Add time:07/16/2019         Source:sciencedirect.com

Quantitative analysis of carboxylic acids in hydrophilic matrixes remains a challenge despite the introduction of derivatization reagents for carboxylic acids nearly three decades ago. Analysis of many bifunctional ester forming polymer cross-linkers are additionally complicated by the their amphiphatic character. We report a sensitive and selective HPLC method to quantify organic dicarboxylic acids resulting from the hydrolytic degradation of cross-linked carbohydrate polyesters. An important group of cross-linkers encompassing C7–C10 aromatic and non-chromophoric aliphatic diacid chlorides were investigated. Specific validation is reported for terephthalic acid, diethylmalonic acid and sebacic acid. Linear calibration curves were obtained in the 0.5–15.0 μg/ml range corresponding to a mass fraction of 0.05–1.5% diacid to polyester. The accuracy and precision in this range was 94.4–114.1 and 6.1–24.8% RSD, respectively. This method is suitable for the routine determination of the molar or mass degree of substitution in carbohydrate polyesters.

We also recommend Trading Suppliers and Manufacturers of DIETHYLMALONIC ACID (cas 510-20-3). Pls Click Website Link as below: cas 510-20-3 suppliers