Phenol, 4-[6-[[4-(trifluoromethoxy)phenyl]amino]-4-pyrimidinyl]-

Details:

Common name: Phenol, 4-[6-[[4-(trifluoromethoxy)phenyl]amino]-4-pyrimidinyl]-

Category:PROTAC functional molecule

Other name: 4-(6-{[4-(trifluoromethoxy)phenyl]amino}pyrimidin-4-yl)phenol

CAS No.: 2489876-34-6

EINECS No.: /

Appearance: Solid

Molecular formula: C17H12F3N3O2

 

Brand Name: Colorcom

Shelf Life: 2 Years

Place of Origin: China

 

Product Specification:

Molecular Weight	347.29
Boiling point	481.0±45.0 °C(Predicted)
Melting point	/
Density	1.411±0.06 g/cm3(Predicted)
Purity	≥99.0%
PH	/
Acidity coefficient (pKa)	8.18±0.30(Predicted)
Soluble	/
Water solubility	/
Color	White

 

 

Product Description:
Phenol, 4 - [6 - [[4 - (trifluoromethoxy)phenyl]amino]-4 - pyrimidinyl]- is often presented as a fine powder, typically in a white to off - white color. Structurally, it combines a phenol moiety with a pyrimidine ring. The pyrimidine ring is further substituted at the 6 - position with an amino group that is attached to a 4 - (trifluoromethoxy)phenyl group. This unique chemical structure endows the compound with distinct properties. The presence of the trifluoromethoxy group on the phenyl ring not only imparts hydrophobic and electron - withdrawing characteristics but also affects the compound's reactivity and solubility. The phenol group, on the other hand, provides a reactive hydroxyl group that can participate in various chemical reactions such as esterification and etherification.

In terms of solubility, it has limited solubility in water due to the hydrophobic nature of the trifluoromethoxy - substituted phenyl and pyrimidine moieties. However, it shows better solubility in organic solvents like chloroform, dichloromethane, and N,N - dimethylformamide (DMF). In chemical reactions, the amino group on the pyrimidine ring and the hydroxyl group of the phenol can engage in nucleophilic substitution reactions, making it a versatile intermediate in organic synthesis.

In the fields of pharmaceutical and agrochemical research, this compound holds significant importance. It can be used as a key intermediate for the synthesis of various bioactive molecules. For example, in drug discovery, it may serve as a starting material for the development of novel pharmaceuticals targeting specific biological pathways. In agrochemicals, it could potentially be involved in the synthesis of pesticides or herbicides with unique modes of action. To ensure its quality and stability, it should be stored in a cool, dry place, away from strong oxidizing agents and sources of heat and light.

 

Application: 

Phenol, 4 - [6 - [[4 - (trifluoromethoxy)phenyl]amino]-4 - pyrimidinyl]- is used as a key intermediate in organic synthesis. In pharmaceutical research, it serves as a starting material for developing novel drugs targeting specific biological pathways. In agrochemicals, it may be involved in synthesizing pesticides or herbicides with unique action modes.

Package: 25kg/drum or bag

Storage: Keep in dark place, Inert atmosphere, 2-8°C

Executive Standards: International Standard.