Factory high qualit...

Factory high quality Hydroxyurea
Factory high quality Hydroxyurea

Factory high quality Hydroxyurea

Min.Order / FOB Price:Get Latest Price

1 Kilogram

FOB Price:USD 7.0000 -8.0000
  • Min.Order :1 Kilogram
  • Purity: purity 98%-101%
  • Payment Terms : T/T,Other

Keywords

Hydroxyurea 127-07-1 Hydroxyurea powder

Quick Details

  • Appearance:white powder
  • Application:Dietary supplements;Food;Additives;Pharmaceuticals;medicines;cosmetics Heart protection
  • PackAge:1kg/bag,5kg/bag,25kg/drum
  • ProductionCapacity:1|Kilogram|Day
  • Storage:20℃
  • Transportation:20

Superiority:

127-07-1 - Physico-chemical Properties

Molecular Formula CH4N2O2
Molar Mass 76.05
Density 1.457±0.06 g/cm3(Predicted)
Melting Point 135-140°C
Boling Point 136.04°C (rough estimate)
Water Solubility soluble
Solubility Soluble in water and hot ethanol, slightly soluble in cold ethanol, insoluble in ether; benzene.
Appearance White powder
Color white
Merck 14,4848
BRN 1741548
pKa 10.56±0.23(Predicted)
Storage Condition 2-8°C
Stability Stable for 2 years as supplied from date of purchase. Solutions in water may be stored at -20°C for up to 3 months.
Refractive Index 1.4840 (estimate)
MDL MFCD00007943
Physical and Chemical Properties Melting point 142-146°C
water-soluble solution
Use Anti-metabolic anticancer drugs, mainly acting on the G1 and S phase of proliferating cells, have a delaying effect on the G1/S interface, and are cell-specific drugs

 

127-07-1 - Introduction

This product is a nucleoside diphosphate reductase inhibitor, which can prevent the reduction of nucleotides to deoxynucleotides, interfere with purine and pyrimidine base biosynthesis, selectively hinder DNA synthesis, and have no blocking effect on RNA and protein synthesis. Cycle-specific drugs, S-phase cells are sensitive.

drug action and clinical application hydroxyurea is an anticancer drug for the treatment of chronic myeloid leukemia. as early as the 20s, it was observed that hydroxyurea caused rabbits to produce giant erythrocyte hemogram similar to pernicious anemia and inhibited leukocyte production. Its inhibitory effect on L1210 mouse leukemia was discovered in 1963. Hydroxyurea can induce bacteria to produce a molecule that is toxic to itself to achieve the purpose of killing bacteria.
Hydroxyurea, also known as hydroxyurea, hydroxyurea, carbamoyl hydroxyurea, is a nucleoside diphosphate reductase inhibitor, which can prevent the reduction of nucleotides to deoxynucleotides, interfere with purine and pyrimidine base biosynthesis, selectively hinder DNA synthesis, and partially inhibit the conversion of ribonucleic acid into deoxyribonucleotides. It has no blocking effect on RNA and protein synthesis. Hydroxyurea is a cycle-specific drug, which is sensitive to S-phase cells and can induce hematological remission of chronic myeloid leukemia. Compared with alkylating agents Baifan and Mafan, the incidence of secondary leukemia is low. The myelosuppressive effect of hydroxyurea lasts several days to several weeks and is easier to control than alkylating agents. Clinically, hydroxyurea is suitable for the treatment of chronic myeloid leukemia, acute lymphocytic and acute non-lymphocytic leukemia with high cell count, spontaneous thrombocytosis, polycythemia vera, and retinoic acid syndrome to prevent acute myeloid leukemia, treatment of sickle cell anemia with frequent pain attacks. In addition, hydroxyurea is also effective in the treatment of head and neck tumors, recurrent metastatic ovarian cancer, and kidney cancer.
usage and dosage common dosage for adults:
① chronic myeloid leukemia, the general starting dose is 20-30 mg/kg per day according to body weight, once or twice orally. when the white blood cell drops below 10 × 109/L, the dosage is reduced to about 20 mg/kg per day, and the oral administration is maintained or changed to intermittent administration.
② head and neck cancer and ovarian cancer, the dose is 60~80 mg/kg per time according to body weight or 2000~3000mg/m2 according to body surface area, taken orally once every 3 days, taken alone or combined with radiotherapy.

Details:

Hydroxyurea

 

CAS:

127-07-1

MF:

CH4N2O2

MW:

76.05

EINECS:

204-821-7

MDL No.:

MFCD00007943

Properties

Melting point:

135-140 °C

Boiling point:

136.04°C (rough estimate)

Density 

1.457±0.06 g/cm3(Predicted)

refractive index 

1.4840 (estimate)

storage temp. 

2-8°C

solubility 

H2O: 50 mg/mL

pka

10.56±0.23(Predicted)

form 

powder

color 

white

Odor

odorless or almost odorless

Water Solubility 

soluble

Merck 

14,4848

BRN 

1741548

Stability:

Stable for 2 years as supplied from date of purchase. Solutions in water may be stored at -20°C for up to 3 months.

Xi'an Eastling biotech Co., Ltd. is dedicated to the research and development, production, and sales of natural plant extracts; With nearly 15 years of experience in identifying, researching, developing, and producing active ingredients for medicinal plants, we focus on providing innovative products and services to customers in industries such as pharmaceuticals, health food, and cosmetics.

 

Eastling Biotechnology has established a global direct harvesting system for plant raw materials, ensuring the high quality and authenticity of raw materials, while also protecting the continuity and diversity of plants; Having strong research and development capabilities, we can develop more effective and specialized plant active ingredients for the pharmaceutical, health food, and cosmetics industries; We have established an advanced quality control system, and the quality control of our products depends on advanced testing instruments and high-level technical experts. The effective combination of the two forms Eastling's ability to quickly and rigorously control product quality.

 

We have a production system that complies with Chinese GMP and American cGMP certifications, as well as advanced and optimized large-scale industrial production technology. In addition to producing specific products for Eastling Biotechnology, we also provide customized services to meet the characteristics and needs of different customers to produce customized products.

We believe that natural active ingredients are the foundation of our service to customers. Scientific and effective production technology is the foundation for us to provide customers with specialized products. We have the ability to serve customers in the pharmaceutical, health food, and cosmetics industries, provide new product solutions, and add new value to their products.

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