The natriuretic peptide family consists of three biologically active peptides: atrial natriuretic peptide (ANP), brain (or B-type) natriuretic peptide (BNP), and C-type natriuretic peptide (CNP). Among these, ANP and BNP are secreted by the heart and act as cardiac hormones. Both ANP and BNP pre...

The synthesis and cardiovascular evaluation of a novel series of [4-alkyl(aryl)quinazolin-2-one-1-yl]alkanoic esters and acids (II) as renal vasodilators is presented. The compound 3-[6,7-dihydroxy-4-methyl-(1H)-quinazoline-2-one-1-yl]propanoic acid (7) was found to be a potent and selective ren...

This paper describes the total synthesis of the hydrochloride salts of (2S)-2-amino-7-methoxytetralin (21-HCl) and (2S)-2-amino-6-fluoro-7-methoxytetralin (ST1214), from a common enantiomerically pure aziridine 4b, which was available from l-aspartic acid β-tert-butyl ester. The synthesis of 21...

The vibrational analysis of the substituted Benzophenone molecule 4-Chloro-3-iodobenzophenone (4, 3-ClIBP) is carried out using both FT-IR and FT-Raman spectra and also quantum chemical calculations of the scaled frequencies using the DFT method B3LYP/LanL2DZ basis set. The natural bond orbital ...

1-(5,6-Dihydro-2H-thiopyran-2-yl)uracil derivatives, a new 4′-thio-D4-nucleoside analogue, were synthesized by reacting 5,6-dihydro-2H-thiopyran sulfoxide and persilylated uracil in a Pummerer-type thioglycosylation reaction. The reaction of 5-alkyl substituted dihydrothiopyran sulfoxide 7 only...

For the sustainable development of oceans, we need a reliable, effective and fast MEIA (Marine Environmental Impact Assessment) System. According to the certain goal of MEIA system, this paper design a preliminary MEIA System based on 3S technology. The system consists of a database management s...

With the rapid development of the global economy, there are more need to and reliance on the mineral resource. How to realize the effective management and the reasonable exploitation of the mineral resource in our country is the problem needing resolving urgently. The appearance and development ...

The main objective of this study is to develop a field survey system for land consolidation based on 3S (geographic information system, GIS; Global Positioning System, GPS; and remote sensing, RS) and speech recognition technology. Field survey in land consolidation is a complex and high-tech pr...

Methane (CH4) oxidation and nitrogen (N2) fixation are simultaneously activated in the roots of rice plants grown in paddy fields with low N input (LN). However, the mechanism of CH4 oxidation-dependent N2 fixation remains largely unknown. In the present study, a15N2-feeding experiment was adopt...

The cross sections for ϒ(1S), ϒ(2S), and ϒ(3S) production in lead–lead (PbPb) and proton–proton (pp) collisions at sNN=5.02 TeV have been measured using the CMS detector at the LHC. The nuclear modification factors, RAA, derived from the PbPb-to-pp ratio of yields for each state, are studied a...

Knowledge workers are highly regarded by employers for their innovation and creativity. Due to the intangible character of knowledge, managing knowledge workers requires different approaches, tools and methods than managing non-knowledge workers. There is a broadly shared idea that knowledge wor...

Accurate quantum dynamics calculations have been carried out for the Na(3S) + DF(ν = 1–4, j = 0) → NaF + D, Na(3P) + DF(ν = 0, j = 0) → NaF + D/Na(3S) + DF and Na(3S) + HF(ν = 2–4, j = 2,4,6,9) → NaF + H reactions. The isotopic substitution decreases the reactivity remarkably in both Na(...

A three-component reaction of aromatic aldehyde, naphthalene-2-amine, and tetrahydro-2,5-dimethoxyfuran in methanol catalyzed by iodine, is described in this paper. With the ring-opening of furan, a series of 3-aryl-2-(3-arylbenzo[f]quinolin-2-yl)benzo[f]quinoline derivatives were obtained in mo...

The acid catalyzed condensation of levulinic acid was studied using a series of solid acid catalysts: Amberlyst-15, SiO2-SO3H, Dowex50WX8, Carbon-SO3H, TiO2-SO3H, Al2O3-SO3H, H3PW12O40, and Nb2O5.H2O under neat conditions at 110–130 °C. The major dimerization product was identified as tetrahyd...

The dehydrofluorination of 2H,3H-decafluoropentane (HFC-4310mee) using 1,8-diazabicyclo[5.4.0]-7-undecene (DBU) selectively gave (Z)-2H-nonafluoropent-2-ene as a bench-stable volatile liquid. Nucleophilic substitution reactions of (Z)-2H-nonafluoropent-2-ene with allylic alcohols gave the corres...

4,7-Dichloro-1-benzothien-2-yl sulfonylaminomethyl boronic acid (DSABA, Compound I) was discovered as the first boronic acid-based class D beta-lactamase inhibitor. It exhibited an IC50 of 5.6 μM against OXA-40. The compound also inhibited class A and C beta-lactamases with sub to low μM IC50,...

Heteropoly acids have attracted increasing attentions in oxidative desulfurization (ODS) field, but the solubility and low surface area hindered their applications. Moreover, bulk silicotungstic acid (HSiW) was less researched, owing to its relative lower activity. Herein, a layered-structure he...

Extractive-catalytic oxidative desulfurization (ECOD) technology is a potential industrial application for attaining low-sulfur fuel oils. In this research, novel graphene oxide (GO)-based heterogeneous catalysts were synthesized by immobilization of different amounts of phosphotungstic acid H3P...

A modified Mannich reaction has been developed for the synthesis of Mannich bases and benzoxazines via the oxidative hydroxylation of arylboronic acids and subsequent coupling with paraformaldehyde and amines in one pot. This modified Mannich reaction is easily carried out to afford the target p...

A facile and effective iododeboronation of variously substituted aryl and heteroarylboronic acids through activation and subsequent ipso-introduction of iodine is presented. The use of KF and I2 at 80 °C in 1,4-dioxane furnishes iodinated compounds in high yields.