Factory high qualit...

Factory high quality Monobenzone
Factory high quality Monobenzone

Factory high quality Monobenzone

Min.Order / FOB Price:Get Latest Price

1 Gram

FOB Price:USD 7.0000 -8.0000
  • Min.Order :1 Gram
  • Purity: purity 98%-101%
  • Payment Terms : L/C,T/T,Other

Keywords

Monobenzone 103-16-2 Monobenzone

Quick Details

  • Appearance:white powder
  • Application:Dietary supplements;Food;Additives;Pharmaceuticals;medicines;cosmetics Heart protection
  • PackAge:1kg/bag,5kg/bag,25kg/drum
  • ProductionCapacity:1|Metric Ton|Day
  • Storage:20°
  • Transportation:20

Superiority:

103-16-2 - Physico-chemical Properties

Molecular Formula C13H12O2
Molar Mass 200.23
Density 1,26 g/cm3
Melting Point 119-120 °C (lit.)
Boling Point 297.96°C (rough estimate)
Water Solubility slightly soluble
Solubility Soluble in alcohol, benzene and ether, almost insoluble in water.
Appearance White to white-like powder
Color Off-white to beige to brown
Merck 14,6248
BRN 1958305
pKa 10.29±0.15(Predicted)
Storage Condition Store below +30°C.
Refractive Index 1.5906 (estimate)
MDL MFCD00002333
Physical and Chemical Properties Melting point 117-122°C
Water solubility slightly soluble
Use Used as a pharmaceutical Intermediate

 

overview monobenzone is a topical decolorant used to treat hyperpigmentation, such as various stains, senile plaques, melanoma, etc., with obvious effect. It can decompose the melanin in the skin, prevent the formation of melanin in the skin, and restore the skin to a healthy color without destroying melanocytes. It is very light in toxicity. It is usually made into ointment or liniment and has been included in the United States Pharmacopoeia., my country has not yet produced. At present, there is no drug for stain treatment in our country, and the cosmetic effect for stain treatment is very little, and some cosmetics add a large amount of harmful substances such as hydroquinone and metal mercury to achieve the effect of removing freckle and whitening. The development of Monobenzong into freckle-removing drugs or cosmetics has good effects and low toxicity. It can meet the urgent needs of a large number of yellow people suffering from stains and will be welcomed by domestic and foreign markets.
application monobenzone (monobenzone) is a topical decolorant used to treat hyperpigmentation, such as various stains, senile plaques, melanoma, etc., with obvious effect. It can decompose melanin (melanin) in the skin, prevent the production of melanin in the skin, and restore the skin to a healthy color without destroying melanocytes. It is very light in toxicity. It is usually made into ointment or liniment and has been included in the United States Pharmacopoeia.
decolorizing agent 4-benzyloxyphenol is a topical decolorizing agent that can decompose melanin (melamin) in the skin, prevent the formation of melanin in the skin, restore healthy color to the skin, and does not destroy melanocytes, thus playing a role in decolorization. Clinically, it is mainly used to treat hyperpigmentation, such as various stains, senile plaques, vitiligo, melanoma, etc.
Preparation Monobenzong was synthesized with hydroquinone, sodium hydroxide and benzyl chloride as raw materials and N,N-dimethylformamide (DMF) as solvent under microwave radiation. The effects of molar ratio of reactants, microwave radiation power and radiation time on the yield of Monobenzone were investigated by single-factor experiment. The experimental results show that when n (benzyl chloride):n (hydroquinone):n (sodium hydroxide) = 1:1.4:1.4, DMF15mL, microwave radiation power 320W, radiation time 60s, the yield of monobenzong is 63.79%. 2.63g(0.028mol) of hydroquinone was added to a 100mL conical flask, 1.12g(0.028mol) of sodium hydroxide was weighed, 8mL of water was added, the sodium hydroxide was dissolved and then dropped into a conical flask containing hydroquinone, shaken well, 15mLDMF and 2.52g(0.02mol) of benzyl chloride were added, and the radiation reaction was 60s under the condition of 320W microwave radiation power. After the reaction, cool to room temperature. First, use 10% sodium hydroxide to be alkaline, filter, and wash the filter cake with 10% sodium hydroxide until the filtrate is colorless (the filter cake is hydroquinone bis benzyl ether, which can be recycled). The filtrate was acidified with hydrochloric acid to completely precipitate monobenzone. After suction filtration and ice water washing, it was recrystallized with alcohol and water and decolorized with activated carbon to obtain 2.55g white solid with a yield of 63.79%.
Use Used as a pharmaceutical intermediate
category toxic substances
toxicity classification poisoning
acute toxicity abdominal cavity-rat LD50:4500 mg/kg
stimulation data skin-guinea pig 5%/48 hours mild
flammability hazard characteristics combustible; combustion releases stimulating smoke
storage and transportation characteristics warehouse ventilation and low temperature drying; separate from food raw materials
fire extinguishing agent dry powder, foam, sand, carbon dioxide, mist water

Details:

Monobenzone

Mol Download Chemical properties

CAS:

103-16-2

MF:

C13H12O2

MW:

200.23

EINECS:

203-083-3

MDL No.:

MFCD00002333

Properties

Melting point:

119-120 °C (lit.)

Boiling point:

297.96°C (rough estimate)

Density 

1,26 g/cm3

refractive index 

1.5906 (estimate)

storage temp. 

Store below +30°C.

solubility 

Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)

pka

10.29±0.15(Predicted)

form 

Powder, Crystals, and/or Chunks

color 

Off-white to beige to brown

Water Solubility 

slightly soluble

Merck 

14,6248

BRN 

1958305

InChIKey

VYQNWZOUAUKGHI-UHFFFAOYSA-N

LogP

2.651 (est)

Xi'an Eastling biotech Co., Ltd. is dedicated to the research and development, production, and sales of natural plant extracts; With nearly 15 years of experience in identifying, researching, developing, and producing active ingredients for medicinal plants, we focus on providing innovative products and services to customers in industries such as pharmaceuticals, health food, and cosmetics.

 

Eastling Biotechnology has established a global direct harvesting system for plant raw materials, ensuring the high quality and authenticity of raw materials, while also protecting the continuity and diversity of plants; Having strong research and development capabilities, we can develop more effective and specialized plant active ingredients for the pharmaceutical, health food, and cosmetics industries; We have established an advanced quality control system, and the quality control of our products depends on advanced testing instruments and high-level technical experts. The effective combination of the two forms Eastling's ability to quickly and rigorously control product quality.

 

We have a production system that complies with Chinese GMP and American cGMP certifications, as well as advanced and optimized large-scale industrial production technology. In addition to producing specific products for Eastling Biotechnology, we also provide customized services to meet the characteristics and needs of different customers to produce customized products.

We believe that natural active ingredients are the foundation of our service to customers. Scientific and effective production technology is the foundation for us to provide customers with specialized products. We have the ability to serve customers in the pharmaceutical, health food, and cosmetics industries, provide new product solutions, and add new value to their products.

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