Factory high quality Pomalidomide

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1 Gram	FOB Price:USD 7.0000 -8.0000

1 Gram

FOB Price:USD 7.0000 -8.0000

Min.Order :1 Gram
Purity: purity 98%-101%
Payment Terms : L/C,T/T,Other

Keywords

Pomalidomide 19171-19-8 Pomalidomide

Quick Details

Appearance:yellow powder
Application:Dietary supplements;Food;Additives;Pharmaceuticals;medicines;cosmetics Heart protection
PackAge:1kg/bag,5kg/bag,25kg/drum
ProductionCapacity:1|Kilogram|Day
Storage:20℃
Transportation:low temp

Superiority:

19171-19-8 - Physico-chemical Properties

Molecular Formula	C13H11N3O4
Molar Mass	273.24
Density	1.570±0.06 g/cm3(Predicted)
Melting Point	318.5 - 320.5°
Boling Point	582.9±45.0 °C(Predicted)
Flash Point	306.3°C
Solubility	DMSO:54 mg/mL (197.62 mM);Water :Insoluble;Ethanol :Insoluble mother liquor preservation: sub-packaging and freezing to avoid repeated freezing and thawing;-20 ℃,1 month;-80 ℃,6
Vapor Presure	1.41E-13mmHg at 25°C
Appearance	Light yellow to yellow solid
Color	yellow
Merck	14,135
pKa	10.75±0.40(Predicted)
Storage Condition	2-8°C
Stability	Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.
Refractive Index	1.691
Use	This product is for scientific research only and shall not be used for other purposes.
In vitro study	Pomalidomide inhibits lipopolysaccharide (LPS)-stimulated release by TNF-alpha, with IC50 values of 13 nM and 25 nM for human PBMC and total human blood, respectively. Pomalidomide inhibited IL-2 of stimulated T regulatory cells with an IC50 of ~ 1 μm. Treatment of human peripheral blood T cells with 6.4 nM-10 μm Pomalidomide increased production by IL-2 and was more effective on the CD4 + subset than on the CD8 + subset. Pomalidoride significantly promoted IFN-γ by CC-5013, IL-2, and IL-5 over IL-10, and slightly promoted IFN-γ over CC-5013. Pomalidomide acts on Jurkat cells to enhance the AP-1 transcriptional activity induced by SEE and Raji cells, up to 4-fold at 1 μm, in a dose-dependent manner. Treatment of Raji cells with different concentrations of pomalido IDE (2.5-40 μg/mL) for 48 hours resulted in a significant decrease in cell proliferation and DNA synthesis by-40% compared to the control group.
In vivo study	Pomalidomide acts on SCID mice to enhance the anticancer effect of Rituximab on B- cell lymphoma. The combination of pomalidoxide and Rituximab resulted in an average life span of 74 days in mice and 58 days in mice treated with CC5013/Rituximab. NK cell depletion completely abolished the synergistic effect of pomalidoride and Rituximab, indicating that the increase in NK cells is a mechanism by which pomalidoride enhances the anticancer effect of Rituximab.

introduction	pomalidomide (Pomalidomide) is a newly listed third-generation immunomodulator (Immuno-modulatorydrug,IMiD), developed by Celgene, USA. it is a drug modified and synthesized on the basis of the chemical structure of the first-generation IMiD thalidomide, it can enhance the immune response mediated by T cells and natural killer cells, inhibit the production of pro-inflammatory cytokines of monocytes, and induce tumor cell apoptosis. It has attracted extensive attention in the treatment of various malignant tumors and immune diseases.
features	compared with the first and second generation IMiD, pomalidomide is relatively more pharmacological, less toxic and better tolerated by patients. its good anti-angiogenesis, anti-tumor and anti-inflammatory effects have been widely recognized in the pre-clinical studies of multiple myeloma (Multiplemyeloma,MM).
Use	The chemical name of pomalidomide is 4-amino-2-(2, 6-dioxo-piperidine-3-yl)-Isodihydroindol-1, 3-dione, is a thalidomide analog, an immunomodulator with anti-tumor activity. In vitro cytology tests, it can inhibit the proliferation of hematopoietic tumor cells and induce apoptosis. In addition, pomalidomide can inhibit the proliferation of lenalidomide-resistant multiple myeloma cell lines and induce tumor cell apoptosis in cooperation with dexamethasone.
biological activity	Pomalidomide inhibit LPS-induced TNF-alpha release with IC50 of 13 nM.
in vitro study	Pomalidomide inhibit lipopolysaccharide (LPS)-stimulated TNF-alpha release, IC50 is 13 nM and 25 nM respectively when acting on human PBMC and all human blood. Pomalidomide inhibit IL-2-stimulated T regulatory cells, IC50 is ~ 1 μM. 6.4 nM-10 μM Pomalidomide to treat human peripheral blood T cells to increase IL-2 yield. It is more effective on CD4 + subsets than CD8 + subsets. Pomalidomide significantly promotes IL-2, IL-5, and IL-10 than CC-5013, and slightly promotes IFN-γ than CC-5013. Pomalidomide acts on Jurkat cells to enhance the AP-1 transcription activity induced by SEE and Raji cells, with a maximum of 4-fold enhancement at 1 μM. This effect is dose-dependent. Treatment of Raji cells with different concentrations of Pomalidomide(2.5-40 μg/mL) for 48 hours resulted in a significant decrease in cell proliferation and DNA synthesis, which was ~ 40% lower than that of the control group.
In vivo studies	Pomalidomide act on SCID mice to enhance the anti-cancer effect of Rituximab on B- cell lymphoma. The average lifespan of rats with Pomalidomide and Rituximab was 74 days, and that of rats treated with CC5013/Rituximab was 58 days. When NK cells are exhausted, the synergistic effect of Pomalidomide and Rituximab is completely abolished, indicating that the increase of NK cells is a mechanism that Pomalidomide enhances Rituximab cancer.
feature	Pomalidomide are Thalidomide derivatives, and the effect is 10,000 times stronger than Thalidomide.
Preparation	is to use 3-nitrophthalic anhydride as the starting material and react with 3-amino-2, 6-piperidinedione, and the prepared product is reduced by Pd/C in a hydrogen environment to obtain the target compound pomalidomide. Although the steps of the reaction route are short, 3-nitrophthalic anhydride is an unstable raw material, which is easy to hydrolyze and deteriorate during transportation or storage, the quality of the raw material is not guaranteed, and the reaction process is an intermittent reaction system., The degree of continuity is low, hydrogen is a high-risk gas, and the safety of the production environment is low.

Details:

Pomalidomide

CAS:

19171-19-8

MF:

C13H11N3O4

MW:

273.24

EINECS:

805-902-5

MDL No.:

MFCD12756407

Properties

Melting point:

318.5 - 320.5°

Boiling point:

582.9±45.0 °C(Predicted)

Density

1.570±0.06 g/cm3(Predicted)

storage temp.

2-8°C

solubility

DMSO: ≥14mg/mL

pka

10.75±0.40(Predicted)

form

powder

color

yellow

Merck

14,135

Stability:

Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.

InChI

InChI=1S/C13H11N3O4/c14-7-3-1-2-6-10(7)13(20)16(12(6)19)8-4-5-9(17)15-11(8)18/h1-3,8H,4-5,14H2,(H,15,17,18)

InChIKey

UVSMNLNDYGZFPF-UHFFFAOYSA-N

SMILES

C1(=O)C2=C(C(N)=CC=C2)C(=O)N1C1CCC(=O)NC1=O

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