The synthesis and characterization of ten new palladium(II) amine bis(phenolate) complexes is reported. Solution and single-crystal X-ray diffraction studies reveal the presence of both κ2-N,N and κ3-N,N,O binding modes in these square planar complexes. For complexes with sterically less deman...

We report herein, the usage of N,O-bis(trimethylsilyl)acetamide (BSA) and dicyclohexyl carbodimide (DCC) as two new catalysts for three component condensation of an aldehyde, ethyl acetoacetate and urea/thiourea under solvent free conditions at 100 °C to afford the corresponding 3,4-dihydropyri...

A method using N,O-bis(trimethylsilyl)acetamide/N-hydroxysuccinimide ester (BSA/NHS) as coupling agents for dipeptide synthesis is descried. The coupling reaction between N-hydroxysuccinimide (NHS) esters and amines could be performed under mild conditions with N,O-bis(trimethylsilyl)acetamide (...

Reaction of PhMgBr with (Me3Si)HNO(SiMe3)[TMSHA] in the presence of CuI or CuCN catalysis (10–20 mol %) in THF:cosolvent (cosolvent = HMPA or TMEDA) at room temperature can provide an atom-economic and step-economic access for arylamine synthesis starting from aryl Grignard reagents. Chemoselec...

The P2Y14 receptor (P2Y14R) plays a key role in the modulation of inflammatory process, but very few classes of antagonists have been reported. A series of 3-amide benzoic acid derivatives were identified as novel and potent P2Y14R antagonists. The most potent antagonist, 16c, showed comparable ...

Flue-gas desulfurization is the main method of coal desulfurization. In this study, a potassium humate (KHA) solution was used to remove SO2 from flue gas, and the effects of the KHA concentration, solution temperature, SO2 concentration and oxygen content on SO2 absorption efficiency were explo...

In the ionic compound potassium amide (KNH2) the amide ions (NH2−) are displaying orientational disorder in the tetragonal and cubic high-temperature phases while they are orientationally ordered in the monoclinic low-temperature phase. From high-resolution neutron powder diffraction measurement...

The reorientational molecular dynamics of the amide ions were investigated in three different phases of KND2 by means of 2H NMR line-shape analyses of solid-echo, T1Z as well as T1Q distorted spectra in a temperature range of 80–420K. The correlation times of the amide dynamics cover roughly ei...

TASK-1 is a two-pore domain potassium channel that is important to modulating cell excitability, most notably in the context of neuronal pathways. In order to leverage TASK-1 for therapeutic benefit, its physiological role needs better characterization; however, designing selective inhibitors th...

The electrochemical behavior of Nd(III) in potassium bis(trifluoromethyl-sulfonyl) amide (KTFSA) melts was investigated in this study. It is speculated that the first reduction peak around + 2.3 V likely corresponds to the formation of Nd(II). The electrochemical analysis revealed that the reduc...

Inactivation, the slow cessation of transmission after activation, is a general feature of potassium channels. It is essential for their function, and malfunctions in inactivation leads to numerous pathologies. The detailed mechanism for the C-type inactivation, distinct from the N-type inactiva...

This paper reports a novel bench-scale hydrometallurgical procedure and electrodeposition using potassium bis(trifluoromethyl-sulfonyl)amide (KTFSA) melts for the recovery of rare earth (RE) elements from Nd-Fe-B magnet waste. The investigations were performed at bench scale to assess the potent...

Isosteric replacement of amide groups is a classic practice in medicinal chemistry. This digest highlights the applications of most commonly employed amide isosteres in drug design aiming at improving potency and selectivity, optimizing physicochemical and pharmacokinetic properties, eliminating...

Three new anthraquinones, (2S)-8-carboxy-9-hydroxy-2-(2-hydroxypropan-2-yl)-1,2-dihydroanthra[2,1-b]furan-6,11-dione (1), 1,2,3,6-tetrahydroxy-9,10-anthraquinone (2), and 1,2,3,5,6-pentahydroxy-9,10-anthraquinone (3), as well as four known 9,10-anthraquinones (4–7) and five known triterpenes (8...

We describe the exploitation of the selective catalytic property of anthraquinone (AQ) for solar photocatalytic synthesis of hydrogen peroxide (H2O2) as a green, sustainable alternative to organic-solvent-based and energy-intensive industry-benchmark processes that also rely on AQ catalysis. We ...

Eight new 9,10-anthraquinones (1–8) including three acetonide derivatives of 3-hydroxy-2-hydroxymethyl-9,10-anthraquinones (6–8) were isolated from an ethanol extract of the roots of Knoxia valerianoides. On the basis of chemical transformation reactions of the co-occurring 14 and 15 combined ...

Seven anthraquinones were isolated from aerial parts of Heterophyllaea lycioides (Rusby) Sandwith (Rubiaceae), including three derivatives that have not been described before: a hetero-bianthraquinone identified as (R)-2-hydroxymethyl-2′methyl-1,1′,6,6′-tetrahydroxy-5,5′ bianthraquinone (lyc...

Antigonon leptopus ethanol extract yielded a known compound, quercetin-3-O-α-rhamnopyranoside and four novel anthraquinones named: 1,8-dihydroxy-6-(hydroxymethyl)-3-methoxy-2-pyrrolidinium anthraquinone, 1,8-dihydroxy-6-(methyl)-3-methoxy-2-pyrrolidinium anthraquinone, 1,8-dihydroxy-6-(hydroxym...

The spectroscopic study was performed on 9,10-anthraquinone derivatives (purpurin, alizarin, carminic acid, and 2-(hydroxymethyl)-9,10-anthraquinone) in dimethylsulfoxide in the presence of triethylamine to bring information on their protonation/deprotonation equilibria in aprotic solvent. An in...

Seven anthraquinones, including two new natural products, hedyanthraquinones A and B (1, 2), were isolated from Hedyotis caudatifolia. The structures were elucidated based on NMR, MS data and physico-chemical properties. Compounds 1 and 2 displayed moderate cytotoxic activities against a panel o...