Ivermectin

Details:

Chinese alias
Ivermectin
ivermectin
Ivermectin
22,23-dihydroAbamidine
English alias
22,23-DIHYDROAVERMECTIN B1
22,23-DIHYDROAVERMECTINE
CARDOMEC
EQVALEN
heartgard-30
IVERMECTIN
IVERMECTINE
IVOMEC
hyvermectin
mk-0933
mk933
IVERMECTIN HCL
Ivermectin EP2000
IVERMECTIN NOT LESS THAN 93.0% OF 22,23-DIHY- DROAVERMECTIN B1A, AND NOT LESS THAN 97.0% OF 22,23-DIHY-DROAVERMECTIN B1(B1A+B1B)
IVERMECTIN EP(CRM STANDARD)
IVERMECTIN USP(CRM STANDARD)
IvermectineEp2000
IVERMECTINE(PATENT-NOSUPPLY)
22,23-Dihydro C-076B1
Ivosint
Category
Raw materials: anti filariasis and anti leishmaniasis drugs
Physical and Chemical Properties
Appearance: Ivermectin contains at least 80% of 22,23-dihydroavermectin B1a. And no more than 20% of 22,23-dihydroavermectin B1b. Class white powder. [α] D+71.5 °± 3 ° (C=0.755, chloroform). UV maximum absorption (methanol): 238245 nm (ε 2710030100). The solubility in water is about 4 μ g/ml. Highly soluble in methyl ethyl ketone, propylene glycol, or polypropylene glycol, insoluble in saturated hydrocarbons such as cyclohexane.
B1a：[71827-03-7]。 Crystallize from ethanol water with a melting point of 155-157 ℃.
Specific rotation D+71.5 ± 3 ° (c=0.755 in chloroform)
RTECS number IH7891500
Storage conditions 2-8 ° C
Storage conditions 2-8 ° C
Solubility H2O: ≤ 1.0% KF
Solubility H2O: ≤ 1.0% KF
Form powder
color white
Water solubility 4mg/L (temperature not stated)
BCS Class4/3
Stable DMSO or ethanol solution can be stored stably for 3 months at -20 ° C.
InChIKeyAZSNMRSAGSSBNP-XPNPUAGNSA-N
CAS Database 70288-86-7 (CAS Data Base Reference)
EPA Chemical Substance Information Ivermectin (70288-86-7)
safety data
GHS hazard pictograms GHS hazard pictograms
GHS06,GHS09
Warning word danger
Hazard Description H300-H311-H410
Preventive instructions P264-P270-P273-P280-P301+P310-P302+P352+P312
Dangerous goods symbol T, Xn, T+
Dangerous goods symbol T, Xn
Hazard category code 61-25-36-36/38-22
Hazard category code 61-25-36-36/38-22-28
Safety instructions 53-26-45-36
Safety instructions 53-26-45-36-36/37-28
Dangerous goods transport number UN 2811 6.1/PG 2
Dangerous goods transport number UN 2811 6.1/PG 2
WGK Germany3
WGK Germany3
Hazard level 6.1 (a)
Packaging Category II
Customs code 29322090
toxicity LD50 in dogs, rhesus monkeys (mg/kg): about 80, more than 24 orally. (MSDS Merck & Co. Inc., 2003)
application area 

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