Neutron reflectometry (NR) measurements of ultrathin films from octafluorocyclobutane (OFCB) and benzene (B) precursors deposited using Plasma Enhanced Chemical Vapor Deposition (PECVD) at two pressures (0.6 and 0.05 torr) reveal that under both deposition conditions there are a 7 nm-thick surfa...

Unimolecular dissociation dynamics of octafluorocyclobutane has been studied using photofragmentation translational spectroscopy. The product translational energy distribution for the reaction cyclo-C4F8 → 2 C2F4 peaks at 31 kJ/mol with an average of 40 kJ/mol, which amounts to about 30% of the...

Cross-sections for electron impact ionization of octafluorocyclobutane (c-C4F8) have been measured from 10 to 200 eV by Fourier transform mass spectrometry. No parent ion is observed, and over half of the dissociative ionization yields C2F4+ and C3F5+. Eleven other fluorocarbon cations are produ...

The suitability of using octafluorocyclobutane (C4F8) patches as hydrophobic valves in microfluidic biochemical applications has been shown. A technique has been developed to generate lithographically defined C4F8 hydrophobic patches in deep reactive ion-etched silicon channels. Some of the adva...

High-resolution (0.03 cm−1) absolute infrared photoabsorption cross-sections of octafluorocyclobutane (c-C4F8) and octafluorocyclopentene (c-C5F8) have been measured using Fourier-transformed infrared (FTIR) spectroscopy at 279 and 297 K. Radiative forcing and global warming potential of these t...

Octafluorocyclobutane and acrylic acid (C4F8-co-AA) plasma copolymer coatings are deposited using a pulsed wave (PW) radio frequency (RF) plasma on low density polyethylene (LDPE). The influence of duty cycle in pulsed process with the monomer feed rate on the surface chemistry and wettability o...

Hydroxycarbonyl compounds are important secondary reaction products in the oxidation of Volatile Organic Compounds (VOCs) in the atmosphere. The atmospheric fate of these oxygenated VOCs is however poorly understood, especially the relevance of the photolytic pathway. In this work, a combined in...

The thermal decompositions of ethyltrichloro-and ethyltrimethyl-silane have been studied in the gas phase at 823K. The main primary process in each case is the dehydrosilylation reaction X3SiCH2CH3 → X3SiH+CH2 = CH2 (X = Cl or Me), though several additional products are formed, mainly in second...

Chemisorbed films of ethyltrichlorosilane (ETS) at the glass/air interface are studied by IR-excitation sum-frequency (SF) spectroscopy. Using two independently tunable infrared pulses in combination with a visible upconversion pulse for the SF-probing process, a time-resolved vibrational spectr...

The effects of chloral hydrate and its main metabolite 2,2,2-trichloroethanol were investigated on the (S)-α-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA)-induced rise of intracellular Ca2+ concentration ([Ca2+]i) in cultured non-pyramidal cortical neurones of rats by using single-cell ...

A screening technique for the detection of the hydroxyl radical on photolysis of drugs or other chemicals is described. The technique depends upon scavenging the radical with 2,2,2-trichloroethanol in buffered aqueous solution and determining the liberated chloride ion. The system was validated ...

A sensitive and reproducible method is described for the analysis of trichloroacetic acid in urine and 1,1,1-trichloroethane in blood using dynamic headspace GC/MS. Samples were analyzed using the soil module of a modified purge and trap autosampler to facilitate the use of disposable purging ve...

Membrane currents in response to the application of α,β-methylene ATP (α,β-meATP) were recorded by the whole-cell patch-clamp technique in human embryonic kidney 293 cells transfected with the human P2X3 receptor (HEK 293-hP2X3 cells). Trichloroethanol, the biologically active metabolite of ...

Occupational trichloroethylene (TCE) exposure could induce generalized skin hypersensitivity reactions complicated with severe liver dysfunctions. Active extracellular matrix degradation and remodeling are involved in the skin hypersensitivity reaction induced by chemical exposure. In the presen...

Human TREK-1 and TRAAK (hTREK-1 and hTRAAK) are the recently cloned tandem pore-domain potassium channels that are highly expressed in the central nervous system (CNS). The roles of 2P domain K+ channels in general anesthesia and neuroprotection have been proposed recently. We have investigated ...

Trichloroethylene (TCE) is widely used as a cleaning and decreasing agent and has been shown to cause liver tumours in rodents and a small incidence of renal tubule tumours in male rats. The basis for the renal tubule injury is believed to be related to metabolism of TCE via glutathione conjugat...

The effects of 2,2,2-trichloroethanol, the active compound of the sedative–hypnotic chloral hydrate, were investigated on N-methyl-d-aspartate (NMDA)-induced increases in intracellular Ca2+ concentration ([Ca2+]i) in cultured mesencephalic and cortical neurones by means of the fura-2 method. Tr...

2,2,2-Trichloroethanol (TCOH) is responsible for the pharmacological actions of chloral hydrate (CH), and is a major metabolite of trichloroethylene. Human exposure to TCOH is known to be increasing. Recently, it was reported that TCOH causes a significant phase delay of Per2 expression in mouse...

Trichloroethylene (TCE) is a widespread and persistent environmental contaminant. Recently, plants, poplar trees in particular, have been investigated as a tool to remove TCE from soil and groundwater. The metabolism of TCE in plants is being investigated for two reasons: one, plant uptake and m...

In this study, a novel and convenient route for the construction of 5-((1H-1,2,4-triazol-1-yl)methyl)-1H-indoles (8) is presented starting from (1H-1,2,4-triazol-1-yl)methanol (5) and indolines (6) under 98% H2SO4 at room temperature for 4–24 h, followed by deacetylation and dehydrogenation. Ba...