lose weight cosmetic Factory direct supply
Best quality, most competitive price. Fast shipment, on-time delivery. One-to-one business communication. OEM/ODM available. We provide convenient one-stop purchasing service. Our professional and thoughtful after-sales service can eliminate your worries. We have many years of export experience in API products and strictly select raw materials.
What is semaglutide?
Semaglutide is the newest GLP-1R agonist and was approved by the FDA in late 2017 as a once-weekly injection for the treatment of type 2 diabetes. The peptide is chemically similar to liraglutide but contains two structural modifications (Lau, Bloch, et al., 2015). First, glycine is replaced at position 2 with the non-proteinogenic amino acid 2-aminoisobutyric acid (Aib). Second, octadecanedioic acid is linked to the side chain of lysine-26 via a short polyethylene glycol (PEG) spacer and a gamma-glutamic acid linker. The amino acid substitutions render the peptide more resistant to DPP-4 than liraglutide, and the presence of the 18-carbon fatty acid moiety results in a high binding affinity to serum albumin, which translates into a half-life of approximately 7 days in humans.
About|Contact|Cas|Product Name|Molecular|Country|Encyclopedia
Message|New Cas|MSDS|Service|Advertisement|CAS DataBase|Article Data|Manufacturers | Chemical Catalog
©2008 LookChem.com,License: ICP
NO.:Zhejiang16009103
complaints:service@lookchem.com Desktop View