The tropomyosin receptor kinases (TrkA/B/C) and colony-stimulating factor-1 receptor (CSF-1R) represent highly pursued oncological therapeutic targets. The 2,4-diaminopyrimidine inhibitor GW2580 (9) has been previously reported as a highly selective low nanomolar TrkB/TrkC/CSF-1R inhibitor. In t...
Diseases triggered by an abnormally high level of cortisol (hypercortisolism), such as the Cushing's and metabolic syndromes, could be successfully tackled by inhibitors of CYP11B1, a steroidal cytochrome P450 enzyme that catalyzes the last hydroxylation step of the cortisol biosynthesis. S...
The thermal decomposition of aluminum sulfate and hafnium sulfate was studied in air by thermogravimetric analysis (TG) and in vacuum by simultaneous TG and evolved gas analysis (EGA). No SO3 was detected by the mass spectrometer. The primary products of decomposition appear to be SO and O2 for ...
A liquid–liquid extractive separation between hafnium and zirconium from thiocyanic acid medium using the mixtures of diisobutyl ketone (DIBK) and di (2-ethylhexyl) phosphoric acid (P204) as the extractant was developed. The effects of the aqueous acidity, the concentration of P204, the contact...
A novel and highly efficient method for activating highly hindered acid anhydrides towards the acylation of alcohols and carbohydrate-derived polyols has been developed. This new method relies on the capacity of the hafnium triflate catalyst Hf(OTf)2 to activate highly hindered acid anhydrides, ...
The tendency of Zr(IV) and Hf(IV) to form polynuclear species (especially mixed Zr–O–Hf complexes) in aqueous solutions is, besides their almost identical chemical properties, one of the main obstacles in their separation. Therefore, finding a suitable way for the aforementioned complexes to d...
A flow injection manifold incorporating a 1 m liquid waveguide capillary cell and a miniature fibre-optic spectrometer for the determination of low phosphorus concentrations in natural waters is reported. The limit of detection (blank + 3 S.D.) was 10 nM using the molybdenum blue chemistry with ...
The proton spin-lattice relaxation time T1 (at 5.4, 10 and 15 MHz) and second moment M2 (at 9.8 MHz) were measured in the temperature range 77–300 K in hydrazinium dihydrogen phosphate N2H5H2PO4 and dihydrazinium hydrogen phosphate (N2H5)2HPO4. In N2H5H2PO4 a well-defined single proton T1, mini...
Two series (para- and meta-substituted) of racemic methyl esters of 3-aryl-3-hydroxypropionic acid were prepared after which the enantiomers were separated by an enzyme-catalyzed transesterification. Several lipases were investigated as the catalyst. The influence of the enzyme pretreatment, as ...
Lipases from Candida rugosa, Candida antartica B and Carica papaya are employed as the biocatalyst for the hydrolytic resolution of methyl 2-fluoro-2-arylpropionates in water-saturated isooctane, in which excellent to good enantioselectivity without the formation of byproducts is obtained for th...
A toxicologic and dermatologic review of (4-methoxyphenyl)methyl isobutyrate when used as a fragrance ingredient is presented. (4-Methoxyphenyl)methyl isobutyrate is a member of the fragrance structural group Aryl Alkyl Alcohol Simple Acid Esters (AAASAE). The AAASAE fragrance ingredients are pr...
A novel series of piperidine-substituted triazine derivatives have been synthesized and evaluated for anti-HIV activities in MT-4 cells. Most compounds displayed extremely promising activity against wild-type HIV-1 with EC50 values in low nanomolar concentration, better than that of Nevirapine, ...
An amine-catalyzed asymmetric formal aza [3 + 3] cycloaddition of α,β-unsaturated aldehydes with N-Ts ketimines derived from both acyclic and cyclic ketones was developed, which was followed by an oxidation to afford chiral piperidine derivatives in good yields and excellent enantioselectiviti...
Propylene glycol ethers are a class of solvents used in a wide array of industrial, commercial and consumer applications, such as in paints, cleaners and inks. A robust toxicity database exists for the propylene glycol ethers that provide strong product safety support. Standard toxicity studies ...
The effect of propylene glycol (PG), its monoalkyl ethers and esters on the micellar behavior of a cationic surfactant tetradecyltrimethylammonium bromide (TTAB) in aqueous solution was examined by employing electrical conductivity and small angle neutron scattering (SANS) technique. From conduc...
Analysis of aqueous solutions comprised of a fluorocarbon-betaine surfactant with and without diethylene glycol butyl ether (DGBE) have provided insight into the effect of DGBE on fire suppression and foam quality. Incorporation of DGBE decreased the Sauter mean bubble size and liquid drainage t...
The relationship of basicity and hydrogen bond with catalytic performance was investigated in synthesis of propylene glycol methyl ether (PGME) catalyzed by various ILs ([Emim][OAC], [Bmim][OAC], [N2222][OAC], [EtOHN111][OAC], [N4444]Br, [Bmim][N(CN)2], [Bmim]Br, [Bmim][PF6]). The basicity and K...
A series of acetate ionic liquids were synthesized using a typical two-step method. The ionic liquids were used as environmentally benign catalysts in the production of propylene glycol ethers from propylene oxide and alcohols under mild conditions. The basic strengths of the ionic liquids were ...
Treatment of methyl 2,3-anhydro-5-deoxy-α-d-ribofuranoside with lithium dimethyl cuprate gave methyl 2,5-dideoxy-2-C-methyl-α-d-arabinofuranoside (54% yield) and methyl 3,5-dideoxy-3-C-methyl-α-d-xylofuranoside (10%). The former was converted into its 3-O-acetyl and 3-O-benzyl derivatives, wh...
The compound (E)-1-(benzo [d] [1, 3] dioxol-6-yl)-3-(6-methoxy naphthalen-2-yl) prop-2-en-1-one (AKN) was synthesized and characterized by FT-IR, NMR, and UV–Vis spectrometer. The optimized molecular geometry, bond lengths, bond angles, atomic charges, harmonic vibrational wave numbers and inte...
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