Appearance:KIND OF WHITE TO WHITE CRYSTALLOID POWDER Application:Trazodone Port:Shanghai
Cas:6969-71-7
Min.Order:1 Kilogram
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inquiryProduct description: Product name 1,2,4-Triazolo[4,3-a]pyridin-3(2H)-one CAS number 6969-71-7 Assay ≥98% Appearance White powder Capacity 200mt/year Application Pharmaceutica
Cas:6969-71-7
Min.Order:10 Gram
FOB Price: $12.0
Type:Lab/Research institutions
inquiryHebei yanxi chemical co., LTD is a professional research, development and production of lead acetate benzene acetamide enterprise backbone members by local well-known entrepreneurs and professional senior engineers in the party's "low carb
Cas:6969-71-7
Min.Order:1 Kilogram
FOB Price: $1.0 / 3.0
Type:Manufacturers
inquiryCAS No.: 6969-71-7 Other Names: 1,2,4-TRIAZOLO-[4,3-A]PYRIDINE-3(2H)-ONE MF: C6H5N3O EINECS No.: 230-191-8 Place of Origin:
Cas:6969-71-7
Min.Order:25 Kilogram
FOB Price: $1000.0
Type:Trading Company
inquiryhigh quality Appearance:White or off-white Solid Storage:Sealed, dry, microtherm , avoid light and smell. Package:According to the demand of customer Application:Organic synthesis Transportation:by air or by sea Port:shanghai
Cas:6969-71-7
Min.Order:1 Gram
Negotiable
Type:Manufacturers
inquiryThe above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi
Cas:6969-71-7
Min.Order:1
Negotiable
Type:Other
inquiryDayangchem's R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. DayangChem can provide different quantities
Cas:6969-71-7
Min.Order:1 Kilogram
FOB Price: $3.0
Type:Lab/Research institutions
inquiryOur main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block
Cas:6969-71-7
Min.Order:5 Kiloliter
FOB Price: $1.2 / 5.0
Type:Manufacturers
inquiryLIDE PHARMACEUTICALS LIMITED is a professional chemicals and APIs leading manufacturer in China. Our core business line covers APIs, Intermediates, Herb extract, etc. We are specialized in chemical synthesis, process development of pharmaceu
Cas:6969-71-7
Min.Order:1 Kilogram
FOB Price: $18.0 / 20.0
Type:Lab/Research institutions
inquiryWith our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufacturin
Cas:6969-71-7
Min.Order:1 Kilogram
FOB Price: $3.0 / 10.0
Type:Trading Company
inquiryOur company was built in 2009 with an ISO certificate.In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.
Cas:6969-71-7
Min.Order:1 Kilogram
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Type:Lab/Research institutions
inquiryWITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et
Cas:6969-71-7
Min.Order:1 Kilogram
FOB Price: $139.0 / 210.0
Type:Trading Company
inquiry1. Product advantages High purity, all above 98.5%, no impurities after dissolution We will test each batch to ensure quality OEM and private brand services designed for free Various cap colors available We can also provide MT1 peptide powder 2. Fact
Cas:6969-71-7
Min.Order:1 Kilogram
FOB Price: $20.0 / 25.0
Type:Trading Company
inquiryProduct Name 124-Triazolo[43-a]pyridin-3(2H)-one Synonyms 124-Triazolopyridin-3-one CAS 6969-71-7 CAS: 6969-71-7 MF: - MW: -
Cas:6969-71-7
Min.Order:5 Metric Ton
FOB Price: $1.0 / 2.0
Type:Other
inquiry1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized
Cas:6969-71-7
Min.Order:1 Kilogram
Negotiable
Type:Lab/Research institutions
inquiryOur Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We
Cas:6969-71-7
Min.Order:10 Kilogram
Negotiable
Type:Trading Company
inquiryOur company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At present
Cas:6969-71-7
Min.Order:1 Kilogram
FOB Price: $45.0 / 55.0
Type:Trading Company
inquiry1,2,4-Triazolo[4,3-a]pyridin-3(2H)-oneCAS:6969-71-7 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high qual
Cas:6969-71-7
Min.Order:1 Gram
Negotiable
Type:Lab/Research institutions
inquiryHello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai
Cas:6969-71-7
Min.Order:1 Kilogram
Negotiable
Type:Lab/Research institutions
inquiryHenan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod
Cas:6969-71-7
Min.Order:0
Negotiable
Type:Lab/Research institutions
inquiryBest quality & Attractive price & Professional service; Trial & Pilot & Commercial Hisunny Chemical is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality intermediates, specia
Cas:6969-71-7
Min.Order:0
Negotiable
Type:Manufacturers
inquiryAppearance:Light Brown to Brown solid Storage:2-8°C Application:1,2,4-Triazolo[4,3-a]pyridin-3(2H)-one was used to prepare a congener of Trazodone (T718500) which was found to be a potent and selective inhibitor of synaptosomal uptake of 5
Cas:6969-71-7
Min.Order:25 Metric Ton
Negotiable
Type:Lab/Research institutions
inquiryHangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det
Cas:6969-71-7
Min.Order:0 Metric Ton
Negotiable
Type:Lab/Research institutions
inquiryJ&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia
Cas:6969-71-7
Min.Order:0
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Type:Lab/Research institutions
inquiryA substitute for perfluorooctanoic acid, mainly used as a surfactant, dispersant, additive, etc Appearance:White solid or Colorless liquid Purity:99.3 % We will ship the goods in a timely manner as required We can provide relevant documents acc
Cas:6969-71-7
Min.Order:4 Kilogram
Negotiable
Type:Lab/Research institutions
inquiryZibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi
Cas:6969-71-7
Min.Order:10 Gram
FOB Price: $100.0
Type:Lab/Research institutions
inquiry1,2,4-Triazolo[4,3-a]pyridin-3(2H)-oneAppearance:white crystalline powder Storage:In Shade Package:according to customers' requirements Application:Pharmaceutical intermediates Transportation:By air(EMS or EUB or FedEx or TNT ect...) or by sea(FOB or
We are one of a few suppliers that can offer custom synthesis service of this product We are specialized in custom synthesis, chemical/pharmaceutical/ pesticides outsourcing and contract research. We are committed to prov
Cas:6969-71-7
Min.Order:100 Gram
FOB Price: $100.0 / 2000.0
Type:Lab/Research institutions
inquirySuperior quality, moderate price & quick delivery. Appearance:light yellow crystals Storage:Stored in cool, dry and ventilation place; Away from fire and heat Package:1kg/bag,or as your request Application:For medicine , pesticide intermedi
Cas:6969-71-7
Min.Order:1 Gram
Negotiable
Type:Trading Company
inquiryGMP standard, high purity, competitive price, in stock 1. Quick Response: within 6 hours after receiving your email. 2. Quality Guarantee: All products are strictly tested by our QC, confirmed by QA, and approved by a third-party lab in China, USA,
Cas:6969-71-7
Min.Order:1 Milligram
Negotiable
Type:Trading Company
inquiry[1,2,4]triazolo[4,3-a]pyridin-3(2H)-one
Conditions | Yield |
---|---|
In N,N-dimethyl-formamide at 140℃; for 24h; Reagent/catalyst; Temperature; Solvent; Schlenk technique; Sealed tube; | 81% |
Conditions | Yield |
---|---|
In neat (no solvent) for 0.0138889h; Microwave irradiation; | 75% |
at 200℃; for 2h; Cyclization; | 57% |
at 130℃; for 3h; | 15% |
at 120 - 160℃; for 4h; Temperature; |
[1,2,4]triazolo[4,3-a]pyridin-3(2H)-one
Conditions | Yield |
---|---|
In N,N-dimethyl-formamide at 140℃; for 24h; Reagent/catalyst; Temperature; Solvent; Schlenk technique; Sealed tube; | 81% |
2-benzyl-[1,2,4]triazolo[4,3-a]pyridin-3(2H)-one
[1,2,4]triazolo[4,3-a]pyridin-3(2H)-one
Conditions | Yield |
---|---|
With trifluorormethanesulfonic acid In toluene at 150℃; for 0.25h; Microwave irradiation; | 72% |
Conditions | Yield |
---|---|
In neat (no solvent) for 0.0138889h; Microwave irradiation; | 75% |
at 200℃; for 2h; Cyclization; | 57% |
at 130℃; for 3h; | 15% |
at 120 - 160℃; for 4h; Temperature; |
2-benzyl-[1,2,4]triazolo[4,3-a]pyridin-3(2H)-one
[1,2,4]triazolo[4,3-a]pyridin-3(2H)-one
Conditions | Yield |
---|---|
With trifluorormethanesulfonic acid In toluene at 150℃; for 0.25h; Microwave irradiation; | 72% |
2-chloropyridine
semicarbazide hydrochloride
[1,2,4]triazolo[4,3-a]pyridin-3(2H)-one
Conditions | Yield |
---|---|
With sulfuric acid In 2-ethoxy-ethanol for 24h; Reflux; | 51% |
With sulfuric acid In 2-ethoxy-ethanol for 0.0333333h; Microwave irradiation; | 48% |
With sulfuric acid In 2-ethoxy-ethanol; water | 35.0 g (59%) |
2-chloropyridine
semicarbazide hydrochloride
[1,2,4]triazolo[4,3-a]pyridin-3(2H)-one
Conditions | Yield |
---|---|
With sulfuric acid In 2-ethoxy-ethanol for 24h; Reflux; | 51% |
With sulfuric acid In 2-ethoxy-ethanol for 0.0333333h; Microwave irradiation; | 48% |
With sulfuric acid In 2-ethoxy-ethanol; water | 35.0 g (59%) |
diethylamine
1-acetyl-1,2,4-triazolo<4,3-a>pyridinium-3-olate
A
diethylacetamide
B
[1,2,4]triazolo[4,3-a]pyridin-3(2H)-one
Conditions | Yield |
---|---|
In tetrahydrofuran at 25℃; Rate constant; |
diethylamine
1-acetyl-1,2,4-triazolo<4,3-a>pyridinium-3-olate
A
diethylacetamide
B
[1,2,4]triazolo[4,3-a]pyridin-3(2H)-one
Conditions | Yield |
---|---|
In tetrahydrofuran at 25℃; Rate constant; |
1-acetyl-1,2,4-triazolo<4,3-a>pyridinium-3-olate
A
acetic acid
B
[1,2,4]triazolo[4,3-a]pyridin-3(2H)-one
Conditions | Yield |
---|---|
With water at 25℃; Rate constant; |
1-acetyl-1,2,4-triazolo<4,3-a>pyridinium-3-olate
A
acetic acid
B
[1,2,4]triazolo[4,3-a]pyridin-3(2H)-one
Conditions | Yield |
---|---|
With water at 25℃; Rate constant; |
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 100 percent / NH2NH2 / 2 h / 100 °C 2: 57 percent / 2 h / 200 °C View Scheme |
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 100 percent / NH2NH2 / 2 h / 100 °C 2: 57 percent / 2 h / 200 °C View Scheme |
2-chloropyridine
hydrazine carboxamide
[1,2,4]triazolo[4,3-a]pyridin-3(2H)-one
Conditions | Yield |
---|---|
With sulfuric acid In 2-ethoxy-ethanol; water |
2-chloropyridine
hydrazine carboxamide
[1,2,4]triazolo[4,3-a]pyridin-3(2H)-one
Conditions | Yield |
---|---|
With sulfuric acid In 2-ethoxy-ethanol; water |
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: hydrazine hydrate / 1,4-dioxane / Reflux 2: 3 h / 130 °C View Scheme | |
Multi-step reaction with 2 steps 1: hydrazine / N,N-dimethyl-formamide / 0.03 h / Microwave irradiation 2: neat (no solvent) / 0.01 h / Microwave irradiation View Scheme |
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: hydrazine hydrate / 1,4-dioxane / Reflux 2: 3 h / 130 °C View Scheme | |
Multi-step reaction with 2 steps 1: hydrazine / N,N-dimethyl-formamide / 0.03 h / Microwave irradiation 2: neat (no solvent) / 0.01 h / Microwave irradiation View Scheme |
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: hydrazine hydrate / ethanol / 12 h / Reflux 2: Triethoxysilane / N,N-dimethyl-formamide / 20 °C 3: N,N-dimethyl-formamide / 24 h / 140 °C / Schlenk technique; Sealed tube View Scheme | |
Multi-step reaction with 2 steps 1: hydrazine / N,N-dimethyl-formamide / 25 h / Heating; Microwave irradiation 2: neat (no solvent) / 0.01 h / Microwave irradiation View Scheme |
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: hydrazine hydrate / ethanol / 12 h / Reflux 2: Triethoxysilane / N,N-dimethyl-formamide / 20 °C 3: N,N-dimethyl-formamide / 24 h / 140 °C / Schlenk technique; Sealed tube View Scheme | |
Multi-step reaction with 2 steps 1: hydrazine / N,N-dimethyl-formamide / 25 h / Heating; Microwave irradiation 2: neat (no solvent) / 0.01 h / Microwave irradiation View Scheme |
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: Triethoxysilane / N,N-dimethyl-formamide / 20 °C 2: N,N-dimethyl-formamide / 24 h / 140 °C / Schlenk technique; Sealed tube View Scheme |
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: Triethoxysilane / N,N-dimethyl-formamide / 20 °C 2: N,N-dimethyl-formamide / 24 h / 140 °C / Schlenk technique; Sealed tube View Scheme |
2-bromo-pyridine
semicarbazide hydrochloride
[1,2,4]triazolo[4,3-a]pyridin-3(2H)-one
Conditions | Yield |
---|---|
With sulfuric acid In 2-ethoxy-ethanol for 0.0333333h; Microwave irradiation; |
2-bromo-pyridine
semicarbazide hydrochloride
[1,2,4]triazolo[4,3-a]pyridin-3(2H)-one
Conditions | Yield |
---|---|
With sulfuric acid In 2-ethoxy-ethanol for 0.0333333h; Microwave irradiation; |
[1,2,4]triazolo[4,3-a]pyridin-3(2H)-one
methyl iodide
2-methyl-2H-[1,2,4]triazolo[4,3-a]pyridin-3-one
Conditions | Yield |
---|---|
In acetone at 40℃; Alkylation; | 100% |
[1,2,4]triazolo[4,3-a]pyridin-3(2H)-one
methyl iodide
2-methyl-2H-[1,2,4]triazolo[4,3-a]pyridin-3-one
Conditions | Yield |
---|---|
In acetone at 40℃; Alkylation; | 100% |
Conditions | Yield |
---|---|
In chloroform Heating; | 96% |
Conditions | Yield |
---|---|
In chloroform Heating; | 96% |
phosgene
[1,2,4]triazolo[4,3-a]pyridin-3(2H)-one
2-chloroformyl-1,2,4-triazolo<4,3-a>pyridin-3-(2H)-one
Conditions | Yield |
---|---|
In tetrahydrofuran for 2h; Heating; | 93% |
phosgene
[1,2,4]triazolo[4,3-a]pyridin-3(2H)-one
2-chloroformyl-1,2,4-triazolo<4,3-a>pyridin-3-(2H)-one
Conditions | Yield |
---|---|
In tetrahydrofuran for 2h; Heating; | 93% |
acetyl chloride
[1,2,4]triazolo[4,3-a]pyridin-3(2H)-one
2-acetyl-1,2,4-triazolo<4,3-a>pyridin-3(2H)-one
Conditions | Yield |
---|---|
In chloroform for 4h; Heating; | 92% |
acetyl chloride
[1,2,4]triazolo[4,3-a]pyridin-3(2H)-one
2-acetyl-1,2,4-triazolo<4,3-a>pyridin-3(2H)-one
Conditions | Yield |
---|---|
In chloroform for 4h; Heating; | 92% |
1,3-chlorobromopropane
[1,2,4]triazolo[4,3-a]pyridin-3(2H)-one
2-(3-chloropropyl)-1,2,4-triazolo<4,3-a>pyridin-3-one
Conditions | Yield |
---|---|
With tetrabutylammomium bromide; potassium carbonate In acetonitrile for 0.0222222h; Solvent; Microwave irradiation; | 92% |
With potassium carbonate In acetonitrile for 8h; Heating / reflux; | 70% |
1,3-chlorobromopropane
[1,2,4]triazolo[4,3-a]pyridin-3(2H)-one
2-(3-chloropropyl)-1,2,4-triazolo<4,3-a>pyridin-3-one
Conditions | Yield |
---|---|
With tetrabutylammomium bromide; potassium carbonate In acetonitrile for 0.0222222h; Solvent; Microwave irradiation; | 92% |
With potassium carbonate In acetonitrile for 8h; Heating / reflux; | 70% |
1-(3-chloropropyl)-4-(3-chlorophenyl)piperazine hydrochloride
[1,2,4]triazolo[4,3-a]pyridin-3(2H)-one
trazodone
Conditions | Yield |
---|---|
With sodium hydroxide In isopropyl alcohol for 26h; Reagent/catalyst; Inert atmosphere; Reflux; | 92% |
With tetrabutylammomium bromide; potassium carbonate In acetonitrile for 0.0222222h; Time; Microwave irradiation; | 92% |
1-(3-chloropropyl)-4-(3-chlorophenyl)piperazine hydrochloride
[1,2,4]triazolo[4,3-a]pyridin-3(2H)-one
trazodone
Conditions | Yield |
---|---|
With sodium hydroxide In isopropyl alcohol for 26h; Reagent/catalyst; Inert atmosphere; Reflux; | 92% |
With tetrabutylammomium bromide; potassium carbonate In acetonitrile for 0.0222222h; Time; Microwave irradiation; | 92% |
Conditions | Yield |
---|---|
With potassium carbonate In acetonitrile at 60℃; for 1.5h; | 70% |
Conditions | Yield |
---|---|
With potassium carbonate In acetonitrile at 60℃; for 1.5h; | 70% |
1,1-dideutero-3-[4-(3-chlorophenyl)piperazin-1-yl]propan-1-ol
[1,2,4]triazolo[4,3-a]pyridin-3(2H)-one
2-(1,1-dideutero-3-(4-(3-chlorophenyl)piperazin-1-yl)propyl)-[1,2,4]triazolo[4,3-a]pyridin-3(2H)one
Conditions | Yield |
---|---|
With triphenylphosphine; diethylazodicarboxylate In tetrahydrofuran at 0 - 20℃; | 69% |
1,1-dideutero-3-[4-(3-chlorophenyl)piperazin-1-yl]propan-1-ol
[1,2,4]triazolo[4,3-a]pyridin-3(2H)-one
2-(1,1-dideutero-3-(4-(3-chlorophenyl)piperazin-1-yl)propyl)-[1,2,4]triazolo[4,3-a]pyridin-3(2H)one
Conditions | Yield |
---|---|
With triphenylphosphine; diethylazodicarboxylate In tetrahydrofuran at 0 - 20℃; | 69% |
Conditions | Yield |
---|---|
With potassium carbonate In N,N-dimethyl-formamide at 20℃; Cooling with ice; | 69% |
Conditions | Yield |
---|---|
With potassium carbonate In N,N-dimethyl-formamide at 20℃; Cooling with ice; | 69% |
1-(3-bromopropyl)-4-(3-chlorophenyl)-piperazine
[1,2,4]triazolo[4,3-a]pyridin-3(2H)-one
trazodone
Conditions | Yield |
---|---|
Stage #1: 1-(3-bromopropyl)-4-(3-chlorophenyl)-piperazine With sodium hydride In 1,4-dioxane for 1h; Reflux; Stage #2: [1,2,4]triazolo[4,3-a]pyridin-3(2H)-one In 1,4-dioxane for 20h; Reflux; | 65% |
1-(3-bromopropyl)-4-(3-chlorophenyl)-piperazine
[1,2,4]triazolo[4,3-a]pyridin-3(2H)-one
trazodone
Conditions | Yield |
---|---|
Stage #1: 1-(3-bromopropyl)-4-(3-chlorophenyl)-piperazine With sodium hydride In 1,4-dioxane for 1h; Reflux; Stage #2: [1,2,4]triazolo[4,3-a]pyridin-3(2H)-one In 1,4-dioxane for 20h; Reflux; | 65% |
benzyl bromide
[1,2,4]triazolo[4,3-a]pyridin-3(2H)-one
A
1-benzyl-[1,2,4]triazolo[4,3-a]pyridinium-3-olate
B
2-benzyl-[1,2,4]triazolo[4,3-a]pyridin-3(2H)-one
Conditions | Yield |
---|---|
With potassium carbonate In 1,4-dioxane at 80℃; for 10h; Alkylation; | A 60% B 32% |
benzyl bromide
[1,2,4]triazolo[4,3-a]pyridin-3(2H)-one
A
1-benzyl-[1,2,4]triazolo[4,3-a]pyridinium-3-olate
B
2-benzyl-[1,2,4]triazolo[4,3-a]pyridin-3(2H)-one
Conditions | Yield |
---|---|
With potassium carbonate In 1,4-dioxane at 80℃; for 10h; Alkylation; | A 60% B 32% |
3-chloropropyl p-toluenesulfonate
[1,2,4]triazolo[4,3-a]pyridin-3(2H)-one
2-(3-chloropropyl)-1,2,4-triazolo<4,3-a>pyridin-3-one
Conditions | Yield |
---|---|
Stage #1: [1,2,4]triazolo[4,3-a]pyridin-3(2H)-one With sodium hydride In DMF (N,N-dimethyl-formamide) for 0.5h; Stage #2: 3-chloropropyl p-toluenesulfonate In DMF (N,N-dimethyl-formamide) at 50℃; for 4h; | 58% |
3-chloropropyl p-toluenesulfonate
[1,2,4]triazolo[4,3-a]pyridin-3(2H)-one
2-(3-chloropropyl)-1,2,4-triazolo<4,3-a>pyridin-3-one
Conditions | Yield |
---|---|
Stage #1: [1,2,4]triazolo[4,3-a]pyridin-3(2H)-one With sodium hydride In DMF (N,N-dimethyl-formamide) for 0.5h; Stage #2: 3-chloropropyl p-toluenesulfonate In DMF (N,N-dimethyl-formamide) at 50℃; for 4h; | 58% |
tert-butyl 2-bromopropionate
[1,2,4]triazolo[4,3-a]pyridin-3(2H)-one
Conditions | Yield |
---|---|
With potassium carbonate In acetonitrile at 60℃; for 20h; | 58% |
tert-butyl 2-bromopropionate
[1,2,4]triazolo[4,3-a]pyridin-3(2H)-one
Conditions | Yield |
---|---|
With potassium carbonate In acetonitrile at 60℃; for 20h; | 58% |
Conditions | Yield |
---|---|
With sodium hydride In N,N-dimethyl-formamide at 20℃; for 6h; | 54.7% |
Conditions | Yield |
---|---|
With sodium hydride In N,N-dimethyl-formamide at 20℃; for 6h; | 54.7% |
benzyl chloroformate
[1,2,4]triazolo[4,3-a]pyridin-3(2H)-one
1-benzyloxycarbonyl-1,2,4-triazolo<4,3-a>pyridinium-3-olate
Conditions | Yield |
---|---|
at 90℃; for 1h; | 52% |
benzyl chloroformate
[1,2,4]triazolo[4,3-a]pyridin-3(2H)-one
1-benzyloxycarbonyl-1,2,4-triazolo<4,3-a>pyridinium-3-olate
Conditions | Yield |
---|---|
at 90℃; for 1h; | 52% |
[1,2,4]triazolo[4,3-a]pyridin-3(2H)-one
Conditions | Yield |
---|---|
With 15-crown-5; sodium hydride In N,N-dimethyl-formamide at 40℃; for 12h; | 46% |
[1,2,4]triazolo[4,3-a]pyridin-3(2H)-one
Conditions | Yield |
---|---|
With 15-crown-5; sodium hydride In N,N-dimethyl-formamide at 40℃; for 12h; | 46% |
C17H16BrF2NO
[1,2,4]triazolo[4,3-a]pyridin-3(2H)-one
2-(5-(3,5-difluorophenoxy)-2-methyl-2,3,4,5-tetrahydro-1H-benzo[c]azepin-8-yl)-[1,2,4]triazolo[4,3-a]pyridin-3(2H)-one
Conditions | Yield |
---|---|
With potassium phosphate; N,N`-dimethylethylenediamine; copper(l) iodide In 1,4-dioxane at 110℃; for 16h; Product distribution / selectivity; | 46% |
1,3-dibromo-1,1,3,3-d4-propane
[1,2,4]triazolo[4,3-a]pyridin-3(2H)-one
2-(1,1,3,3-tetradeutero-3-bromopropyl)-[1,2,4]triazolo[4,3-a]pyridin-3(2H)-one
Conditions | Yield |
---|---|
With potassium carbonate In acetonitrile at 60℃; for 18h; | 31% |
C17H16BrF2NO
[1,2,4]triazolo[4,3-a]pyridin-3(2H)-one
2-(5-(3,5-difluorophenoxy)-2-methyl-2,3,4,5-tetrahydro-1H-benzo[c]azepin-8-yl)-[1,2,4]triazolo[4,3-a]pyridin-3(2H)-one
Conditions | Yield |
---|---|
With potassium phosphate; N,N`-dimethylethylenediamine; copper(l) iodide In 1,4-dioxane at 110℃; for 16h; Product distribution / selectivity; | 46% |
3-chloro-1-[4-(3-chlorophenyl)piperazin-1-yl]propan-1-one
[1,2,4]triazolo[4,3-a]pyridin-3(2H)-one
1-(3-chloro-phenyl)-4-[3-(3-oxo-[1,2,4]triazolo[4,3-a]pyridin-2-yl)-propionyl]-piperazine
Conditions | Yield |
---|---|
With tetrabutylammomium bromide; potassium hydroxide In toluene at 110℃; for 16h; | 30% |
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