Following incubation with activated neutrophils, two metabolites of 5-aminosalicylic acid (5-ASA) were identified by HPLC. These two metabolites accounted for approximately 60% and 20% of the original 5-ASA. The formation of the major metabolite was prevented by pre-incubation with the peroxidas...

As a part of our project aimed at developing new agents of potential application in AD, a new series of 2-phenoxy-indan-1-one derivatives which possess alkylamine side chain were designed, synthesized, and evaluated for their inhibitory activity against AChE and BuChE. Most of the compounds were...

A facile method for the synthesis of a new series of R,R-2-(4-(2-(4-(5-chloro-3-halopyridin-2-yloxy)-phenoxy)-propionyloxy)-phenoxy)-propionic acid ester derivatives containing a halo-substituted pyridine carrying two R,R chiral centers from (R)-2-(4-hydroxyphenoxy)propionic acid, halopyridines ...

A phenyl ring substitution strategy was employed to optimize the ACC2 potency and selectivity profiles of a recently discovered phenoxy thiazolyl series of acetyl-CoA carboxylase inhibitors. Ring substituents were shown to dramatically affect isozyme selectivity. Modifications that generally imp...

Selective reduction of hydrogen bonds of a phenoxy resin gave samples particularly suitable to investigate specific interactions in associative polymers. The glass transition temperature decreased when reducing hydrogen bonds, but dielectric results indicated that α and β relaxations are rathe...

The following labeled compounds were isolated and identified after incubation of 8,11,14-eicosatrien[1-14C]oic acid with human platelets: 12-l-hydroxy-8, 10,14-eicosatrienoic acid, 8,11,12-trihydroxy-9,14-eicosadienoic acid, 8,9,12-trihydroxy-10, 14-eicosadienoic acid, 12-l-hydroxy-8,10-heptadec...

Dietary conjugated linoleic acid (CLA) is associated with decreased 12-O-tetradecanoyl-phorbol-13-acetate (TPA)-induced tumor promotion in mouse skin. In addition, CLA decreases TPA-induced prostaglandin E synthesis and ornithine decarboxylase activity in cultured keratinocytes compared with lin...

A new reversed-phase high-performance liquid chromatography method for the separation of regioisomeric products from lipoxygenase acting on linoleic acid was studied. The addition of salts to the mobile phase improved the retention and separation behaviour of 13-hydroperoxy-9,11-octadecadienoic ...

9-Hydroxy-10,12-octadecadienoic acid and 13-hydroxy-9,11-octadeca-dienoic acid are formed from linoleic acid upon incubation with the microsomal fraction of homogenates of the sheep vesicular gland (Hamberg M. and Samuelsson B. (1967) J. Biol. Chem. bd242, 5344–5354. This communication is conce...

Two types of hydroxy acids, (10E, 12Z)-9-hydroxy-10,12-octadecadienoic acid [1] and (9Z, 11E)-13-hydroxy-9,11-octadecadienoic acid [2], were obtained as cytotoxic compounds from a water extract of rice bran. The cytotoxicity of acid 1 was stronger than that of acid 2 in vitro, against P388 mouse...

Various conditions for conversion of (9S,10E,12Z)-9-hydroperoxy-10,12-octadecadienoic acid (9S-HPODE) and (13S,9Z,10E)-13-hydroperoxy-9,11-octadecadienoic acid (13S-HPODE) into the corresponding hydroxy acids, (9S,10E,12Z)-9-hydroxy-10,12-octadecadienoic acid (9S-HODE) and (13S,9Z,10E)-13-hydrox...

We report a rechargeable pH differential vanadium-hydrogen (V-H2) flow battery with a practical open circuit voltage of 1.93 V and a discharge voltage of 1.73 V. This value is among the highest reported values for rechargeable flow batteries with aqueous electrolytes to date. This proposed V-H2 ...

As one of the most important components of the vanadium redox flow battery (VRFB), the electrolyte can impose a significant impact on cell properties, performance and capital cost. In particular, the electrolyte composition will influence energy density, operating temperature range and the pract...

This review surveys the organometallic chemistry of vanadium during the period 1993–2014. It is an updated version of the ‘Vanadium’ chapter in COMC-III (2007) that originally covered the period 1993–2004. The synthesis, characterization, reactivity, and applications of organovanadium comple...

Benzene hydroxylation to phenol by using vanadium based catalysts and product recovery were performed in a two-phase membrane reactor. Benzene permeates, through the hydrophobic polypropylene membrane, in the aqueous phase containing the catalyst while phenol permeates back accumulating in the o...

Vanadium is an element with a fascinating history, a widespread diffusion in bacteria and eukaryan organisms, and rich coordination chemistry. The properties of vanadium compounds attracted the interest of researchers in different fields, such as biochemistry, medicinal chemistry, and catalysis,...

The resin-activated carbon composite (RAC) electrodes were fabricated and applied in capacitive deionization for recovery of V(V) from complex vanadium solution. The adsorption capacity of the RAC electrode for V(V) is extremely low and the reduction of V(V) is significant in low pH solution, bu...

In order to identify new active drug candidates against cancer diseases we investigated the tumor cell growth inhibition, formation of reactive oxygen species, mitochondrial membrane damage, cell cycle arrest and DNA binding activity of a new bis(triethylammonium) tris[1,1-bis(indol-3-yl)-1-(3,4...

Redox flow batteries (RFBs) have been limited by low energy density and high cost. Here, we employ highly-soluble, inexpensive and reversible polysulfide and iodide species to demonstrate a high-energy and low-cost all-liquid polysulfide/iodide redox flow battery (PSIB). In contrast to metal-hyb...

In the last 30 years, since the discovery that vanadium is a cofactor found in certain enzymes of tunicates and possibly in mammals, different vanadium-based drugs have been developed targeting to treat different pathologies. So far, the in vitro studies of the insulin mimetic, antitumor and ant...