BIBW2992 DiMaleate

BIBW2992 DiMaleate
BIBW2992 DiMaleate
BIBW2992 DiMaleate
BIBW2992 DiMaleate
BIBW2992 DiMaleate

BIBW2992 DiMaleate

Min.Order / FOB Price:Get Latest Price

0 Metric Ton

Negotiable

  • Min.Order :0 Metric Ton
  • Purity: 99%

Keywords

BIBW 2992MA2 BIBW2992 DiMaleate BIBW2992 DiMaleate

Quick Details

  • Appearance:white powder
  • Application:Pharma;Industry;Agricultural;chemical reaserch
  • PackAge:25kg,50kg,180kg,200kg,250kg,1000kg，customization
  • ProductionCapacity:15|Metric Ton|Month
  • Storage:Keep it in dry,shady and cool place
  • Transportation:Transit could be DHL,UPS,TNT,EMS,Fedex,and so on. For mass orders, it will be delivered by air or sea. For small order, please expect 3-7 days by UPS DHL EMS. For mass order, please allow 5-8 days.

Superiority:

1,we produce and sell good chemicals around the world.
2,our success rate is about 95%. this means, if customer order is accepted, the probability that the customer will obtain the ordered substances, is 95%.
3,our staff consists of highly qualified individuals with bsc, msc and ph.d degrees in chemistry, as well as excellent carbohydrates,nucleosides, small molecules and rare chemicals.
4,imaginechem's chemists are skilled at performing complex, multi-step syntheses and solving difficult chemistry-related problems. because of our better, concentracted size and low overheads, we are able to offer prompt quotations, very competitive prices, high quality products and fast delivery.
5,all chemicals are typically >97% for building blocks, the structure and purity is confirmed by nmr and lc-ms. intermediates and final products are analyzed by gc, hplc, ir, nmr, ms, elemental analysis, atom-absorpting analysis and crystallographical methods.
165,Customers-oriented strategy, exclusive supply chain management, professional R&D team, experienced production workers, energetic sales team enable us to offer best service andgood-value products to all of our customers and gradually reach our final goals: becoming global leading supplier for portable products and solutions.

Details:

Product Name:    Afatinib dimaleate
Synonyms:    BIBW2992 DiMaleate;BIBW2992-MA2;Afatinib (diMaleate);Afatinib (diMaleate), BIBW2992;2-ButenaMide, N-[4-[(3-chloro-4-fluorophenyl)aMino]-7-[[(3S)-tetrahydro-3-furanyl]oxy]-6-quinazolinyl]-4-(diMethylaMino)-, (2E)-, (2Z)-2-butenedioate (1:2);(2E)-N-(4-[(3-chloro-4-fluorophenyl)aMino]-7-{[(3S);Afatinib double Maleate;Afatinib (BIBW2992) Dimaleate
CAS:    850140-73-7
form     Solid
color     White to Pale Yellow
Description    Afatinib dimaleate was approved by the U.S. Food and Drug Administration (FDA) in 2013 for the treatment of non-small cell lung cancer (NSCLC). Specifically, it was approved for patients presenting with metastatic NSCLC tumors which contain epidermal growth factor receptor (EGFR) exon deletions or exon 21 mutations. Afatinib dimaleate is a covalent inhibitor of ErbB tyrosine kinases (tyk), which downregulates ErbB signaling by irreversible binding of EGFR tyk binding sites. While no manufacturing route has been disclosed to date, the most scalable published route likely derives from two Boehringer Ingelheim patents.

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