Four stereoisomers of 3,5-bis(2-hydroxybut-3-en-1-yl)-1,2,4-thiadiazole, named insatindigothiadiazoles A–D (1a–1d), were isolated from the roots of Isatis indigotica. Their structures were determined by spectroscopic analysis; specifically, the absolute configurations were assigned by using th...
A toxicologic and dermatologic review of 1-(2,6,6-trimethyl-2-cyclohexen-1-yl)pent-1-en-3-one when used as a fragrance ingredient is presented. 1-(2,6,6-Trimethyl-2-cyclohexen-1-yl)pent-1-en-3-one is a member of the fragrance structural group Alkyl Cyclic Ketones. These fragrances can be describ...
The key intermediate of misoprostol, methyl 7-(3-hydroxy-5-oxocyclopent-1-en-1-yl)-heptanoate was prepared from commercially available suberic acid in 40% yield over five steps. The key step involved a ZnCl2 catalyzed Friedel-Crafts reaction between furan and 2,9-oxonanedione. Sulfuric acid cata...
The 1-(6-chloro-2-methyl-4-phenylquinolin-3-yl)-3-(aryl)prop-2-en-1-ones were synthesized by microwave assisted synthesis, the antimicrobial activities of synthesized compounds were screened against Gram negative organisms such as Escherichia coli (ATCC 25922), Bacillus subtilis (ATCC 117788), S...
Additional structural modifications of the new chemical entity, 2,8-dicyclopentyl-4-methylquinoline (DCMQ; MIC = 6.25 μg/mL, M. tuberculosis H37Rv) resulted in the synthesis of four new series of the ring-substituted quinolinecarbohydrazides (series 1–4) constituting 22 analogues. All new deri...
This Letter details our efforts to replace the 3-amino moiety, an essential pharmacophore for M4 PAM activity in most M4 PAMs to date, within the thieno[2,3-b]pyridine core, as the β-amino carboxamide motif has been shown to engender poor solubility, varying degrees of P-gp efflux and represent...
A series of novel quinoline-2-carboxamides 15–28 was synthesized and evaluated in vitro as dual COXs/LOX inhibitors. Compounds 19 and 27 exhibited the highest potency and selectivity for COX-2 inhibitory activity (IC50 = 1.21 and 1.13 μM, respectively; selectivity index (COX-1/COX-2) = 6.52 an...
Multi-ions doped bioactive calcium phosphate (dCaP) layers were developed by pulse current deposition onto surgical grade titanium alloy material (Ti6Al4V). The coatings were electrodeposited from base electrolyte containing adequate amounts of calcium nitrate and ammonium dihydrogen phosphate a...
The objective of this study was to synthesize extractive scintillating resins for the direct, real-time analysis of uranium in neutral pH environmental waters. In the first synthetic approach, a methyl phosphonic acid-derivatized resin was prepared by suspension polymerization to create a matrix...
Most Ru(II) complex-sensitized TiO2 systems for hydrogen (H2) production suffer from instability of the photosensitized system because the anchoring groups of Ru(II) dyes, which are required for their adsorption on TiO2, are intrinsically vulnerable to chemical and photochemical cleavage. In thi...
In this work cerium tri(bis(2-ethylhexyl)phosphate) (Ce(DEHP)3) particles were used as anti-corrosion pigments in epoxy coatings applied on steel coupons. The composition of the corrosion inhibitor was designed to introduce pH-stimulated corrosion healing in the coating. Electrochemical Impedanc...
In recent years, the magnesium phosphate cements showed impressive advantages for their setting property, mechanical strength, and resorption rate in laboratory investigation. While it remained a big challenge to develop the magnesium phosphate cements with ideal self-setting properties, suffici...
A series of bulky palladium catalysts based on N-heterocyclic carbene, (Pd(NHC)(acac)Cl: NHC = IPr*me = N,N′-bis(2,6-bis(di-p-tolylmethyl)-4-methylphenyl)-imidazol-2 -ylidene, Pd(IPr*me)(acac)Cl; NHC = IPr*ipr = N,N′-bis(2,6-bis(di-4-isopropylphenyl)-4-methylphenyl)-imidazol-2 -ylidene, Pd(IPr...
An efficient method has been developed for the synthesis of 7′-arylspiro{adamantane-[2,3′]-(1′,2′,4′,5′,7′-tetraoxazocanes)} by the ring transformation reaction of spiro{adamantane-[2,3’]-(1′,2′,4′,5′,7′-pentaoxacane)} with arylamines in the presence of Sm(NO3)3·6H2O as the catalys...
The standard (p° = 0.1 MPa) molar enthalpies of formation, in the crystalline phase, of 1-phenylpyrrole and 1-(4-methylphenyl)pyrrole, at T = 298.15 K, were derived from the standard molar energies of combustion in oxygen, measured by static-bomb combustion calorimetry. For these compounds, the...
The cross sections for ϒ(1S), ϒ(2S), and ϒ(3S) production in lead–lead (PbPb) and proton–proton (pp) collisions at sNN=5.02 TeV have been measured using the CMS detector at the LHC. The nuclear modification factors, RAA, derived from the PbPb-to-pp ratio of yields for each state, are studied a...
Accurate quantum dynamics calculations have been carried out for the Na(3S) + DF(ν = 1–4, j = 0) → NaF + D, Na(3P) + DF(ν = 0, j = 0) → NaF + D/Na(3S) + DF and Na(3S) + HF(ν = 2–4, j = 2,4,6,9) → NaF + H reactions. The isotopic substitution decreases the reactivity remarkably in both Na(...
There is little information available on methyl derivatives of anthracene and their interaction with the enzymes of bacterial consortia that could be found in petroleum sludge. In this study a theoretical investigation of all dimethylanthracenes (DMA) isomers and their relation to biodegradation...
Fluorescence depolarization is used to investigate the motions of four rigid probes of different sizes, 9,10-dimethylanthracene (DMA), 1,4-diphenylbutadiene (DPBD), 1,6-diphenylhexatriene (DPHT), and 1,8-diphenyloctatetraene (DPOT) inserted in a polyisoprene (IR 307), two polybutadienes (Diene 4...
Pyrimidin-2-yl 2,3,4,6-tetra-O-benzyl-1-thio-α-d-mannopyrano side (9), pyrimidin-2-yl 2,3,4-tri-O-benzyl-α-l-rhamnopyranoside (10), pyrimidin-2-yl 2-O-acetyl-3,4,6-tri-O-benzyl-1-thio-α-d-mannopyranoside (7), and pyrimidin-2-yl 2-O-acetyl-3,4-di-O-benzyl-1-thio-α-l-rhamnopyranoside (8) were ...
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