Ponatinib Hydrochlo...

Ponatinib Hydrochloride
Ponatinib Hydrochloride
Ponatinib Hydrochloride
Ponatinib Hydrochloride
Ponatinib Hydrochloride

Ponatinib Hydrochloride

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0 Metric Ton

Negotiable

  • Min.Order :0 Metric Ton
  • Purity: 99%

Keywords

3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)benzamide hydrochloride Ponatinib Hydrochloride Ponatinib Hydrochloride

Quick Details

  • Appearance:white powder
  • Application:Pharma;Industry;Agricultural;chemical reaserch
  • PackAge:25kg,50kg,180kg,200kg,250kg,1000kg，customization
  • ProductionCapacity:15|Metric Ton|Month
  • Storage:Keep it in dry,shady and cool place
  • Transportation:Transit could be DHL,UPS,TNT,EMS,Fedex,and so on. For mass orders, it will be delivered by air or sea. For small order, please expect 3-7 days by UPS DHL EMS. For mass order, please allow 5-8 days.

Superiority:

1,we produce and sell good chemicals around the world.
2,our success rate is about 95%. this means, if customer order is accepted, the probability that the customer will obtain the ordered substances, is 95%.
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Details:

Product Name:    Ponatinib Hydrochloride
Synonyms:    AP24534 Mono-hydrochloride;Ponatinib Mono-hydrochloride;3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)benzamide hydrochloride;Ponatinib hydrochloride;Ponatinib-HCl;AP24534-HCl;3-(2-(Imidazo[1,2-b]pyridazin-3-yl)ethynyl)-4-methyl-n-(4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl)benzamide hydrochloride;Ponatinib Hyd
CAS:    1114544-31-8
form     A solid
color     Off-white to light yellow
Description    In December 2012, the US FDA approved ponatinib (also referred to as AP 24534) for the treatment of adult patients with chronic phase, accelerated phase, or blast phase chronicmyeloid leukemia (CML). Ponatinib is a pan-Bcr–Abl TKI that blocks both the native (IC50=0.4 nM) and Bcr– AblT315I mutated kinases (IC50=2.0 nM) in addition to othermutated kinases in CML patients. In the Ba/F3 cell proliferation assay, ponatinib inhibits ABL and the T315I Abl mutant with IC50s of 1.2 and 8.8 nM, respectively. Ponatinib was identified by a structure-based drug design approach. Ponatinib binds to the kinase domain in a DFG-out conformation; the ethynyl moiety helps the inhibitor evade the mutant gatekeeper isoleucine residue at position 315. In addition to Abl and the T315I mutant of Abl, ponatinib inhibits VEGFR, PDGFR, FGFR, SRC, KIT, RET, TIE2, FLT3, and EPH receptors at concentrations ranging from0.1 to 20 nM.

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