is white or almost white crystalline powder, odorless and bitter in taste. Very slightly soluble in water, ethanol-soluble, soluble in chloroform, slightly soluble in acetone.
Use	is an adrenocortical hormone drug, used for neurodermatitis, eczema, psoriasis, Arthralgia, bronchial asthma and other diseases
category	toxic substances
toxicity grade	high toxicity
Acute toxicity	subcutaneous-rat LD50: 13.1 mg/kg; Intraperitoneal-mouse LD50: 105 mg/kg
flammability hazard characteristics	flammability; Toxic fluoride smoke from combustion
storage and transportation characteristics	The warehouse is ventilated and dried at low temperature; Stored separately from food raw materials

Details:

Triamcinolone acetonide

CAS:

76-25-5

MF:

C24H31FO6

MW:

434.5

EINECS:

200-948-7

MDL No.:

MFCD00056834

Properties

Melting point:

274-278°C (dec.)

alpha

D23 +109° (c = 0.75 in chloroform)

Boiling point:

576.9±50.0 °C(Predicted)

Density

1.1517 (estimate)

refractive index

1.5980 (estimate)

storage temp.

Refrigerator

solubility

Practically insoluble in water, sparingly soluble in ethanol (96 per cent).

pka

12.87±0.10(Predicted)

color

White to Off-White

Water Solubility

Soluble in DMSO or ethanol. Slightly soluble in water.

Merck

9596

BCS Class

Stability:

Combustible. Incompatible with strong oxidizing agents.

InChIKey

YNDXUCZADRHECN-JNQJZLCISA-N

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