2-Amino glucose ((2S,3R,4S,5S,6R)-2-amino-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol) as a substrate for the synthesis of NiFe2O4@SiO2@amino glucose supply an environmentally friendly procedure for the synthesis of bis(1,2-dihydro-4-hydroxy-2-oxoquinolin-3-yl)methanes through one-pot conde...

Phosphonylation of the pretreated 2-(hydroxymethyl)phenol derivatives with acetic anhydride using trialkylphosphites as the nucleophilic reagents was reported, providing a practical way to the synthesis of novel highly steric 3,3′-bis-substituted benzo[d][1,2]oxaphosphole 2-oxides.

Further studies on 6,7-bis(hydroxymethyl)-1H,3H-pyrrolo[1,2-c]thiazoles as anticancer agents against breast cancer are reported, allowing to demonstrate the potential of these compounds for the therapy of the triple-negative breast cancer, the most challenging tumors in clinical practice. These ...

Isoretronecanol and trachelantamidine (laburnine) are naturally occurring pyrrolizidine alkaloids which display potent biological activity, and as such these compounds have, in recent years, attracted significant interest from the bioorganic and synthetic communities. This review delineates both...

Two different green biocatalytic methods were investigated for the transformation of 5-hydroxymethylfurfural (HMF) to valuable disubstituted furan derivatives. 2,5-bis(hydroxymethyl) furan (BHMF) was obtained by biocatalytic reduction using lyophilized plant tissues. 5-(hydroxymethyl)furfurylami...

This study reveals that the Ru-catalyzed ring-closing metathesis of N-homoallyl-2-(hydroxymethyl)acrylamides is promoted by substrate-catalyst hydrogen bonding as well as dipole repulsion between the electron-rich side-chain and the carbonyl group, providing clues for designing effective synthet...

This contribution is about the investigation of osmotic coefficients and the water activity of binary water/ 5-(hydroxymethyl)furfural (5-(hydroxymethyl)furan-2-carbaldehyde, HMF) and ternary water/5-(hydroxymethyl)furfural/salt (salt = NaCl or LiCl) solutions. Osmotic coefficients were determin...

Both Z and E isomers of 10-(1,2-dibromoprop-1-en-1-yl)-10H-phenothiazine were given by bromine addition to 10-(prop-1-yn-1-yl)-10H-phenothiazine with little stereoselectivity. The crystal structure of the Z isomer showed a usual butterfly structure, while that of the E isomer afforded an anomalo...

Stereoselective synthesis of an advanced taxusin intermediate is described. The key step is the successful application of the type 2 intramolecular Diels–Alder (IMDA) reaction for the assembly of the tricyclic core of this natural product.

The putative Taxol biosynthesis metabolites, taxa-4(20),11(12)-diene-5α,13α-diol (7), taxa-4(20),11(12)-diene-5α,9α,13α-triol (9), and taxa-4(20),11(12)-diene-5α,10β,13α-triol (10), have been prepared by Barton deoxygenation of the C-9 and C10-hydroxyl groups of protected derivatives of ...

A high-performance liquid chromatographic method for the determination of N-1-hydroxyethylflurazepam, the major urinary metabolite of flurazepam, in human urine is described. Urine specimens were incubated enzymatically to deconjugate N-1-hydroxyethylflurazepam glucuronide (metabolite) and were ...

Publisher SummaryFlurazepam hydrochloride is 7-chloro-1-(2- [diethylamino] ethyl)-5-(o-fluorophenyl)-1,3-dihydro-2H-1,4-benzodiazepin-2-one dihydrochloride. Flurazepam hydrochloride occurs as off-white to yellow, nearly odorless, crystalline powder. Flurazepam hydrochloride melts with decomposit...

The molecular structures of 2,2′-thiodibenzoyl chloride and 2,2′-dithiodibenzoyl chloride have been determined by X-ray diffraction and compared with those of analogous methyl esters. No essential change in conformation and structural data occurs when o-COOMe is replaced by o-COCl. The sulphid...

A toxicologic and dermatologic review of 1,1-dimethyl-2-phenylethyl isobutyrate when used as a fragrance ingredient is presented. 1,1-Dimethyl-2-phenylethyl isobutyrate is a member of the fragrance structural group Aryl Alkyl Alcohol Simple Acid Esters (AAASAE). The AAASAE fragrance ingredients ...

Candida antarctica lipase B (CAL-B) is one of the most useful enzymes for preparation of optically active alcohols and amines. However, CAL-B substrate’s scope for enzymatic kinetic resolution (EKR) of carboxylic acids and their derivatives is limited, especially by low stereoselectivity. In an...

A toxicologic and dermatologic review of 2-hydroxy-2-phenylethyl acetate when used as a fragrance ingredient is presented. 2-Hydroxy-2-phenylethyl acetate is a member of the fragrance structural group aryl alkyl alcohol simple acid esters (AAASAE). The AAASAE fragrance ingredients are prepared b...

‘Higher’ alcohols, which contain more than two carbons, have a higher boiling point, higher cetane number, and higher energy density than ethanol. Blends of biodiesel and higher alcohols can be used in internal combustion engines as next-generation biofuels without any modification and are min...

Aryl alcohol alkyl carboxylic acid esters constitute a wide-employed class of fragrance materials. Outcomes presented within this study illustrate formulation of a read-across protocol for 90-day, repeat-dose toxicity within a series of these compounds, extending in scope to the dodecanoic acid ...

ObjectiveTo study the characteristic 2-(2-phenylethyl)chromone components of endophytic fungal strain of Aquilaria sinensis by solid culture.

Adsorption of 2-phenylethyl alcohol (PEA) from supercritical CO2 onto silica aerogel was investigated. A monolayer to multilayer adsorption isotherm was observed, measured at 15.0 MPa and 323.2 K, from the PEA-unsaturated to PEA-saturated supercritical CO2, indicating the potential utility of th...