Protein misfolding, aggregation and amyloid fibril formation lead to a number of human diseases. Monitoring the fibrillation of proteins and interfering the formation of the disease associated protein fibers are among the most important tasks in the field. Herein, we describe that bromophenol bl...

In this study, bromophenol blue was degraded by NiTiO3 nanoparticles under UV and Visible light irradiation. Due to the toxicity and harmful effects of the bromophenol blue compound in ground and surface water, its photocatalytic decomposition is of utmost importance. NiTiO3 photocatalyst was sy...

Graphene-polymer nanocomposites are innovative materials that have attracted much attention due to their novel features. Herein, we report photocatalytic and antibacterial properties of GNP-PPy nanocomposites. The formation of nanocomposites was confirmed by various characterization techniques. ...

We reported a spectrophotometric method for the determination of norfloxacin. The method is based on the reaction of the drug with bromophenol blue in acetate buffer at pH 4.1 and measurement of the yellow complex formed at 416 nm. Linear calibration graph was obtained from 5 to 150 ppm of norfl...

In this paper, an imidazolium-based gemini surfactant [C14-4-C14im]Br2 was fabricated as modifiers of vermiculite, silica nanosheets (from acid treating vermiculite) and montmorillonite. The modified clays were characterized with FT-IR, XRD, TG, EA, SEM and Washburn capillary rise method and inv...

In this study, the perichromic behavior of bromophenol blue (BPB) in various binary solvent mixtures was investigated. The binary mixtures considered were comprised of water and methanol (MeOH), ethanol (EtOH), n-propanol (n-PrOH), isopropanol (iso-PrOH) or t-butanol (t-BuOH). The investigation ...

The condensation of per(trimethyl)silylbarbital and -phenobarbital with 1,2,3,4,6-penta-O-acetyl-β-d-glucopyranose in the presence of stannic chloride in dichloroethane gave moderate yields of the β-coupled barbiturate N-d-glucopyranosyl derivatives. Reaction of metharbital and mephobarbital u...

A standardized procedure for the routine measurement of hepatic mixed function oxidases including aminopyrine N-demethylase, p-nitroanisole O-demethylase, aniline hydroxylase, and azoreductase was used to examine enzyme alteration due to chronic drug administration. Oral treatment of monkeys or ...

A quantitative chromatographic separation followed by UV spectrophotometric determination is presented for the analysis of a commercial tablet formulation containing mephobarbital and diphenylhydantoin. A patented activated magnesium silicate is used for the chromatographic column separation. Me...

Summary:We sequenced all nine exons and exon-intron junctions of the cytochrome P450 2C19 (CYP2C19) gene from a Japanese subject with a lowered capacity of CYP2C19-mediated 4′-hydroxylation after an oral administration of mephobarbital. We found a novel single nucleotide polymorphism (SNP) of C...

The synthesis and characterization of barbital, phenobarbital, metharbital, and mephobarbital glucuronides is reported. The condensation of per(trimethylsilyl)-barbital and -phenobarbital with methyl 1,2,3,4-tetra-O-acetyl-β-d-glucopyranuronate in the presence of trimethylsilyl trifluoromethane...

SummaryAim of this study was to determine whether the carbon-11-labeled antiepileptic drug [11C]mephobarbital is a substrate of P-glycoprotein (Pgp) and can be used to assess Pgp function at the blood–brain barrier (BBB) with positron emission tomography (PET). We performed paired PET scans in ...

In this work, a batch chemiluminescence (CL) method has been proposed for the simultaneous determination of two structurally similar alkaloids, noscapine and thebaine. The method is based on the kinetic distinction of the CL reactions of noscapine and thebaine with Ru(bipy)32+ and Ce(IV) system ...

Opium poppy products are often illegally used for both recreational and medicinal purposes. In order to demonstrate the ingestion of opium poppy substances, morphine, codeine and their metabolites have been identified. However, morphine and codeine also originate from the ingestion of therapeuti...

A variant plant of opium poppy (Papaver somniferum L.) having high thebaine was obtained from the dose of 10 kR (kilo rad) + 0.4% EMS during an extensive mutation breeding experiment. The M2 seeds of variant plant were subjected to in vitro studies to investigate the prospects of thebaine produc...

Noted as a rich source of thebaine and a potential alternative to Papaver somniferum for production of codeine and some semi-synthetic antagonist drugs (namely naloxone and naltrexone), Papaver bracteatum is a perennial species belongs to the section oxytona. Benzylisoquinoline alkaloids (BIAs) ...

Successful development of stable and adaptable crop varieties solely depend on the positive results obtained from the interaction between genotype and environment that consequently has significant impact on breeding strategies. GEI is a finest breeding approach that helps in the development of v...

The presence of methanol decreases the efficiency of radiation-induced decomposition of alkaloids in wastewater. Intermediate products were observed before the complete degradation of irradiated alkaloids. In order to identify the structure of the by-products and the formation pathway, thebaine,...

Trifluoroacetyl acetylenes, highly reactive dienophiles and electrophiles, were used as the probe for study competitive [4+2] vs nucleophilic addition reactions in thebaine series. Unlike thebaine itself that reacts with these electron deficient acetylenes giving rise to the adducts resulted fro...

Thebaine 6-O-demethylase (T6ODM) from Papaver somniferum (opium poppy), which belongs to the non-heme 2-oxoglutarate/Fe(II)-dependent dioxygenases (ODD) family, is a key enzyme in the morphine biosynthesis pathway. Initially, T6ODM was characterized as an enzyme catalyzing O-demethylation of the...