As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch
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inquiryWelcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our
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inquiryhigh quality Appearance:white powder Storage:Sealed, dry, microtherm , avoid light and smell Package:According to the demand of customer Application:Pharmaceutical intermediates Transportation:by air or by sea Port:shanghai
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inquiryThe above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi
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inquiryOur main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block
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inquiryName:6-Methoxy-2-(4-methoxyphenyl)benzobithiophene CAS NO: 63675-74-1 Grade:Medical scientific research and export Molecular formula: C16H14O2S Molecular weight:270.3462 Product Quality 12 years of chemical raw materials Mature operation
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inquiry6-Methoxy-2-(4-methoxyphenyl)benzobithiophene Basic information Product Name: 6-Methoxy-2-(4-methoxyphenyl)benzobithiophene Synonyms: 4-(6-METHOXY-1-BENZOTHIOPHEN-2-YL)PHENYL METHYL ETHE
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inquiryWith our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufacturin
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inquiryWITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et
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inquiry1. Product advantages High purity, all above 98.5%, no impurities after dissolution We will test each batch to ensure quality OEM and private brand services designed for free Various cap colors available We can also provide MT1 peptide powd
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inquiryProduct Name: 6-Methoxy-2-(4-methoxyphenyl)benzobithiophene Appearance: White crystal powder M.F.: C16H14O2S M.W.: 270.35 CAS NO.: 63675-74-1 EINECS NO.: 264-408-2 Appearance:White powder Storage:RT. Package:drum Application: Pharmaceutical
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inquiryC16H14O2S 6-Methoxy-2-(4-methoxyphenyl)benzobithiophene 63675-74-1 1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; Appearan
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inquiry1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized
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inquiryPackage:25kgs/fiber drum Application:Raloxifene intermediate Port:any port in China
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inquiryOur company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At present,
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inquiry6-Methoxy-2-(4-methoxyphenyl)benzobithiophene CAS:63675-74-1 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in
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inquiryHello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai
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inquiryHenan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod
Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det
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inquiryJ&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia
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inquiryZibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi
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inquirySuperior quality, moderate price & quick delivery. Appearance:white powder Storage:Stored in cool, dry and ventilation place; Away from fire and heat Package:10g/bag,or as your request Application:For medicine , pesticide intermediates Tran
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inquiryProduct Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,
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inquiryProduct name: 6-Methoxy-2-(4-Methoxyphenyl)Benzobithiophene CAS No.:63675-74-1 Molecule Formula:C16H14O2S Molecule Weight:270.34 Purity: 98% Package: 25kg/drum Description:White powder Manufacture Standards:Enterprise Standard TE
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inquiryOur Advantages A. International Top level TechnologyOur company owned biomedicine experts are famous at home and abroad with rich experience in research and development in the field of efficient chiral functional molecules research and development an
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inquiryHANGZHOU THINK CHEMICAL CO., LTD. (THINKCHEM) is an integrative corporation of trade, research and contract manufacture. With about ten years of business experiences on the marketing & distribution, thinkchem specializes in exp
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inquiryfactory?direct?saleAppearance:White Powder Storage:Store In Dry, Cool And Ventilated Place Package:25kg/drum, also according to the clients requirement Application:It is widely used as a thickener, emulsifier and stabilizer Transportation:By Sea Or B
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inquiryWe Huarong Pharm can provide Customized Synthesis & Process R&D & APIs and intermediates Production & Quality Research & Registration Application, especially our GMP validation service which complies with SFDA, FDA, WHO and EU EMPA. O
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inquiry(5-methoxy-2-((4-methoxyphenyl)ethynyl)phenyl)(methyl)-sulfane
2-(4'-methoxyphenyl)-6-methoxybenzothiophene
Conditions | Yield |
---|---|
With trifluoroacetic acid; silver(l) oxide at 25℃; for 1.5h; Schlenk technique; | 89% |
6-methoxy-benzo[b]thiophene
para-iodoanisole
2-(4'-methoxyphenyl)-6-methoxybenzothiophene
Conditions | Yield |
---|---|
With dichloro(2,2'-bipyridine)nickel(II); lithium hexamethyldisilazane In 2-methyltetrahydrofuran at 120℃; for 16h; Schlenk technique; Sealed tube; Inert atmosphere; Glovebox; regiospecific reaction; | 85% |
With palladium diacetate; silver trifluoroacetate; trifluoroacetic acid In water at 20℃; for 48h; Inert atmosphere; | 60% |
para-iodoanisole
6-methoxy-benzo[b]thiophen-2-yl boronic acid
2-(4'-methoxyphenyl)-6-methoxybenzothiophene
Conditions | Yield |
---|---|
With tetrakis(triphenylphosphine) palladium(0); sodium carbonate In water at 110℃; for 12h; Suzuki coupling; Ionic liquid; Inert atmosphere; | 81% |
With sodium carbonate; tetrakis(triphenylphosphine)palladium (0) In toluene | 1.25 g (96%) |
6-methoxy-2-iodobenzo[b]thiophene
4-methoxyphenylboronic acid
2-(4'-methoxyphenyl)-6-methoxybenzothiophene
Conditions | Yield |
---|---|
80% |
α-(3-methoxyphenyl-thio)-4-methoxyacetophenone
2-(4'-methoxyphenyl)-6-methoxybenzothiophene
Conditions | Yield |
---|---|
Stage #1: α-(3-methoxyphenyl-thio)-4-methoxyacetophenone In toluene under 760.051 Torr; for 2h; Reflux; Inert atmosphere; Dean-Stark; Large scale; Stage #2: With methanesulfonic acid In toluene at 90℃; for 4h; Inert atmosphere; Large scale; Stage #3: In n-heptane; toluene at 80 - 90℃; for 4h; Reagent/catalyst; Solvent; Temperature; Inert atmosphere; Large scale; | 79.6% |
With PPA at 85 - 95℃; for 1.25h; | |
With polyphosphoric acid at 90℃; for 1h; Inert atmosphere; | |
With PPA |
4-methoxyphenylacetylen
2-(4'-methoxyphenyl)-6-methoxybenzothiophene
Conditions | Yield |
---|---|
With eosin y In dimethyl sulfoxide for 14h; Irradiation; | 70% |
With titanium(III) chloride In N,N-dimethyl-formamide at -25 - 20℃; Cycloaddition; | 60% |
2-(4'-methoxyphenyl)-6-methoxybenzothiophene
Conditions | Yield |
---|---|
With Octanethiol; trifluorormethanesulfonic acid In dichloromethane at 40℃; for 12h; | 70% |
α-(3-methoxyphenyl-thio)-4-methoxyacetophenone
A
2-(4'-methoxyphenyl)-6-methoxybenzothiophene
B
2-(4'-methoxyphenyl)-4-methoxybenzo[b]thiophene
Conditions | Yield |
---|---|
With PPA at 85 - 90℃; for 1h; | A 69% B n/a |
With PPA at 70℃; | A 68% B 23% |
With PPA Heating; Yield given; Yields of byproduct given; | |
With polyphosphoric acid at 65 - 90℃; for 2h; Product distribution / selectivity; |
6-methoxy-benzo[b]thiophene
1-bromo-4-methoxy-benzene
2-(4'-methoxyphenyl)-6-methoxybenzothiophene
Conditions | Yield |
---|---|
With potassium acetate; {1,3-bis(2,6-diethylaniline)acenaphthylenyl-4,5-imidazolium-2-ylidene}PdCl2-(pyridine) In N,N-dimethyl acetamide at 130℃; for 12h; Inert atmosphere; Sealed tube; | 67% |
2-fluoro-4-methoxy-benzaldehyde
p-methoxybenzylmercaptan
2-(4'-methoxyphenyl)-6-methoxybenzothiophene
Conditions | Yield |
---|---|
With potassium carbonate In N,N-dimethyl-formamide at 60 - 160℃; for 66h; | 55% |
4-Methoxy-2-methylsulfenylaniline
phenylacetylene
2-(4'-methoxyphenyl)-6-methoxybenzothiophene
Conditions | Yield |
---|---|
With tert.-butylnitrite In nitromethane at 80℃; for 12h; Schlenk technique; Inert atmosphere; | 50% |
4-methoxyphenylboronic acid
2-(4'-methoxyphenyl)-6-methoxybenzothiophene
Conditions | Yield |
---|---|
With sodium carbonate; tetrakis(triphenylphosphine) palladium(0) at 100℃; for 4h; Yield given; |
1-bromo-4-methoxy-benzene
6-methoxy-benzo[b]thiophen-2-yl boronic acid
2-(4'-methoxyphenyl)-6-methoxybenzothiophene
Conditions | Yield |
---|---|
With tetrakis(triphenylphosphine) palladium(0); sodium carbonate Suzuki coupling reaction; |
6-methoxy-benzo[b]thiophene
2-(4'-methoxyphenyl)-6-methoxybenzothiophene
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: BuLi 1.2: B(OiPr)3 1.3: HCl 2.1: Na2CO3; Pd(PPh3)4 View Scheme | |
Multi-step reaction with 2 steps 1.1: n-butyllithium / tetrahydrofuran; hexane / 2.08 h / -78 °C / Inert atmosphere 1.2: 3 h / -78 - 20 °C / Inert atmosphere 2.1: N-Bromosuccinimide / tetrahydrofuran; hexane / 3 h / -78 °C / Inert atmosphere 2.2: 0.5 h / -78 - 20 °C / Inert atmosphere View Scheme |
3-methoxybenzenethiol
2-(4'-methoxyphenyl)-6-methoxybenzothiophene
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: K2CO3 / acetone 1.2: BF3*Et2O 2.1: BuLi 2.2: B(OiPr)3 2.3: HCl 3.1: Na2CO3; Pd(PPh3)4 View Scheme |
6-methoxybenzothiazol-2-ylamine
2-(4'-methoxyphenyl)-6-methoxybenzothiophene
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: aq. KOH / 17 h / Heating 1.2: 92 percent / 1 h / 20 °C 2.1: aq. HCl; NaNO2 2.2: 57 percent / aq. HBF4 / 0 - 20 °C 3.1: 60 percent / TiCl3 / dimethylformamide / -25 - 20 °C View Scheme | |
Multi-step reaction with 3 steps 1.1: potassium hydroxide / water / 17 h / Reflux 1.2: 1 h / 20 °C 2.1: fluoroboric acid; sodium nitrite / water / 0.67 h / 0 - 5 °C / Enzymatic reaction 3.1: eosin y / dimethyl sulfoxide / 14 h / Irradiation View Scheme | |
Multi-step reaction with 2 steps 1: potassium hydroxide; methyl iodide 2: tert.-butylnitrite / nitromethane / 12 h / 80 °C / Schlenk technique; Inert atmosphere View Scheme |
4-Methoxy-2-methylsulfenylaniline
2-(4'-methoxyphenyl)-6-methoxybenzothiophene
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: aq. HCl; NaNO2 1.2: 57 percent / aq. HBF4 / 0 - 20 °C 2.1: 60 percent / TiCl3 / dimethylformamide / -25 - 20 °C View Scheme | |
Multi-step reaction with 2 steps 1: fluoroboric acid; sodium nitrite / water / 0.67 h / 0 - 5 °C / Enzymatic reaction 2: eosin y / dimethyl sulfoxide / 14 h / Irradiation View Scheme |
4-methoxy-aniline
2-(4'-methoxyphenyl)-6-methoxybenzothiophene
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1.1: 62 percent / Br2; AcOH / 0.75 h / 20 °C 2.1: aq. KOH / 17 h / Heating 2.2: 92 percent / 1 h / 20 °C 3.1: aq. HCl; NaNO2 3.2: 57 percent / aq. HBF4 / 0 - 20 °C 4.1: 60 percent / TiCl3 / dimethylformamide / -25 - 20 °C View Scheme | |
Multi-step reaction with 3 steps 1.1: 51 percent / CuI / o-xylene / 94 h / 145 °C 2.1: aq. HCl; NaNO2 2.2: 57 percent / aq. HBF4 / 0 - 20 °C 3.1: 60 percent / TiCl3 / dimethylformamide / -25 - 20 °C View Scheme | |
Multi-step reaction with 4 steps 1.1: acetic acid; bromine / 3 h / 10 °C 2.1: potassium hydroxide / water / 17 h / Reflux 2.2: 1 h / 20 °C 3.1: fluoroboric acid; sodium nitrite / water / 0.67 h / 0 - 5 °C / Enzymatic reaction 4.1: eosin y / dimethyl sulfoxide / 14 h / Irradiation View Scheme |
1-(1,1-Dichloro-ethyl)-4-methoxy-benzene
2-(4'-methoxyphenyl)-6-methoxybenzothiophene
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: NaNH2; NH3 2: 60 percent / TiCl3 / dimethylformamide / -25 - 20 °C View Scheme |
1-(4-methoxyphenyl)ethanone
2-(4'-methoxyphenyl)-6-methoxybenzothiophene
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: PCl5 / benzene 2: NaNH2; NH3 3: 60 percent / TiCl3 / dimethylformamide / -25 - 20 °C View Scheme | |
Multi-step reaction with 2 steps 1.1: bromine / methanol / 2.5 h / 10 °C 1.2: 4 h / 0 - 20 °C 2.1: polyphosphoric acid / 2 h / 65 - 90 °C View Scheme |
3-methoxybenzenethiol
2-(4'-methoxyphenyl)-6-methoxybenzothiophene
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: NaOH / ethanol 2: polyphosphoric acid / Heating View Scheme | |
Multi-step reaction with 2 steps 1: 80 percent / KOH / aq. ethanol; ethyl acetate / 3 h / Ambient temperature 2: 68 percent / polyphosphoric acid / 70 °C View Scheme | |
Multi-step reaction with 2 steps 1: 80.4 percent / KOH / ethanol; H2O; ethyl acetate / Ambient temperature 2: 69 percent / PPA / 1 h / 85 - 90 °C View Scheme |
2-Bromo-4'-methoxyacetophenone
2-(4'-methoxyphenyl)-6-methoxybenzothiophene
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: NaOH / ethanol 2: polyphosphoric acid / Heating View Scheme | |
Multi-step reaction with 2 steps 1: 80 percent / KOH / aq. ethanol; ethyl acetate / 3 h / Ambient temperature 2: 68 percent / polyphosphoric acid / 70 °C View Scheme | |
Multi-step reaction with 2 steps 1: 80.4 percent / KOH / ethanol; H2O; ethyl acetate / Ambient temperature 2: 69 percent / PPA / 1 h / 85 - 90 °C View Scheme |
2-(4'-methoxyphenyl)-6-methoxybenzothiophene
Conditions | Yield |
---|---|
With toluene-4-sulfonic acid In toluene for 1.5h; Heating / reflux; | |
With toluene-4-sulfonic acid In toluene for 6h; Heating / reflux; |
3-methoxybenzenethiol
2-Bromo-4'-methoxyacetophenone
2-(4'-methoxyphenyl)-6-methoxybenzothiophene
Conditions | Yield |
---|---|
With potassium hydroxide; PPA In ethanol; water; ethyl acetate | |
With potassium hydroxide; PPA In ethanol; water; ethyl acetate |
Lawessons reagent
2-(4'-methoxyphenyl)-6-methoxybenzothiophene
Conditions | Yield |
---|---|
With methanesulfonic acid In chlorobenzene | |
With methanesulfonic acid In chlorobenzene |
4-methoxybenzo[b]thiophene
acetophenone
2-(4'-methoxyphenyl)-6-methoxybenzothiophene
Conditions | Yield |
---|---|
With PPA; phosphoric acid In water; toluene |
3-methoxybenzenethiol
2-Bromo-4'-methoxyacetophenone
A
2-(4'-methoxyphenyl)-6-methoxybenzothiophene
B
α-(3-methoxyphenyl-thio)-4-methoxyacetophenone
Conditions | Yield |
---|---|
With potassium hydroxide In ethanol; water; Petroleum ether | A 78.5 g (76%) B n/a |
2-(4'-methoxyphenyl)-6-methoxybenzothiophene
1,2-bis(4-methoxyphenyl)ethane
Conditions | Yield |
---|---|
W-2 Raney Ni In ethanol for 0.5h; Heating; | 100% |
2-(4'-methoxyphenyl)-6-methoxybenzothiophene
3-bromo-6-methoxy-2-(4-methoxyphenyl)benzo[b]thiophene
Conditions | Yield |
---|---|
With bromine In chloroform at 60℃; | 100% |
With bromine In chloroform at 60℃; | 100% |
With N-Bromosuccinimide In tetrahydrofuran at 0 - 20℃; for 3h; | 97% |
2-(4'-methoxyphenyl)-6-methoxybenzothiophene
4-chlorobenzoyl chloride
4-Bromophenyl-[6-methoxy-2-(4-methoxy-phenyl)benzo[b]thien-3-yl]methanone
Conditions | Yield |
---|---|
With aluminum (III) chloride In dichloromethane at 0 - 25℃; for 3.5h; Friedel-Crafts Acylation; | 96% |
With copper(II) bis(trifluoromethanesulfonate) at 100℃; for 2h; Friedel Crafts acylation; Ionic liquid; Inert atmosphere; | 79% |
With aluminium trichloride In dichloromethane | 65% |
4-(2-chloro-ethoxy)-benzoyl chloride
2-(4'-methoxyphenyl)-6-methoxybenzothiophene
Conditions | Yield |
---|---|
With aluminum (III) chloride In dichloromethane at 50℃; for 12h; Friedel-Crafts Acylation; Inert atmosphere; | 95% |
acetic anhydride
2-(4'-methoxyphenyl)-6-methoxybenzothiophene
6-acetoxy-2-(4-acetoxyphenyl)benzo[b]thiophene
Conditions | Yield |
---|---|
Stage #1: 2-(4'-methoxyphenyl)-6-methoxybenzothiophene With pyridine; hydrogenchloride; tributyl-amine at 170 - 180℃; Stage #2: With water In ethyl acetate for 0.25h; Stage #3: acetic anhydride With triethylamine In ethyl acetate at 25 - 65℃; for 1h; | 91.1% |
2-(4'-methoxyphenyl)-6-methoxybenzothiophene
Conditions | Yield |
---|---|
Stage #1: C15H24N3O2S(1+)*F6Sb(1-); 2-(4'-methoxyphenyl)-6-methoxybenzothiophene In acetonitrile at 70℃; for 16h; Inert atmosphere; Stage #2: sodium hexafluoroantimonate In dichloromethane; water for 0.0833333h; Inert atmosphere; regioselective reaction; | 90% |
2-(4'-methoxyphenyl)-6-methoxybenzothiophene
6-hydroxy-2-(4-hydroxyphenyl)benzo[B]-thiophene
Conditions | Yield |
---|---|
With boron tribromide In dichloromethane at 0 - 5℃; | 89.3% |
With pyridine hydrochloride at 190℃; for 1h; | 87% |
With pyridine hydrochloride at 180℃; for 1h; | 87% |
2-(4'-methoxyphenyl)-6-methoxybenzothiophene
3,4,5-triethoxybenzoyl chloride
Conditions | Yield |
---|---|
With aluminium trichloride In dichloromethane for 0.5h; | 88% |
AlCl3 In dichloromethane; water | |
aluminum (III) chloride In dichloromethane for 0.75h; |
2-(4'-methoxyphenyl)-6-methoxybenzothiophene
dimethyl sulfoxide
Conditions | Yield |
---|---|
Stage #1: 2-(4'-methoxyphenyl)-6-methoxybenzothiophene; dimethyl sulfoxide With trifluoromethylsulfonic anhydride In dichloromethane at -30 - 20℃; for 1.75h; Inert atmosphere; Stage #2: With diethylamine In dichloromethane at 20℃; for 6h; Inert atmosphere; | 88% |
4-fluorobenzoyl chloride
2-(4'-methoxyphenyl)-6-methoxybenzothiophene
6-methoxy-2-(4-methoxyphenyl)-3-(4-fluorobenzoyl)benzo[b]thiophene
Conditions | Yield |
---|---|
With aluminum (III) chloride In dichloromethane at 0℃; for 72h; Inert atmosphere; | 87% |
With aluminium trichloride In dichloromethane | 74% |
With aluminum (III) chloride In dichloromethane for 18h; Friedel-Crafts Acylation; Inert atmosphere; | 69% |
4-azidobenzoyl chloride
2-(4'-methoxyphenyl)-6-methoxybenzothiophene
3-(4-Azidobenzoyl)-6-methoxy-2-(4-methoxyphenyl)benzothiophene
Conditions | Yield |
---|---|
With titanium tetrachloride In dichloromethane at 20℃; for 5.5h; in the dark; | 82% |
2-(4'-methoxyphenyl)-6-methoxybenzothiophene
3,4-dimethoxybenzoic acid chloride
Conditions | Yield |
---|---|
aluminum (III) chloride In dichloromethane for 7h; | 76% |
aluminum (III) chloride In dichloromethane for 7h; | 76% |
AlCl3 In dichloromethane; water |
2-(4'-methoxyphenyl)-6-methoxybenzothiophene
ethyl 4-(chlorocarbonyl)benzoate
3-<(4'-ethoxycarbonyl)benzoyl>-6-methoxy-2-(4-methoxyphenyl)benzothiophene
Conditions | Yield |
---|---|
With aluminium trichloride In dichloromethane for 12h; | 73% |
4-fluorobenzoyl chloride
2-(4'-methoxyphenyl)-6-methoxybenzothiophene
Conditions | Yield |
---|---|
With aluminum (III) chloride In dichloromethane at 20℃; for 18h; Friedel-Crafts Acylation; Inert atmosphere; | 70% |
2-(4'-methoxyphenyl)-6-methoxybenzothiophene
benzenesulfonic acid-4-[6-methoxy-2-(4-methoxy-phenyl)-benzo[b]thiophene-3-carbonyl]-phenyl ester
Conditions | Yield |
---|---|
iron(III) sulfate pentahydrate; iron In toluene at 100 - 111℃; for 5.5h; Product distribution / selectivity; | 66.4% |
Stage #1: 2-(4'-methoxyphenyl)-6-methoxybenzothiophene; p-benzenesulfonyloxybenzoyl chloride; iron(III) sulfate pentahydrate; iron In toluene at 99 - 114℃; Stage #2: With sodium hydroxide In water; toluene at 62 - 66℃; Product distribution / selectivity; Inert atmosphere; | 66.4% |
With iron; iron(III) sulfate pentahydrate In toluene at 98 - 111℃; for 16.5h; Product distribution / selectivity; Inert atmosphere; | 66.4% |
iron(III) chloride In toluene at 23 - 63℃; for 6h; Product distribution / selectivity; Friedel Crafts Acylation; |
3,4,5-Trimethoxybenzoyl chloride
2-(4'-methoxyphenyl)-6-methoxybenzothiophene
Conditions | Yield |
---|---|
With aluminium trichloride In dichloromethane for 5h; | 63% |
With aluminium trichloride In dichloromethane | |
AlCl3 In dichloromethane; water | |
aluminum (III) chloride In dichloromethane for 5h; |
2-(4'-methoxyphenyl)-6-methoxybenzothiophene
2,6-dimethoxybenzoyl chloride
Conditions | Yield |
---|---|
With aluminium trichloride In dichloromethane for 6h; | 60% |
With aluminium trichloride In dichloromethane | |
AlCl3 In dichloromethane; water | |
aluminum (III) chloride In dichloromethane for 6h; |
2-(4'-methoxyphenyl)-6-methoxybenzothiophene
4-iodobenzoic acid chloride
(4-iodophenyl)(6-methoxy-2-(4-methoxyphenyl)benzo[b]thiophen-3-yl)methanone
Conditions | Yield |
---|---|
With aluminum (III) chloride In dichloromethane at 20℃; for 24h; Friedel-Crafts Acylation; Inert atmosphere; | 60% |
With aluminum (III) chloride In dichloromethane for 3h; |
4-(toluene-4-sulfonyloxy)-benzoyl chloride
2-(4'-methoxyphenyl)-6-methoxybenzothiophene
toluene-4-sulfonic acid 4-[6-methoxy-2-(4-methoxyphenyl)benzo[b]thiophene-3-carbonyl]phenyl ester
Conditions | Yield |
---|---|
iron(III) sulfate pentahydrate; iron In toluene for 10.5h; Reflux; | 58.4% |
iron(III) sulfate pentahydrate; iron In toluene for 10.5h; Friedel Crafts Acylation; Reflux; | |
Stage #1: 4-(toluene-4-sulfonyloxy)-benzoyl chloride; 2-(4'-methoxyphenyl)-6-methoxybenzothiophene; iron(III) sulfate pentahydrate; iron In toluene for 10.5h; Reflux; Stage #2: With sodium hydroxide In water; toluene at 60 - 70℃; for 0.75h; Product distribution / selectivity; | |
With iron; iron(III) sulfate pentahydrate In toluene for 10.5h; Reflux; |
6-bromohexanoyl chloride
2-(4'-methoxyphenyl)-6-methoxybenzothiophene
3-(6-bromohexanoyl)-6-methoxy-2-(4-methoxyphenyl)benzo[b]thiophen
Conditions | Yield |
---|---|
With aluminium trichloride In 1,2-dichloro-ethane for 1h; Ambient temperature; | 55% |
AlCl3 In 1,2-dichloro-ethane | 55% |
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