Ten cats were injected in cortical area 6aβ with HRP. The distribution of the cortico-cortical and thalamo-cortical afferent neurones were analysed. In the ipsilateral cortex, labelled cells were found in the following gyri: sigmoid, coronal, anterior ectosylvian, anterior suprasylvian, and orb...

The treatment of hexahydro-1.3-pentalenedimethanol 1 with MCPB acid gave a pentalenofurane compound 7 instead of an epoxide, in >90% yield by participation of the closer hydroxymethyl group in epoxidation. Acyl-protected derivatives 1a–1e gave a mixture of exo- and endo-epoxides 5/6 as expected...

Dieckmann cyclisation of some β,γ-unsaturated diesters of the indane series gives as major product of the ring closure the compound derived from the more carbanion formed under standardised reaction conditions. The methyl β-(2-methoxycarbonylmethyl-7-methylinden-3-yl)propionate (2) on Dieckma...

Tetrahydro-β-carboline alkaloids are biologically active compounds that occur in foodstuffs. 1,2,3,4-Tetrahydro-β-carboline-3-carboxylic acid, a tetrahydro-β-carboline derived from a Pictet–Spengler condensation reaction among l-tryptophan and formaldehyde, was identified by GC–MS as its N-...

A series of 3-acetyl-8-methoxycoumarin appended thiosemicarbazones (1–4) was prepared from the reaction of 3-acetyl-8-methoxycoumarin with 4(N)-substituted thiosemicarbazides in a view of ascertaining their biological properties with the change of N-terminal substitution in the thiosemicarbazid...

Spodoptera exigua (Lepidoptera: Noctuidae) larvae were used to analyze the regulation of lipid, protein and carbohydrate metabolism in host larvae infected with the Heliothis virescens ascovirus 3h (HvAV-3h). Using histological sections, significant pathological changes were found in the fat bod...

Metal complexes of Ni(II), Co(II), Cd(II), VO(IV) and UO2(VI) as well as several Cu(II) salts, including Cl-,NO3-,AcO-,ClO4- and SO4-2 with a tridentate O2N donor Schiff base ligand (H2L), synthesized by condensation of 5-acetyl-4-hydroxy-2H-1,3-thiazine-2,6(3H)-dione with 2-aminophenol, were pr...

A series of thirty-six novel 5-(2-(4-(benzo[d]isoxazol-3-yl)piperazin-1-yl)acetyl)indolin-2-one and 5-(2-(4-substitutedpiperazin-1-yl)acetyl)indolin-2-one analogues were synthesized, characterized and screened for their in vitro anti-tubercular activity against Mycobacterium tuberculosis H37Rv s...

Antiepileptic and network inhibitory actions of Q5 (2-methyl-4-oxo-3H-quinazoline-3-acetyl piperidine) have recently been described in hippocampal slices. Here we present evidence on the in vivo antiabsence effect of Q5. All doses of Q5 tested (0.3 mg/kg, 0.9 mg/kg, 2.8 mg/kg) decreased the numb...

New 2-(4-(2-(dimethylamino)ethyl)-4H-1,2,4-triazol-3-yl)pyridine derivatives were synthesized and evaluated for their in vitro cytotoxicity against five cancer cell lines namely MKN-45, H460, HT-29, A549 and U87MG, as well as the normal cell line WI-38. Nearly all the compounds exhibited superio...

Studies on the metabolism and on the toxicological analysis of mefenorex [R,S-N-(3-chloropropyl)-α-methylphenethylamine, MF] using gas chromatography–mass spectrometry (GC–MS) and fluorescence polarization immunoassay (FPIA) are described. The metabolites were identified in urine samples of v...

Mefenorex, used for 20 years as an anorexic drug, has not been studied so far with regard to its central mechanism of action, although its chemical structure suggests a serotonergic mechanism. In the present study, the effect of mefenorex on serotonin (5-HT) release was investigated both in vitr...

Mefenorex, N-(3-chloropropyl)-α-methylphenethylamine, (RONDIMEN®), is included in the list of centrally acting stimulants and/or hallucinogens or related compounds to be considered by a World Health Organization (WHO) Expert Committee in 1985 for possible scheduling under the Convention on Psyc...

Three groups, each of 11 healthy male subjects, were given either 40, 20 or 0 mg of benzoctamine (Tacitin ®, Ciba-Geigy). They were tested with a battery of motor-skill tests and questionnaires both before and after alcohol intoxication (induced average blood alcohol level: 0.083%). In 3 out of ...

Benzoctamine(TACITINR), 1-methylamino-methyldibenzo [b,e]bicyclo[2.2.2] octadiene, is a new psychoactive agent which possesses tranquillizing properties. Its effects on catecholamine metabolism have been studied. Benzoctamine produced no marked change in the catecholamine concentration of variou...

SUMMARYA double-blind trial has been performed to investigate the respiratory effects of low oral doses of benzoctamine, and to compare them with diazepam and a placebo. The displacement of the carbon dioxide response curves indicated that whilst diazepam caused respiratory depression, benzoctam...

Treatment of osteitis in the mandible after surgery is still a clinical problem. Levels of four antibiotics — azidocillin, erythromycin, doxycycline, and clindamycin — were measured in serum and dental alveolar serum in 42 patients undergoing oral surgery. The systemic serum concentrations wer...

Treatment of osteitis after surgical removal of the third molar of the mandible is still a clinical problem. A total of 140 patients undergoing operations for removal of an impacted third molar of the mandible, ware included in a double-blind study. Placebo or antibiotics — azidocillin, erythro...

Postoperative complications after surgery in the mandible are still a clinical problem. Levels of four antibiotics – azidocillin, erythromycin, doxycycline and clindamycin – were measured in serum, dental alveolar serum, saliva and mandibular bone in 24 patients undergoing surgical removal of ...

A novel base treatment followed by liquid-liquid extraction was developed to remove the interference of excess derivatization reagent BSTFA [N,O-Bis(trimethylsilyl)trifluoroacetamide] and its byproducts for trace determination of 1-chloro-2-propanol and 2-chloro-1-propanol in a food additive. Th...