Factory high qualit...

Factory high quality Azelaic Acid
Factory high quality Azelaic Acid

Factory high quality Azelaic Acid

Min.Order / FOB Price:Get Latest Price

1 Gram

FOB Price:USD 6.0000 -7.0000

  • Min.Order :1 Gram
  • Purity: purity 98%-101%
  • Payment Terms : L/C,T/T,Other

Keywords

Azelaic Acid 123-99-9 Azelaic Acid

Quick Details

  • Appearance:white powder
  • Application:Dietary supplements;Food;Additives;Pharmaceuticals;medicines;cosmetics Heart protection
  • PackAge:1kg/bag,5kg/bag,25kg/drum
  • ProductionCapacity:1|Metric Ton|Day
  • Storage:20°
  • Transportation:20

Superiority:

123-99-9 - Physico-chemical Properties

Molecular Formula C9H16O4
Molar Mass 188.22
Density 1,029 g/cm3
Melting Point 98 °C
Boling Point 286°C100mm Hg(lit.)
Flash Point 215 °C
Water Solubility 2.4 g/L (20 ºC)
Solubility Soluble in boiling water and ethanol, soluble in organic solvents, slightly soluble in benzene.
Vapor Presure <1 mm Hg ( 20 °C)
Vapor Density 6.5 (vs air)
Appearance White flakes
Color White to slightly yellow
Merck 14,905
BRN 1101094
pKa 4.53, 5.33(at 25℃)
PH 3.5 (1g/l, H2O)
Storage Condition Store below +30°C.
Stability Stable. Combustible. Incompatible with bases, strong oxidizing agents. Readily biodegrades in soil and water with >70% DOC reduction after 28 days.
Sensitive Easily absorbing moisture
Refractive Index 1.4303
MDL MFCD00004432
Physical and Chemical Properties Melting point 98-103°C
boiling point 286 ° C (100 mmHg)
flash point 215°C
water-soluble 2.4g/L (20°C)
Use Used as a raw material for the production of plasticizer dioctyl nonanediate and perfume, lubricating oil, oil agent, polyamide resin

 

overview azelaic acid is a skin disease prevention and treatment drug, mainly used to treat acne, chloasma and skin melanin deposition. It is also an important organic synthesis intermediate, used in plastics, rubber and other industries to synthesize plasticizers, in aviation oil for the synthesis of low-temperature high-speed lubricating oil, electrolytic capacitor manufacturing and other aspects of important applications. Using unsaturated fatty acids such as oleic acid and corresponding triglycerides such as castor oil and cotton seed oil to prepare azelaic acid is the main production method at present.
pharmacological action azelaic acid can inhibit or kill anaerobic bacteria and aerobic bacteria in skin. In vivo tests show that topical application of azelaic acid cream for 2-3 months can significantly reduce the number of skin bacteria and propionibacterium in hair follicles, indicating that this product has direct antibacterial effect. In addition, topical application of azelaic acid can reduce the composition of free fatty acids and lipids on the skin surface. It shows anti-keratinization effect on the skin of normal people or acne patients. Its principle of action is mainly due to reducing the synthesis of filamentous keratin, thereby reducing hyperkeratosis of hair follicles. Azelaic acid selectively acts on abnormal melanocytes and inhibits their excessive activity. Therefore, topical application of azelaic acid for a long time can reduce the production of skin melanin in patients with senile plaque. But this product has no depigmentation effect on the pigment of normal skin. Azelaic acid also has anti-cell proliferation and anti-cytotoxic effects. Its principle of action is mainly through the destruction of mitochondrial respiratory pathway and cell DNA synthesis.
indications for melanosis, chloasma, malignant nevus, melanoma, sunburn, etc. It has a good effect on acne vulgaris, and it is also effective on rosacea and seborrheic dermatitis.
Preparation A method for preparing azelaic acid catalyzed by solid acid, characterized in that it has the following process and steps: unsaturated fatty acids or mixed fatty acids produced by hydrolysis of animal and vegetable oils, solid acid catalyst, and hexyltrimethyl ammonium chloride are mixed, stirred and heated to 50-70°C, A mixed gas with an ozone concentration of 2-10g/L is introduced at a flow rate of 500 ml/min, a hydrogen peroxide solution with a weight percentage of 20-40% is added in batches, and the reaction temperature is controlled to not exceed 70 ℃; after the raw materials are added, the temperature is raised to 95 ℃ ~ 110 ℃ for 5-12 hours; after the reaction, the reaction mixture is placed in a separatory funnel to separate the solid acid catalyst layer, oil layer and water layer; the water layer is refrigerated and crystallized at 3°C, and white azelaic acid is precipitated, filtered, and dried; the oil layer is extracted with boiling water and then refrigerated and crystallized at 3°C, and azelaic acid is also obtained after suction filtration; the azelaic acid is combined After recrystallization with hot water, purified azelaic acid is obtained; the amount of the solid acid catalyst is 5-20% of the weight of unsaturated fatty acids or mixed fatty acids; the amount of hydrogen peroxide solution is 2-5 times the volume of unsaturated fatty acid or mixed fatty acid; the amount of decyltrimethylammonium chloride is 1%-5% of the weight of unsaturated fatty acid or mixed fatty acid.
use most azelaic acid is used to produce dioctyl azelate (DOZ) plasticizer, and other uses are used as raw materials for perfume, lubricating oil, oil and polyamide resin. DOZ is used for cold resistance and plasticity of cables, films, artificial leather, etc., with low volatility and aging resistance. DOZ can also be used as a softener for synthetic rubber. The azelaic acid used in the production of DOZ in Japan accounts for about 70% of the total consumption of azelaic acid. Azelaic acid is dehydrated by ammonia, and nondinitrile can be produced.
Azelaic acid can be used as a reagent and also used in organic synthesis. For example, it can be used as a raw material for the production of plasticizer dioctyl azelate and perfumes, lubricants, oils, and polyamide resins. In addition, azelaic acid is widely used in medicine and cosmetics.
production method is obtained by oxidation of oleic acid by nitric acid or ozone. It can also be obtained by cracking industrial castor as a raw material. 1, 5-dibromopentane is condensed with acetonitrile, or azelaic acid can be prepared from dimethyl azelaic by ketone dimethyl azelic acid using monomethyl methyl glutarate as raw material.

Details:

Azelaic acid

 

CAS:

123-99-9

MF:

C9H16O4

MW:

188.22

EINECS:

204-669-1

MDL No.:

MFCD00004432

Properties

Melting point:

98 °C

Boiling point:

286 °C100 mm Hg(lit.)

Density 

1,029 g/cm3

vapor density 

6.5 (vs air)

vapor pressure 

<1 mm Hg ( 20 °C)

refractive index 

1.4303

Flash point:

215 °C

storage temp. 

Store below +30°C.

solubility 

2.4g/l

pka

4.53, 5.33(at 25℃)

form 

Slightly Crystalline Powder or Flakes

color 

White to slightly yellow

PH

3.5 (1g/l, H2O)

Water Solubility 

2.4 g/L (20 ºC)

Merck 

14,905

BRN 

1101094

Stability:

Stable. Combustible. Incompatible with bases, strong oxidizing agents. Readily biodegrades in soil and water with >70% DOC reduction after 28 days.

InChIKey

BDJRBEYXGGNYIS-UHFFFAOYSA-N

LogP

1.57 at 25℃

Xi'an Eastling biotech Co., Ltd. is dedicated to the research and development, production, and sales of natural plant extracts; With nearly 15 years of experience in identifying, researching, developing, and producing active ingredients for medicinal plants, we focus on providing innovative products and services to customers in industries such as pharmaceuticals, health food, and cosmetics.

 

Eastling Biotechnology has established a global direct harvesting system for plant raw materials, ensuring the high quality and authenticity of raw materials, while also protecting the continuity and diversity of plants; Having strong research and development capabilities, we can develop more effective and specialized plant active ingredients for the pharmaceutical, health food, and cosmetics industries; We have established an advanced quality control system, and the quality control of our products depends on advanced testing instruments and high-level technical experts. The effective combination of the two forms Eastling's ability to quickly and rigorously control product quality.

 

We have a production system that complies with Chinese GMP and American cGMP certifications, as well as advanced and optimized large-scale industrial production technology. In addition to producing specific products for Eastling Biotechnology, we also provide customized services to meet the characteristics and needs of different customers to produce customized products.

We believe that natural active ingredients are the foundation of our service to customers. Scientific and effective production technology is the foundation for us to provide customers with specialized products. We have the ability to serve customers in the pharmaceutical, health food, and cosmetics industries, provide new product solutions, and add new value to their products.

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