Heat capacities of 2,5-dichlorothiophene were measured between 13 and 300 K using an adiabatic calorimeter. Fusion temperature at the triple point was found to be 232.72 K and the enthalpy and entropy of fusion were determined to be 11.87 kJ mol−1 and 51.0 J K−1 mol−1, respectively. The glass tr...

We report a five step method for the synthesis of furo[2,3-c]pyridazin-4(1H)-one derivatives representing a novel heteroaromatic ring-system. The first synthesis of 3-carboxylic and methyl-3-carboxylate derivatives of the 1-phenyl and 1-(p-methoxyphenyl) compounds are reported.

This chapter describes methods of synthesis, pharmacological properties, and the use of derivatives of 1-phenyl-3-(piperidin-1-yl)propan- and butan-1-ol, such as trihexyphenidyl, biperiden, pridinol, cycrimine, and diphenidol, and pirmenol; derivatives of 2-(piperidin-1-yl)ethan-1-ol or 3-(piper...

In this report, we describe the parallel as well as conventional synthesis of 1,2-diaryl-1-ethanones via environmentally benign acylation of arenes with in situ generated arylacetyl trifluoroacetates. A wide variety of arylacetic acids I participated in trifluoroacetic anhydride/ phosphoric acid...

Thirteen compounds, based on benzofuran skeleton bearing aryl substituents at its C-3 position through methanone linker, were synthesized and screened for their antibacterial and antifungal activities against four bacteria Escherichia coli, Staphylococcus aureus, Methicillin-resistant S. aureus,...

A convenient metal-free one-pot synthesis of benzofuran derivatives starting from simple ynones has been developed. Various functionalized benzofurans closely related to bioactive molecules can be obtained in moderate to good yields (up to 90%) through aza-Michael/Michael/annulation sequence. Pr...

Seventeen benzofuran derivatives were synthesized and screened for their antibacterial activities against Escherichia coli, Staphylococcus aureus, Methicillin-resistant S. aureus, Bacillus subtilis, and Pseudomonas aeruginosa. Seven of them have showed excellent antibacterial activities compared...

A new benzofuran, eupatarone, together with 2-hydroxy-4, 5-dimethoxybenzaldehyde, 12-hydroxy-2, 3-dihydroeuparine, spathulenol, precocene II, dammaradienol, dammaradienol acetate, 5, 3′-dihydroxy-7, 4′-dimethoxyflavanone and 5, 7-dihydroxy-4′-methoxyflavanone, have been isolated from aerial p...

The cytotoxicity of 8 natural dyes, commercially available as food additives in Japan, was studied on cultured fetal rat hepatocytes. Laccaic acid, one of the carminic acid samples and monascus pigments were found to be very toxic to cultured hepatocytes. Laccaic acid caused an increase in γ-gl...

Conformations and spectroscopic properties of laccaic acid A (lacA) were studied by means of the experimental and theoretical approaches. The minimum energy conformers of lacA in the gas phase and in implicit water obtained from the B3LYP/6-311G(d,p) calculations displayed the same orientation o...

The hybrid-race silk yarn was dyed till equilibrium with natural lac dye (laccaic acid) and the thermodynamics of dyeing were investigated. The adsorption isotherm obtained was identified to be a Langmuir type. When the temperature increased, the partition ratio and the standard affinity decreas...

This study aimed to investigate the formation of three inclusion complexes of laccaic acid A (the main component of the lac dye, named as LA) with β-cyclodextrin (β-CD), methyl-β-cyclodextrin (M-β-CD), or (2-hydroxyethyl)-β-cyclodextrin (HP-β-CD), exploring particularly the effects of CDs ...

We have investigated the nonlinear optical properties, including the optical limiting behaviour for five different concentrations of laccaic acid dye in solution and a thin film obtained through doping in poly (methyl methacrylate) (PMMA) polymer. The experiments were performed by using single b...

Despite an incessant advancement in the treatment of Colorectal Cancer (CRC), 40% of individuals suffer from disease relapse which marks the need for new treatment options. In this study we report synergistic antitumor activity of Laccaic acid (LA) and Phenethyl isothiocyanate (PEITC) combinatio...

A variety of heterocyclic spiranes were prepared by cyclization of dinucleophiles with 1,1-bis(tosyloxymethyl)cyclopropane and -cyclobutane.

The fruit of the white mulberry tree (Morus alba L.) is a multiple fruit with a sweet flavor commonly consumed around the world. Chemical investigation of the fruits led to the isolation of two indole acetic acid derivatives (1 −2) including a new compound, which turned out to be an isolation ar...

A 6-azido-2-tosylenolate, obtained from D-glucono-1,5-lactone in six steps, underwent an intramolecular cycloaddition–elimination pathway under mild conditions, yielding a chiral, substituted 5,6-dihydro-4H-pyrrolo[1,2-c]-1,2,3-triazole. The conditions were optimized to give exclusive formation...

A simple 3-step method for the introduction of a 3,3-dimethylallyl unit ortho to a phenolic OH group is described. 7-Hydroxycoumarin, 1, was converted to its 1,1-dimethylallyl ether, 5, by reaction with 3-chloro-3-methylbutyne followed by partial hydrogenation. Pyrolysis of 5 gave mainly the C-8...

The structure of the natural coumarins, 5-methoxyseselin 7 and trachyphyllin 14 have been confirmed by total syntheses from 7-acetoxy-5-prenyloxycoumarin 1 in good overall yields. Convenient synthetic routes to the natural coumarins, coumurrayin 4 and xanthoxyletin 10 have also been established.

The structure of the natural coumarin, trachyphyllin (12) has been confirmed by a total synthesis from 5,7-diacetoxycoumarin (1). Convenient synthetic routes to coumurrayin (5) and xanthoxyletin (10) have been established.