Nowadays, smart polymers have been received a great attention in biomedical applications, especially in sensors because of their novel and peculiar properties. In this study, sphere-like structure of poly-N-isopropylacrylamide (PNIPAM) microgel was prepared via one-step precipitation polymerizat...
Chlorpromazine has been used widely as an antipsychotic agent and its major metabolic pathways include 7-hydroxylation, N-dealkylation, N-oxidation and S-oxidation. The present work focuses on in situ monitoring of the radical intermediate, for clarifying the mechanism diversity in anodic oxidat...
We report a novel electrochemical sensor for the sensitive and selective determination of the antipsychotic drug chlorpromazine (CPZ) based on the iron (Fe) nanoparticles-loaded graphene oxide (GO-Fe)/three dimensional (3D) honeycomb-like zinc oxide (ZnO) nanohybrid modified screen printed carbo...
The abatement of dissolved organochlorinated pharmaceuticals from water by catalytic hydrodechlorination has been scarcely studied so far, but it represents a promising process for such goal. This work aims to evaluate the feasibility of this system for the removal of chlorpromazine, one of the ...
A specific and sensitive capillary liquid chromatography-ultraviolet detection (cap-LC-UV) method in combination with a micro-extraction by packed sorbent (MEPS) sample clean-up procedure has been developed and validated for the simultaneous analysis of chlorpromazine, olanzapine and their flavi...
The L-Cysteine modified carbon paste electrode (Cys-CPE) has been employed for the electrochemical determination of Chlorpromazine (CPM). The anodic behaviour of CPM was investigated by cyclic voltammetry (CV), differential pulse voltammetry (DPV) and square wave voltammetry (SWV). The Cys-CPE s...
Two assay methods for antipyrine (AP) and its main metabolites 3-hydroxymethylantipyrine (3-HMA), norantipyrine (NORA) and 4-hydroxyantipyrine (4-HA) in urine samples have been compared. Method I involved a 3 h incubation at 37°C with β-glucuronidase, whereas method II used acid hydrolysis wit...
In a previous study we observed, during separation of total antipyrine metabolites by high-performance liquid chromatography and after enzymatic hydrolysis, an unidentified peak corresponding to an ionic compound with pyrazolinone features. In the present study, this compound was identified as t...
Seven new lanthanide(III) complexes with 4-hydroxyantipyrine were synthesized. These complexes were characterized by elemental analysis, molar conductance, magnetic moment measurements, FT-IR, electronic and 1HNMR spectra, X-ray powder diffraction, and thermogravimetric studies. The ligand, 4-hy...
From the nisZ gene sequence, a non-radioactive digoxigenin-labeled DNA probe, was tested for detection of nisin-producing strains using polymerase chain reaction amplification. The digoxigenin-labeled DNA probe clearly discriminated between nisin-producing and non-producing strains with a high d...
The use of digoxigenin-labelled probes was studied for quantitation of HBV-DNA during antiviral drug evaluation. Digoxigenin (dig)-labelled probes were generated either via incorporation of dig-dUTP in a polymerase chain reaction (PCR) or a random priming reaction. Using the PCR-labelled probe (...
To spatially control the delivery of multiple viral vectors from biomaterial scaffolds, digoxigenin (DIG) was conjugated to adenoviral capsid proteins as an antigenic determinant for antibody immobilization. The infectivity, toxicity, specificity and immobilization stability of DIG-modified aden...
Small ligands and their receptors are widely used non-covalent couplers in various biotech applications. One prominent example, the digoxigenin–antibody complex, was often used to immobilize samples for single molecule force measurements by optical trap or AFM. Here, we employed dynamic AFM spe...
In the course of detecting nuclear transcription factors by electrophoretic mobility shift assay using digoxigenin (DIG)-labeled probes, we encountered a problem with a considerable nonspecific shift band in negative control lanes from which protein extracts were omitted. This nonspecific shift ...
We report on a competitive, homogeneous immunoassay for the detection of the hapten digoxigenin. The assay is based on competitive fluorescence quenching by gold nanoparticles. Digoxigenin is indirectly labeled with the fluorophore Cy3B through bovine serum albumin and used as a marker. Gold nan...
Two isoforms of a ligand-activated nuclear receptor, RORγ and RORγT, have been implicated in various physiological functions, including energy metabolism, circadian rhythm and immune system development. Using a stably transfected reporter cell line, we screened two chemical libraries and ident...
Cardiac glycosides show anticancer activities and their deoxy-sugar chains are vital for their anticancer effects. In order to study the structure-activity relationship (SAR) of cardiac glycosides toward cancers and get more potent anticancer agents, a series of MeON-neoglycosides of digoxigenin...
Cardiac glycosides exhibit significant anticancer effects and the glycosyl substitution at C3 position of digoxigenin is pivotal for their biological activity. In order to study the structure-activity relationship (SAR) of cardiac glycosides toward cancers and explore more potent anticancer agen...
Based on a new polyfunctional derivative of dihydroxyisophtalic aldehyde (1) spiropyrans of 1,3-benzoxazin-4-one series with two carbonyl and a hydroxygroup in the [2H]-chromene fragment were synthesized. The results of single crystal X-ray analysis of 6′-carbomethoxy-3,5-dimethyl-8′-formyl-5′...
Five new complexes were obtained from solution of transition metal salts (M=Co(II), Cu(II)) with 4-amino-3,5-bis(pyridin-2-yl)-1,2,4-triazole (abpt) in different molar ratios. X-ray structural elucidation revealed low-dimensional compounds with the metal ions assembled in monomers, dimers or cha...
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