The heat capacity of 2-amino-2-methyl-1,3-propanediol was measured from 280 K to the melting point by means of an automated adiabatic calorimeter. A bifurcated solid-solid transition for the compound was found with the maxima occurring at 352.89 and 353.72 K. The enthalpy of the bifurcated trans...

The phase diagram of the plastic crystals neopentylglycol (NPG) and 2-amino, 2-methyl-1,3-propanediol (AMP) has been determined. The phase diagram shows an extensive diversity of two-phase regions, due to the polymorphism of the pure substances. The binary system is characterized by two eutectoi...

2-Amino-2-methyl-1,3-propanediol (AMP), 2-amino-2-hydroxymethyl-1,3-propanediol (TRIS) and the mixture (AMP+TRIS, mole ratio 50:50) are being considered as potential candidates for the thermal storage of energy. The thermal conductivities have been measured with an uncertainty of ±3% from 20°C...

Solid state phase change materials are considered as potential candidates for thermal energy storage. Among the solid–solid heat storage materials, the most promising heat storage materials are organic polyalcohol globular tetrahedral molecular crystals such as (CH3)C(CH2OH)3 for PG, (NH2)C(CH2...

Three cobalt complexes have been synthesized using 2-amino-2-methyl-1,3-propanediol (ampdH2) and its Schiff base derivative ligands and structurally characterized. The three complexes 1, 2 and 3 are very different and consist of mononuclear Co(II), mixed-valence binuclear Co(II,III) and mixed-va...

Kinetics of CO2 with a sterically hindered amine, 2-amino-2-methyl-1,3-propanediol (AMPD), in aqueous solutions were studied at temperatures of 303, 313, and 318K and over the concentration ranging from 5 to 25wt% AMPD using a wetted-wall column absorber. The N2O analogy was applied to estimate ...

An important solid–solid phase change heat storage material (PCM) 2-amino-2-methyl-1,3-propanediol was investigated by calorimetric methods. The molar heat capacities of the compound were measured in the temperature range from 78 to 405 K by means of a small sample automated adiabatic calorimet...

The FTIR and FT-Raman spectra of 2-amino-2-methyl-1,3-propanediol were recorded in the regions 4000–400 cm−1 and 4000–50 cm−1 respectively. The structural and spectroscopic data of the molecule in the ground state were calculated using Hartee-Fock and density functional method (B3LYP) with the...

The use of phase change materials (PCMs) for heat storage and as a heat source has become an important aspect for energy management. Some PCMs store energy when in a non-equilibrium state (a supercooling state), and supply energy when released from this state. This means PCMs have the ability to...

Microglia polarization plays a vital role in brain inflammatory injury following intracerebral hemorrhage (ICH). Previous studies have shown that sinomenine possesses potential immunoregulatory capabilities. However, microglia polarization's exact mechanisms in ICH remain uncertain. Therefo...

Pathological changes, such as articular cartilage degeneration, destruction, and hyperosteogeny, are regarded as the main features of osteoarthritis (OA). Sinomenine (SIN) is a monomeric component purified from the plant Sinomenium acutum which has been found to have anti-inflammatory effects, h...

The aim of this study was to investigate the release behaviors of sinomenine hydrochloride loaded via in situ hexagonal liquid crystal (ISH), and its potential to improve the local bioavailability in knee joints of sinomenine hydrochloride (SMH) after intra-articular administration. The ISH was ...

The aim of this study was to investigate in piglets, the anti-endotoxin and anti-inflammatory effects of sinomenine, an agent commonly found in Chinese herbal medicines. In high-, middle- and low-dose sinomenine groups, piglets were initially challenged with endotoxin (i.e., 1 mg lipopolysacchar...

AimsSinomenine, an anti-rheumatoid arthritis drug used in China for decades, is usually co-administered with cardiovascular (CV) drugs to reduce arthritis-related risk of cardiovascular diseases. This study was to investigate whether and how CV drugs affect the pharmacokinetic profile of sinomenine.

Stephania epigaea Lo is an important herbal medicine used as antiphlogistic and analgesic drugs. Its major components are dicentrine (1) and sinomenine (2). In the present study, a rapid, accurate, and precise method for simultaneous quantitation of dicentrine (1) and sinomenine (2) in S. epigea...

ObjectiveThe purpose of this study was to develop an injectable in situ liquid crystal formulation for intra-articular administration and evaluate its pharmacokinetics characteristics on Microdialysis Technology.

Background Prostate cancer is an extremely common disease in males, and the mortality of prostate cancer has been rising year by year. Sinomenine has been reported to exhibit anti-tumor effect on various cancers, but the function of Sinomenine in prostate cancer remains unclear. The study aimed ...

Sinomenine, an alkaloid originally isolated from the roots and the rhizome of Sinomenium acutum is used as a traditional Chinese herbal medicines for rheumatoid arthritis and neuralgia. The aims of this study were to investigate the effects of oral administration of shinomenine on formalin-induc...

At pH 1.4–2.0 and in the presence of Triton X-100 the resonance light-scattering (RLS) spectrum of pyrocatechol violet (PV) has a maximum peak at 341 nm with two wide bands centering on 399 and 468 nm, respectively. If micro protein coexists in the system, the RLS intensities of PV at 399 and 4...

A stable electroactive thin film of pyrocatechol violet (PCV) was electrochemically deposited on the surface of glassy carbon electrode previously activated in alkaline solution. The cyclic voltammograms of the modified electrode indicated that the surface confined PCVs were strongly dependent o...