A highly sensitive and specific high-performance liquid chromatographic method with coulometric detection was developed for the simultaneous assay of fluphenazine decanoate and fluphenazine in plasma. The extraction and sample clean-up procedures are simple, rapid to execute, yet yield chromatog...
Electrocatalytic determination of NADH using a hybrid surface-modified electrode with multi-wall carbon nanotubes (MWCNTs) and a novel electrogenerated redox mediator is described. The redox mediator precursor — fluphenazine (Flu) was adsorbed on MWCNT-modified glassy carbon (GC) electrode whic...
Antisera to fluphenazine sulfoxide were raised in New Zealand white rabbits to an immunogen synthesized by covalent linkage of bovine serum albumin to 10-[[3-[4-(4-carboxybutyl)-1-piperazinyl] propyl]]-2-trifluoromethyl-10H-phenothiazine 5-sulfoxide. With use of an antiserum, a radioimmunoassay ...
Metformin, an antidiabetic drug with one of the highest consumption rates of all pharmaceuticals worldwide, is biologically degraded to guanylurea in wastewater treatment plants. Due to high metformin influent concentrations of up to 100 μg/L and its high but incomplete degradation both compoun...
The objective of this work was to develop and validate a HILIC–MS/MS method for the simultaneous determination of metformin and vildagliptin in human plasma. Chromatographic separation was achieved using an Atlantis HILIC Silica 150-mm × 2.1-mm, 3-μm particle size column maintained at 40 °C....
Metformin (MET) is a pharmaceutical with very high use worldwide that is excreted in unchanged form, leading to concern about potential aquatic life impacts associated with MET, and its primary transformation product guanylurea (GUU). This study presents, in two companion papers, a risk assessme...
The aim of this work was to investigate the occurrence and fate of the antidiabetic metformin (MF) and its transformation products (TPs) in wastewater and surface water samples. New TPs of MF were approached by electrochemical degradation with a boron-doped-diamond electrode (at 1.5 V for 10 min...
A new coordination compound with the formula [Cu(dmpd)Cl2], where dmpd stands for 2,2-dimethylpropane-1,3-diamine, was prepared and structurally characterised by elemental analyses, IR and UV/Vis spectroscopic studies. The single crystal X-ray crystallographic study revealed the copper cation to...
The IR spectra of the title compounds matrix isolated in argon and nitrogen at 14 K, were recorded with the hot nozzle method at temperatures of 300, 450, 700 and 900 K. In 1,3-Dichloro-2,2-dimethylpropane a third conformer (AA) with C2v symmetry was detected in addition to those with C2 (GG) an...
The IR and Raman spectra of 1,2,2,3-tetrachloropropane and 1,3-dichloro-2,2-dimethylpropane are recorded as liquids and as solids both at low temperature and at high pressure. Both compounds exist as a mixture of at least 2 conformers in the liquid phase and crystallize in the GG conformation at...
DCA-sensitized electron-transfer photooxygenation of tetraphenylallene (1) in acetonitrile yields benzophenone (3) and polymeric material. In acetone, the yield of 3 is better than twice the amount obtained in acetonitrile and very little of polymeric material is observed. If the acetone solutio...
Graphite is introduced as a convenient catalyst for cyclohexene-promoted photooxidation of p-xylene, ethylbenzene, and cumene by air. Availability of the reagent (air), lack of chemical waste, low toxicity, and reusability of the catalyst make the process a good green alternative of oxidation of...
Hydroperoxo intermediates formed by the interaction of [FeII(BPMEN)(MeCN)2](ClO4)2 [BPMEN = N,N’-dimethyl-N,N’-bis-(2-pyridylmethyl)-1,2-diaminoethane] with H2O2 in a CH2Cl2–MeCN mixture were characterised using EPR spectroscopy.
The C2 molecule (1,2-ethynediyl) has been prepared by dehydrohalogenation of 1,2-dibromoethylene with an excess of potassium tert-butoxide in 2,3-dimethyl-2-butene as the solvent and the reagent. The major products of this reaction were 2,3-dimethylbut-3-en-2-ol and dibromoacetylene.
The synthetic protocols for entrapment of transition metal complexes reported here are to expand the diversity in catalysis made possible by the ability of microporous solid to select reactants, transition states, and products based on their molecular size. Herein, we report a synthetic route fo...
Three new 2-phenylnaphthalene derivatives, cherrevenaphthalenes A–C (1–3), and a new polyoxygenated cyclohexene derivative, (−)-uvaribonol F (4) together with six known compounds, 5–10, were isolated from the stem and root extracts of Uvaria cherrevensis (Annonaceae). The structures of all is...
The mild epoxidation of strained alkenes using (DMPO)2MnCl catalyst (DMPO = 1,2-dimethyl-4(1H)-pyridinone-3-olate) in the presence of various oxidants was studied. Hydrogen peroxide and monopersulfate were found to be the best oxidants when used with imidazole in acetonitrile at 4 °C, with up t...
In this paper, the influence of pseudohalide ligands coordinated to the ruthenium center on the hydrogenation of cyclohexene was investigated. The pseudohalide complexes containing ruthenium were synthesized from the cis-[RuCl2(dppb)(N-N)] {where N-N = 2,2′-bipyridine (bipy) (1A), 4,4′-dimethy...
The aim of the study was to examine functional brain activity in response to unpleasant images in individuals with the 7-repeat (7R) allele compared to individuals with the 4-repeat (4R) allele of the dopamine receptor D4 (DRD4) gene (VNTR in exon 3). Based on the response ready hypothesis, indi...
Background and purposeMultiple sclerosis (MS) is a neurological disease of the central nervous system (CNS) that causes physical and cognitive impairments. IL-7Ra is a key non-MHC gene associated with MS. IL-7Ra is a likely functional candidate for this complex disease because it is involved in ...
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