Praziquantel

Superiority:

Praziquantel has a good anti worm (flatworm) effect.
Related categories
Signal pathways>>Anti infection>>Parasitic organisms
Research Fields>>Infection
references
[1]. Coeli, R., et al., Praziquantel treatment decreases Schistosoma mansoni genetic diversity in experimental infections. PLoS Negl Trop Dis, 2013. 7(12): p. e2596.

[2]. Mekonnen, A., et al., Efficacy of Praziquantel against Schistosoma haematobium in Dulshatalo village, western Ethiopia. BMC Res Notes, 2013. 6: p. 392.

Physical and chemical properties of praziquantel
Density 1.2 ± 0.1 g/cm3
Boiling point 544.1 ± 50.0 ° C at 760 mmHg
Melting point 136-142 º C
Molecular formula C19H24N2O2
Molecular weight 312.406
Flash point 254.6 ± 22.5 ° C
Accurate quality 312.183777
PSA    40.62000
LogP    2.44
Appearance: White or almost white crystalline powder
Steam pressure 0.0 ± 1.5 mmHg at 25 ° C
Refractive index 1.615
Storage conditions
Sealed and stored at -20 º C

stability
If used and stored according to specifications, it will not decompose and there are no known hazardous reactions

SOLUBLE     ethanol: soluble5mg/mL | Freely soluble in ethanol or dichloromethane. Slightly soluble in water
computational chemistry
1. Reference value for hydrophobic parameter calculation (XlogP): 2.7

2. Number of hydrogen bond donors: 0

3. Number of hydrogen bond acceptors: 2

4. Number of rotatable chemical bonds: 1

5. Number of tautomers: 2

6. Topological molecular polarity surface area 40.6

7. Number of heavy atoms: 23

8. Surface charge: 0

9. Complexity: 472

10. Number of isotopic atoms: 0

11. Determine the number of atomic stereocenters: 0

12. Uncertain number of atomic stereocenters: 1

13. Determine the number of chemical bond stereocenters: 0

14. Number of uncertain chemical bond stereocenters: 0

15. Number of covalent bond units: 1

more
1. Appearance: White or off white crystalline powder, odorless, slightly bitter in taste, hygroscopic.

2. Density (g/mL, 25 º C): undetermined

3. Relative vapor density (g/mL, air=1): not determined

4. Melting point (º C): 136-138

5. Boiling point (º C): 544

6. Boiling point (º C, 9mm Hg): undetermined

7. Refractive index: undetermined

8. Flash point (° C): undetermined

9. Specific rotation (º C): not determined

10. Spontaneous combustion point or ignition temperature (º C): not determined

11. Vapor pressure (kPa, 25 º C): 7E-12 (25 ° C)

12. Saturated vapor pressure (kPa, 60 º C): not determined

13. Combustion heat (KJ/mol): undetermined

14. Critical temperature (º C): not determined

15. Critical pressure (KPa): undetermined

16. Logarithmic value of oil-water (octanol/water) partition coefficient: undetermined

17. Explosion upper limit (%, V/V): undetermined

18. Lower explosive limit (%, V/V): not determined

19. Solubility: soluble in dimethyl sulfoxide, insoluble in ether
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