A simple and efficient synthesis of 4,5-dihydro-4-oxo-3-furancarboxylates using an acylative intramolecular cyclization of sulfonium salts is described. The reaction involved the efficient formation of a mixed anhydride between a linear carboxylic acid and trifluoroacetic anhydride in the presen...

Nineteen ursolic acid derivatives (15 novel compounds) modified at the C-3 and the C-28 positions were synthesized. The cytotoxic activity of the derivatives was evaluated against HeLa, BGC-823 and SKOV3 cells by MTT assay. Inducing apoptosis and affecting cell cycle distribution by the derivati...

Development of a new, efficient resolution method of α-cyano-α-fluoro-p-tolylacetic acid (CFTA) 2a has been successfully achieved, which has been troublesome to obtain by conventional methods, in spite of its outstanding ability as an NMR chiral derivatizing agent. Fractional recrystallization...

Tamiflu readily undergoes endogenous hydrolysis to give oseltamivir carboxylic acid (OC) as the active anti-influenza agent to inhibit the viral neuraminidase (NA). GOC is derived from OC by replacing the 5-amino group with a guanidino group. In this study, OC and GOC congeners with the carboxyl...

Monodisperse molecularly imprinted polymers (MIPs) for chlorpromazine (CPZ) and bromopromazine (BPZ), MIPCPZ and MIPBPZ, were prepared using methacrylic acid as a functional monomer and ethylene glycol dimethacrylate as a crosslinker by multi-step swelling and polymerization. The retention and m...

Inorganic arsenic (iAs), a ubiquitous element and a natural drinking water contaminant, has been found to impair male reproductive function. However, the effect of long-term exposure to arsenic on testis damage and its underlying mechanisms still require further evaluation. In the study, male C5...

Arsenite-oxidizing bacteria (AOB) play a key role in the biogeochemical cycle of arsenic in the environment, and are used for the bioremediation of As contaminated groundwater; however, it is not yet known about how arsenic affects biofilm formations of AOB, and how biofilm formations affect bac...

Arsenite exposure can induce a biphasic response called “hormesis”, and oxidative stress has been proposed to play critical roles in the hormesis effect. However, the precise mechanisms underlying the hormesis effect induced by arsenite is largely unknown. Recently, N6-methyladenosine (m6A) mo...

Ferroptosis is a novel iron-dependent form of cell death implicated in brain pathology. However, whether arsenite is an inducer of ferroptosis in the neuron remains completely unknown. In this study, the seven-week-old healthy C57BL/6 J male mice were treated with environmental related doses (0....

A new Mo/V-arsenite-based heteropolyoxometalate, (NH4)6[As4Mo6V3O36H3]·5H2O (1) has been synthesized and structurally characterized. The novel {As4Mo6V3O36H3} building block consists of one Anderson-type {AsMo6O27} unit and one ring-like {As3V3O15} unit linked together via μ3-O2– moieties, wh...

Since trivalent arsenite (As III) is considerably more toxic and more difficult to remove from water than pentavalent arsenate (As V), conversion of As III into As V is regarded as an efficient strategy for mitigating arsenic pollution issues. Herein we report a precious-metal-free electrocataly...

Sodium arsenite (NaAsO2) was especially used as a dormant spray to control grapevine trunk diseases (GTDs) in European vineyards until 2003 when it was banned. It was an efficient product but it was banned due to high risk for human health and the environment. Now, as one of the consequences wit...

With the crystal structure parameters and crystal field stabilization energy of lattice cations, the Yoon–Salman–Donnay equation is used to calculate the theoretical point of zero charges (pzc) of huebnerite and ferbrite. The calculated pzc of 2.8 and 2.0, respectively, are in excellent agreem...

Quartz-vein-type wolframite deposits are a primary type of tungsten deposits. Traditionally, F and Cl were considered as important agents in tungsten transportation during ore formation process. However, ore-forming fluids enriched in CO2 were commonly observed in natural fluid inclusions associ...

Large-size single-crystal samples of huebnerite natural multiferroic MnWO4 were analyzed by neutron and synchrotron X-ray single-crystal diffraction as well as by polarized Raman spectroscopy. Both neutron and X-ray diffraction analyzes reveal polar space-group symmetry P2 for the nuclear struct...

The magnetic structure of the multiferroic phase AF2 of huebnerite (MnWO4) has been re-investigated based on the polar space group P2, instead of P2/c widely accepted in literature. The site character between two independent sites for Mn2+, Mna and Mnb, fairly differs from each other in terms of...

The addition of sepiolite in fibre-cement is analysed as a possible additive constituent of MgO-SiO2 binders. In order to optimise the Mg-SiO2 cementitious system in fibre-cement sheets, small cement replacement (1 and 2 wt%) by sepiolite is introduced and its effects are studied, firstly, in ha...

MnCrOx/Sepiolite solid materials were successfully synthesized by hydrothermal method. The samples were characterized by XRD, SEM, TEM, BET, XPS, H2-TPR, NH3-TPD, NH3-SCR and activation energy tests. The results showed that the 3D nanoflower MnCrOx with heat treatment of 3 h and sepiolite as the...

The hydrogenolysis of neopentyl iodide on reduced Co or Pt dispersed on MgO support yields increasing amounts of 2-metylbutane and 2-methylbutenes in addition to neopentane, as the temperature is raised from 50 to 150°C. These results support the idea that a π-complexed half-reaction state is ...

Primary neopentyl iodides react with aryl Grignard reagents in the presence of 10 mol% (dppf)NiCl2 to give the cross-coupled product.