A novel synthetic method for methyl 5-substituted thiazole-4-carboxylates (5) by the reaction of methyl 3-substituted 3-bromo-2-isocyanoacrylates(BICA)(1) with hydrogen sulfide in the presence of triethylamine in N,N-dimethylformamide was explored, and the reaction mechanism was elucidated.
New anthranilic acid derivatives, 2-substituted-3-(4-bromo-2-carboxyphenyl)-5-methyl-4-thiazolidinone, were synthesized and evaluated for their anti-inflammatory activity against carrageenan-induced oedema in albino rats. The most active member of the series, 3-(4-bromo-2-carboxyphenyl)-2-(2-flu...
2-(5-Methyl-1H-benzimidazol-2-yl)-4-bromo/nitro-phenols (HLBr and HLNO2) and their Zn(II) complexes with ZnX2 (X = Cl, I, NO3) were synthesized and characterized by elemental analysis, molar conductivity, IR, 1H and 13C NMR spectra. The OH proton appears near the NH protons in the 1H NMR spectra...
VO(acac)2 reacted with a new ONO tridentate Schiff base, 4-bromo-2-((2-hydroxy-5-methylphenylimino)methyl)phenol, (H2L) in methanol to afford a new V(V) complex, [VO(L)(MeO)(MeOH)]. Characterization by elemental analysis, molar conductivity, FT-IR, electronic spectroscopy, 1H NMR, single crystal...
Bisphenol A (BPA), bisphenol F (BPF), and bisphenol A diglycidyl ether (BADGE) are common components of epoxy coatings used in food packaging and in drinking water distribution systems. Thus, leachates from the epoxy may be exposed to the disinfectants free chlorine (Cl2/HOCl/OCl−) and monochlor...
A fluorescence polarization (FP) assay for the simultaneous determination of bisphenol A (BPA), bisphenol F (BPF), bisphenol A diglycidyl ether (BADGE) and bisphenol F diglycidyl ether (BFDGE) was developed. The method was based on the competition between bisphenols (BPs) and fluorescein-labeled...
The curing reaction of the epoxy system “diglycidyl ether of bisphenol-A” (DGEBA) and the tertiary amine “2-[(2-dimethyl-amino)-ethoxy] ethanol” (DMAE), with different DMAE concentrations was studied by means of rheometric analysis using the Rubber Process Analyzer (RPA). A novel simple tech...
To study the impact of different semi-solid dosage form components on the leaching of Bisphenol A (BPA) and Bisphenol A diglycidyl ether (BADGE) from the epoxy resin-based inner lacquer of aluminium tubes, the tubes were filled with different matrix preparations and stored at an elevated tempera...
A novel soft segment adipic acid-polyoxypropylene diamine copolymer with Mw = ~2000 (AA-PPA 2000) was well obtained through chain extending of bio-based polyoxypropylene diamine D400 using adipic acid (AA). This copolymer was then used to modify the diglycidyl ether of bisphenol A (DGEBA) epoxy/...
Epoxy coatings are commonly used to protect the interior (and exterior) surfaces of water mains and storage tanks and can be used on the interior surfaces of water pipes in homes, hospitals, hotels, and other buildings. Common major components of epoxies include bisphenols, such as bisphenol A (...
Although studies have examined leaching of bisphenol A (BPA) from dental sealants into saliva, occurrence of BPA, bisphenol A diglycidyl ether (BADGE), and their derivatives in dental sealants themselves has not been investigated. In this study, concentrations of eight bisphenol analogues (BPs),...
BADGE (bisphenol A diglycidyl ether) is a synthesis product of bisphenol A (BPA), which, like other plasticizers, can cross the human placenta and reach the foetus. However, compared to BPA, there is almost no toxicological information. This work investigates the toxicity, endocrine and lipid di...
Publisher SummaryThe literature on unsaturated monobasic acids is dominated by the numerous investigations of the biologically important fatty acids, such as the C20 acid—arachidonic acid; the C18 acids – oleic, linoleic and linolenic; the ω-3 fatty acids; and related compounds. A number of m...
Von Ebner's gland protein (VEGP) is a secretory protein, which is abundantly expressed in the small von Ebner's salivary glands of the tongue. VEGP as component of the perireceptor environment around taste papillae might function as transporter of hydrophobic molecules, for example bit...
Denatonium, one of the bitterest substances known to man, was recently identified as wastewater borne micropollutant in surface waters. Therefore, photodegradation experiments and electrochemical degradation were performed to identify abiotic and putative biotic transformation products (TPs). In...
Fluphenazine-14C, 4-[1-14C-3-[2-(trifluoromethyl)phenothiazin-10-yl]propyl]-1-piperazineethanol dihydrochloride, was administered orally to dogs at 10 and 40 mg./kg. and to monkeys at 10 mg./kg. After an oral dose of 10 mg./kg., dogs excreted 2-4% and 75-89% of the dose in the urine and feces, r...
Publisher SummaryFluphenazine enanthate is 4-[3-[2-(trifluoromethyl) phenothiazin – 10- y1]-propyl]-1 piperazine ethanol heptanoate (ester): also know as fluphenazine heptanoate. Fluphenazine enanthate is a pale yellow to yellow orange, clear to slightly turbid, viscous liquid with a characteri...
A sensitive radioimmunoassay was developed to determine the steady-state, fixed-dose pharmacokinetic profile of fluphenazine decanoate in nine outpatients. To see if neuroleptic blood levels measured by this assay correlated with a clinical event, we performed a cross-sectional study of fluphena...
A new procedure based on generation and subsequent reduction of orange-colored fluphenazine hydrochloride radical (FPH+) is presented for the screening of total antioxidant capacity (TAC) of various fruit matrices. The FPH+ was obtained by mixing fluphenazine hydrochloride with persulfate (final...
Rats were given 5, 10, or 20 mg/kg oral doses of fluphenazine (FLU) dihydrochloride daily for 15 days. FLU and its sulfoxide (FL-SO), 7-hydroxy (7-OH-FLU) and N4′-oxide (FLU-NO) metabolites were assayed in plasma, liver, kidney, fat, whole brain, and brain regions by specific and sensitive radi...
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