Product Name

  • Name

    6-Methoxy-2-(4-methoxyphenyl)benzobithiophene

  • EINECS 264-408-2
  • CAS No. 63675-74-1
  • Article Data47
  • CAS DataBase
  • Density 1.194 g/cm3
  • Solubility
  • Melting Point 191-197 °C
  • Formula C16H14O2S
  • Boiling Point 435.7 °C at 760 mmHg
  • Molecular Weight 270.352
  • Flash Point 217.3 °C
  • Transport Information UN 2585 8/PG 3
  • Appearance white to almost white crystalline powder
  • Safety 26-36/37/39-45-27
  • Risk Codes 34-22
  • Molecular Structure Molecular Structure of 63675-74-1 (6-Methoxy-2-(4-methoxyphenyl)benzobithiophene)
  • Hazard Symbols CorrosiveC
  • Synonyms 2-(4-Methoxyphenyl)-6-methoxybenzo[b]thiophene;6-Methoxy-2-(4-methoxyphenyl)benzo[b]thiophene;
  • PSA 46.70000
  • LogP 4.58550

Synthetic route

(5-methoxy-2-((4-methoxyphenyl)ethynyl)phenyl)(methyl)-sulfane
1163701-10-7

(5-methoxy-2-((4-methoxyphenyl)ethynyl)phenyl)(methyl)-sulfane

2-(4'-methoxyphenyl)-6-methoxybenzothiophene
63675-74-1

2-(4'-methoxyphenyl)-6-methoxybenzothiophene

Conditions
ConditionsYield
With trifluoroacetic acid; silver(l) oxide at 25℃; for 1.5h; Schlenk technique;89%
6-methoxy-benzo[b]thiophene
90560-10-4

6-methoxy-benzo[b]thiophene

para-iodoanisole
696-62-8

para-iodoanisole

2-(4'-methoxyphenyl)-6-methoxybenzothiophene
63675-74-1

2-(4'-methoxyphenyl)-6-methoxybenzothiophene

Conditions
ConditionsYield
With dichloro(2,2'-bipyridine)nickel(II); lithium hexamethyldisilazane In 2-methyltetrahydrofuran at 120℃; for 16h; Schlenk technique; Sealed tube; Inert atmosphere; Glovebox; regiospecific reaction;85%
With palladium diacetate; silver trifluoroacetate; trifluoroacetic acid In water at 20℃; for 48h; Inert atmosphere;60%
para-iodoanisole
696-62-8

para-iodoanisole

6-methoxy-benzo[b]thiophen-2-yl boronic acid
182133-35-3

6-methoxy-benzo[b]thiophen-2-yl boronic acid

2-(4'-methoxyphenyl)-6-methoxybenzothiophene
63675-74-1

2-(4'-methoxyphenyl)-6-methoxybenzothiophene

Conditions
ConditionsYield
With tetrakis(triphenylphosphine) palladium(0); sodium carbonate In water at 110℃; for 12h; Suzuki coupling; Ionic liquid; Inert atmosphere;81%
With sodium carbonate; tetrakis(triphenylphosphine)palladium (0) In toluene1.25 g (96%)
6-methoxy-2-iodobenzo[b]thiophene
183133-89-3

6-methoxy-2-iodobenzo[b]thiophene

4-methoxyphenylboronic acid
5720-07-0

4-methoxyphenylboronic acid

2-(4'-methoxyphenyl)-6-methoxybenzothiophene
63675-74-1

2-(4'-methoxyphenyl)-6-methoxybenzothiophene

Conditions
ConditionsYield
80%
α-(3-methoxyphenyl-thio)-4-methoxyacetophenone
63675-73-0

α-(3-methoxyphenyl-thio)-4-methoxyacetophenone

2-(4'-methoxyphenyl)-6-methoxybenzothiophene
63675-74-1

2-(4'-methoxyphenyl)-6-methoxybenzothiophene

Conditions
ConditionsYield
Stage #1: α-(3-methoxyphenyl-thio)-4-methoxyacetophenone In toluene under 760.051 Torr; for 2h; Reflux; Inert atmosphere; Dean-Stark; Large scale;
Stage #2: With methanesulfonic acid In toluene at 90℃; for 4h; Inert atmosphere; Large scale;
Stage #3: In n-heptane; toluene at 80 - 90℃; for 4h; Reagent/catalyst; Solvent; Temperature; Inert atmosphere; Large scale;		79.6%
With PPA at 85 - 95℃; for 1.25h;
With polyphosphoric acid at 90℃; for 1h; Inert atmosphere;
With PPA
4-methoxyphenylacetylen
768-60-5

4-methoxyphenylacetylen

4-methoxy-2-(methylthio)benzenediazonium tetrafluoroborate

4-methoxy-2-(methylthio)benzenediazonium tetrafluoroborate

2-(4'-methoxyphenyl)-6-methoxybenzothiophene
63675-74-1

2-(4'-methoxyphenyl)-6-methoxybenzothiophene

Conditions
ConditionsYield
With eosin y In dimethyl sulfoxide for 14h; Irradiation;70%
With titanium(III) chloride In N,N-dimethyl-formamide at -25 - 20℃; Cycloaddition;60%
6-methoxy-2-(4-methoxyphenyl)-3-methylsulfinylbenzo[b]thiophene

6-methoxy-2-(4-methoxyphenyl)-3-methylsulfinylbenzo[b]thiophene

2-(4'-methoxyphenyl)-6-methoxybenzothiophene
63675-74-1

2-(4'-methoxyphenyl)-6-methoxybenzothiophene

Conditions
ConditionsYield
With Octanethiol; trifluorormethanesulfonic acid In dichloromethane at 40℃; for 12h;70%
α-(3-methoxyphenyl-thio)-4-methoxyacetophenone
63675-73-0

α-(3-methoxyphenyl-thio)-4-methoxyacetophenone

A

2-(4'-methoxyphenyl)-6-methoxybenzothiophene
63675-74-1

2-(4'-methoxyphenyl)-6-methoxybenzothiophene

B

2-(4'-methoxyphenyl)-4-methoxybenzo[b]thiophene
90433-54-8

2-(4'-methoxyphenyl)-4-methoxybenzo[b]thiophene

Conditions
ConditionsYield
With PPA at 85 - 90℃; for 1h;A 69%
B n/a
With PPA at 70℃;A 68%
B 23%
With PPA Heating; Yield given; Yields of byproduct given;
With polyphosphoric acid at 65 - 90℃; for 2h; Product distribution / selectivity;
6-methoxy-benzo[b]thiophene
90560-10-4

6-methoxy-benzo[b]thiophene

1-bromo-4-methoxy-benzene
104-92-7

1-bromo-4-methoxy-benzene

2-(4'-methoxyphenyl)-6-methoxybenzothiophene
63675-74-1

2-(4'-methoxyphenyl)-6-methoxybenzothiophene

Conditions
ConditionsYield
With potassium acetate; {1,3-bis(2,6-diethylaniline)acenaphthylenyl-4,5-imidazolium-2-ylidene}PdCl2-(pyridine) In N,N-dimethyl acetamide at 130℃; for 12h; Inert atmosphere; Sealed tube;67%
2-fluoro-4-methoxy-benzaldehyde
331-64-6

2-fluoro-4-methoxy-benzaldehyde

p-methoxybenzylmercaptan
6258-60-2

p-methoxybenzylmercaptan

2-(4'-methoxyphenyl)-6-methoxybenzothiophene
63675-74-1

2-(4'-methoxyphenyl)-6-methoxybenzothiophene

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 60 - 160℃; for 66h;55%
4-Methoxy-2-methylsulfenylaniline
1658-03-3

4-Methoxy-2-methylsulfenylaniline

phenylacetylene
536-74-3

phenylacetylene

2-(4'-methoxyphenyl)-6-methoxybenzothiophene
63675-74-1

2-(4'-methoxyphenyl)-6-methoxybenzothiophene

Conditions
ConditionsYield
With tert.-butylnitrite In nitromethane at 80℃; for 12h; Schlenk technique; Inert atmosphere;50%
4-methoxyphenylboronic acid
5720-07-0

4-methoxyphenylboronic acid

3-iodo-6-methoxy-benzo[b]thiophene

3-iodo-6-methoxy-benzo[b]thiophene

2-(4'-methoxyphenyl)-6-methoxybenzothiophene
63675-74-1

2-(4'-methoxyphenyl)-6-methoxybenzothiophene

Conditions
ConditionsYield
With sodium carbonate; tetrakis(triphenylphosphine) palladium(0) at 100℃; for 4h; Yield given;
1-bromo-4-methoxy-benzene
104-92-7

1-bromo-4-methoxy-benzene

6-methoxy-benzo[b]thiophen-2-yl boronic acid
182133-35-3

6-methoxy-benzo[b]thiophen-2-yl boronic acid

2-(4'-methoxyphenyl)-6-methoxybenzothiophene
63675-74-1

2-(4'-methoxyphenyl)-6-methoxybenzothiophene

Conditions
ConditionsYield
With tetrakis(triphenylphosphine) palladium(0); sodium carbonate Suzuki coupling reaction;
6-methoxy-benzo[b]thiophene
90560-10-4

6-methoxy-benzo[b]thiophene

2-(4'-methoxyphenyl)-6-methoxybenzothiophene
63675-74-1

2-(4'-methoxyphenyl)-6-methoxybenzothiophene

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: BuLi
1.2: B(OiPr)3
1.3: HCl
2.1: Na2CO3; Pd(PPh3)4
View Scheme
Multi-step reaction with 2 steps
1.1: n-butyllithium / tetrahydrofuran; hexane / 2.08 h / -78 °C / Inert atmosphere
1.2: 3 h / -78 - 20 °C / Inert atmosphere
2.1: N-Bromosuccinimide / tetrahydrofuran; hexane / 3 h / -78 °C / Inert atmosphere
2.2: 0.5 h / -78 - 20 °C / Inert atmosphere
View Scheme
3-methoxybenzenethiol
15570-12-4

3-methoxybenzenethiol

o-CHO-C6H4-X (X=NO2 or F)

o-CHO-C6H4-X (X=NO2 or F)

2-(4'-methoxyphenyl)-6-methoxybenzothiophene
63675-74-1

2-(4'-methoxyphenyl)-6-methoxybenzothiophene

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: K2CO3 / acetone
1.2: BF3*Et2O
2.1: BuLi
2.2: B(OiPr)3
2.3: HCl
3.1: Na2CO3; Pd(PPh3)4
View Scheme
6-methoxybenzothiazol-2-ylamine
1747-60-0

6-methoxybenzothiazol-2-ylamine

2-(4'-methoxyphenyl)-6-methoxybenzothiophene
63675-74-1

2-(4'-methoxyphenyl)-6-methoxybenzothiophene

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: aq. KOH / 17 h / Heating
1.2: 92 percent / 1 h / 20 °C
2.1: aq. HCl; NaNO2
2.2: 57 percent / aq. HBF4 / 0 - 20 °C
3.1: 60 percent / TiCl3 / dimethylformamide / -25 - 20 °C
View Scheme
Multi-step reaction with 3 steps
1.1: potassium hydroxide / water / 17 h / Reflux
1.2: 1 h / 20 °C
2.1: fluoroboric acid; sodium nitrite / water / 0.67 h / 0 - 5 °C / Enzymatic reaction
3.1: eosin y / dimethyl sulfoxide / 14 h / Irradiation
View Scheme
Multi-step reaction with 2 steps
1: potassium hydroxide; methyl iodide
2: tert.-butylnitrite / nitromethane / 12 h / 80 °C / Schlenk technique; Inert atmosphere
View Scheme
4-Methoxy-2-methylsulfenylaniline
1658-03-3

4-Methoxy-2-methylsulfenylaniline

2-(4'-methoxyphenyl)-6-methoxybenzothiophene
63675-74-1

2-(4'-methoxyphenyl)-6-methoxybenzothiophene

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: aq. HCl; NaNO2
1.2: 57 percent / aq. HBF4 / 0 - 20 °C
2.1: 60 percent / TiCl3 / dimethylformamide / -25 - 20 °C
View Scheme
Multi-step reaction with 2 steps
1: fluoroboric acid; sodium nitrite / water / 0.67 h / 0 - 5 °C / Enzymatic reaction
2: eosin y / dimethyl sulfoxide / 14 h / Irradiation
View Scheme
4-methoxy-aniline
104-94-9

4-methoxy-aniline

2-(4'-methoxyphenyl)-6-methoxybenzothiophene
63675-74-1

2-(4'-methoxyphenyl)-6-methoxybenzothiophene

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: 62 percent / Br2; AcOH / 0.75 h / 20 °C
2.1: aq. KOH / 17 h / Heating
2.2: 92 percent / 1 h / 20 °C
3.1: aq. HCl; NaNO2
3.2: 57 percent / aq. HBF4 / 0 - 20 °C
4.1: 60 percent / TiCl3 / dimethylformamide / -25 - 20 °C
View Scheme
Multi-step reaction with 3 steps
1.1: 51 percent / CuI / o-xylene / 94 h / 145 °C
2.1: aq. HCl; NaNO2
2.2: 57 percent / aq. HBF4 / 0 - 20 °C
3.1: 60 percent / TiCl3 / dimethylformamide / -25 - 20 °C
View Scheme
Multi-step reaction with 4 steps
1.1: acetic acid; bromine / 3 h / 10 °C
2.1: potassium hydroxide / water / 17 h / Reflux
2.2: 1 h / 20 °C
3.1: fluoroboric acid; sodium nitrite / water / 0.67 h / 0 - 5 °C / Enzymatic reaction
4.1: eosin y / dimethyl sulfoxide / 14 h / Irradiation
View Scheme
1-(1,1-Dichloro-ethyl)-4-methoxy-benzene
69151-26-4

1-(1,1-Dichloro-ethyl)-4-methoxy-benzene

2-(4'-methoxyphenyl)-6-methoxybenzothiophene
63675-74-1

2-(4'-methoxyphenyl)-6-methoxybenzothiophene

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: NaNH2; NH3
2: 60 percent / TiCl3 / dimethylformamide / -25 - 20 °C
View Scheme
1-(4-methoxyphenyl)ethanone
100-06-1

1-(4-methoxyphenyl)ethanone

2-(4'-methoxyphenyl)-6-methoxybenzothiophene
63675-74-1

2-(4'-methoxyphenyl)-6-methoxybenzothiophene

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: PCl5 / benzene
2: NaNH2; NH3
3: 60 percent / TiCl3 / dimethylformamide / -25 - 20 °C
View Scheme
Multi-step reaction with 2 steps
1.1: bromine / methanol / 2.5 h / 10 °C
1.2: 4 h / 0 - 20 °C
2.1: polyphosphoric acid / 2 h / 65 - 90 °C
View Scheme
3-methoxybenzenethiol
15570-12-4

3-methoxybenzenethiol

2-(4'-methoxyphenyl)-6-methoxybenzothiophene
63675-74-1

2-(4'-methoxyphenyl)-6-methoxybenzothiophene

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: NaOH / ethanol
2: polyphosphoric acid / Heating
View Scheme
Multi-step reaction with 2 steps
1: 80 percent / KOH / aq. ethanol; ethyl acetate / 3 h / Ambient temperature
2: 68 percent / polyphosphoric acid / 70 °C
View Scheme
Multi-step reaction with 2 steps
1: 80.4 percent / KOH / ethanol; H2O; ethyl acetate / Ambient temperature
2: 69 percent / PPA / 1 h / 85 - 90 °C
View Scheme
2-Bromo-4'-methoxyacetophenone
2632-13-5

2-Bromo-4'-methoxyacetophenone

2-(4'-methoxyphenyl)-6-methoxybenzothiophene
63675-74-1

2-(4'-methoxyphenyl)-6-methoxybenzothiophene

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: NaOH / ethanol
2: polyphosphoric acid / Heating
View Scheme
Multi-step reaction with 2 steps
1: 80 percent / KOH / aq. ethanol; ethyl acetate / 3 h / Ambient temperature
2: 68 percent / polyphosphoric acid / 70 °C
View Scheme
Multi-step reaction with 2 steps
1: 80.4 percent / KOH / ethanol; H2O; ethyl acetate / Ambient temperature
2: 69 percent / PPA / 1 h / 85 - 90 °C
View Scheme
E/Z-t-butyl 4,4'-dimethoxystilbenyl sulfoxide

E/Z-t-butyl 4,4'-dimethoxystilbenyl sulfoxide

2-(4'-methoxyphenyl)-6-methoxybenzothiophene
63675-74-1

2-(4'-methoxyphenyl)-6-methoxybenzothiophene

Conditions
ConditionsYield
With toluene-4-sulfonic acid In toluene for 1.5h; Heating / reflux;
With toluene-4-sulfonic acid In toluene for 6h; Heating / reflux;
3-methoxybenzenethiol
15570-12-4

3-methoxybenzenethiol

2-Bromo-4'-methoxyacetophenone
2632-13-5

2-Bromo-4'-methoxyacetophenone

2-(4'-methoxyphenyl)-6-methoxybenzothiophene
63675-74-1

2-(4'-methoxyphenyl)-6-methoxybenzothiophene

Conditions
ConditionsYield
With potassium hydroxide; PPA In ethanol; water; ethyl acetate
With potassium hydroxide; PPA In ethanol; water; ethyl acetate
Lawessons reagent
19172-47-5

Lawessons reagent

2-(4'-methoxyphenyl)-6-methoxybenzothiophene
63675-74-1

2-(4'-methoxyphenyl)-6-methoxybenzothiophene

Conditions
ConditionsYield
With methanesulfonic acid In chlorobenzene
With methanesulfonic acid In chlorobenzene
4-methoxybenzo[b]thiophene
3781-90-6

4-methoxybenzo[b]thiophene

a-(-methoxyphenylthio)-4-methoxyacetophenone

a-(-methoxyphenylthio)-4-methoxyacetophenone

acetophenone
98-86-2

acetophenone

2-(4'-methoxyphenyl)-6-methoxybenzothiophene
63675-74-1

2-(4'-methoxyphenyl)-6-methoxybenzothiophene

Conditions
ConditionsYield
With PPA; phosphoric acid In water; toluene
...Expand
3-methoxybenzenethiol
15570-12-4

3-methoxybenzenethiol

2-Bromo-4'-methoxyacetophenone
2632-13-5

2-Bromo-4'-methoxyacetophenone

A

2-(4'-methoxyphenyl)-6-methoxybenzothiophene
63675-74-1

2-(4'-methoxyphenyl)-6-methoxybenzothiophene

B

α-(3-methoxyphenyl-thio)-4-methoxyacetophenone
63675-73-0

α-(3-methoxyphenyl-thio)-4-methoxyacetophenone

Conditions
ConditionsYield
With potassium hydroxide In ethanol; water; Petroleum etherA 78.5 g (76%)
B n/a
...Expand
2-(4'-methoxyphenyl)-6-methoxybenzothiophene
63675-74-1

2-(4'-methoxyphenyl)-6-methoxybenzothiophene

1,2-bis(4-methoxyphenyl)ethane
1657-55-2

1,2-bis(4-methoxyphenyl)ethane

Conditions
ConditionsYield
W-2 Raney Ni In ethanol for 0.5h; Heating;100%
2-(4'-methoxyphenyl)-6-methoxybenzothiophene
63675-74-1

2-(4'-methoxyphenyl)-6-methoxybenzothiophene

3-bromo-6-methoxy-2-(4-methoxyphenyl)benzo[b]thiophene
176672-06-3

3-bromo-6-methoxy-2-(4-methoxyphenyl)benzo[b]thiophene

Conditions
ConditionsYield
With bromine In chloroform at 60℃;100%
With bromine In chloroform at 60℃;100%
With N-Bromosuccinimide In tetrahydrofuran at 0 - 20℃; for 3h;97%
2-(4'-methoxyphenyl)-6-methoxybenzothiophene
63675-74-1

2-(4'-methoxyphenyl)-6-methoxybenzothiophene

4-chlorobenzoyl chloride
586-75-4

4-chlorobenzoyl chloride

4-Bromophenyl-[6-methoxy-2-(4-methoxy-phenyl)benzo[b]thien-3-yl]methanone
206434-78-8

4-Bromophenyl-[6-methoxy-2-(4-methoxy-phenyl)benzo[b]thien-3-yl]methanone

Conditions
ConditionsYield
With aluminum (III) chloride In dichloromethane at 0 - 25℃; for 3.5h; Friedel-Crafts Acylation;96%
With copper(II) bis(trifluoromethanesulfonate) at 100℃; for 2h; Friedel Crafts acylation; Ionic liquid; Inert atmosphere;79%
With aluminium trichloride In dichloromethane65%
4-(2-chloro-ethoxy)-benzoyl chloride
65136-50-7

4-(2-chloro-ethoxy)-benzoyl chloride

2-(4'-methoxyphenyl)-6-methoxybenzothiophene
63675-74-1

2-(4'-methoxyphenyl)-6-methoxybenzothiophene

[4-(2-chloro-ethoxy)-phenyl]-[6-methoxy-2-(4-methoxy-phenyl)-benzo[b]thiophen-3-yl]-methanone

[4-(2-chloro-ethoxy)-phenyl]-[6-methoxy-2-(4-methoxy-phenyl)-benzo[b]thiophen-3-yl]-methanone

Conditions
ConditionsYield
With aluminum (III) chloride In dichloromethane at 50℃; for 12h; Friedel-Crafts Acylation; Inert atmosphere;95%
acetic anhydride
108-24-7

acetic anhydride

2-(4'-methoxyphenyl)-6-methoxybenzothiophene
63675-74-1

2-(4'-methoxyphenyl)-6-methoxybenzothiophene

6-acetoxy-2-(4-acetoxyphenyl)benzo[b]thiophene
84449-63-8

6-acetoxy-2-(4-acetoxyphenyl)benzo[b]thiophene

Conditions
ConditionsYield
Stage #1: 2-(4'-methoxyphenyl)-6-methoxybenzothiophene With pyridine; hydrogenchloride; tributyl-amine at 170 - 180℃;
Stage #2: With water In ethyl acetate for 0.25h;
Stage #3: acetic anhydride With triethylamine In ethyl acetate at 25 - 65℃; for 1h;		91.1%
sodium hexafluoroantimonate

sodium hexafluoroantimonate

C15H24N3O2S(1+)*F6Sb(1-)

C15H24N3O2S(1+)*F6Sb(1-)

2-(4'-methoxyphenyl)-6-methoxybenzothiophene
63675-74-1

2-(4'-methoxyphenyl)-6-methoxybenzothiophene

C27H33N2O2S2(1+)*F6Sb(1-)

C27H33N2O2S2(1+)*F6Sb(1-)

Conditions
ConditionsYield
Stage #1: C15H24N3O2S(1+)*F6Sb(1-); 2-(4'-methoxyphenyl)-6-methoxybenzothiophene In acetonitrile at 70℃; for 16h; Inert atmosphere;
Stage #2: sodium hexafluoroantimonate In dichloromethane; water for 0.0833333h; Inert atmosphere; regioselective reaction;		90%
...Expand
2-(4'-methoxyphenyl)-6-methoxybenzothiophene
63675-74-1

2-(4'-methoxyphenyl)-6-methoxybenzothiophene

6-hydroxy-2-(4-hydroxyphenyl)benzo[B]-thiophene
63676-22-2

6-hydroxy-2-(4-hydroxyphenyl)benzo[B]-thiophene

Conditions
ConditionsYield
With boron tribromide In dichloromethane at 0 - 5℃;89.3%
With pyridine hydrochloride at 190℃; for 1h;87%
With pyridine hydrochloride at 180℃; for 1h;87%
2-(4'-methoxyphenyl)-6-methoxybenzothiophene
63675-74-1

2-(4'-methoxyphenyl)-6-methoxybenzothiophene

3,4,5-triethoxybenzoyl chloride
50915-97-4

3,4,5-triethoxybenzoyl chloride

3-(3',4',5'-triethoxybenzoyl)-2-(4'-methoxyphenyl)-6-methoxybenzo[b]-thiophene

3-(3',4',5'-triethoxybenzoyl)-2-(4'-methoxyphenyl)-6-methoxybenzo[b]-thiophene

Conditions
ConditionsYield
With aluminium trichloride In dichloromethane for 0.5h;88%
AlCl3 In dichloromethane; water
aluminum (III) chloride In dichloromethane for 0.75h;
2-(4'-methoxyphenyl)-6-methoxybenzothiophene
63675-74-1

2-(4'-methoxyphenyl)-6-methoxybenzothiophene

dimethyl sulfoxide
67-68-5

dimethyl sulfoxide

6-methoxy-2-(4-methoxyphenyl)-3-methylthiobenzo[b]thiophene

6-methoxy-2-(4-methoxyphenyl)-3-methylthiobenzo[b]thiophene

Conditions
ConditionsYield
Stage #1: 2-(4'-methoxyphenyl)-6-methoxybenzothiophene; dimethyl sulfoxide With trifluoromethylsulfonic anhydride In dichloromethane at -30 - 20℃; for 1.75h; Inert atmosphere;
Stage #2: With diethylamine In dichloromethane at 20℃; for 6h; Inert atmosphere;		88%
4-fluorobenzoyl chloride
403-43-0

4-fluorobenzoyl chloride

2-(4'-methoxyphenyl)-6-methoxybenzothiophene
63675-74-1

2-(4'-methoxyphenyl)-6-methoxybenzothiophene

6-methoxy-2-(4-methoxyphenyl)-3-(4-fluorobenzoyl)benzo[b]thiophene
206434-77-7

6-methoxy-2-(4-methoxyphenyl)-3-(4-fluorobenzoyl)benzo[b]thiophene

Conditions
ConditionsYield
With aluminum (III) chloride In dichloromethane at 0℃; for 72h; Inert atmosphere;87%
With aluminium trichloride In dichloromethane74%
With aluminum (III) chloride In dichloromethane for 18h; Friedel-Crafts Acylation; Inert atmosphere;69%
4-azidobenzoyl chloride
14848-01-2

4-azidobenzoyl chloride

2-(4'-methoxyphenyl)-6-methoxybenzothiophene
63675-74-1

2-(4'-methoxyphenyl)-6-methoxybenzothiophene

3-(4-Azidobenzoyl)-6-methoxy-2-(4-methoxyphenyl)benzothiophene
133295-96-2

3-(4-Azidobenzoyl)-6-methoxy-2-(4-methoxyphenyl)benzothiophene

Conditions
ConditionsYield
With titanium tetrachloride In dichloromethane at 20℃; for 5.5h; in the dark;82%
2-(4'-methoxyphenyl)-6-methoxybenzothiophene
63675-74-1

2-(4'-methoxyphenyl)-6-methoxybenzothiophene

3,4-dimethoxybenzoic acid chloride
3535-37-3

3,4-dimethoxybenzoic acid chloride

3-(3',4'-dimethoxybenzoyl)-2-(4'-methoxyphenyl)-6-methoxybenzo[b]thiophene

3-(3',4'-dimethoxybenzoyl)-2-(4'-methoxyphenyl)-6-methoxybenzo[b]thiophene

Conditions
ConditionsYield
aluminum (III) chloride In dichloromethane for 7h;76%
aluminum (III) chloride In dichloromethane for 7h;76%
AlCl3 In dichloromethane; water
2-(4'-methoxyphenyl)-6-methoxybenzothiophene
63675-74-1

2-(4'-methoxyphenyl)-6-methoxybenzothiophene

ethyl 4-(chlorocarbonyl)benzoate
27111-45-1

ethyl 4-(chlorocarbonyl)benzoate

3-<(4'-ethoxycarbonyl)benzoyl>-6-methoxy-2-(4-methoxyphenyl)benzothiophene
141563-37-3

3-<(4'-ethoxycarbonyl)benzoyl>-6-methoxy-2-(4-methoxyphenyl)benzothiophene

Conditions
ConditionsYield
With aluminium trichloride In dichloromethane for 12h;73%
4-fluorobenzoyl chloride
403-43-0

4-fluorobenzoyl chloride

2-(4'-methoxyphenyl)-6-methoxybenzothiophene
63675-74-1

2-(4'-methoxyphenyl)-6-methoxybenzothiophene

C29H20F2O4S

C29H20F2O4S

Conditions
ConditionsYield
With aluminum (III) chloride In dichloromethane at 20℃; for 18h; Friedel-Crafts Acylation; Inert atmosphere;70%
2-(4'-methoxyphenyl)-6-methoxybenzothiophene
63675-74-1

2-(4'-methoxyphenyl)-6-methoxybenzothiophene

p-benzenesulfonyloxybenzoyl chloride

p-benzenesulfonyloxybenzoyl chloride

benzenesulfonic acid-4-[6-methoxy-2-(4-methoxy-phenyl)-benzo[b]thiophene-3-carbonyl]-phenyl ester
1293362-49-8

benzenesulfonic acid-4-[6-methoxy-2-(4-methoxy-phenyl)-benzo[b]thiophene-3-carbonyl]-phenyl ester

Conditions
ConditionsYield
iron(III) sulfate pentahydrate; iron In toluene at 100 - 111℃; for 5.5h; Product distribution / selectivity;66.4%
Stage #1: 2-(4'-methoxyphenyl)-6-methoxybenzothiophene; p-benzenesulfonyloxybenzoyl chloride; iron(III) sulfate pentahydrate; iron In toluene at 99 - 114℃;
Stage #2: With sodium hydroxide In water; toluene at 62 - 66℃; Product distribution / selectivity; Inert atmosphere;		66.4%
With iron; iron(III) sulfate pentahydrate In toluene at 98 - 111℃; for 16.5h; Product distribution / selectivity; Inert atmosphere;66.4%
iron(III) chloride In toluene at 23 - 63℃; for 6h; Product distribution / selectivity; Friedel Crafts Acylation;
3,4,5-Trimethoxybenzoyl chloride
4521-61-3

3,4,5-Trimethoxybenzoyl chloride

2-(4'-methoxyphenyl)-6-methoxybenzothiophene
63675-74-1

2-(4'-methoxyphenyl)-6-methoxybenzothiophene

(6-methoxy-2-(4-methoxyphenyl)benzo[b]thiophen-3-yl)(3,4,5-trimethoxyphenyl)methanone

(6-methoxy-2-(4-methoxyphenyl)benzo[b]thiophen-3-yl)(3,4,5-trimethoxyphenyl)methanone

Conditions
ConditionsYield
With aluminium trichloride In dichloromethane for 5h;63%
With aluminium trichloride In dichloromethane
AlCl3 In dichloromethane; water
aluminum (III) chloride In dichloromethane for 5h;
2-(4'-methoxyphenyl)-6-methoxybenzothiophene
63675-74-1

2-(4'-methoxyphenyl)-6-methoxybenzothiophene

2,6-dimethoxybenzoyl chloride
1989-53-3

2,6-dimethoxybenzoyl chloride

3-(2', 6'-dimethoxybenzoyl)-2-(4'-methoxyphenyl)-6-methoxybenzo[b]thiophene

3-(2', 6'-dimethoxybenzoyl)-2-(4'-methoxyphenyl)-6-methoxybenzo[b]thiophene

Conditions
ConditionsYield
With aluminium trichloride In dichloromethane for 6h;60%
With aluminium trichloride In dichloromethane
AlCl3 In dichloromethane; water
aluminum (III) chloride In dichloromethane for 6h;
2-(4'-methoxyphenyl)-6-methoxybenzothiophene
63675-74-1

2-(4'-methoxyphenyl)-6-methoxybenzothiophene

4-iodobenzoic acid chloride
1711-02-0

4-iodobenzoic acid chloride

(4-iodophenyl)(6-methoxy-2-(4-methoxyphenyl)benzo[b]thiophen-3-yl)methanone
166975-67-3

(4-iodophenyl)(6-methoxy-2-(4-methoxyphenyl)benzo[b]thiophen-3-yl)methanone

Conditions
ConditionsYield
With aluminum (III) chloride In dichloromethane at 20℃; for 24h; Friedel-Crafts Acylation; Inert atmosphere;60%
With aluminum (III) chloride In dichloromethane for 3h;
4-(toluene-4-sulfonyloxy)-benzoyl chloride
64675-83-8

4-(toluene-4-sulfonyloxy)-benzoyl chloride

2-(4'-methoxyphenyl)-6-methoxybenzothiophene
63675-74-1

2-(4'-methoxyphenyl)-6-methoxybenzothiophene

toluene-4-sulfonic acid 4-[6-methoxy-2-(4-methoxyphenyl)benzo[b]thiophene-3-carbonyl]phenyl ester
1293362-53-4

toluene-4-sulfonic acid 4-[6-methoxy-2-(4-methoxyphenyl)benzo[b]thiophene-3-carbonyl]phenyl ester

Conditions
ConditionsYield
iron(III) sulfate pentahydrate; iron In toluene for 10.5h; Reflux;58.4%
iron(III) sulfate pentahydrate; iron In toluene for 10.5h; Friedel Crafts Acylation; Reflux;
Stage #1: 4-(toluene-4-sulfonyloxy)-benzoyl chloride; 2-(4'-methoxyphenyl)-6-methoxybenzothiophene; iron(III) sulfate pentahydrate; iron In toluene for 10.5h; Reflux;
Stage #2: With sodium hydroxide In water; toluene at 60 - 70℃; for 0.75h; Product distribution / selectivity;
With iron; iron(III) sulfate pentahydrate In toluene for 10.5h; Reflux;
6-bromohexanoyl chloride
22809-37-6

6-bromohexanoyl chloride

2-(4'-methoxyphenyl)-6-methoxybenzothiophene
63675-74-1

2-(4'-methoxyphenyl)-6-methoxybenzothiophene

3-(6-bromohexanoyl)-6-methoxy-2-(4-methoxyphenyl)benzo[b]thiophen
220469-39-6

3-(6-bromohexanoyl)-6-methoxy-2-(4-methoxyphenyl)benzo[b]thiophen

Conditions
ConditionsYield
With aluminium trichloride In 1,2-dichloro-ethane for 1h; Ambient temperature;55%
AlCl3 In 1,2-dichloro-ethane55%

6-Methoxy-2-(4-methoxyphenyl)benzobithiophene Specification

The 6-Methoxy-2-(4-methoxyphenyl)benzo[b]thiophene is an organic compound with the formula C16H14O2S. The IUPAC name of this chemical is 6-methoxy-2-(4-methoxyphenyl)-1-benzothiophene. With the CAS registry number 63675-74-1, it is also named as benzo[b]thiophene, 6-methoxy-2-(4-methoxyphenyl)-. The product's categories are Benzothiophenes; Building Blocks; Heterocyclic Building Blocks. It is almost white crystals should be sealed in the container, stored in the cool and dry place and avoided direct sunshine.

The other characteristics of 6-Methoxy-2-(4-methoxyphenyl)benzo[b]thiophene can be summarized as: (1)ACD/LogP: 5.87; (2)# of Rule of 5 Violations: 1; (3)#H bond acceptors: 2; (4)#H bond donors: 0; (5)#Freely Rotating Bonds: 3; (6)Polar Surface Area: 46.7 Å2; (7)Index of Refraction: 1.629; (8)Molar Refractivity: 80.42 cm3; (9)Molar Volume: 226.3 cm3; (10)Polarizability: 31.88×10-24 cm3; (11)Surface Tension: 43.4 dyne/cm; (12)Enthalpy of Vaporization: 66.53 kJ/mol; (13)Vapour Pressure: 2.19E-07 mmHg at 25°C; (14)Rotatable Bond Count: 3; (15)Exact Mass: 270.07145; (16)MonoIsotopic Mass: 270.07145; (17)Topological Polar Surface Area: 46.7; (18)Heavy Atom Count: 19; (19)Complexity: 289.

People can use the following data to convert to the molecule structure.
1. SMILES:O(c3ccc(c2sc1cc(OC)ccc1c2)cc3)C
2. InChI:InChI=1/C16H14O2S/c1-17-13-6-3-11(4-7-13)15-9-12-5-8-14(18-2)10-16(12)19-15/h3-10H,1-2H3
3. InChIKey:HRWAGCVMOGWQJF-UHFFFAOYAU
4. Std. InChI:InChI=1S/C16H14O2S/c1-17-13-6-3-11(4-7-13)15-9-12-5-8-14(18-2)10-16(12)19-15/h3-10H,1-2H3
5. Std. InChIKey:HRWAGCVMOGWQJF-UHFFFAOYSA-N

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