Natural product drugs play a dominant role in pharmaceutical care. Nature is an attractive source of new therapeutic candidate compounds as a tremendous chemical diversity is found in millions of species of plants, animals, marine organism and micro-organism. A antifungal activity against import...

Tumor necrosis factor-α is an important pro-inflammatory cytokine having a key role in hosts defensive process of immune systems and its over expression led to a diverse range of inflammatory diseases such as Rheumatoid arthritis, Cronh’s disease, psoriasis, etc. This paper describes our medic...

It is presently unclear whether the antiseizure effects exerted by NSAIDs are totally dependent on COX inhibition or not. To clarify this point we investigated whether 7-methyl-2-phenylimidazo[1,2-b]pyridazine-3-carboxylic acid (DM1) and 6-methoxy-2-phenylimidazo[1,2-b]pyridazine-3-carboxylic ac...

SummaryA series of 2,3-disubstituted-6-alkoxyimidazo[1,2-b]pyridazines has been synthesized and evaluated for in vitro affinity for the benzodiazepine receptor (BZR). 3-(Benzamidomethyl or substituted benzamidomethyl)-6-methoxy-2-(3,4-methylenedioxyphenyl)imidazo[1,2-b]pyridazines were found to ...

Pd-bis(azido) compounds [Pd(dppn)(N3)2] and [Pd(dppf)(N3)2], which contain bulky chelating bis(phosphine) ligands (dppn=1,8-bis(diphenylphosphino)naphthalene, dppf=1,1′-bis(diphenylphosphino)ferrocene), were prepared from the corresponding chlorides and NaN3. We also prepared the Pt-bis(azido) ...

The reactions of Na[BArF] (BArF = tetrakis(3,5-bis(trifluoromethyl)phenyl)borate) with a series of [Pd(dpEMc)Cl2] (dpEMc = 1,1′-bis(diphenylphosphino)ruthenocene (dppr), 1,1′-bis(diphenylphosphino)osmocene (dppo) or 1,1′-bis(diphenylarsino)ferrocene (dpaf)) compounds were examined. The reacti...

Hetero-trinuclear complexes of formula [(C6F5)2Pt(μ-PPh2)2M(dppf)] [dppf = 1,1′-bis(diphenylphosphino)ferrocene, M = Pt (1), M = Pd (2)] were prepared by coupling between cis-[(C6F5)2Pt(PPh2)2]Li2 and cis-MCl2(dppf). Reaction of the Pt/Pt/Fe species 1 with [Ag(OClO3)(PPh3)] or I2 resulted in t...

Palladium(II) complexes with 1,1′-bis(diphenylphosphino)ferrocene (dppf), 1,1′-bis(diphenylphosphino)octamethylferrocene (dppomf), 1,1′-bis(diphenylphosphino)ruthenocene (dppr) and 1,1′-bis(diphenylphosphino)osmocene (dppo) have been synthesized and used to catalyze the methoxycarbonylation ...

A 1,1′ bis(diphenylphosphino ferrocene)dioxide complex of uranyl nitrate was synthesized and characterized by IR, 1H and 31P{1H} NMR spectroscopic and X-ray diffraction methods. The structure of the compound shows that the uranium atom is surrounded by eight oxygen atoms in a hexagonal bi-pyram...

The oxidative electrochemistry of 1,1′-bis(diphenylphosphino)ferrocene (dppf) and 1,1′-bis(diphenylphosphino)ruthenocene (dppr) was investigated at a variety of temperatures and concentrations. In addition, the oxidative electrochemistry of [NiCl2(dppf)] and [MCl2(dppr)] (M=Ni, Pd or Pt) compo...

The clusters [Ru6C(CO)16{Fe(C5H4P(Ph)2)2}] 2 and [Ru6C(CO)15{μ-Fe(C5H4P(Ph)2)2}] 3 have been synthesised from the reaction of the parent cluster [Ru6C(CO)17] 1 with 1,1′-bis(diphenylphosphino)ferrocene (dppf) in THF. The related compound [Ru5C(CO)13{μ-Fe(C5H4P(Ph)2)2}] 4 is produced from 2 an...

The one-electron oxidation of 1,1′-bis(diphenylphosphino)-2-[1-((boronato-functionalised)amino)ethyl)]ferrocenes leads to ferrocenium congeners which are generally more stable than the unsubstituted 1,1′-bis(diphenylphosphino)ferrocenium ion. 1,1′-bis(Diphenylphosphino)ferrocenes bearing in p...

The oxidative electrochemistry of 1,1′-bis(diphenylphosphino)osmocene (dppo) and 1,1′-bis(diphenylarsino)ferrocene (dpaf) was studied in dichloromethane with tetrabutylammonium hexafluorophosphate as the supporting electrolyte. The [MCl2(P∩P)] (M = Pd or Pt; P∩P = dppo or 1,1′-bis(diphenylp...

The last decade was marked by the growing interest of researchers in the chemistry of 1,1′-bis(ortho-carborane) and transition metal complexes based thereof. In this review various types of transition metal complexes with 1,1′-bis(ortho-carborane) based ligands will be considered including tho...

Herein, we report the identification, design, and synthesis of a series of 4-substituted 2-amino-3,4-dihydroquinazolines with hairpin turn side chains as novel inhibitors of BACE-1. The dihydroquinazoline derivatives were rationally designed by modifying the amide group and relocating the α -hy...

Our previous study with radioiodinated 1-methyl-1-(2-hydroxyethyl)-4-phenylpiperazinium derivatives indicated that these compounds localize selectively in the rat myocardium. Based upon these results, 1-[11C]methyl-1-alkyl-4-phenylpiperazinium cations were synthesized and evaluated for their pot...

This report describes the synthesis of radioiodinated 1-carboxamidino-4-phenylpiperazine, an aralkyl- guanidine with good adrenal and myocardial selectivity. As a tertiary aniline, the benzene portion of the molecule readily undergoes direct electrophilic radioiodination under mild reaction cond...

A new series of 2,4,6-trisubstituted bis-pyrimidines were synthesized and evaluated for in vitro antiamoebic activity against HM1:IMSS strain of Entamoeba histolytica. Out of 16 compounds 8 compounds have shown IC50 values in the range of 0.10–1.86 μM. Bis-pyrimidine having methyl-, methoxy-, ...

A d-glucuronic acid derivative fully protected with hydrogenolyzable groups except at C-6 has been synthesized. Successive tritylation and benzoylation of benzyl β-d-glucopyranoside gave benzyl 2,3,4-tri-O-benzoyl-6-O-trityl-β-d-glucopyranoside (1). The benzoyl groups in 1 were replaced with b...

Earlier observations on the reaction of some 2-naphthylamine metabolites with thiols have been extended. 2-Amino-1-naphthyl sulphate, bis-(2-amino-1-naphthyl)-hydrogen phosphate and 2-amino-1-naphthyl glucosiduronic acid arylate N-acetylcysteine and glutathione at pH 7.0 at 37° to give the corr...