The reactivity of neopentyl iodide with coadsorbed hydrogen or deuterium on a Pt(1 1 1) single-crystal surface was studied by temperature programmed desorption (TPD). It was determined that the neopentyl surface groups resulting from an early C–I bond scission are easily hydrogenated to neopent...

The chemistry of neopentyl iodide on Pt(1 1 1) single-crystal surfaces was characterized by temperature programmed desorption and reflection-absorption infrared spectroscopy. As with many other halo hydrocarbons, the first thermal reaction observed with neopentyl iodide on the platinum surface i...

Alkyl iodides give products from the neopentyl rearrangement on reaction with xenon difluoride. Neopentyl iodide performs a double rearrangement and yields a gem-difluoro product, 2,2-difluoro-3-methylbutane. Studies of the mechanism show that an alkene intermediate is involved in the double rea...

Neopentyl iodide (NpI) has been shown to be an inefficient carbon-doping source for GaAs and AlGaAs, but is some two orders of magnitude more efficient in AlAs. This difference in NpI doping behaviour is attributed to a significant difference in the surface chemistry of NpI on AlAs, possibly due...

1-(3-Chlorophenyl)-3-(5-chlorothiophen-2-yl)-5-phenyl-4,5-dihydro-1H-pyrazole was synthesized by condensation/cyclisation reaction of (E)-1-(5-chlorothiophen-2-yl)-3-phenylprop-2-en-1-one and (3-chlorophenyl)hydrazine hydrochloridein the presence of 3–4 drops of conc. hydrochloric acid in methy...

Several 2-(2-chlorophenyl)-1-phenylethanones and (2-chlorophenyl)(phenyl)methanones were prepared by the Friedel–Crafts acylation reaction of 2-(2-chlorophenyl) acetic acids and 2-chlorocarboxylic acids, respectively, in the presence of cyanuric chloride, pyridine, and AlCl3 or FeCl3 using micr...

Two new coordination complexes containing 5-(4-chlorophenyl)tetrazolato (4-Clptz) and polypyridyl ligands, [Cu2(bipy)2(4-Clptz)4] [1, bipy = 2,2′-bipyridine] and [Cu2(phen)2(4-Clptz)4] [2, phen = 1, 10 phenanthroline] have been synthesized following metal ligated [2 + 3] cycloaddition reaction ...

Cumulative dose-response curves were constructed to determine the comparative potency of pipecuronium and pancuronium. From these, the ED50 and ED95 values were calculated. These were 24.96 πg kg−1 and 44.96 μg kg−1, respectively, for pipecuronium and 30.42 μg kg−1 and 61.12 μg kg−1, respect...

The effect of pancuronium bromide on the canine myocardium was studied by observing several indices of myocardial contractility during i.v. and intracoronary infusion of the drug in an anaesthetized, open-chested dog preparation. Pancuronium produced tachycardia when given for 2 min by i.v. and ...

This paper reports on 12 patients in a 3-year period (from 1st July 1980 to 1st July 1983) who were treated with artificial ventilation and with the muscle relaxant pancuronium bromide (Pavulon®), over a period of 6 days or longer. After discontinuation of this drug these patients developed seve...

Pancuronium bromide (10−7 to 10−4 M) failed to produce contraction of the isolated rat vas deferens. Also, no contractions were seen when the animals were pretreated with an MAO inhibitor (iproniazid 80 mg/kg, p.o.). On the other hand, pancuronium bromide (10−6 to 10−4 M) produced 1.62- to 2.65-...

The interaction between two non-depolarizing neuromuscular blocking agents, pancuronium bromide and vecuronium bromide, has been studied at standardized levels of neuromuscular blockade and alternating the sequence of their administration, in 40 surgical patients. The drug administered first app...

Intravascular fetal transfusion can be complicated by difficulty in maintaining vascular access because of fetal movements. Treatment by intramuscular pancuronium bromide has been proposed as a means of arresting fetal movements, although this treatment requires a separate puncture for injection...

The interaction between the steroidal neuromuscular blocking agent pancuronium bromide and two anaesthetic agents was investigated in cats. Thiopentone or halothane reduced the effective neuromuscular blocking dose of pancuronium bromide. Under the influence of these the block anaesthetics induc...

Because of recurrent needle dislodgement secondary to fetal movement, we have altered our intravascular transfusion technique by replacing maternal premedication (meperidine and diazepam [group 1]) with fetal intravascular infusion of pancuronium bromide (Pavulon [group 2]), a nondepolarizing ne...

N,N-Bis(halomethyldimethydimethylsilyl)acetamides, MeCON(SiMe2CH2X)2, (X = Cl, Br) were prepared by transsilylation of N,O-bis(trimethylsilyl)acetamide with halomethyldimethylchlorosilane. With water and methanol, instead of the expected SiN cleavage, nucleophilic substitution of halogen took ...

Trimethylsilylation of secondary amines by the common reagent N,O-bis(trimethylsilyl)trifluoroacetamide (BSTFA) in the presence of dimethylformamide (DMF) produces the previously unknown N-(aminomethylene)-2,2,2-triftuoroacetamide (AMT) derivative, in addition to the trimethylsilyl derivative. T...

A new synthesis of N,N-bis(trimethylsilyl)enamines from straight chain olefinic amines has been devised which makes use of iron pentacarbonyl photocatalysed isomerisation. Complete conversion of the olefinic amines to the enamines was observed for substituted N,N-bis(trimethylsilyl)allylamines a...

Understanding the formation of biogenic molecules in abiotic conditions is a prerequisite in the origin-of-life studies. Determining the conditions allowing an efficient one-pot synthesis of the largest possible panel of biogenic compounds may shed light on the plausible scenario in which the pr...

This paper reports an improved silylation procedure for simultaneous determination of the steroid hormones 17α-ethinylestradiol (EE2) and estrone (E1) using gas chromatography–mass spectrometry (GC–MS). This follows a re-assessment of some of the popular silylation procedures using N-methyl-N...