Compounds incorporating the bicyclic 5-5 heterocyclic ring system with one ring junction nitrogen atom and three extra heteroatoms (mainly, O, N, and S) have useful physical with important technological applications as photographic dyes (yellow, magenta, and cyan), polymer films, corrosion inhib...

Various C-glucopyranosyl-1,2,4-triazolones were designed as potential inhibitors of glycogen phosphorylase. Syntheses of these compounds were performed with O-perbenzoylated glucose derivatives as precursors. High temperature ring closure of N1-carbamoyl-C-β-D-glucopyranosyl formamidrazone gave...

Aniline–terephthalaldehyde resin p-toluenesulfonic acid (ATRT) salt was easily prepared by the reaction of aniline with 1.25 equiv of terephthalaldehyde in the presence of 1.0 equiv of p-toluenesulfonic acid at 75 °C for 24 h in EtOH. ATRT efficiently catalyzed the tetrahydropyranylation of al...

The Henry reaction between d-glyceraldehyde and ethyl nitroacetate allowed the practical development of a diastereoselective synthesis of 3,4,5-trihydroxy-2-nitropentanoic acid esters, which were reduced to polyoxamic acids, which were used in a new diastereoselective synthesis of 3,4-dihydroxyp...

The usefulness of Toluidine blue dye in the detection of anogenital injuries in sixty females aged 16–40 years of age with a history of consensual sexual intercourse within 48 h of intercourse were included for the study from the Gynaecology outpatient department of the Institute of Medicine, M...

Grape bagasse is an agro-industrial solid waste produced in large quantities representing an environmental issue for wineries. An organic-inorganic hybrid material was obtained by the acid catalyzed sol-gel route in the presence of grape bagasse for application as dye adsorbent. Analysis by FT-I...

In this article, morphology, structure and size controllable chitosan microspheres with high mechanical strength were synthesized by microfluidic technology combining chemical crosslinking and used as an adsorbent for methyl orange. The synthesized adsorbents were characterized using scanning el...

In this article, Sm2O3 doped Lithium Alumino-borate (LABS) glasses were prepared by melt-quench technique. Physical, structural, thermal and spectroscopic properties are investigated by various techniques. The emission spectra consist of three sharp peaks at 562.5, 599, 645.5 nm within the 4f el...

The effect of ohmic-vacuum heating conditions (OHVC) was evaluated on quality parameters during concentration process of orange juice and compared with ohmic heating process under atmospheric conditions (OHAC) and conventional vacuum heating (CVH). The decline of vitamin C in OHVC treatments (10...

Endogenous scopolin and its aglycon scopoletin were tested in various plant cell suspensions by HPLC. The results indicate that the levels of these compounds varied greatly from one plant cell suspension to another (10−3–5 mg/g dry mass). Both scopoletin and scopolin were detected in the Nicoti...

An efficient and stereoselective approach to the bicyclo[9.3.0]tetradecenone core structure of clavulactone starting from readily and abundantly available 2-methyl-1,3-cyclopentandione employing microbial desymmetrization and cyanohydrin alkylation as the key steps is described. The synthetic ro...

One new dolabellane-type diterpenoid, named clavirolide G (1), and one known related analogue (3), have been isolated from the soft coral Clavularia viridis collected off the Xisha Islands in the South China Sea. Its structure and absolute configuration were determined on the basis of spectrosco...

Four methods have been screened for the synthesis of some α-d-glucopyranosides, with the recently reported (Mukaiyama) combination of 2,3,4,6-tetra-O-benzyl-α-d-glucopyranosyl iodide and triphenylphosphine oxide being the most successful, especially in the diastereoselectivity exhibited. The α...

The selective oxidation of lactams to cyclic imides is an important transformation considering the wide range of applications in the synthesis of pharmaceutical drugs and intermediates. This chapter highlights the metal- and nonmetal-mediated oxidative transformations of lactams, specifically py...

This letter describes the discovery of a novel series of potent Kv1.5 ion channel antagonists based on a diisopropyl amide scaffold. Structure–activity relationships of functionalized analogs are discussed. Key compound 1-(3-(diisopropylcarbamoyl)-2-phenyl-3-(pyridin-3-yl)propyl)-3-(2-fluoroben...

Novel pyrido[1,2-a]pyrimidin-4-ones have been synthesized and evaluated for their antimalarial activity by SYBR Green I assay against erythrocytic stages of chloroquine (CQ) sensitive Pf 3D7 strain. The antimalarial screening of 42 different compounds revealed that 3-Fluorobenzyl(4-oxo-4H-pyrido...

A new method is described for producing 3,3,3-trifluoroethyl isocyanate from perfluoroisobutene (PFIB). Isocyanate was used for synthesis of carbamates and ureas. A series of trifluoroethyl-substituted ureas has been tested in the National Cancer Institute (NCI, Bethesda, USA) by the NCI-60 DTP ...

In this study, we have developed a series of new monofunctional Ru(II) complexes of the general formula mer-[Ru(Cl-Ph-tpy)(N-N)Cl]Cl in which Cl-Ph-tpy is 4′-(4-chlorophenyl)-2,2′:6′,2″-terpyridine, N-N is a bidentate chelating ligand (1,2-diaminoethane (en, 1), 1,2-diaminocyclohexane (dach,...

Etherification of ethylene and propylene glycols with isobutylene was carried out in the presence of cation exchange resin catalysts, Amberlyst-15, Indion-130, and a homogeneous catalyst, p-toluene sulfonic acid. Kinetics of these reactions was studied in a magnetically stirred 1.0 × 10−4 m3 ca...

Glycol ethers are a widely used class of solvents that may lead to both workplace and general population exposures. Biomonitoring studies are available that have quantified glycol ethers or their metabolites in blood and/or urine amongst exposed populations. These biomonitoring levels indicate e...