1-Adamantanamine hydrochloride

Min.Order / FOB Price:Get Latest Price

1 Kilogram	Negotiable

1 Kilogram

Negotiable

Min.Order :1 Kilogram
Purity: 98%
Payment Terms : T/T,

Keywords

665-66-7 1-Adamantanamine hydrochloride adamantane

Quick Details

Appearance:almost white powder
Application:665-66-7
PackAge:25kg/drum
ProductionCapacity:50|Metric Ton|Year
Storage:AMB
Transportation:665-66-7

Superiority:

Molecular Structure:
Molecular Formula: C₁₀H₁₈ClN
Molecular Weight: 187.71g/mol
CAS NO: 665-66-7
Mol File: 665-66-7.mol
EINECS: 211-560-2
H bond acceptors: 1
H bond donors: 2
Freely Rotating Bonds: 1
Polar Surface Area: 3.24 Å²
Melting Point: >300 °C(lit.)
Boiling point: 225.7 °C at 760 mmHg
Flash Point: 96 °C
Water Solubility: 50 mg/mL
Sensitive: Hygroscopic
Enthalpy of Vaporization: 46.22 kJ/mol
Vapour Pressure: 0.0852 mmHg at 25°C
Appearance: Crystalline Solid
IUPAC Name: Adamantan-1-amine hydrochloride
InChI : InChI=1/C10H17N.ClH/c11-10-4-7-1-8(5-10)3-9(2-7)6-10;/h7-9H,1-6,11H2;1H
Smiles: Cl.C1C2CC3CC1CC(C3)(C2)N
Product Categories of Amantadine hydrochloride (CAS NO.665-66-7): Adamantane derivatives; chiral; Adamantanes; Intermediates & Fine Chemicals; Pharmaceuticals; API's; Dopamine receptor

Details:

Amantadine hydrochloride (CAS NO.665-66-7) is used as NMDA-receptor antagonist.

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
dog	LD50	intravenous	37mg/kg (37mg/kg)	BEHAVIORAL: TREMOR BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: DYSPNEA	Toxicology and Applied Pharmacology. Vol. 15, Pg. 642, 1969.
guinea pig	LD50	oral	360mg/kg (360mg/kg)	BEHAVIORAL: TREMOR LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD	Toxicology and Applied Pharmacology. Vol. 15, Pg. 642, 1969.
man	LDLo	oral	28571ug/kg (28.571mg/kg)	BEHAVIORAL: TOXIC PSYCHOSIS LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMA BLOOD: HEMORRHAGE	American Journal of Psychiatry. Vol. 145, Pg. 267, 1988.
man	LDLo	oral	286mg/kg (286mg/kg)	BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS" BEHAVIORAL: EXCITEMENT BEHAVIORAL: TOXIC PSYCHOSIS	American Journal of Psychiatry. Vol. 145, Pg. 267, 1988.
man	TDLo	oral	13mg/kg/5D-I (13mg/kg)	BEHAVIORAL: EUPHORIA BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS"	American Journal of Psychiatry. Vol. 143, Pg. 1170, 1985.
man	TDLo	oral	24mg/kg/1D-I (24mg/kg)	BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS" BEHAVIORAL: EXCITEMENT	Annals of Emergency Medicine. Vol. 19, Pg. 668, 1990.
mouse	LD50	intraperitoneal	198mg/kg (198mg/kg)		Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 19, Pg. 164, 1988.
mouse	LD50	intravenous	95mg/kg (95mg/kg)		Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 19, Pg. 164, 1988.
mouse	LD50	oral	700mg/kg (700mg/kg)	BEHAVIORAL: TREMOR BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES	Toxicology and Applied Pharmacology. Vol. 15, Pg. 642, 1969.
mouse	LD50	subcutaneous	290mg/kg (290mg/kg)		Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 19, Pg. 164, 1988.
rat	LD50	intraperitoneal	150mg/kg (150mg/kg)	BEHAVIORAL: TREMOR LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD	Toxicology and Applied Pharmacology. Vol. 15, Pg. 642, 1969.
rat	LD50	intravenous	90mg/kg (90mg/kg)		Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 19, Pg. 164, 1988.
rat	LD50	oral	800mg/kg (800mg/kg)		Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 19, Pg. 164, 1988.
rat	LD50	subcutaneous	500mg/kg (500mg/kg)		Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 13, Pg. 1269, 1971.
women	LDLo	oral	50mg/kg (50mg/kg)	BEHAVIORAL: COMA CARDIAC: PULSE RATE INCREASE WITHOUT FALL IN BP CARDIAC: PULSE RATE	American Journal of Medicine. Vol. 77, Pg. 388, 1984.

Safety Information of Amantadine hydrochloride (CAS NO.665-66-7):
Hazard Codes: Xn Harmful
Risk Statements: 22-40-20/21/22
20: Harmful by inhalation
21: Harmful in contact with skin
22: Harmful if swallowed
40: Limited evidence of a carcinogenic effect
Safety Statements: 22-36/37-36
22: Do not breathe dust
36: Wear suitable protective clothing
37: Wear suitable gloves

The chemical synonyms of Amantadine hydrochloride (CAS NO.665-66-7): 1-Adamantanamine hydrochloride ; AI3-52211 ; Adamantanamine hydrochloride ; Adamantine hydrochloride ; Amantadine HCl ; Amantan ; Amazolon ; Aminoadamantane hydrochloride ; EXP 105-1 ; GP 38026 ; Influenol ; Mydantane ; NSC 83653 ; Symmetrel ; Trivaline ; UNII-M6Q1EO9TD0 ; Tricyclo(3.3.1.1(sup 3,7))decan-1-amine, hydrochloride (9CI) ; Tricyclo(3.3.1.13,7)decan-1-amine, hydrochloride .

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