Factory high quality Dexamethasone

Min.Order / FOB Price:Get Latest Price

1 Gram	FOB Price:USD 6.0000 -9.0000

1 Gram

FOB Price:USD 6.0000 -9.0000

Min.Order :1 Gram
Purity: purity 98%-101%
Payment Terms : L/C,T/T,Other

Keywords

Dexamethasone 50-02-2 dexamethasone acetate

Quick Details

Appearance:white powder
Application:Dietary supplements;Food;Additives;Pharmaceuticals;medicines;cosmetics Heart protection
PackAge:1kg/bag,5kg/bag,25kg/drum
ProductionCapacity:1|Kilogram|Day
Storage:20℃
Transportation:low temp

Superiority:

50-02-2 - Physico-chemical Properties

Molecular Formula	C22H29FO5
Molar Mass	392.47
Density	1.1283 (estimate)
Melting Point	262-264 °C (lit.)
Boling Point	568.2±50.0 °C(Predicted)
Specific Rotation(α)	75 º (c=1, dioxane)
Flash Point	9℃
Water Solubility	10 mg/100 mL (25 ºC)
Solubility	ethanol: 1mg/mL
Vapor Presure	2.81E-15mmHg at 25°C
Appearance	White crystalline solid
Color	off-white
Merck	14,2943
BRN	2066651
pKa	12.13±0.70(Predicted)
Storage Condition	2-8°C
Stability	Stable. Combustible. Incompatible with strong oxidizing agents, strong bases, acid anhydrides, acid chlorides. May be light sensitive.
Sensitive	Light Sensitive
Refractive Index	76 ° (C=1, Dioxane)
MDL	MFCD00064136
Physical and Chemical Properties	Melting point 255-264°C specific rotation 75 ° (c = 1, dioxane) water-soluble 10 mg/100 mL (25°C)
Use	Mainly used for anti-inflammatory and anti-allergic, suitable for rheumatoid arthritis and other collagen diseases

introduction	dexamethasone is one of the commonly used drugs in clinic. It is often used with other drugs in clinical practice. It has anti-inflammatory, anti-toxic and anti-allergic effects. However, it has no therapeutic effect on the disease and can only reduce or inhibit the manifestations of inflammation. Therefore, we must pay attention to it in clinical medication. Generally, it is not used alone and must be used in conjunction with other drugs to play a better role. The anti-inflammatory effect of this product and the effect of controlling skin allergy are more significant than prednisone, but it has a slight effect on water and sodium retention and promoting potassium excretion, and has a stronger inhibitory effect on the pituitary-adrenal cortex axis. Intramuscular injection of dexamethasone sodium phosphate or dexamethasone acetate, respectively in 1 hour or 8 hours of blood concentration peak.
traits	acetate is commonly used, which is white or white-like crystal or crystalline powder. No odor, slightly bitter taste. Soluble in acetone, dissolved in methanol or absolute ethanol, slightly soluble in ethanol or chloroform, slightly soluble in ether, insoluble in water. Its sodium phosphate salt is easily soluble in water.
use	dexamethasone (dexamethasone sodium phosphate EP impurity A) is a glucocorticoid used as an anti-inflammatory agent. Dexamethasone regulates T cell survival, growth and differentiation. Dexamethasone inhibits the induction of nitric oxide synthase. Mainly used for anti-inflammatory and anti-allergic, suitable for rheumatoid arthritis and other collagen diseases.
Pharmacological effects	Dexamethasone (Dexamethasone,DSMS), also known as flumesong, fluometholone, and Desameisone, is a synthetic adrenal cortex hormone. It is glucocorticoid anti-inflammatory and anti-allergic drugs. Its pharmacological effects are mainly anti-inflammatory, anti-toxic, anti-allergic, anti-rheumatic, and it is widely used clinically. In recent years, the European Union believes that eating beef containing hormones such as estradiol, progesterone, and medroxyprogesterone can disrupt the normal functions of the human endocrine, growth and development, immune system, and reproductive system, and may also cause cancer and teratogenicity. Therefore, the use of such hormones in animals is prohibited. In addition, dexamethasone is also used as an animal growth regulator to promote animal protein synthesis and metabolism, and increase meat production. It has been widely used as livestock, poultry, and use. However, through long-term laboratory studies, it has been found that dexamethasone can cause cancer and gene mutations in experimental animals. Dexamethasone and its residues have obvious side effects on humans and animals. The use of high doses of dexamethasone can cause muscle atrophy, Growth inhibition and other side effects. It is inferred from this that human beings can also undergo canceration and gene mutation in livestock and poultry that use such drugs for a long time or eat such growth promoting agents for a long time. Therefore, such drugs are prohibited from being used in treatment and feed.
Side effects	Dexamethasone is a synthetic adrenal cortex hormone, which belongs to long-acting glucocorticoid drugs. Glucocorticoids can promote the metabolism of three major nutrients. At the same time, it can prevent protein synthesis. Long-term external use can lead to more serious consequences, but the adverse reactions are much smaller than oral medication, common systemic glucocorticoid side effects include: stomach discomfort, increased sensitivity to gastric ulcer. increased appetite, resulting in significant weight gain. Potential diabetic patients: Glucose intolerance is an aggravation of the patient's original diabetes. Mental illness, including personality changes, irritability, excitement, mania. long-term treatment of osteoporosis: pathological fracture (such as hip joint). Elevated liver enzymes, fatty hepatolenticular degeneration (usually reversible). Long-term high-dose medication for patients with nephrotic syndrome is easy to cause gastrointestinal ulcers, aseptic necrosis of the femoral head and other major side effects. It is better to treat nephrotic syndrome with prednisone acetate tablets. Dexamethasone can be used to treat high altitude cerebral edema and pulmonary edema. People use it during mountaineering expeditions to alleviate altitude sickness. Combined with marbofloxacin, clotrimazole, etc. to treat ear infections or allergies in dogs or birds.
drug interaction	(1) oral antacids can reduce gastrointestinal absorption of dexamethasone. (2) amloxide can inhibit the function of adrenal cortex, accelerate the metabolism of this drug, and shorten its half-life. Hydrocortisone can be used in patients who use amloxide for corticosteroids. (3) Dexamethasone can weaken the effects of oral hypoglycemic drugs, anticoagulants and neuromuscular blockers, and the dosage should be adjusted. (4) barbiturates, phenytoin and rifampicin will weaken the metabolic promotion of dexamethasone. (5) Dexamethasone can increase the toxicity of salicylic acid. (6) Dexamethasone is antagonistic to vitamin A and should be avoided.
Production method	A new production process method of dexamethasone 21-hydroxyl, using intermediate 21-acetate as the substrate and containing 0 ~ 10% chloroform The appropriate amount of methanol is used as a solvent to semi-dissolve the substrate, and alkali is used as a catalyst for hydrolysis reaction. After the reaction is complete, it is neutralized with acetic acid, concentrate the reaction solution under reduced pressure to an appropriate volume, cool down, filter, rinse the filter cake with water, and dry to obtain 21-hydroxyl. The process can shorten the production cycle, improve the quality and yield of 21-hydroxyl, and reduce the content of impurities in 21-hydroxyl.

Details:

Dexamethasone

CAS:

50-02-2

MF:

C22H29FO5

MW:

392.47

EINECS:

200-003-9

MDL No.:

MFCD00064136

Properties

Melting point:

262-264 °C (lit.)

alpha

75 º (c=1, dioxane)

Boiling point:

568.2±50.0 °C(Predicted)

Density

1.1283 (estimate)

refractive index

76 ° (C=1, Dioxane)

Flash point:

9℃

storage temp.

2-8°C

solubility

ethanol: 1 mg/mL

pka

12.13±0.70(Predicted)

form

powder

color

off-white

Water Solubility

10 mg/100 mL (25 ºC)

Sensitive

Light Sensitive

Merck

14,2943

BRN

2066651

BCS Class

1 (CLogP), 3 (LogP)

Stability:

Stable. Combustible. Incompatible with strong oxidizing agents, strong bases, acid anhydrides, acid chlorides. May be light sensitive.

InChIKey

UREBDLICKHMUKA-CXSFZGCWSA-N

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