Manganese (Mn) and lead (Pb) exposures during developmental period can impair development by direct neurotoxicity or through interaction with iron metabolism. Therefore, we examined the effects of maternal ingestion of Mn or Pb in drinking water during gestation and lactation on iron metabolism ...

This paper studies the synergism between transition metals (TMs) and activated carbon (AC) as a catalyst support used in the catalytic decomposition of PCBs. A series of AC-supported TM catalysts was prepared according to two distinct methods: impregnation and ion exchange which were defined as ...

Superparamagnetic iron oxide nanoparticles (SPION) are contrast agents used for noninvasive tumor magnetic resonance imaging (MRI). SPION with active targeting by tumor-specific ligands can effectively enhance the MRI sensitivity and specificity of tumors. However, the challenge remains when the...

New 2-pyridyl, 3-pyridyl and 4-pyridyl derivatives of iminobisphosphonic acid were prepared by addition of tris(trimethylsilyl)phosphite to the corresponding derivatives of pyridineimine-methylphosphonates 3 and subsequent methanolysis of the silylated products 4. Solution studies on the coordin...

Aminophosphonates were found to be effective metal ion chelators. Ethylenediamine (EN) itself binds strongly to a series of metal ions forming efficient five-membered chelate ring using two nitrogen donors. Combination of EN with phosphonate function results in the family of low molecular chelat...

Hydrothermal reactions of divalent transition metal salts with imino-bis(methylphosphonic acid), NH(CH2PO3H2)2 (H4L) afforded three new metal phosphonates, namely, Cu[NH(CH2PO3H)2] 1, {Co[NH2(CH2PO3H)(CH2PO3)](H2O)2}·H2O 2 and Mn[NH2(CH2PO3H)(CH2PO3)](H2O) 3. When HO2C(CH2)3N(CH2PO3H2)2 was use...

Aldo-keto reductase 1C3 (AKR1C3) also known as type 5 17β-hydroxysteroid dehydrogenase has been implicated as one of the key enzymes driving the elevated intratumoral androgen levels observed in castrate resistant prostate cancer (CRPC). AKR1C3 inhibition therefore presents a rational approach ...

Using a single chiral scaffold, (1R,2S)-norephedrine, a series of monophosphine ligands have been prepared. The ligands prepared, β-acyloxy-(o-diphenylphosphino)amides and β-amido-(o-diphenylphosphino)esters, give rise to enantiomerically divergent products in the Tsuji-Trost asymmetric allyli...

The reaction of AgCF3SO3 with diphenylphosphinobenzoic acids leads to a cyclic dinuclear or a polynuclear silver(I) compound, depending on the relative position of phosphine versus carboxylic functional group. The dimers [Ag2(OSO2CF3)2(μ-O,P-PPh2C6H4COOH-o)2] 1 or [{Ag(μ-O,P-PPh2C6H4COOH-o)(OH...

Complexes of Pd(II) and Fe(III) with the condensation derivative of 2-(diphenylphosphino)benzaldehyde and ethyl carbazate were synthesized, characterized, and their antimicrobial activity was evaluated. The structures of the Pd(II) and Fe(III) complexes in solid state were determined by IR, elem...

3,5-bis(diphenylphosphino)benzoic acid (LH) reacted with Pd(COD)Cl2 to give [Pd(μ-LH)Cl2]2 (1) in which the Cl ligands are trans. Solventless grinding of 1 and ferric nitrate yielded an insoluble networked Pd–phosphine complex [LPdCl2Fe2/3]∞ (2), in which Fe atom bonds to the carboxylate grou...

The palladium-catalyzed regio- and diastereo-selective allylic alkylation of allyl acetates with carbon nucleophiles occurred. The stereochemistry was highly controlled by the palladium catalyst with 2-(diphenylphosphino)benzoic acid as the ligand, and vicinal quaternary and tertiary carbon cent...

“N,N-Dichloro-4-methylbenzenesulphonamide” (Dichloramine-T) reacts with 2,2′-dihalodiethyl sulfide instantaneously, even at sub-zero temperature, to yield p-toluenesulphonamide, 2-haloethyl 1-chloro-2- halovinyl sulfide and hydrogen chloride. A homolytic mechanism is proposed for the reaction...

Ethyl 2-chloroacetoacetate and its 4-chloro isomer react with cyanoacetamide in the presence of the mild, nonnucleophilic base, triethylamine under stoichiometric conditions to give high yields of ethyl 4-cyano-2-hydroxy-2-methyl-5-oxopyrrolidine-3-carboxylate and ethyl (4-cyano-2-hydroxy-5-oxop...

N-chloro-N′-arylbenzamidines react with 1,1-diaminoethenes to give in good yields 4-amino-5-chloroimidazoles. The behaviour of these compounds in some nucleophilic substitution reactions and their reduction to 4-amino-5-unsubstituted imidazoles is reported.

The work described in this paper is a further example of the utility of Appel's salt in the conception of novel heterocyclic rings. We confirmed that primary alkyldiamines may react easily with the methyl N-(4-chloro-5H-1,2,3-dithiazol-5-ylidene)-anthranilates to afford quinazolines, which ...

The Rhodococcus erythropolis strain (N′4) possesses the ability to convert 4-chloro-3-hydroxybutyronitrile into the corresponding acid. This conversion was determined to be performed by its nitrile hydratase and amidase. Ammonium sulfate fractionation, DEAE ion exchange chromatography, and phen...

Reactions of methyl N-(4-chloro-5H-1,2,3-dithiazol-5-ylidene)anthranilates with tryptamine at room temperature produced 2-cyano-3-[2-(indol-3-yl)ethyl]-4(3H)-quinazolinones, which underwent cyclization on heating with TFAA/HCl(g) to afford quinazolinocarboline alkaloids rutaecarpine (1a), hortia...

Herein, we described the design and synthesis of a series of pyridazine-3-carboxamides to be CB2-selective agonists via a combination of scaffold hopping and bioisosterism strategies. The compounds were subjected to assessment of their potential activities through calcium mobilization assays. Am...

The hitherto unknown α-(trifluoromethyl)phenylacetonitrile has been synthesized by reduction of the cyanohydrin of α,α,α-trifluoroacetophenone. Sodium borohydride reduction of the corresponding cyanohydrin tosylate resulted in reductive decyanation in dimethyl sulphoxide and in reduction of ...