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Dayang Chem (Hangzhou) Co.,Ltd.

DayangChem exported this product to many countries and regions at best price in China. If you are looking for the product’s supplier in China, DayangChem is your best choice. Pls contact with us freely for getting detailed product specifica

4-Chloro-3-nitrobenzotrifluoride

Cas:121-17-5

Min.Order:1 Kilogram

FOB Price: $2.0

Type:Lab/Research institutions

inquiry

Jiangsu Huaen Energy Co., Ltd.

Our Advantages: Geographical advantages: the processing base is located in Jiangsu Coastal Chemical Industrial Park with convenient transportation, good human, economic and social environment, and huge potential for market development; Technol

4-Chloro-3-Nitrobenzotrifluoride

Cas:121-17-5

Min.Order:0 Metric Ton

Negotiable

Type:Trading Company

inquiry

Simagchem Corporation

Welcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our

High quality 4-Chloro-3-Nitrobenzotrifluoride supplier in China

Cas:121-17-5

Min.Order:0 Metric Ton

Negotiable

Type:Manufacturers

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Henan Allgreen Chemical Co.,Ltd

high quality Appearance:white powder Storage:Sealed, dry, microtherm , avoid light and smell. Package:According to the demand of customer Application:Organic synthesis Transportation:by air or by sea Port:shanghai

4-Chloro-3-nitrobenzotrifluoride, 98%

Cas:121-17-5

Min.Order:1 Kilogram

Negotiable

Type:Manufacturers

inquiry

Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply 4-chloro-α,α,α-trifluoro-3-nitrotoluene

Cas:121-17-5

Min.Order:1

Negotiable

Type:Other

inquiry

Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

4-Chloro-3-nitrobenzotrifluoride

Cas:121-17-5

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

inquiry

Henan Tianfu Chemical Co., Ltd.

CAS No.121-17-5 Our company was built in 2009 with an ISO certificate.In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scie

CAS No.121-17-5 4-Chloro-3-nitrobenzotrifluoride

Cas:121-17-5

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Henan Sinotech Import&Export Corporation

Product Name 4-Chloro-3-nitrobenzotrifluoride Synonyms TIMTEC-BB SBB009923;1-chloro-2-nitro-4-(trifluoromethyl)-benzen;2-Chloro-5-(trifluoromethyl)nitrobenzene;3-Nitro-4-(chloro)trifluoromethylbenzene;3-N

4-Chloro-3-nitrobenzotrifluoride CAS: 121-17-5

Cas:121-17-5

Min.Order:5 Metric Ton

FOB Price: $1.0 / 2.0

Type:Other

inquiry

Changchun Artel lmport and Export trade company

Minimum Order Qty. 10 Gram Supply Ability 500 Kilograms/Month Storage store in cool, dry, ventilated place 20℃ Delivery Time 3 business days after payment Payment Term TT,western union,Paypal,MoneyGram Package 10g,20g,50g,100g,500g,1KGS,

4-Chloro-3-nitrobenzotrifluoride suppliers in Chian CAS NO.121-17-5

Cas:121-17-5

Min.Order:10 Gram

Negotiable

Type:Trading Company

inquiry

Hangzhou Keyingchem Co.,Ltd

Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det

4-Chloro-3-nitrobenzotrifluoride

Cas:121-17-5

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

4-Chloro-3-nitrobenzotrifluoride

Cas:121-17-5

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Shanghai Massive Chemical Technology Co., Ltd.

Massive Chemical is certified with ISO9001 and ISO14001 manufacturer for this product. We will offer all documents as requirement for the materials which includes, Certificate of Analysis, Material Safety Data Sheet, and Method of Analysis and

4-Chloro-3-nitrobenzotrifluoride/Manufacturer/High quality/Best price

Cas:121-17-5

Min.Order:1 Gram

FOB Price: $1.0

Type:Lab/Research institutions

inquiry

Hangzhou Lingrui Chemical Co.,Ltd.

4-Chloro-3-nitrobenzotrifluorideAppearance:Pls see the Details Storage:Keep away of light, hot, water, Store in dry, dark and ventilated place Package:according to customers' requirements Application:Steroids, Cosmetics Ingredients, APIs, Intermediat

4-Chloro-3-nitrobenzotrifluoride

Cas:121-17-5

Min.Order:1 Gram

Negotiable

Type:Other

inquiry

Zibo Dorne chemical technology co. LTD

Product Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,

4-Chloro-3-nitrobenzotrifluoride

Cas:121-17-5

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Henan Wentao Chemical Product Co., Ltd.

1)quick response within 12 hours; 2)quality guarantee: all products are strictly tested by our qc, confirmed by qa and approved by third party lab in china, usa, canada, germany, uk, italy, france etc. 3) oem/odm available; 4) rea

4-Chloro-3-nitrobenzotrifluorideCAS NO.: 121-17-5

Cas:121-17-5

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

inquiry

Hunan chemfish Pharmaceutical co.,Ltd

Appearance:95%+ Package:R&D,Pilot run Transportation:per client require Port:Express ,Air, Sea

4-Chloro-3-nitrobenzotrifluoride

Cas:121-17-5

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

HANGZHOU YUNUO CHEMICAL CO.,LTD

Superior quality, moderate price & quick delivery. Appearance:light yellow liquid Storage:stored in a cool, dry and ventilated place to provent sun and rain Package:25kg/drum, or as per your request. Application:Used as Pharmaceutical Inter

4-Chloro-3-nitrobenzotrifluoride

Cas:121-17-5

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

Changzhou Anchor Biological Technology Co., Ltd.

Our company is engaged in customizing the benzene ring and pyridine derivative organic intermediates, and the quantity is flexible according to customer's needs. It mainly provides high-quality intermediates for domestic and foreign pharmaceutical an

Kono Chem Co.,Ltd

high purity lowest priceAppearance:solid or liquid Storage:in sealed air resistant place Package:drum and bag Application:for pharma use Transportation:by sea or air Port:Beijing or Guangzhou

4-Chloro-3-nitrobenzotrifluoride

Cas:121-17-5

Min.Order:0

Negotiable

Type:Other

inquiry

GIHI CHEMICALS CO.,LIMITED

high purity,in stock Package:25kg/drum,or as per customers'demand Application:API,Pharmaceutical intermediates Transportation:air,sea,courier

4-Chloro-3-nitrobenzotrifluoride

Cas:121-17-5

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

JINHUA HUAYI CHEMICAL CO., LTD.

Jinhua huayi chemical co., ltd. is dedicated to the development, production and marketing of chemicals. On the basis of equality and mutual benefit, and under the principle of customer first, credit first, quality first, we are ready to join hands

3-Nitro-4-Chlorobenzotrifluoride

Cas:121-17-5

Min.Order:100 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Aecochem Corp.

Our clients, like BASF,CHEMO,Brenntag,ASR,Evonik,Merck and etc.Appearance:COA Storage:in stock Application:MSDS/TDS

4-Chloro-3-Nitrobenzotrifluoride

Cas:121-17-5

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Enke Pharma-tech Co.,Ltd. (Cangzhou, China )

Cangzhou Enke Pharma Tech Co.,ltd. is located in Cangzhou City, Hebei province ,where is a famous petroleum chemical industry city?in China. Enke Pharma a high-tech enterprise ,and we are dedicated to developing and manufacturing new api,?intermediat

4-Chloro-3-nitrobenzotrifluoride

Cas:121-17-5

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Antimex Chemical Limied

Ansciep Chemical is a professional enterprise manufacturing and distributing fine chemicals and speciality chemicals. We have been dedicated to heterocycle compounds and phenyl rings for tens of years. This is our mature product for export. Our quali

4-Chloro-3-nitrobenzotrifluoride

Cas:121-17-5

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Zhuozhou Wenxi import and Export Co., Ltd

Product Description Description & Specification Category Pharmaceutical Raw Materials, Fine Chemicals, Bulk drug Standard Medical standard

High quality CAS 121-17-5 with best price

Cas:121-17-5

Min.Order:1 Kilogram

FOB Price: $112.0

Type:Trading Company

inquiry

Xiamen AmoyChem Co.,Ltd

Amoychem is committed to providing the top-quality chemical products and services Internationally. We offer our customers with friendly, professional service and reliable, high performance products that have been manufactured according to the accredi

4-Chloro-3-nitrobenzotrifluoride

Cas:121-17-5

Min.Order:0

Negotiable

Type:Other

inquiry

Hubei Langyou International Trading Co., Ltd

TIANFUCHEM--High purity 121-17-5 4-Chloro-3-nitrobenzotrifluoride Application:TIANFUCHEM--High purity 121-17-5 4-Chloro-3-nitrobenzotrifluoride

TIANFUCHEM--High purity 121-17-5 4-Chloro-3-nitrobenzotrifluoride

Cas:121-17-5

Min.Order:0

Negotiable

Type:Other

inquiry

Changzhou Ansciep Chemical Co.,Ltd.

reagent grade ex stockAppearance:white or off-white crystalline powder Storage:Keep away of light,cool place Package:1L 5L 10L 25L bottle Application:pharma intermediate Transportation:by Fedex, ship or plane

4-Chloro-3-nitrobenzotrifluoride

Cas:121-17-5

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou ZeErRui Chemical Co., Ltd.

Hangzhou ZeErRui Chemical Co., Ltd. located in Lingang industrial areas, our plant covers an area of 6000 square meters.ZeErRui dedicated to the development, production and marketing of chemicals. We have earned ourselves a good reputation at home an

4-Chloro-3-Nitrobenzotrifluoride manufacture

Cas:121-17-5

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Hunan Longxianng Runhui Trading Co.,Ltd

TIANFUCHEM--High purity 121-17-5 4-Chloro-3-nitrobenzotrifluorideAppearance:powder Storage:room tempurature Package:As required Application:medical Transportation:By express (Door to door) such as FEDEX, DHL, EMS for small amount. By air(airport to

TIANFUCHEM--High purity 121-17-5 4-Chloro-3-nitrobenzotrifluoride

Cas:121-17-5

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Synthetic route

4-chlorobenzotrifluoride
98-56-6

4-chlorobenzotrifluoride

2-chloro-3-nitro-5-trifluoromethylbenzene
121-17-5

2-chloro-3-nitro-5-trifluoromethylbenzene

Conditions
ConditionsYield
With ammonium nitrate; 3-(N,N-dimethyldodecylammonium)propanesulfonic acid hydrogen sulphate at 70℃; for 9h; Temperature;85%
With sulfuric acid; nitric acid73.2%
With sulfuric acid; nitric acid
4-Chloro-3-nitroaniline
635-22-3

4-Chloro-3-nitroaniline

trifluoromethylsilver

trifluoromethylsilver

2-chloro-3-nitro-5-trifluoromethylbenzene
121-17-5

2-chloro-3-nitro-5-trifluoromethylbenzene

Conditions
ConditionsYield
Stage #1: 4-Chloro-3-nitroaniline With hydrogenchloride In water at 0℃; for 0.0833333h; Inert atmosphere; Schlenk technique;
Stage #2: With tert.-butylnitrite at 0℃; for 0.25h; Inert atmosphere; Schlenk technique;
Stage #3: trifluoromethylsilver at -78 - 20℃; for 4h; Inert atmosphere; Schlenk technique;
81%
Stage #1: 4-Chloro-3-nitroaniline With hydrogenchloride In water at 0℃; for 0.0833333h; Sandmeyer Reaction; Schlenk technique;
Stage #2: With tert.-butylnitrite In water at -196 - 20℃; Sandmeyer Reaction; Schlenk technique; Inert atmosphere;
Stage #3: trifluoromethylsilver In water at -78 - 20℃; for 5h; Sandmeyer Reaction; Schlenk technique; Inert atmosphere;
81%
2-nitro-4-trifluoromethylbenzoic acid
320-94-5

2-nitro-4-trifluoromethylbenzoic acid

2-chloro-3-nitro-5-trifluoromethylbenzene
121-17-5

2-chloro-3-nitro-5-trifluoromethylbenzene

Conditions
ConditionsYield
With copper(l) iodide; oxygen; copper(l) chloride In dimethyl sulfoxide at 160℃; under 760.051 Torr; for 30h; Schlenk technique; Sealed tube;44%
With 2.9-dimethyl-1,10-phenanthroline; oxygen; copper (I) acetate; silver sulfate; sodium chloride In dimethyl sulfoxide at 160℃; for 24h; Schlenk technique;20%
With 2.9-dimethyl-1,10-phenanthroline; oxygen; copper diacetate; silver sulfate; sodium chloride In dimethyl sulfoxide at 160℃; under 760.051 Torr; for 20h; Schlenk technique;16%
4-chlorotrichloromethylbenzene
5216-25-1

4-chlorotrichloromethylbenzene

2-chloro-3-nitro-5-trifluoromethylbenzene
121-17-5

2-chloro-3-nitro-5-trifluoromethylbenzene

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: hydrogen fluoride / 110 °C / 7355.08 - 10297.1 Torr
2: Nitrierung
View Scheme
piperazine
110-85-0

piperazine

2-chloro-3-nitro-5-trifluoromethylbenzene
121-17-5

2-chloro-3-nitro-5-trifluoromethylbenzene

1,4-Bis(1'-nitro-3'-(trifluoromethyl)-6'-phenyl)piperazine
137918-81-1

1,4-Bis(1'-nitro-3'-(trifluoromethyl)-6'-phenyl)piperazine

Conditions
ConditionsYield
With triethylamine In tetrahydrofuran at 100℃; under 6000480 Torr; for 120h;100%
piperidine
110-89-4

piperidine

2-chloro-3-nitro-5-trifluoromethylbenzene
121-17-5

2-chloro-3-nitro-5-trifluoromethylbenzene

1-(2-nitro-4-(trifluoromethyl)phenyl)piperidine
1692-79-1

1-(2-nitro-4-(trifluoromethyl)phenyl)piperidine

Conditions
ConditionsYield
In N,N-dimethyl-formamide at 0℃; for 0.666667h; Product distribution / selectivity;100%
With N,N,N',N'-tetramethyl-1,8-diaminonaphthalene In various solvent(s) at 26.84℃; Kinetics; Further Variations:; Reagents;
In acetonitrile at 25℃; Kinetics; Further Variations:; amine concentration;
2-chloro-3-nitro-5-trifluoromethylbenzene
121-17-5

2-chloro-3-nitro-5-trifluoromethylbenzene

Conditions
ConditionsYield
With potassium cyanocarbonimidodithioate In N,N-dimethyl-formamide at 80 - 90℃; for 24h;99%
With selenium; sodium thiosulfate In dimethyl sulfoxide50%
With sodium disulfide In ethanol
2-chloro-3-nitro-5-trifluoromethylbenzene
121-17-5

2-chloro-3-nitro-5-trifluoromethylbenzene

N-<2-chloro-5-(trifluoromethyl)phenyl>hydroxylamine
51571-00-7

N-<2-chloro-5-(trifluoromethyl)phenyl>hydroxylamine

Conditions
ConditionsYield
With 5% rhodium-on-charcoal; hydrazine hydrate In tetrahydrofuran at 0℃; for 1.5h; Inert atmosphere;99%
With 5% rhodium-on-charcoal; hydrazine hydrate In tetrahydrofuran at 0℃; Inert atmosphere;99%
With ammonium chloride; zinc In ethanol; water for 0.5h; Heating;90%
With sodium hypophosphite; palladium on activated charcoal In tetrahydrofuran
With 5% rhodium-on-charcoal; hydrazine hydrate In tetrahydrofuran at 0 - 20℃; Inert atmosphere;
2-chloro-3-nitro-5-trifluoromethylbenzene
121-17-5

2-chloro-3-nitro-5-trifluoromethylbenzene

phenylboronic acid
98-80-6

phenylboronic acid

2-nitro-4-(trifluoromethyl)-1,1'-biphenyl
2613-38-9

2-nitro-4-(trifluoromethyl)-1,1'-biphenyl

Conditions
ConditionsYield
With bis(η3-allyl-μ-chloropalladium(II)); N,N,N',N'-tetra(diphenylphosphinomethyl)benzene-1,3-diamine; potassium carbonate In N,N-dimethyl acetamide at 130℃; for 20h; Time; Concentration; Suzuki-Miyaura Coupling; Inert atmosphere; Schlenk technique;99%
With potassium carbonate; bis(η3-allyl-μ-chloropalladium(II)); Tedicyp In xylene at 130℃; for 20h; Suzuki reaction;95%
With tetrakis(triphenylphosphine) palladium(0); potassium carbonate In water; toluene for 4h; Suzuki-Miyaura cross coupling; Heating;91%
With potassium phosphate; tetraphosphine N,N,N′,N′-tetra(diphenylphosphinomethyl)-pyridine-2,6-diamine; palladium dichloride In toluene at 120℃; for 72h; Reagent/catalyst; Solvent; Temperature; Suzuki-Miyaura Coupling; Inert atmosphere; Schlenk technique;91%
isobutylamine
78-81-9

isobutylamine

2-chloro-3-nitro-5-trifluoromethylbenzene
121-17-5

2-chloro-3-nitro-5-trifluoromethylbenzene

N-isobutyl-2-nitro-4-(trifluoromethyl)aniline
891849-41-5

N-isobutyl-2-nitro-4-(trifluoromethyl)aniline

Conditions
ConditionsYield
With triethylamine In tetrahydrofuran for 20h; Heating;99%
2-chloro-3-nitro-5-trifluoromethylbenzene
121-17-5

2-chloro-3-nitro-5-trifluoromethylbenzene

1-bromo-2-chloro-3-nitro-5-(trifluoromethyl)benzene

1-bromo-2-chloro-3-nitro-5-(trifluoromethyl)benzene

Conditions
ConditionsYield
With 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione; sulfuric acid at 15℃; for 18h;99%
ethanolamine
141-43-5

ethanolamine

2-chloro-3-nitro-5-trifluoromethylbenzene
121-17-5

2-chloro-3-nitro-5-trifluoromethylbenzene

2-((2-nitro-4-(trifluoromethyl)phenyl)amino)ethanol
10442-83-8

2-((2-nitro-4-(trifluoromethyl)phenyl)amino)ethanol

Conditions
ConditionsYield
With potassium carbonate In ethanol for 5h; Reflux;98%
With potassium carbonate In butan-1-ol for 4.5h; Reflux;97%
Heating;95%
dibromodifluoromethane
75-61-6

dibromodifluoromethane

2-chloro-3-nitro-5-trifluoromethylbenzene
121-17-5

2-chloro-3-nitro-5-trifluoromethylbenzene

1,4-Bis(trifluoromethyl)-2-nitro-benzene
320-88-7

1,4-Bis(trifluoromethyl)-2-nitro-benzene

Conditions
ConditionsYield
With copper In N,N-dimethyl acetamide at 100℃; for 4h; Product distribution; with or without charcoal;98%
With copper; pyrographite In N,N-dimethyl acetamide at 100℃; for 2h;98 % Turnov.
2-chloro-3-nitro-5-trifluoromethylbenzene
121-17-5

2-chloro-3-nitro-5-trifluoromethylbenzene

N-butylamine
109-73-9

N-butylamine

N-butyl-2-nitro-4-(trifluoromethyl)aniline
182565-78-2

N-butyl-2-nitro-4-(trifluoromethyl)aniline

Conditions
ConditionsYield
With potassium carbonate In butan-1-ol at 145℃; for 15h;98%
In N,N-dimethyl-formamide at 80℃; for 4h;90.5%
With sodium hydroxide; tetrabutylammomium bromide In water; benzene at 31℃; Product distribution; Rate constant; various amines under different reaction conditions;
for 3.5h; Heating;
In acetonitrile at 25℃; Kinetics; Further Variations:; amine concentration;
2-chloro-3-nitro-5-trifluoromethylbenzene
121-17-5

2-chloro-3-nitro-5-trifluoromethylbenzene

phenol
108-95-2

phenol

2-nitro-1-phenoxy-4-(trifluoromethyl)benzene
1960-59-4

2-nitro-1-phenoxy-4-(trifluoromethyl)benzene

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 100℃; Inert atmosphere;98%
With 18-crown-6 ether; Methyl trichloroacetate; potassium carbonate at 150℃; for 2h;72%
With potassium hydroxide In ethanol at 45℃; for 2h;
pyridine
110-86-1

pyridine

2-chloro-3-nitro-5-trifluoromethylbenzene
121-17-5

2-chloro-3-nitro-5-trifluoromethylbenzene

1-[2-nitro-4-(trifluoromethyl)phenyl]pyridinium chloride

1-[2-nitro-4-(trifluoromethyl)phenyl]pyridinium chloride

Conditions
ConditionsYield
at 90℃; for 1h;98%
at 90℃;
2-chloro-3-nitro-5-trifluoromethylbenzene
121-17-5

2-chloro-3-nitro-5-trifluoromethylbenzene

diethyl malonate
105-53-3

diethyl malonate

diethyl 2-(2-nitro-4-(trifluoromethyl)phenyl)malonate
13088-15-8

diethyl 2-(2-nitro-4-(trifluoromethyl)phenyl)malonate

Conditions
ConditionsYield
With potassium carbonate; sodium hydroxide In N,N-dimethyl-formamide at 45℃; for 1h;98%
2-chloro-3-nitro-5-trifluoromethylbenzene
121-17-5

2-chloro-3-nitro-5-trifluoromethylbenzene

cyanoacetic acid amide
107-91-5

cyanoacetic acid amide

2-cyano-2-(2-nitro-4-(trifluoromethyl)phenyl)acetamide

2-cyano-2-(2-nitro-4-(trifluoromethyl)phenyl)acetamide

Conditions
ConditionsYield
With potassium hydroxide In N,N-dimethyl-formamide at 30℃; for 1h;98%
nitromethane
75-52-5

nitromethane

2-chloro-3-nitro-5-trifluoromethylbenzene
121-17-5

2-chloro-3-nitro-5-trifluoromethylbenzene

2-nitro-1-(nitromethyl)-4-(trifluoromethyl)benzene

2-nitro-1-(nitromethyl)-4-(trifluoromethyl)benzene

Conditions
ConditionsYield
Stage #1: nitromethane With sodium hydroxide In 1-methyl-pyrrolidin-2-one at 5℃; for 0.5h;
Stage #2: 2-chloro-3-nitro-5-trifluoromethylbenzene In 1-methyl-pyrrolidin-2-one at 5℃; for 2h;
98%
2-hydroxybromobenzene
95-56-7

2-hydroxybromobenzene

2-chloro-3-nitro-5-trifluoromethylbenzene
121-17-5

2-chloro-3-nitro-5-trifluoromethylbenzene

1-(2-bromophenoxy)-2-nitro-4-(trifluoromethyl)benzene
2069-14-9

1-(2-bromophenoxy)-2-nitro-4-(trifluoromethyl)benzene

Conditions
ConditionsYield
With potassium carbonate In dimethyl sulfoxide at 100℃; Inert atmosphere;97%
With sodium methylate In ethanol at 195℃;
With potassium hydroxide
2-chloro-3-nitro-5-trifluoromethylbenzene
121-17-5

2-chloro-3-nitro-5-trifluoromethylbenzene

ethyl 2-cyanoacetate
105-56-6

ethyl 2-cyanoacetate

Ethyl 2-cyano-2-(2-nitro-4-(trifluoromethyl)phenyl)acetate
13544-04-2

Ethyl 2-cyano-2-(2-nitro-4-(trifluoromethyl)phenyl)acetate

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 50℃; for 1h;97%
With N,N,N',N'-tetramethylguanidine In dichloromethane at 50℃; under 3878.71 Torr; Reagent/catalyst; Solvent; Temperature; Flow reactor;96%
With potassium carbonate In N,N-dimethyl-formamide at 100℃;74%
With potassium carbonate In N,N-dimethyl-formamide
With sodium ethanolate 1.) EtOH, 2.) EtOH, reflux, 8 h; Multistep reaction;
dibromodifluoromethane
75-61-6

dibromodifluoromethane

2-chloro-3-nitro-5-trifluoromethylbenzene
121-17-5

2-chloro-3-nitro-5-trifluoromethylbenzene

A

1,4-Bis(trifluoromethyl)-2-nitro-benzene
320-88-7

1,4-Bis(trifluoromethyl)-2-nitro-benzene

B

4-Pentafluoroethyl-3-nitro-benzotrifluoride
133391-56-7

4-Pentafluoroethyl-3-nitro-benzotrifluoride

Conditions
ConditionsYield
With ISOPROPYLAMIDE; copper at 100℃; for 8h;A 97%
B 3%
2-chloro-3-nitro-5-trifluoromethylbenzene
121-17-5

2-chloro-3-nitro-5-trifluoromethylbenzene

(1H-indol-2-yl)(piperazin-1-yl)methanone

(1H-indol-2-yl)(piperazin-1-yl)methanone

1-(indolyl-2-carbonyl)-4-<2-nitro-4-(trifluoromethyl)phenyl>piperazine
153473-69-9

1-(indolyl-2-carbonyl)-4-<2-nitro-4-(trifluoromethyl)phenyl>piperazine

Conditions
ConditionsYield
With potassium carbonate In acetonitrile for 4h; Ambient temperature;97%
thiophenol
108-98-5

thiophenol

2-chloro-3-nitro-5-trifluoromethylbenzene
121-17-5

2-chloro-3-nitro-5-trifluoromethylbenzene

(2-nitro-4-(trifluoromethyl)phenyl)phenylthioether
346-44-1

(2-nitro-4-(trifluoromethyl)phenyl)phenylthioether

Conditions
ConditionsYield
With ethylenediamine; copper(l) chloride In water at 120℃; for 36h; Inert atmosphere;97%
With sodium In methanol at 20℃;85%
With sodium hydroxide In ethanol; water
With potassium hydroxide; copper In ethanol; water
benzyl 2-cyanoacetate
14447-18-8

benzyl 2-cyanoacetate

2-chloro-3-nitro-5-trifluoromethylbenzene
121-17-5

2-chloro-3-nitro-5-trifluoromethylbenzene

benzyl 2-cyano-2-(2-nitro-4-trifluoromethylphenyl)ethanoate

benzyl 2-cyano-2-(2-nitro-4-trifluoromethylphenyl)ethanoate

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 70℃; for 24h;97%
copper(I) cyanide
544-92-3

copper(I) cyanide

2-chloro-3-nitro-5-trifluoromethylbenzene
121-17-5

2-chloro-3-nitro-5-trifluoromethylbenzene

2-nitro-4-trifluoromethyl-benzonitrile
778-94-9

2-nitro-4-trifluoromethyl-benzonitrile

Conditions
ConditionsYield
lithium bromide In tetrahydrofuran at 130℃; for 6h; Product distribution / selectivity;97%
In acetonitrile at 110℃; for 6h; Product distribution / selectivity;93%
lithium bromide In acetonitrile at 110℃; for 6h; Product distribution / selectivity;91%
decylthiol
143-10-2

decylthiol

2-chloro-3-nitro-5-trifluoromethylbenzene
121-17-5

2-chloro-3-nitro-5-trifluoromethylbenzene

4-decylthio-3-nitrobenzotrifluoride
119116-02-8

4-decylthio-3-nitrobenzotrifluoride

Conditions
ConditionsYield
With sodium methylate In methanol96.9%
2-chloro-3-nitro-5-trifluoromethylbenzene
121-17-5

2-chloro-3-nitro-5-trifluoromethylbenzene

6-trifluoromethyl-1-hydroxybenzotriazole
26198-21-0

6-trifluoromethyl-1-hydroxybenzotriazole

Conditions
ConditionsYield
With hydrazine hydrate In ethanol for 24h; Heating;96%
With hydrazine hydrate In ethanol; sodium carbonate
With hydrazine hydrate In ethanol for 24h; Reflux;
With hydrazine hydrate In ethanol for 24h; Reflux;
2-chloro-3-nitro-5-trifluoromethylbenzene
121-17-5

2-chloro-3-nitro-5-trifluoromethylbenzene

2,5-dimethoxyaniline
102-56-7

2,5-dimethoxyaniline

2,5-Dimethoxy-2'-nitro-4'-trifluoromethyldiphenylamine
146828-21-9

2,5-Dimethoxy-2'-nitro-4'-trifluoromethyldiphenylamine

Conditions
ConditionsYield
With 1-methyl-pyrrolidin-2-one; potassium carbonate at 140℃;96%
2-chloro-3-nitro-5-trifluoromethylbenzene
121-17-5

2-chloro-3-nitro-5-trifluoromethylbenzene

phenylacetylene
536-74-3

phenylacetylene

2-nitro-1-(phenylethynyl)-4-(trifluoromethyl)benzene

2-nitro-1-(phenylethynyl)-4-(trifluoromethyl)benzene

Conditions
ConditionsYield
With potassium phosphate; bis(η3-allyl-μ-chloropalladium(II)); tetraphosphine N,N,N′,N′-tetra(diphenylphosphinomethyl)-pyridine-2,6-diamine In N,N-dimethyl acetamide; water at 100℃; for 20h; Catalytic behavior; Time; Sonogashira Cross-Coupling; Schlenk technique; Inert atmosphere;96%
With potassium carbonate; bis(η3-allyl-μ-chloropalladium(II)); (1RS,2RS,3SR,4SR)-1,2,3,4-tetrakis((diphenylphosphanyl)methyl)cyclopentane In N,N-dimethyl-formamide at 100℃; for 20h; Sonogashira cross-coupling;91%
2-chloro-3-nitro-5-trifluoromethylbenzene
121-17-5

2-chloro-3-nitro-5-trifluoromethylbenzene

5-trifluoromethylbenzofuroxan
41153-85-9

5-trifluoromethylbenzofuroxan

Conditions
ConditionsYield
With sodium azide; N-ethyl-N-methylpyrrolidinium tetrafluoroborate; tetrabutylammomium bromide In water at 60℃; for 4h;96%
1,2,3-Benzotriazole
95-14-7

1,2,3-Benzotriazole

2-chloro-3-nitro-5-trifluoromethylbenzene
121-17-5

2-chloro-3-nitro-5-trifluoromethylbenzene

1-[2-nitro-4-(trifluoromethyl)phenyl]-1H-1,2,3-benzotriazole
131182-89-3

1-[2-nitro-4-(trifluoromethyl)phenyl]-1H-1,2,3-benzotriazole

Conditions
ConditionsYield
With copper(l) iodide; N-[phenyl(acetylamino)methyl]acetamide; sodium methylate In dimethyl sulfoxide at 130℃; for 12h;95%
With copper 2-phenylcyclopropanecarboxylate; cetyltrimethylammonim bromide; potassium carbonate In xylene for 8h; Arylation; Heating;89%
With copper(l) iodide; (E)-3-(dimethylamino)-1-(2-hydroxyphenyl)prop-2-en-1-one; caesium carbonate In acetonitrile at 82℃; for 12h; Ullmann type coupling; Inert atmosphere;89%
With triethylamine In N,N-dimethyl-formamide at 100℃; for 17h;87%
2-Mercaptobenzothiazole
149-30-4

2-Mercaptobenzothiazole

2-chloro-3-nitro-5-trifluoromethylbenzene
121-17-5

2-chloro-3-nitro-5-trifluoromethylbenzene

2-((2-nitro-4-(trifluoromethyl)phenyl)thio)benzo[d]thiazole
131182-91-7

2-((2-nitro-4-(trifluoromethyl)phenyl)thio)benzo[d]thiazole

Conditions
ConditionsYield
With triethylamine In N,N-dimethyl-formamide at 70℃; for 1.5h;95%
L-valine methyl ester
4070-48-8

L-valine methyl ester

2-chloro-3-nitro-5-trifluoromethylbenzene
121-17-5

2-chloro-3-nitro-5-trifluoromethylbenzene

N-(2-nitro-4-trifluoromethylphenyl)valine methyl ester

N-(2-nitro-4-trifluoromethylphenyl)valine methyl ester

Conditions
ConditionsYield
at 20℃; for 3h; Irradiation;95%
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