Why is SINOWAY: 1) Specialized in pharmaceutical and healthcare industrial for 34 years. 2) ISO 9001:2015 & SGS audited supplier . 3) Accept various payment terms : T.T 30-60 days. 4) We have warehouse in USA with quickly shipment . 5) We c
Cas:84449-90-1
Min.Order:1 Kilogram
Negotiable
Type:Trading Company
inquirySpecifications CAS No.: 84449-90-1 Other Names: Raloxifene hydrochloride MF: C28H27NO4S EINECS No.:
1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; ...... Appearance:Light yellow powder Storage:Desiccate at +4°C Package:1kg/foi
Cas:84449-90-1
Min.Order:500 Gram
FOB Price: $10.0
Type:Trading Company
inquiryXi’an Quanao Biotech Co., Ltd. with 18 years experience in plant extract filed. Product grade: Medicine, Health care product, Cosmetics, Food, Beverage, Feed. Hot selling market: Europe, North America, South America, Middle East, Asia Pacifi
Cas:84449-90-1
Min.Order:1 Kilogram
FOB Price: $259.0 / 269.0
Type:Manufacturers
inquiry1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s
Cas:84449-90-1
Min.Order:1 Gram
FOB Price: $0.1
Type:Manufacturers
inquiryShanghai Seasonsgreen Chemical is a high-tech research and development, production, sale and custom synthesis set in one high-tech chemical products enterprises. Our sales and marketing division is located in Shanghai, serving international pharmaceu
Cas:84449-90-1
Min.Order:1 Kilogram
FOB Price: $1.0
Type:Manufacturers
inquiryOur main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block
Raloxifene Basic information Application in Particular Diseases Product Name: Raloxifene Synonyms: [6-Hydroxy-2-(4-hydroxyphenyl)benzo[b]thien-3-y1][4-[2-(1-piperidinyl)ethoxy]phenyl]methamone;Evista;[4-[2-(1-Piperidinyl) Ethoxy] Phenyl]methano
Our advantages: 1, High quality with competitive price: 1) Standard:BP/USP/EP/Enterprise standard 2) All Purity≥99% 3) We are manufacturer and can provide high quality products with factory price. 2, Fast and safe delivery 1) Parcel can be sent
Name: Raloxifene CAS No.: 84449-90-1 Formula: C28H27NO4S Molecular Weight: 473.58 Synonyms: Keoxifene;LY 139481;[2-(4-Hydroxyphenyl)-6-hydroxybenzo[b]thien-3-yl][4-(2-(1-piperidinyl)ethoxy)phenyl]methanone; Density: 1.289 g/cm3 Solubility: DM
1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; Appearance: yellow powder Storage:Store in sealed containers at cool &
Cas:84449-90-1
Min.Order:100 Gram
Negotiable
Type:Other
inquiry1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized
Cas:84449-90-1
Min.Order:1 Kilogram
Negotiable
Type:Lab/Research institutions
inquiryRaloxifene CAS:84449-90-1 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermediates,
Cas:84449-90-1
Min.Order:1 Gram
Negotiable
Type:Lab/Research institutions
inquiryHello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai
Cas:84449-90-1
Min.Order:1 Kilogram
Negotiable
Type:Lab/Research institutions
inquiryTriumph has the complete production of G- KG - MT service chain,we can make the new technology into productivity quickly in the research and development of new products. Main Business Custom Synthesis: Trading(Raw M
Cas:84449-90-1
Min.Order:0 Metric Ton
FOB Price: $18.0 / 20.0
Type:Lab/Research institutions
inquiryWe have overseas warehouses in California, Nuevo Laredo, Mexico, Vancouver, Canada, Amsterdam, The Netherlands and Melbourne, Australia. Overseas warehouses can provide some of the best selling products. We look forward to cooperating with strong loc
Cas:84449-90-1
Min.Order:1 Kilogram
Negotiable
Type:Trading Company
inquiryOur Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We
Cas:84449-90-1
Min.Order:10 Kilogram
Negotiable
Type:Trading Company
inquiryJ&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia
Our Advantage & Service 1.Top quality: Using high quality material and establishing a strict quality control system,assigning specific persons in charge of each part of production,from raw material purchase to assembly. 2 Professional R&D
Cas:84449-90-1
Min.Order:10 Gram
FOB Price: $8.0 / 10.0
Type:Trading Company
inquiryZibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi
Cas:84449-90-1
Min.Order:10 Gram
FOB Price: $100.0
Type:Lab/Research institutions
inquirySuperior quality, moderate price & quick delivery. Appearance:white powder Storage:Stored in cool, dry and ventilation place; Away from fire and heat Package:10g/bag,or as your request Application:Used as Pharmaceutical Intermediates Transporta
Cas:84449-90-1
Min.Order:1 Gram
Negotiable
Type:Trading Company
inquiryEstablished in May 2015, TaiChem Ltd. is initially invested by a British research and development company and started by PhDs back from aboard. The company is registered in China Medical City (CMC), Taizhou, Jiangsu Province, and the production site
Our company was built in 2009 with an ISO certificate.In the past 6 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.O
Cas:84449-90-1
Min.Order:1 Kilogram
FOB Price: $1000.0
Type:Lab/Research institutions
inquiryProduct Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,
Our Advantages A. International Top level TechnologyOur company owned biomedicine experts are famous at home and abroad with rich experience in research and development in the field of efficient chiral functional molecules research and development an
GMP standard, high purity, competitive price, in stock 1. Quick Response: within 6 hours after receiving your email. 2. Quality Guarantee: All products are strictly tested by our QC, confirmed by QA, and approved by a third-party lab in China, USA,
factory?direct?saleAppearance:White Powder Storage:Store In Dry, Cool And Ventilated Place Package:25kg/drum, also according to the clients requirement Application:It is widely used as a thickener, emulsifier and stabilizer Transportation:By Sea Or B
Cas:84449-90-1
Min.Order:1 Kilogram
FOB Price: $18.0 / 20.0
Type:Trading Company
inquiryZhenyu biotech exported this product to many countries and regions at best price. if you are looking for the material's manufacturer or supplier in china, zhenyu biotech is your best choice. pls contact with us freely for getting detailed
Cas:84449-90-1
Min.Order:1 Kilogram
FOB Price: $2.0
Type:Lab/Research institutions
inquiryShandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W
Cas:84449-90-1
Min.Order:1 Gram
Negotiable
Type:Lab/Research institutions
inquiry1.Applied in food field.it can improve the immune system and prolong life. 2.Appliedin cosmetic field.it can improve the skin care. 3.Applied in pharmaceutical field.it can treat various dieases. 4.Our product quality assurance will make our customer
Cas:84449-90-1
Min.Order:1 Metric Ton
FOB Price: $1.5
Type:Trading Company
inquiryraloxifene hydrochloride
Raloxifen
Conditions | Yield |
---|---|
Stage #1: raloxifene hydrochloride With sodium hydroxide In water; acetone at 20℃; Stage #2: With acetic acid In water; acetone at 16 - 20℃; for 1.75h; pH=8; | 100% |
Stage #1: raloxifene hydrochloride With sodium hydroxide In water; acetone at 20℃; Stage #2: With acetic acid In water; acetone at 16 - 18℃; for 0.75h; pH=8; | 100% |
With sodium hydroxide; water; isopropyl alcohol at 20℃; for 5h; pH=9; | |
With sodium hydroxide In methanol; water at 15 - 30℃; for 12.5h; pH=8 - 8.5; | 180 g |
1-(2-(4-[6-Hydroxy-2-(4-hydroxy-phenyl)-benzo[b]thiophene-3-carbonyl]-phenoxy)-ethyl)-piperidinium bromide
Raloxifen
Conditions | Yield |
---|---|
Stage #1: 1-(2-(4-[6-Hydroxy-2-(4-hydroxy-phenyl)-benzo[b]thiophene-3-carbonyl]-phenoxy)-ethyl)-piperidinium bromide With sodium hydroxide In water; acetone at 20℃; Stage #2: With acetic acid In water; acetone at 12℃; for 1h; pH=8 - 9; | 100% |
Stage #1: 1-(2-(4-[6-Hydroxy-2-(4-hydroxy-phenyl)-benzo[b]thiophene-3-carbonyl]-phenoxy)-ethyl)-piperidinium bromide With sodium hydroxide In 1,4-dioxane; water at 16 - 20℃; Stage #2: With acetic acid In 1,4-dioxane; water for 0.166667h; pH=8; Product distribution / selectivity; | 85.8% |
[6-Methoxy-2-(4-Methoxyphenyl)benzo[b]thien-3-yl]-[4-[2-(1-Piperidinyl)ethoxy]phenyl] Methanone
Raloxifen
Conditions | Yield |
---|---|
With aluminum (III) chloride In dichloromethane at 50℃; | 90% |
With aluminium trichloride; ethanethiol demethylation; | 78% |
In dichloromethane for 6h; Ionic liquid; Reflux; | 61% |
1-piperidinoethanol
[2-(4-hydroxyphenyl)-6-hydroxybenzo[b]thien-3-yl] [4-fluorophenyl]methanone
Raloxifen
Conditions | Yield |
---|---|
With sodium hydride In N,N-dimethyl-formamide at 50℃; for 5h; | 86% |
<6-<(methylsulfonyl)oxy>-2-<4-<(methylsulfonyl)oxy>phenyl>benzothien-3-yl><4-<2-(1-pyrrolidinyl)ethoxy>phenyl>methanone hydrochloride
Raloxifen
Conditions | Yield |
---|---|
Stage #1: <6-<(methylsulfonyl)oxy>-2-<4-<(methylsulfonyl)oxy>phenyl>benzothien-3-yl><4-<2-(1-pyrrolidinyl)ethoxy>phenyl>methanone hydrochloride With potassium hydroxide; water In dimethyl sulfoxide at 60 - 62℃; for 4h; Stage #2: With acetic acid In water; dimethyl sulfoxide at 20℃; Stage #3: With ammonia In water; dimethyl sulfoxide at 20℃; Product distribution / selectivity; | 70.5% |
Stage #1: <6-<(methylsulfonyl)oxy>-2-<4-<(methylsulfonyl)oxy>phenyl>benzothien-3-yl><4-<2-(1-pyrrolidinyl)ethoxy>phenyl>methanone hydrochloride With potassium hydroxide; water In dimethyl sulfoxide at 60 - 62℃; for 4h; Stage #2: With hydrogenchloride In water; dimethyl sulfoxide at 20℃; for 1h; Stage #3: With ammonia In water; dimethyl sulfoxide at 20℃; Product distribution / selectivity; | 66.33% |
With sodium hydroxide In ethanol for 1.5h; Heating; | 42% |
Raloxifen
Conditions | Yield |
---|---|
With potassium hydroxide In dimethyl sulfoxide Inert atmosphere; | 67% |
Stage #1: 6-methanesulfonyloxy-2-(4-methanesulfonyloxyphenyl)-3-[4-(2-piperidinoethoxy)-benzoyl]benzo[b]thiophene With sodium hydroxide; ethanol; water for 1.5h; Stage #2: In water Acidic aqueous solution; Stage #3: With sodium hydrogencarbonate In water Product distribution / selectivity; | 42.2% |
With sodium hydroxide In tetrahydrofuran; methanol; chloroform | |
With sodium hydroxide In tetrahydrofuran; methanol; chloroform | |
With sodium hydroxide In tetrahydrofuran; methanol; chloroform |
1-piperidinoethanol
Raloxifen
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 90 percent / NaH / dimethylformamide / 0.5 h / 20 °C 2: 78 percent / AlCl3; ethanethiol View Scheme | |
Multi-step reaction with 3 steps 1: 97 percent / NaH / dimethylformamide / 0.25 h / 20 °C 2: 90 percent / tetrahydrofuran / 2 h / 5 - 23 °C 3: 78 percent / AlCl3; ethanethiol View Scheme |
4-fluorobenzoyl chloride
Raloxifen
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: 70 percent / chlorobenzene / 20 °C 2: 97 percent / NaH / dimethylformamide / 0.25 h / 20 °C 3: 90 percent / tetrahydrofuran / 2 h / 5 - 23 °C 4: 78 percent / AlCl3; ethanethiol View Scheme | |
Multi-step reaction with 4 steps 1: 70 percent / chlorobenzene / 20 °C 2: 83 percent / tetrahydrofuran / 1 h / 5 - 23 °C 3: 90 percent / NaH / dimethylformamide / 0.5 h / 20 °C 4: 78 percent / AlCl3; ethanethiol View Scheme | |
Multi-step reaction with 4 steps 1: 70 percent / chlorobenzene / 20 °C 2: 97 percent / dimethylformamide / 0.25 h / 20 °C 3: 90 percent / tetrahydrofuran / 2 h / 5 - 23 °C 4: 78 percent / AlCl3; ethanethiol View Scheme | |
Multi-step reaction with 3 steps 1: 74 percent / AlCl3 / CH2Cl2 2: 81 percent / BBr3 / CH2Cl2 / 3 h / 5 °C 3: 86 percent / NaH / dimethylformamide / 5 h / 50 °C View Scheme |
6-methoxy-N,N-dimethylbenzo[b]thiophen-2-amine
Raloxifen
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: 70 percent / chlorobenzene / 20 °C 2: 97 percent / NaH / dimethylformamide / 0.25 h / 20 °C 3: 90 percent / tetrahydrofuran / 2 h / 5 - 23 °C 4: 78 percent / AlCl3; ethanethiol View Scheme | |
Multi-step reaction with 4 steps 1: 70 percent / chlorobenzene / 20 °C 2: 83 percent / tetrahydrofuran / 1 h / 5 - 23 °C 3: 90 percent / NaH / dimethylformamide / 0.5 h / 20 °C 4: 78 percent / AlCl3; ethanethiol View Scheme | |
Multi-step reaction with 4 steps 1: 70 percent / chlorobenzene / 20 °C 2: 97 percent / dimethylformamide / 0.25 h / 20 °C 3: 90 percent / tetrahydrofuran / 2 h / 5 - 23 °C 4: 78 percent / AlCl3; ethanethiol View Scheme |
[2-dimethylamino-6-methoxybenzothien-3-yl] [4-[2-(1-piperidinyl)ethoxy]phenyl]-methanone
Raloxifen
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 90 percent / tetrahydrofuran / 2 h / 5 - 23 °C 2: 78 percent / AlCl3; ethanethiol View Scheme |
6-methoxy-2-(4-methoxyphenyl)-3-(4-fluorobenzoyl)benzo[b]thiophene
Raloxifen
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 90 percent / NaH / dimethylformamide / 0.5 h / 20 °C 2: 78 percent / AlCl3; ethanethiol View Scheme | |
Multi-step reaction with 2 steps 1: 81 percent / BBr3 / CH2Cl2 / 3 h / 5 °C 2: 86 percent / NaH / dimethylformamide / 5 h / 50 °C View Scheme |
(2-dimethylamino-6-methoxy-benzo[b]thiophen-3-yl)-(4-fluoro-phenyl)-methanone
Raloxifen
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 97 percent / NaH / dimethylformamide / 0.25 h / 20 °C 2: 90 percent / tetrahydrofuran / 2 h / 5 - 23 °C 3: 78 percent / AlCl3; ethanethiol View Scheme | |
Multi-step reaction with 3 steps 1: 83 percent / tetrahydrofuran / 1 h / 5 - 23 °C 2: 90 percent / NaH / dimethylformamide / 0.5 h / 20 °C 3: 78 percent / AlCl3; ethanethiol View Scheme | |
Multi-step reaction with 3 steps 1: 97 percent / dimethylformamide / 0.25 h / 20 °C 2: 90 percent / tetrahydrofuran / 2 h / 5 - 23 °C 3: 78 percent / AlCl3; ethanethiol View Scheme |
2-(4'-methoxyphenyl)-6-methoxybenzothiophene
Raloxifen
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 74 percent / AlCl3 / CH2Cl2 2: 81 percent / BBr3 / CH2Cl2 / 3 h / 5 °C 3: 86 percent / NaH / dimethylformamide / 5 h / 50 °C View Scheme | |
Multi-step reaction with 4 steps 1: 71 percent / pyridine hydrochloride / 6 h / 220 °C 2: 99 percent / 4-(dimethylamino)pyridine, pyridine / Ambient temperature 3: 93 percent / trifluoromethanesulfonic acid / 1,2-dichloro-ethane / Heating 4: 42 percent / 5 N aq. NaOH / ethanol / 1.5 h / Heating View Scheme |
3-methoxybenzenethiol
Raloxifen
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1: 80.4 percent / KOH / ethanol; H2O; ethyl acetate / Ambient temperature 2: 69 percent / PPA / 1 h / 85 - 90 °C 3: 71 percent / pyridine hydrochloride / 6 h / 220 °C 4: 99 percent / 4-(dimethylamino)pyridine, pyridine / Ambient temperature 5: 93 percent / trifluoromethanesulfonic acid / 1,2-dichloro-ethane / Heating 6: 42 percent / 5 N aq. NaOH / ethanol / 1.5 h / Heating View Scheme |
6-hydroxy-2-(4-hydroxyphenyl)benzo[B]-thiophene
Raloxifen
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 99 percent / 4-(dimethylamino)pyridine, pyridine / Ambient temperature 2: 93 percent / trifluoromethanesulfonic acid / 1,2-dichloro-ethane / Heating 3: 42 percent / 5 N aq. NaOH / ethanol / 1.5 h / Heating View Scheme |
4-(2-(piperidin-1-yl)ethoxy)benzoyl chloride
Raloxifen
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 93 percent / trifluoromethanesulfonic acid / 1,2-dichloro-ethane / Heating 2: 42 percent / 5 N aq. NaOH / ethanol / 1.5 h / Heating View Scheme |
α-(3-methoxyphenyl-thio)-4-methoxyacetophenone
Raloxifen
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: 69 percent / PPA / 1 h / 85 - 90 °C 2: 71 percent / pyridine hydrochloride / 6 h / 220 °C 3: 99 percent / 4-(dimethylamino)pyridine, pyridine / Ambient temperature 4: 93 percent / trifluoromethanesulfonic acid / 1,2-dichloro-ethane / Heating 5: 42 percent / 5 N aq. NaOH / ethanol / 1.5 h / Heating View Scheme |
6-<(methylsulfonyl)oxy>-2-<4-<(methylsulfonyl)oxy>phenyl>benzothiophene
Raloxifen
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 93 percent / trifluoromethanesulfonic acid / 1,2-dichloro-ethane / Heating 2: 42 percent / 5 N aq. NaOH / ethanol / 1.5 h / Heating View Scheme | |
Multi-step reaction with 3 steps 1: aluminum (III) chloride / 1,2-dichloro-ethane / 20.5 h / 20 °C / Inert atmosphere 2: sodium t-butanolate / acetonitrile / 16 h / 80 °C / Inert atmosphere 3: potassium hydroxide / dimethyl sulfoxide / Inert atmosphere View Scheme |
4-(2-piperidin-1-ylethoxy)benzoic acid hydrochloride
Raloxifen
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: SOCl2, DMF / toluene 2: 93 percent / trifluoromethanesulfonic acid / 1,2-dichloro-ethane / Heating 3: 42 percent / 5 N aq. NaOH / ethanol / 1.5 h / Heating View Scheme |
2-Bromo-4'-methoxyacetophenone
Raloxifen
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1: 80.4 percent / KOH / ethanol; H2O; ethyl acetate / Ambient temperature 2: 69 percent / PPA / 1 h / 85 - 90 °C 3: 71 percent / pyridine hydrochloride / 6 h / 220 °C 4: 99 percent / 4-(dimethylamino)pyridine, pyridine / Ambient temperature 5: 93 percent / trifluoromethanesulfonic acid / 1,2-dichloro-ethane / Heating 6: 42 percent / 5 N aq. NaOH / ethanol / 1.5 h / Heating View Scheme |
6-acetoxy-2-(4-acetoxyphenyl)-3-[4-(2-piperidinoethoxy)benzoyl]benzo[b]thiophene, hydrochloride
Raloxifen
Conditions | Yield |
---|---|
With sodium hydroxide In methanol; chloroform; water | |
With sodium hydroxide In methanol; chloroform; water |
6-benzoyloxy-2-(4-benzoyloxyphenyl)-3-[4-(2-piperidinoethoxy)benzoyl]benzo[b]thiophene, hydrochloride
Raloxifen
Conditions | Yield |
---|---|
With methanesulfonic acid In ethanol; water |
Conditions | Yield |
---|---|
Stage #1: 6-methanesulfonyloxy-2-(4-methanesulfonyloxyphenyl)-3-[4-(2-piperidinoethoxy)-benzoyl]benzo[b]thiophene With sodium hydroxide; water In N,N-dimethyl-formamide at 80 - 90℃; for 3h; Stage #2: With hydrogenchloride In water; N,N-dimethyl-formamide at 20℃; for 1h; Stage #3: With ammonia In water; N,N-dimethyl-formamide Product distribution / selectivity; | |
Stage #1: 6-methanesulfonyloxy-2-(4-methanesulfonyloxyphenyl)-3-[4-(2-piperidinoethoxy)-benzoyl]benzo[b]thiophene With sodium hydroxide; water In tetrahydrofuran at 60 - 62℃; for 14h; Stage #2: With acetic acid In tetrahydrofuran; water at 20℃; for 0.333333h; Stage #3: With ammonia In tetrahydrofuran; water Product distribution / selectivity; |
C24H20O10S4
Raloxifen
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: sodium t-butanolate / acetonitrile / 16 h / 80 °C / Inert atmosphere 2: potassium hydroxide / dimethyl sulfoxide / Inert atmosphere View Scheme |
methanesulfonic acid 4-chlorocarbonyl-phenyl ester
Raloxifen
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: aluminum (III) chloride / 1,2-dichloro-ethane / 20.5 h / 20 °C / Inert atmosphere 2: sodium t-butanolate / acetonitrile / 16 h / 80 °C / Inert atmosphere 3: potassium hydroxide / dimethyl sulfoxide / Inert atmosphere View Scheme |
methyl 4-hydroxylbenzoate
Raloxifen
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1: potassium carbonate / acetone / Reflux 2: hydrogenchloride; water / tetrahydrofuran 3: thionyl chloride / dichloromethane 4: aluminum (III) chloride / dichloromethane / 12 h / 50 °C / Inert atmosphere 5: neat liquid / 12 h / Inert atmosphere; Reflux 6: aluminum (III) chloride / dichloromethane / 50 °C View Scheme |
4-(2-Chloroethoxy)benzoic acid methyl ester
Raloxifen
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: hydrogenchloride; water / tetrahydrofuran 2: thionyl chloride / dichloromethane 3: aluminum (III) chloride / dichloromethane / 12 h / 50 °C / Inert atmosphere 4: neat liquid / 12 h / Inert atmosphere; Reflux 5: aluminum (III) chloride / dichloromethane / 50 °C View Scheme |
4-(2-chloroethoxy)benzoic acid
Raloxifen
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: thionyl chloride / dichloromethane 2: aluminum (III) chloride / dichloromethane / 12 h / 50 °C / Inert atmosphere 3: neat liquid / 12 h / Inert atmosphere; Reflux 4: aluminum (III) chloride / dichloromethane / 50 °C View Scheme |
4-(2-chloro-ethoxy)-benzoyl chloride
Raloxifen
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: aluminum (III) chloride / dichloromethane / 12 h / 50 °C / Inert atmosphere 2: neat liquid / 12 h / Inert atmosphere; Reflux 3: aluminum (III) chloride / dichloromethane / 50 °C View Scheme |
Raloxifen
[6-hydroxy-2-(4-hydroxyphenyl)-benzothiophene-3-yl]-[4-[2-(1-piperidyl)ethoxy]phenyl]methanone sulfamate
Conditions | Yield |
---|---|
With aminosulfonic acid In water; acetonitrile at 80℃; Product distribution / selectivity; | 96.4% |
Raloxifen
[2-(4-Hydroxyphenyl)-6-hydroxybenzo[b]thien-3-yl][4-[2-(1-piperidinyl)ethoxy]phenyl]methanol
Conditions | Yield |
---|---|
With lithium aluminium tetrahydride In tetrahydrofuran at 0℃; for 6h; | 91% |
Raloxifen
1-(2-(4-[6-Hydroxy-2-(4-hydroxy-phenyl)-benzo[b]thiophene-3-carbonyl]-phenoxy)-ethyl)-piperidinium bromide
Conditions | Yield |
---|---|
With hydrogen bromide In methanol; water at 1 - 35℃; pH=1.5; Reflux; | 87.4% |
With hydrogen bromide In methanol; water at 35℃; pH=1.5; Reflux; | 87.4% |
trifluoromethylsulfonic anhydride
Raloxifen
Conditions | Yield |
---|---|
With triethylamine In 1,2-dichloro-ethane | 51% |
With pyridine In dichloromethane at 0 - 20℃; for 1h; | 0.16 g |
benzyl chloride
Raloxifen
A
[6-Benzyloxy-2-(4-hydroxy-phenyl)-benzo[b]thiophen-3-yl]-[4-(2-piperidin-1-yl-ethoxy)-phenyl]-methanone
Conditions | Yield |
---|---|
With sodium hydride In N,N-dimethyl-formamide | A 20% B 20% C 20% |
Raloxifen
tert-butyldimethylsilyl chloride
A
(6-((tert-butyldimethylsilyl)oxy)-2-(4-hydroxyphenyl)benzo[b]thiophen-3-yl)(4-(2-(piperidin-1-yl)ethoxy)phenyl)methanone
B
2-[4-[[(1,1-dimethylethyl)dimethylsilyl]oxy]phenyl]-6-hydroxybenzo[b]thiophen-3-yl 4-[2-(1-piperidinyl)ethoxy]phenyl ketone
Conditions | Yield |
---|---|
With dmap In tetrahydrofuran; N,N-dimethyl-formamide | A 20% B 20% C 20% |
benzoyl chloride
Raloxifen
4-(6-hydroxy-3-(4-(2-(piperidin-1-yl)ethoxy)phenylcarbonyl)benzo[b]thiophen-2-yl)phenyl benzoate
Conditions | Yield |
---|---|
Stage #1: Raloxifen With sodium hydride In N,N-dimethyl-formamide; mineral oil at 20℃; for 0.0833333h; Stage #2: benzoyl chloride In N,N-dimethyl-formamide at 20℃; for 0.25h; | 7.8% |
Raloxifen
tert-butyldimethylsilyl chloride
A
(6-((tert-butyldimethylsilyl)oxy)-2-(4-hydroxyphenyl)benzo[b]thiophen-3-yl)(4-(2-(piperidin-1-yl)ethoxy)phenyl)methanone
B
2-[4-[[(1,1-dimethylethyl)dimethylsilyl]oxy]phenyl]-6-hydroxybenzo[b]thiophen-3-yl 4-[2-(1-piperidinyl)ethoxy]phenyl ketone
Conditions | Yield |
---|---|
With dmap 1.) THF, DMF, RT, 1 h, 2.) THF, DMF, RT, 72 h; Yield given. Multistep reaction. Yields of byproduct given; | |
With dmap In tetrahydrofuran; N,N-dimethyl-formamide |
Raloxifen
[2-(4-hydroxyphenyl)-6-hydroxybenzo[b]thien-3-yl][4-[2-(1-piperidinyl)ethoxy]phenyl]methane
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 91 percent / LiAlH4 / tetrahydrofuran / 6 h / 0 °C 2: 72 percent / Et3SiH, CF3CO2H / CH2Cl2 / 16 h / 0 °C View Scheme |
Raloxifen
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 20 percent / DMAP / tetrahydrofuran; dimethylformamide 2: 85 percent / Et3N / CH2Cl2 3: 1.) Pd(OAc)2, bis-diphenylphosphinopropane, Et3N, 2.) TBAF / 1) DMF; 2) CH2Cl2 View Scheme | |
Multi-step reaction with 4 steps 1: 1.) DMAP / 1.) THF, DMF, RT, 1 h, 2.) THF, DMF, RT, 72 h 2: 88 percent / Et3N / 1,2-dichloro-ethane / Ambient temperature 3: Et3N, Pd(OAc)2, 1,3-bis(diphenylphosphino)propane / dimethylformamide / 4 h / 100 °C 4: tetra-N-butylammoium fluoride / tetrahydrofuran / 3 h View Scheme |
Raloxifen
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 20 percent / DMAP / tetrahydrofuran; dimethylformamide 2: 85 percent / Et3N / CH2Cl2 3: 1.) Pd(OAc)2, bis-diphenylphosphinopropane, Et3N, 2.) TBAF / 1) DMF; 2) CH2Cl2 View Scheme | |
Multi-step reaction with 4 steps 1: 1.) DMAP / 1.) THF, DMF, RT, 1 h, 2.) THF, DMF, RT, 72 h 2: 88 percent / Et3N / 1,2-dichloro-ethane / Ambient temperature 3: Et3N, Pd(OAc)2, 1,3-bis(diphenylphosphino)propane / dimethylformamide / 10 h / 75 °C 4: tetra-N-butylammonium fluoride / tetrahydrofuran View Scheme |
Raloxifen
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 20 percent / DMAP / tetrahydrofuran; dimethylformamide 2: 85 percent / Et3N / CH2Cl2 3: 1.) Pd(OAc)2, bis-diphenylphosphinopropane, Et3N, 2.) TBAF / 1) DMF; 2) CH2Cl2 View Scheme | |
Multi-step reaction with 4 steps 1: 1.) DMAP / 1.) THF, DMF, RT, 1 h, 2.) THF, DMF, RT, 72 h 2: 88 percent / Et3N / 1,2-dichloro-ethane / Ambient temperature 3: Et3N, Pd(OAc)2, 1,3-bis(diphenylphosphino)propane / dimethylformamide / 19 h / 80 °C 4: tetra-N-butylammonium fluoride / tetrahydrofuran / 3 h View Scheme |
Raloxifen
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: 20 percent / DMAP / tetrahydrofuran; dimethylformamide 2: 85 percent / Et3N / CH2Cl2 3: 1.) Pd(OAc)2, bis-diphenylphosphinopropane, Et3N, 2.) TBAF / 1) DMF; 2) CH2Cl2 4: NH3 / methanol View Scheme | |
Multi-step reaction with 5 steps 1: 1.) DMAP / 1.) THF, DMF, RT, 1 h, 2.) THF, DMF, RT, 72 h 2: 88 percent / Et3N / 1,2-dichloro-ethane / Ambient temperature 3: 54 percent / Et3N, Pd(OAc)2, 1,3-bis(diphenylphosphino)propane / dimethylformamide / 4.5 h / 70 °C 4: MeAl(Cl)NH2 / toluene / Ambient temperature 5: 1N aq. HCl / tetrahydrofuran / 5 h / Heating View Scheme |
Raloxifen
4-{6-Hydroxy-3-[4-(2-piperidin-1-yl-ethoxy)-benzoyl]-benzo[b]thiophen-2-yl}-benzoic acid methyl ester
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 20 percent / DMAP / tetrahydrofuran; dimethylformamide 2: 85 percent / Et3N / CH2Cl2 3: 1.) Pd(OAc)2, bis-diphenylphosphinopropane, Et3N, 2.) TBAF / 1) DMF; 2) CH2Cl2 View Scheme | |
Multi-step reaction with 3 steps 1: 1.) DMAP / 1.) THF, DMF, RT, 1 h, 2.) THF, DMF, RT, 72 h 2: 88 percent / Et3N / 1,2-dichloro-ethane / Ambient temperature 3: 27 percent / Et3N, Pd(OAc)2, 1,3-bis(diphenylphosphino)propane / dimethylformamide / 4.5 h / 70 °C View Scheme | |
Multi-step reaction with 4 steps 1: 1.) DMAP / 1.) THF, DMF, RT, 1 h, 2.) THF, DMF, RT, 72 h 2: 88 percent / Et3N / 1,2-dichloro-ethane / Ambient temperature 3: 54 percent / Et3N, Pd(OAc)2, 1,3-bis(diphenylphosphino)propane / dimethylformamide / 4.5 h / 70 °C 4: tetra-n-butylammonium fluoride / tetrahydrofuran View Scheme |
Raloxifen
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: 20 percent / DMAP / tetrahydrofuran; dimethylformamide 2: 85 percent / Et3N / CH2Cl2 3: 1.) Pd(OAc)2, bis-diphenylphosphinopropane, Et3N, 2.) TBAF / 1) DMF; 2) CH2Cl2 4: Me3Al / toluene View Scheme | |
Multi-step reaction with 5 steps 1: 1.) DMAP / 1.) THF, DMF, RT, 1 h, 2.) THF, DMF, RT, 72 h 2: 88 percent / Et3N / 1,2-dichloro-ethane / Ambient temperature 3: 54 percent / Et3N, Pd(OAc)2, 1,3-bis(diphenylphosphino)propane / dimethylformamide / 4.5 h / 70 °C 4: Me3Al / toluene / 21 h / 50 °C 5: tetra-N-butylammonium fluoride / tetrahydrofuran / 3 h View Scheme |
Raloxifen
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 20 percent / DMAP / tetrahydrofuran; dimethylformamide 2: 85 percent / Et3N / CH2Cl2 3: 1.) Pd(OAc)2, bis-diphenylphosphinopropane, Et3N, 2.) TBAF / 1) DMF; 2) CH2Cl2 View Scheme | |
Multi-step reaction with 4 steps 1: 1.) DMAP / 1.) THF, DMF, RT, 1 h, 2.) THF, DMF, RT, 72 h 2: 88 percent / Et3N / 1,2-dichloro-ethane / Ambient temperature 3: Et3N, Pd(OAc)2, 1,3-bis(diphenylphosphino)propane / dimethylformamide / 4.5 h / 70 °C 4: tetra-N-butylammonium fluoride / tetrahydrofuran / 3 h View Scheme |
Raloxifen
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 20 percent / DMAP / tetrahydrofuran; dimethylformamide 2: 85 percent / Et3N / CH2Cl2 3: 1.) Pd(PPh3)4, 2.) TBAF / 1) MeCN; 2) CH2Cl2 View Scheme | |
Multi-step reaction with 4 steps 1: 1.) DMAP / 1.) THF, DMF, RT, 1 h, 2.) THF, DMF, RT, 72 h 2: 88 percent / Et3N / 1,2-dichloro-ethane / Ambient temperature 3: Pd(PPh3)4, 2,6-lutidine / acetonitrile / 16 h / 70 °C 4: tetra-N-butylammonium fluoride / tetrahydrofuran / 3 h View Scheme |
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