Piperazine-related drugs are sold as party pills in the form of tablets, capsules, liquids or powders. These party pills can contain several piperazine derivatives, or even a mixture of piperazines and amphetamine derivatives. This paper describes a screening method using a gas chromatography–m...

Chromium(III) heterocomplexes, H[Cr(NCS)4(BzH)2]·C2H5OH, H[Cr(NCS)4(MeBzH)2]·2H2O, and [Cr(NCS)2(MeBzH)4][Cr(NCS)4(MeBzH)2]·8H2O where BzH = benzimidazole = C7H6N2, and MeBzH = 2-methylbenzimidazole = C8H8N2, have been prepared by substitution in K3[Cr(NCS)6]. Their μeff values at room tempe...

Thermoanalytical studies carried out on complex salts Ag3[Cr(SCN)6], Tl3[Cr(SCN)6] and Hg3[Cr(SCN)6]2. On the basis of thermal analysis, and X-ray and chemical analyses of their decomposition products, schematic representations of the thermal decomposition reactions were established. From thermo...

An early report on the solvent dependence of the electronic spectra of complex ions considered the electrostatic effect of solvent molecules in the second coordination sphere, on the position of the absorption bands.1 Solvent effects on the ligand field bands for solutions of K[Cr(NH32(NCS)4] ha...

Lead (25–200 μg) is precipitated as Pb3[Cr(SCN)6]2. The filtered precipitate is treated with 10% carbonate solution, and the thiocyanate dissolved is oxidized by iodine to sulphate at pH 8.2. After acidification, the excess of iodine is extracted into chloroform, and the iodide ion retained in...

Silver (25–300 μg) is precipitated as Ag3 [Cr(SCN)6]. The precipitate is collected and then treated with 10% sodium carbonate solution, and the thiocyanate dissolved is oxidized to sulfate by iodine at pH 8.2. After acidification, the excess of iodine is extracted into chloroform, and the iodi...

Piperidinium hexathiocyanatochromate(III), (pipH)3[Cr(NCS)6], was synthesized using the molten salt pipHSCN and was found to contain nitrogen-bonded thiocyanate. The (pipH)3[Cr(NCS)6] decomposes in the range 250–370°C with the primary reaction being complete disruption of the compound to Cr(NC...

Heterocyclic compounds and their metal complexes display a broad spectrum of pharmacological properties. This work reports the preparation and characterization of four novel gold(I) complexes containing tertiary phosphine and 3-benzyl-1,3-thiazolidine-2-thione, 5-phenyl-1,3,4-oxadiazole-2-thione...

The synthesis of triethylphosphine gold(I) 4-nitrobenzenethiolate, Et3PAu(SC6H4NO2-4), is reported. Et3PAu(SC6H4NO2-4) displays a low energy visible electronic absorption band which is solvent dependent: EtOH (λmax = 385 nm), acetonitrile (λmax = 391 nm), THF (λmax = 395 nm), and DMSO (λmax ...

Gold(I) complexes containing stabilising ligands such as phosphines or N-heterocyclic carbenes (NHCs) are known to be inhibitors of the enzyme thioredoxin reductase (TrxR) and therefore act as potential apoptosis-inducing anticancer drug candidates. The conjugation of biomolecules overexpressed ...

The last decade has witnessed tremendous advances in the design of anticancer gold complexes containing tertiary phosphines, a class of ligands that have significantly contributed to the development of metal complexes owing to their stabilizing effect. The promising in vitro antiproliferative pr...

The present review deals with the chemistry of complexes of gold(I) and gold(III) with organic ligands. Compounds classified according to the type of coordinating ligands and donor atoms are considered from the point of view of their potential application as precursors in the MOCVD process, whic...

The antiproliferative activity of the gold complex [Au(tpp)Cl] (1) (tpp = triphenyphosphine) against human breast adenocarcinoma cells (MCF-7) and normal human fetal lung fibroblast cells (MRC-5) was investigated. The compound exhibits stronger activity against MCF-7 cells than cisplatin. The ap...

The interaction of thiourea (Tu) with auranofin (Et3PAuSATg) and its analogue, Et3PAuCl has been studied using 13C, 31P and 15N NMR spectroscopy. It is observed that Tu is able to replace both the ligands, Et3P and SATg− simultaneously from gold(I) in auranofin, forming [Et3P-Au-Tu]+ and Tu-Au-S...

The current anticancer and antileishmanial drug arsenal presents several limitations concerning their specificity, efficacy, costs and the emergence of drug-resistant cells lines, which encourages the urgent need to search for new alternatives. Inspired by the fact that gold(I)-based compounds a...

EPR spectroscopy was applied to determine the binding site of chloro(triethylphosphine)gold(I), (ClAuPEt3), in bovine serum albumin (BSA). The EPR spectrum of the spin marker covalently bonded to the sulphydryl group of polypeptide chain shows the presence of two 3-maleimidoPROXYL populations wh...

A novel series of chiral ligands was synthesized having a cyclopentadienyl (Cp) ring attached to an ether moiety. Four chiral monoCp zirconium derivatives contain these ligands in a bidentate Cp/O coordination mode. Complexes 4d, 6d, and 7d bear an aryl group at the end of the ether chain. The r...

Increased blood lactate concentration and alterations of substrate utilization have been shown to be partly involved in development of insulin resistance in obese and type 2 diabetic patients. As blood represents the first great distribution space and participates to lactate exchange in whole bo...

Many health authorities have targeted salt reduction in food products as a means to reduce dietary sodium intake due to the harmful effects associated with its excessive consumption. In the present work, we evaluated the effect of reducing sodium chloride (NaCl) content on the microbiological an...

In a study designed to assess the potential sensitizing and granulomagenic capacities of selected metallic salts, rabbits were inoculated intradermally with zirconium aluminum glycinate (ZAG), sodium zirconium lactate (NZL), aluminum chlorhydrate (ACH), BeSO4, and ovalbumin (OVA) by single and m...