Phosphonic acids are commonly used as scale and corrosion inhibitors, but little is known about their solubility and stoichiometry. Hence, questions concerning the retention mechanisms of phosphonates in reservoir systems remain unanswered. A method is described in this paper to measure the solu...

1,1-Bis(dimethylamino)-2,2,2-trifluoroethane is an excellent synthetic building-block replacement for trifluoroacetaldehyde in condensation reactions with ketones using 36% aqueous HCl catalysis. Moderate to good yields (43–68%) of trifluoromethyl carbinols are obtained with symmetric and unsym...

A palladium-catalyzed and stereoselective Heck-type reaction between the iodine heterocycle, 3,7-bis(N,N-dimethylamino)-10H-dibenz[b,e]iodinium iodide and α,β-unsaturated carbonyl compounds wasaccomplished at mild temperature in good yields.

We describe the synthesis, the structure, and the behavior as a chiral solvating agent of the enantiomers of α,α′-bis(trifluoromethyl)-10,10′-(9,9′-biantryl)dimethanol. The thermodynamics of several associations are presented. We conclude that the association needs the approximation of the ...

Condensation of the dianion of the bisaminonitrile α,α′-dicyano-α,α′-bis(dimethylamino)-m-xylene (8) with bis[p-(p-fluorobenzoyl)phenyl] ether (9) and 2,6-dibromopyridine (12) yielded the corresponding new poly(bisaminonitrile)s poly{oxy-p-phenylenecarbonyl-p-phenylene-[α,α′-dicyano-α,...

In this study, we used a solution of FeCl3 in THF to facilitate the Mannich-type reaction of aldehyde, amine and phosphite compounds to form corresponding α-aminophosphonates in a one-pot, three-component reaction. Selected α-aminophosphonates were entered into a biological assay test and were...

2-(α-Hydroxybenzhydryl)- 6 and 2,7-di(α-hydroxybenzhydryl)-1,8-bis(dimethylamino)naphthalenes 8 have been shown to exist in crystals as in/out conformers stabilized by O–H⋯N intramolecular hydrogen bonding. In agreement with X-ray studies, the NMR data are also consistent with 7 retaining its...

Four monomeric titanium(IV) dichloride complexes of amine-bis(phenolate) ligands having an extra donor arm (2a–2d) and one oxo-bridged complex 3 were successfully synthesized in the reaction of TiCl4 with a sodium salt of the appropriate ligand, and they were characterized by 1H NMR spectroscop...

The employment of pyridine-2,6-dimethanol (pdmH2) in zinc(II) carboxylate chemistry is reported. The syntheses, crystal structures, and spectroscopic characterization are described for the structurally similar cluster compounds [Zn6(OH)2(O2CR)8(pdmH)2] (R = Ph (1); But (2)), obtained in very goo...

Highly monodisperse water soluble cobalt ferrite (CoFe2O4) and manganese ferrite (MnFe2O4) nanoparticles were synthesised by the hot injection thermolysis of pivalate clusters as single source precursors. The precursors [Fe2CoO(O2CtBu)6(HO2CtBu)3] (1) and [Fe2MnO(O2CtBu)6(HO2CtBu)3] (2) were dec...

The dinuclear complex [Zn2(DPCPMP)(pivalate)](ClO4), where DPCPMP is the new unsymmetrical ligand [2-(N-(3-((bis((pyridin-2-yl)methyl)amino)methyl)-2-hydroxy-5-methylbenzyl)-N-((pyridin-2-yl)methyl)amino)acetic acid], has been synthesized and characterized. The complex is a functional model for ...

Techniques for synthesizing Zn(II)-Fe(III) heterometallic molecular complexes [Fe2Zn4O2(Piv)10] (1), [Fe4Zn3O3(Piv)12(H2O)]·1.5Et2O (2) and [Fe3Zn2O2(Piv)9(1,10-phen)] (3) (where HPiv is pivalic acid, 1,10-phen – C12H8N2) have been developed. It has been found that recrystallization of the sol...

The reaction of Zn(O2CtBu)2 with 4-(dimethylamino)pyridine (DMAP) in 1:2 and 1:1 mol ratios afforded [Zn(O2CtBu)2(DMAP)2]·H2O (1·H2O) and [Zn5(μ3-OH)2(O2CtBu)2(μ2-κ1O:κ1O′-O2CtBu)6(DMAP)2] (2) in 95% and 98% yields, respectively. Complex 1·H2O upon crystallization from CHCl3/n-hexane mix...

A triangular [Zn3(μ3-OH)(OC(O)tBu)(μ2-κ1O:κ1O′–O2CtBu)4(3,5-lutidine)3] (1), a paddlewheel based dinuclear [Zn(μ2-κ1O:κ1O′–O2CtBu)2L]2 [L = 2,4-lutidine (2), 3,4-lutidine (3), and 2,3-lutidine (4)] and an hourglass based linear trinuclear [Zn3(μ2-κ1O:κ1O′-O2CtBu)6(pyridine)2] (5) ...

Reactions between zinc(II) or cadmium(II) pivalates and 2,2′-bipyridine, various substituted 1,10-phenanthroline derivatives or 2,2′:6′,2″-terpyridine have resulted in ten mono- and binuclear complexes with general formula [M(piv)2L] or [Cd2(piv)4L2], where piv is the pivalate anion, L is N,...

A highly sensitivity liquid chromatography–tandem mass spectrometry method has been developed for the quantitation of sodium cromoglycate (SCG) in human plasma. The method was validated over a linear range of 0.100–50.0 ng/ml, using 13C4 sodium cromoglycate as the internal standard. Compounds ...

SummaryMany patients with severe refractory asthma, which is insufficiently controlled by additional high-dose of inhaled corticosteroids, require oral corticosteroids and/or immunosuppressant. Clinicians should seek for suitable medications, for its' chronic use may induce high risk of sid...

An ion-pair liquid high-performance chromatography method with solid-phase extraction for measuring urinary concentrations of sodium cromoglycate following inhalation has been developed and validated. Sodium cromoglycate was extracted from urine on a 100-mg phenyl cartridge (Isolute, Jones Chrom...

Chitosan has more and more been suggested as a material for use as adsorbent in the treatment of effluents as well as in the synthesis of drug-loaded nanoparticles for controlled release. In both cases, a good understanding of the process of adsorption, both kinetically and in terms of equilibri...

Experiments were designed to evaluate changes in the histamine release, mast cell number and neuronal damage in hippocampus induced by status epilepticus. We also evaluated if sodium cromoglycate, a stabilizer of mast cells with a possible stabilizing effect on the membrane of neurons, was able ...