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Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

S)-3-Cyano-5-methyl hexanoic acid ethyl ester

Cas:181289-39-4

Min.Order:10 Kilogram

Negotiable

Type:Trading Company

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LIDE PHARMACEUTICALS LIMITED

Advantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the

Hexanoic acid, 3-cyano-5-methyl-, ethyl ester, (3S)-/ LIDE PHARMA- Factory supply / Best price

Cas:181289-39-4

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Qingdao Beluga Import and Export Co., LTD

S)-3-Cyano-5-methyl hexanoic acid ethyl ester CAS:181289-39-4 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing i

S)-3-Cyano-5-methyl hexanoic acid ethyl ester CAS:181289-39-4

Cas:181289-39-4

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

Hexanoic acid, 3-cyano-5-methyl-, ethyl ester, (3S)-

Cas:181289-39-4

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Triumph International Development Limilted

Storage:Store in a cool,dry place and keep away from direct strong light Package:As customer request Application:Used for research and industrial manufacture. Transportation:Common products:Sea/Air/Courier Dangerous Chem:Sea/Ai

(S)-3-cyano-5-methylhexanoic acid ethyl ester

Cas:181289-39-4

Min.Order:100 Metric Ton

Negotiable

Type:Lab/Research institutions

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Hangzhou Keyingchem Co.,Ltd

Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det

S)-3-Cyano-5-methyl hexanoic acid ethyl ester

Cas:181289-39-4

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

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Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

(3S)-3-Cyano-5-methyl-Hexanoic acid ethyl ester CAS NO.181289-39-4

Cas:181289-39-4

Min.Order:10 Gram

Negotiable

Type:Lab/Research institutions

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Henan Tianfu Chemical Co., Ltd.

Tianfu Chemical, built in 2009, is a professional supplier for API materials in China. With 10 years development, we have bulit our own factory and lab to produce a certain of products. And we have established stable business relationships with ma

TIANFU 181289-39-4 S)-3-Cyano-5-methyl hexanoic acid ethyl ester

Cas:181289-39-4

Min.Order:1 Kilogram

FOB Price: $200.0

Type:Lab/Research institutions

inquiry

Siwei Development Group Ltd.

Product name: (S)-Ethyl 3-Cyano-5-Methylhexanoate CAS No.:181289-39-4 Molecule Formula:C10H17NO2 Molecule Weight:183.25 Purity: 98.0% Package: 25kg/drum Description:White to off-white powder Manufacture Standards:Enterprise Standard

Best Quality (S)-Ethyl 3-Cyano-5-Methylhexanoate

Cas:181289-39-4

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

Xiamen Jenny Chemical Technology Co., Ltd.

GMP standard, high purity, competitive price, in stock 1. Quick Response: within 6 hours after receiving your email. 2. Quality Guarantee: All products are strictly tested by our QC, confirmed by QA, and approved by a third-party lab in China, USA,

S)-3-Cyano-5-methylhexanoicacidethylester

Cas:181289-39-4

Min.Order:1 Milligram

Negotiable

Type:Trading Company

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EAST CHEMSOURCES LIMITED

factory?direct?saleAppearance:White Powder Storage:Store In Dry, Cool And Ventilated Place Package:25kg/drum, also according to the clients requirement Application:It is widely used as a thickener, emulsifier and stabilizer Transportation:By Sea Or B

S)-3-Cyano-5-methyl hexanoic acid ethyl ester

Cas:181289-39-4

Min.Order:1 Kilogram

FOB Price: $18.0 / 20.0

Type:Trading Company

inquiry

Shandong Mopai Biotechnology Co., LTD

Shandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W

Hexanoic acid, 3-cyano-5-methyl-, ethyl ester, (3S)-

Cas:181289-39-4

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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KAISA GROUP INC

1.Applied in food field.it can improve the immune system and prolong life. 2.Appliedin cosmetic field.it can improve the skin care. 3.Applied in pharmaceutical field.it can treat various dieases. 4.Our product quality assurance will make our customer

S)-3-Cyano-5-methyl hexanoic acid ethyl ester

Cas:181289-39-4

Min.Order:1 Metric Ton

FOB Price: $1.5

Type:Trading Company

inquiry

Suzhou Health Chemicals Co., Ltd.

High quality,stable supply chain.Appearance:white/off-white or light yellow Storage:Store in cool and dry place, keep away from strong light and heat. Package:aluminum bottle,glass bottle,PTFE bottle,cardboard drum Application:This product can be use

S)-3-Cyano-5-methyl hexanoic acid ethyl ester

Cas:181289-39-4

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Golden Pharma Co., Limited

GOLDEN PHARMA CO.,LIMITED.is a professional pharmaceutical company,our team have more than 20years expereince in pharmaceutical production and sales. we are a professional technical enterprise specializing in the R & D, production,QA regulation

(S)-ethyl 3-cyano-5-methylhexanoate

Cas:181289-39-4

Min.Order:1 Kilogram

Negotiable

Type:Other

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Bluecrystal chem-union

We are a Union of chemistry in China, consists of chemists,engineers, laboratories,factories in China. We organize surplus capacity of R&D and production as well as custom synthesis for chemical products and chemical business project. We are supp

S)-3-Cyano-5-methyl hexanoic acid ethyl ester

Cas:181289-39-4

Min.Order:1 Metric Ton

FOB Price: $1.0

Type:Trading Company

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Xi`an Eastling Biotech Co., Ltd.

high purity lowest priceAppearance:solid or liquid Storage:in sealed air resistant place Package:Foil bag; Drum; Plastic bottle Application:Pharma;Industry;Agricultural Transportation:by sea or air Port:Beijing or Guangzhou

S)-3-Cyano-5-methyl hexanoic acid ethyl ester

Cas:181289-39-4

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Koning Pharmchem Co., Ltd.

KONING PHARMCHEM CO., LTD. has committed itself to a strategy of providing a unique service for companies involved in the manufacture of pharmaceuticals, healthcare products, food, cosmetics and other fine chemicals. Our products including but not li

(S)-3-cyano-5-methylhexanoic acid ethyl ester

Cas:181289-39-4

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Hebei Sankai Chemical Technology Co., Ltd

1. Product advantages? High purity, all above 98.5%, no impurities after dissolution? We will test each batch to ensure quality? OEM and private brand services designed for free? Various cap colors available? We can also provide MT1 peptide powder2.

Hexanoic acid, 3-cyano-5-methyl-, ethyl ester, (3S)-

Cas:181289-39-4

Min.Order:0

Negotiable

Type:Trading Company

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Antimex Chemical Limied

factory?direct?sale Application:Fine chemical intermediates, used as the main raw material for the synthesis of various pesticides, medicines, surfactants, polymer monomers, and antifungal agents

Hexanoic acid, 3-cyano-5-methyl-, ethyl ester, (3S)-

Cas:181289-39-4

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Guangdong Juda Chemical Industrial Co.,Limited

Appearance:solid or liquid Storage:sealed in cool and dry place Package:As customer's requested Application:Pharma Intermediate Transportation:by courier/air/sea Port:Any port in China

S)-3-Cyano-5-methyl hexanoic acid ethyl ester CAS No.181289-39-4

Cas:181289-39-4

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Wuhan Circle Star Chem-medical Technology co.,Ltd.

good quality, competitive price, thoughtful after sale serviceAppearance:white powder Storage:Keep it in dry,shady and cool place Package:25kg,50kg,180kg,200kg,250kg,1000kg,customization Application:Pharma;Industry;Agricultural;chemical reaserch Tran

S)-3-Cyano-5-methyl hexanoic acid ethyl ester

Cas:181289-39-4

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Henan Kanbei Chemical Co.,LTD

factory?direct?saleAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:healing drugs Transportation:By sea Port:Shanghai/tianjin

Hexanoic acid, 3-cyano-5-methyl-, ethyl ester, (3S)-

Cas:181289-39-4

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Saiwante (shanghai) New Material Technology Co., Ltd.

Stable supply of goods and provision of high-quality services Application:As raw materials in the field of medicine and biology

S)-3-Cyano-5-methyl hexanoic acid ethyl ester

Cas:181289-39-4

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Chemlyte Solutions

factory?direct?sale Application:Fine chemical intermediates, used as the main raw material for the synthesis of various pesticides, medicines, surfactants, polymer monomers, and antifungal agents

Hexanoic acid, 3-cyano-5-methyl-, ethyl ester, (3S)-

Cas:181289-39-4

Min.Order:0

Negotiable

Type:Other

inquiry

ZHEJIANG JIUZHOU CHEM CO.,LTD

factory?direct?saleAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:healing drugs Transportation:By sea Port:Shanghai/tianjin

Hexanoic acid, 3-cyano-5-methyl-, ethyl ester, (3S)-

Cas:181289-39-4

Min.Order:0

Negotiable

Type:Trading Company

inquiry

NUTROCHEM- MANUFACTURE PLACE

best seller Application:API

Hexanoic acid, 3-cyano-5-methyl-, ethyl ester, (3S)-

Cas:181289-39-4

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Changzhou Pesan Chemical Co.,Ltd

Strong R&D strength and team We have a R&D team with around 30 R&D personnel.All of our employees have chemical backgrounds and have worked in the chemical industry for many years.Our laboratory can synthesize target products with wei

(3S)-3-Cyano-5-methyl-Hexanoic acid ethyl ester

Cas:181289-39-4

Min.Order:1 Kilogram

FOB Price: $1.0 / 99999.0

Type:Other

inquiry

Shanghai AngewChem Co., Ltd.

99%, in stock Shanghai AngewChemCo., Ltd. is an innovative enterprise on fine chemicals and pharmaceuticals. Based on Shanghai R&D center and Hunan chemical manufacturing plant, we offer chemical research, process development, and large-scale

(S)-3-cyano-5-methylhexanoic acid ethyl ester manufacturer high quality

Cas:181289-39-4

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Henan Wising Chem Co., Ltd

Henan Wising Chem Co., Ltd is a national high-tech enterprise with a passion for selling and an emphasis on customer care. We are committed to providing quality chemical products that help us become one of the most reputable, reliable and lea

(S)-3-Cyano-5-methylhexanoic acid ethyl ester

Cas:181289-39-4

Min.Order:0 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Synthetic route

potassium cyanide

potassium cyanide

5-methyl-2-hexenoic acid ethyl ester
34993-63-0, 79918-80-2, 2351-89-5

5-methyl-2-hexenoic acid ethyl ester

(S)-3-cyano-5-methylhexanoic acid ethyl ester
181289-39-4

(S)-3-cyano-5-methylhexanoic acid ethyl ester

Conditions
ConditionsYield
With 1-(9-methylanthracene)-((R)-(6-hydroxy-4-quinolinyl)phenoxymethyl-2-yl)-5-ethenyl-1-azabicyclo[2.2.2]octane In hexane; water at 20℃; for 15h; Michael Addition; Green chemistry; stereoselective reaction;93.4%
4-isobutyl-2-oxopyrrolidine-3-carboxylic acid

4-isobutyl-2-oxopyrrolidine-3-carboxylic acid

(S)-3-cyano-5-methylhexanoic acid ethyl ester
181289-39-4

(S)-3-cyano-5-methylhexanoic acid ethyl ester

Conditions
ConditionsYield
With hydrogenchloride; acetic acid In water at 80 - 110℃;80%
(R,S)-3-cyano-5-methylhexanoic acid ethyl ester
181289-17-8

(R,S)-3-cyano-5-methylhexanoic acid ethyl ester

(S)-3-cyano-5-methylhexanoic acid ethyl ester
181289-39-4

(S)-3-cyano-5-methylhexanoic acid ethyl ester

Conditions
ConditionsYield
With sodium hydroxide; Candida antarctica lipase B In water at 15℃; pH=7.2; Aqueous phosphate buffer; Resolution of racemate;77%
(E)-ethyl 3-cyano-5-methylhex-2-enoate
1335223-63-6

(E)-ethyl 3-cyano-5-methylhex-2-enoate

(S)-3-cyano-5-methylhexanoic acid ethyl ester
181289-39-4

(S)-3-cyano-5-methylhexanoic acid ethyl ester

Conditions
ConditionsYield
With NADP In isopropyl alcohol at 30℃; for 96h; Enzymatic reaction; enantioselective reaction;68.8%
With Citrobacter sp. N-ethylmaleimide reductase; NADPH; NADH In dimethyl sulfoxide at 30℃; for 22h; pH=7; Product distribution / selectivity; Enzymatic reaction; Aqueous phosphate buffer;n/a
With nicotinamide-dependent cyclohexenone reductase from Zymomonas mobilis; NADH In aq. buffer at 30℃; for 24h; pH=7.5; Reagent/catalyst; Green chemistry; Enzymatic reaction; stereoselective reaction;n/a
3-cyano-5-methyl-hex-3-enoic acid ethyl ester
350801-68-2

3-cyano-5-methyl-hex-3-enoic acid ethyl ester

A

5-methyl-3-cyanohexanoic acid ethyl ester

5-methyl-3-cyanohexanoic acid ethyl ester

B

(S)-3-cyano-5-methylhexanoic acid ethyl ester
181289-39-4

(S)-3-cyano-5-methylhexanoic acid ethyl ester

Conditions
ConditionsYield
With hydrogen; (Z,Z)-cycloocta-1,5-diene(R,R-1,2-bis(2,5-diethylphospholanyl)benzene)rhodium(I) tetrafluoroborate In methanol at 55℃; under 5171.48 Torr; Product distribution; Further Variations:; Reagents; Temperatures; Pressures;
(3S)-3-cyano-2-ethoxycarbonyl-5-methyl-hexanoic acid

(3S)-3-cyano-2-ethoxycarbonyl-5-methyl-hexanoic acid

A

3-(S)-cyano-5-methyl-hexanoic acid
181289-37-2

3-(S)-cyano-5-methyl-hexanoic acid

B

(S)-3-cyano-5-methylhexanoic acid ethyl ester
181289-39-4

(S)-3-cyano-5-methylhexanoic acid ethyl ester

Conditions
ConditionsYield
With water; sodium chloride In dimethyl sulfoxide at 88 - 135℃; for 20.5h;A n/a
B n/a
(S)-2-ethoxycarbonyl-3-cyano-5-methylhexanoic acid sodium salt

(S)-2-ethoxycarbonyl-3-cyano-5-methylhexanoic acid sodium salt

(S)-3-cyano-5-methylhexanoic acid ethyl ester
181289-39-4

(S)-3-cyano-5-methylhexanoic acid ethyl ester

Conditions
ConditionsYield
With water; sodium chloride In toluene at 75 - 85℃; for 2h; Heating / reflux;
L-leucine
61-90-5

L-leucine

(S)-3-cyano-5-methylhexanoic acid ethyl ester
181289-39-4

(S)-3-cyano-5-methylhexanoic acid ethyl ester

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: sodium nitrite; sulfuric acid; potassium bromide / water / 6.5 h / -14 - 20 °C
2.1: thionyl chloride / cyclohexane / 13 h / 60 - 80 °C / Inert atmosphere
2.2: 25 °C / Inert atmosphere
3.1: phosphorus pentoxide / 80 °C / 12 Torr
4.1: sodium hydride / N,N-dimethyl-formamide; paraffin oil (nujol) / 10 - 25 °C
5.1: potassium chloride / water; dimethyl sulfoxide / 4 h / 150 - 160 °C
View Scheme
Multi-step reaction with 7 steps
1.1: sodium nitrite; sulfuric acid; potassium bromide / water / 6.5 h / -14 - 20 °C
2.1: thionyl chloride / cyclohexane / 13 h / 60 - 80 °C / Inert atmosphere
2.2: 25 °C / Inert atmosphere
3.1: phosphorus pentoxide / 80 °C / 12 Torr
4.1: sodium hydride / N,N-dimethyl-formamide; paraffin oil (nujol) / 10 - 25 °C
5.1: potassium chloride / water; dimethyl sulfoxide / 4 h / 150 - 160 °C
6.1: sodium ethanolate / ethanol / 25 - 85 °C
7.1: sodium hydroxide / Candida antarctica lipase B / water / 15 °C / pH 7.2 / Aqueous phosphate buffer; Resolution of racemate
View Scheme
(S)-2-bromo-4-methylpentanoic acid
28659-87-2

(S)-2-bromo-4-methylpentanoic acid

(S)-3-cyano-5-methylhexanoic acid ethyl ester
181289-39-4

(S)-3-cyano-5-methylhexanoic acid ethyl ester

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: thionyl chloride / cyclohexane / 13 h / 60 - 80 °C / Inert atmosphere
1.2: 25 °C / Inert atmosphere
2.1: phosphorus pentoxide / 80 °C / 12 Torr
3.1: sodium hydride / N,N-dimethyl-formamide; paraffin oil (nujol) / 10 - 25 °C
4.1: potassium chloride / water; dimethyl sulfoxide / 4 h / 150 - 160 °C
View Scheme
Multi-step reaction with 6 steps
1.1: thionyl chloride / cyclohexane / 13 h / 60 - 80 °C / Inert atmosphere
1.2: 25 °C / Inert atmosphere
2.1: phosphorus pentoxide / 80 °C / 12 Torr
3.1: sodium hydride / N,N-dimethyl-formamide; paraffin oil (nujol) / 10 - 25 °C
4.1: potassium chloride / water; dimethyl sulfoxide / 4 h / 150 - 160 °C
5.1: sodium ethanolate / ethanol / 25 - 85 °C
6.1: sodium hydroxide / Candida antarctica lipase B / water / 15 °C / pH 7.2 / Aqueous phosphate buffer; Resolution of racemate
View Scheme
ethyl 2-cyano-4-methylpentanoate
7352-02-5

ethyl 2-cyano-4-methylpentanoate

(S)-3-cyano-5-methylhexanoic acid ethyl ester
181289-39-4

(S)-3-cyano-5-methylhexanoic acid ethyl ester

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: sodium hydride / N,N-dimethyl-formamide; paraffin oil (nujol) / 10 - 50 °C / Inert atmosphere
1.2: 20 °C / Inert atmosphere
2.1: dimethyl sulfoxide / 4 h / 150 - 160 °C
3.1: sodium hydroxide / Candida antarctica lipase B / water / 15 °C / pH 7.2 / Aqueous phosphate buffer; Resolution of racemate
View Scheme
Multi-step reaction with 3 steps
1.1: sodium hydride / 1,2-dimethoxyethane; paraffin oil (nujol) / 10 - 50 °C
1.2: 20 °C
2.1: dimethyl sulfoxide / 4 h / 150 - 160 °C
3.1: sodium hydroxide / Candida antarctica lipase B / water / 15 °C / pH 7.2 / Aqueous phosphate buffer; Resolution of racemate
View Scheme
(3R)-3-cyano-5-methylhexanoic acid

(3R)-3-cyano-5-methylhexanoic acid

(S)-3-cyano-5-methylhexanoic acid ethyl ester
181289-39-4

(S)-3-cyano-5-methylhexanoic acid ethyl ester

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: dicyclohexyl-carbodiimide / dichloromethane / 13 h / 0 - 25 °C
2: sodium ethanolate / ethanol / 25 - 85 °C
3: sodium hydroxide / Candida antarctica lipase B / water / 15 °C / pH 7.2 / Aqueous phosphate buffer; Resolution of racemate
View Scheme
(S)-3-cyano-2-ethoxycarbonyl-5-methyl-hexanoic acid ethyl ester
1232146-79-0

(S)-3-cyano-2-ethoxycarbonyl-5-methyl-hexanoic acid ethyl ester

(S)-3-cyano-5-methylhexanoic acid ethyl ester
181289-39-4

(S)-3-cyano-5-methylhexanoic acid ethyl ester

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: potassium chloride / water; dimethyl sulfoxide / 4 h / 150 - 160 °C
2: sodium ethanolate / ethanol / 25 - 85 °C
3: sodium hydroxide / Candida antarctica lipase B / water / 15 °C / pH 7.2 / Aqueous phosphate buffer; Resolution of racemate
View Scheme
(S)-3-cyano-2-ethoxycarbonyl-5-methyl-hexanoic acid ethyl ester
1232146-79-0

(S)-3-cyano-2-ethoxycarbonyl-5-methyl-hexanoic acid ethyl ester

A

5-methyl-3-cyanohexanoic acid ethyl ester

5-methyl-3-cyanohexanoic acid ethyl ester

B

(S)-3-cyano-5-methylhexanoic acid ethyl ester
181289-39-4

(S)-3-cyano-5-methylhexanoic acid ethyl ester

Conditions
ConditionsYield
With potassium chloride In water; dimethyl sulfoxide at 150 - 160℃; for 4h;A n/a
B n/a
(2S)-2-bromo-4-methylpentanamide
28659-89-4

(2S)-2-bromo-4-methylpentanamide

(S)-3-cyano-5-methylhexanoic acid ethyl ester
181289-39-4

(S)-3-cyano-5-methylhexanoic acid ethyl ester

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: phosphorus pentoxide / 80 °C / 12 Torr
2: sodium hydride / N,N-dimethyl-formamide; paraffin oil (nujol) / 10 - 25 °C
3: potassium chloride / water; dimethyl sulfoxide / 4 h / 150 - 160 °C
View Scheme
Multi-step reaction with 5 steps
1: phosphorus pentoxide / 80 °C / 12 Torr
2: sodium hydride / N,N-dimethyl-formamide; paraffin oil (nujol) / 10 - 25 °C
3: potassium chloride / water; dimethyl sulfoxide / 4 h / 150 - 160 °C
4: sodium ethanolate / ethanol / 25 - 85 °C
5: sodium hydroxide / Candida antarctica lipase B / water / 15 °C / pH 7.2 / Aqueous phosphate buffer; Resolution of racemate
View Scheme
(2S)-2-bromo-4-methylpentanenitrile
28659-90-7

(2S)-2-bromo-4-methylpentanenitrile

(S)-3-cyano-5-methylhexanoic acid ethyl ester
181289-39-4

(S)-3-cyano-5-methylhexanoic acid ethyl ester

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: sodium hydride / N,N-dimethyl-formamide; paraffin oil (nujol) / 10 - 25 °C
2: potassium chloride / water; dimethyl sulfoxide / 4 h / 150 - 160 °C
View Scheme
Multi-step reaction with 4 steps
1: sodium hydride / N,N-dimethyl-formamide; paraffin oil (nujol) / 10 - 25 °C
2: potassium chloride / water; dimethyl sulfoxide / 4 h / 150 - 160 °C
3: sodium ethanolate / ethanol / 25 - 85 °C
4: sodium hydroxide / Candida antarctica lipase B / water / 15 °C / pH 7.2 / Aqueous phosphate buffer; Resolution of racemate
View Scheme
ethyl 3-carbamoyl-5-methylhexanoate
1350373-53-3

ethyl 3-carbamoyl-5-methylhexanoate

(S)-3-cyano-5-methylhexanoic acid ethyl ester
181289-39-4

(S)-3-cyano-5-methylhexanoic acid ethyl ester

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: thionyl chloride / 13 h / 80 °C
2: sodium hydroxide / Candida antarctica lipase B / water / 15 °C / pH 7.2 / Aqueous phosphate buffer; Resolution of racemate
View Scheme
diethyl 2-cyano-2-isobutylsuccinate
1350373-50-0

diethyl 2-cyano-2-isobutylsuccinate

(S)-3-cyano-5-methylhexanoic acid ethyl ester
181289-39-4

(S)-3-cyano-5-methylhexanoic acid ethyl ester

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: dimethyl sulfoxide / 4 h / 150 - 160 °C
2: sodium hydroxide / Candida antarctica lipase B / water / 15 °C / pH 7.2 / Aqueous phosphate buffer; Resolution of racemate
View Scheme
3-(ethoxycarbonyl)-2-(2-methylpropyl)propanoic acid

3-(ethoxycarbonyl)-2-(2-methylpropyl)propanoic acid

(S)-3-cyano-5-methylhexanoic acid ethyl ester
181289-39-4

(S)-3-cyano-5-methylhexanoic acid ethyl ester

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: thionyl chloride / cyclohexane / 13 h / 60 - 80 °C / Inert atmosphere
1.2: 25 °C / Inert atmosphere
2.1: thionyl chloride / 13 h / 80 °C
3.1: sodium hydroxide / Candida antarctica lipase B / water / 15 °C / pH 7.2 / Aqueous phosphate buffer; Resolution of racemate
View Scheme
isopentanoyl chloride
108-12-3

isopentanoyl chloride

(S)-3-cyano-5-methylhexanoic acid ethyl ester
181289-39-4

(S)-3-cyano-5-methylhexanoic acid ethyl ester

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: toluene; acetonitrile / 4 h / 100 - 105 °C
2.1: n-butyllithium / hexane; tetrahydrofuran / 0.5 h / 0 °C
2.2: 0 - 20 °C
3.1: NADH; NADPH; Citrobacter sp. N-ethylmaleimide reductase / dimethyl sulfoxide / 22 h / 30 °C / pH 7 / Enzymatic reaction; Aqueous phosphate buffer
View Scheme
Multi-step reaction with 3 steps
1.1: toluene; acetonitrile / 4 h / 100 - 105 °C
2.1: n-butyllithium / hexane; tetrahydrofuran / 0.5 h / 0 °C
2.2: 0 - 20 °C
3.1: NADH; NADPH; Lycopersicon esculentum 12-oxophytodienoate reductase / dimethyl sulfoxide / 22 h / 30 °C / pH 7 / Enzymatic reaction; Aqueous phosphate buffer
View Scheme
isopentanoyl chloride
108-12-3

isopentanoyl chloride

A

5-methyl-3-cyanohexanoic acid ethyl ester

5-methyl-3-cyanohexanoic acid ethyl ester

B

(S)-3-cyano-5-methylhexanoic acid ethyl ester
181289-39-4

(S)-3-cyano-5-methylhexanoic acid ethyl ester

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: toluene; acetonitrile / 4 h / 100 - 105 °C
2.1: n-butyllithium / hexane; tetrahydrofuran / 0.5 h / 0 °C
2.2: 0 - 20 °C
3.1: NADPH; recombinant OPR1 reductase (tomato) / dimethyl sulfoxide / 45 h / 30 °C / pH 7 / Enzymatic reaction; Aqueous phosphate buffer
View Scheme
4-methyl-2-pentanone
108-10-1

4-methyl-2-pentanone

(S)-3-cyano-5-methylhexanoic acid ethyl ester
181289-39-4

(S)-3-cyano-5-methylhexanoic acid ethyl ester

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: sodium hydride / tetrahydrofuran / 0.33 h / 5 - 15 °C / Inert atmosphere
1.2: 19 h / 15 - 25 °C
1.3: pH 6
2.1: tetramethyl ammoniumhydroxide / hexane; water / 0.67 h / 5 - 15 °C / Inert atmosphere
2.2: 2.5 h / 5 - 10 °C
3.1: tetrakis(triphenylphosphine) palladium(0) / N,N-dimethyl-formamide / 15 h / 70 °C / Inert atmosphere
4.1: NADH; NADPH; Citrobacter sp. N-ethylmaleimide reductase / dimethyl sulfoxide / 22 h / 30 °C / pH 7 / Enzymatic reaction; Aqueous phosphate buffer
View Scheme
Multi-step reaction with 4 steps
1.1: sodium hydride / tetrahydrofuran / 0.33 h / 5 - 15 °C / Inert atmosphere
1.2: 19 h / 15 - 25 °C
1.3: pH 6
2.1: tetramethyl ammoniumhydroxide / hexane; water / 0.67 h / 5 - 15 °C / Inert atmosphere
2.2: 2.5 h / 5 - 10 °C
3.1: tetrakis(triphenylphosphine) palladium(0) / N,N-dimethyl-formamide / 15 h / 70 °C / Inert atmosphere
4.1: NADH; NADPH; Lycopersicon esculentum 12-oxophytodienoate reductase / dimethyl sulfoxide / 22 h / 30 °C / pH 7 / Enzymatic reaction; Aqueous phosphate buffer
View Scheme
Multi-step reaction with 4 steps
1.1: sodium hydride / tetrahydrofuran / 0.33 h / 5 - 15 °C / Inert atmosphere
1.2: 19 h / 15 - 25 °C
1.3: pH 6
2.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.5 h / 0 - 10 °C / Inert atmosphere
2.2: 1.5 h / 0 - 10 °C
3.1: tetrakis(triphenylphosphine) palladium(0) / N,N-dimethyl-formamide / 15 h / 70 °C / Inert atmosphere
4.1: NADH; NADPH; Lycopersicon esculentum 12-oxophytodienoate reductase / dimethyl sulfoxide / 22 h / 30 °C / pH 7 / Enzymatic reaction; Aqueous phosphate buffer
View Scheme
4-methyl-2-pentanone
108-10-1

4-methyl-2-pentanone

A

5-methyl-3-cyanohexanoic acid ethyl ester

5-methyl-3-cyanohexanoic acid ethyl ester

B

(S)-3-cyano-5-methylhexanoic acid ethyl ester
181289-39-4

(S)-3-cyano-5-methylhexanoic acid ethyl ester

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: sodium hydride / tetrahydrofuran / 0.33 h / 5 - 15 °C / Inert atmosphere
1.2: 19 h / 15 - 25 °C
1.3: pH 6
2.1: tetramethyl ammoniumhydroxide / hexane; water / 0.67 h / 5 - 15 °C / Inert atmosphere
2.2: 2.5 h / 5 - 10 °C
3.1: tetrakis(triphenylphosphine) palladium(0) / N,N-dimethyl-formamide / 15 h / 70 °C / Inert atmosphere
4.1: NADPH; recombinant OPR1 reductase (tomato) / dimethyl sulfoxide / 45 h / 30 °C / pH 7 / Enzymatic reaction; Aqueous phosphate buffer
View Scheme
Multi-step reaction with 4 steps
1.1: sodium hydride / tetrahydrofuran / 0.33 h / 5 - 15 °C / Inert atmosphere
1.2: 19 h / 15 - 25 °C
1.3: pH 6
2.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.5 h / 0 - 10 °C / Inert atmosphere
2.2: 1.5 h / 0 - 10 °C
3.1: tetrakis(triphenylphosphine) palladium(0) / N,N-dimethyl-formamide / 15 h / 70 °C / Inert atmosphere
4.1: NADPH; recombinant OPR1 reductase (tomato) / dimethyl sulfoxide / 45 h / 30 °C / pH 7 / Enzymatic reaction; Aqueous phosphate buffer
View Scheme
Multi-step reaction with 4 steps
1.1: sodium hydride / tetrahydrofuran; mineral oil / 0 - 20 °C
1.2: 19 h / 0 - 20 °C
2.1: tetramethyl ammoniumhydroxide / water; hexane / 0.67 h / 5 - 15 °C / Inert atmosphere
2.2: 2.5 h / 5 - 10 °C / Inert atmosphere
3.1: tetrakis(triphenylphosphine) palladium(0) / N,N-dimethyl-formamide / 15 h / 70 °C / Inert atmosphere
4.1: Saccharomyces pastorianus old yellow enzyme, isoenzyme OYE3; NADH / aq. buffer / 24 h / 30 °C / pH 7.5 / Green chemistry; Enzymatic reaction
View Scheme
5-methyl-3-oxo-hexanoic acid ethyl ester
34036-16-3

5-methyl-3-oxo-hexanoic acid ethyl ester

(S)-3-cyano-5-methylhexanoic acid ethyl ester
181289-39-4

(S)-3-cyano-5-methylhexanoic acid ethyl ester

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.5 h / 0 - 10 °C / Inert atmosphere
1.2: 1.5 h / 0 - 10 °C
2.1: tetrakis(triphenylphosphine) palladium(0) / N,N-dimethyl-formamide / 15 h / 70 °C / Inert atmosphere
3.1: NADH; NADPH; Lycopersicon esculentum 12-oxophytodienoate reductase / dimethyl sulfoxide / 22 h / 30 °C / pH 7 / Enzymatic reaction; Aqueous phosphate buffer
View Scheme
Multi-step reaction with 3 steps
1.1: tetramethyl ammoniumhydroxide / hexane; water / 0.67 h / 5 - 15 °C / Inert atmosphere
1.2: 2.5 h / 5 - 10 °C
2.1: tetrakis(triphenylphosphine) palladium(0) / N,N-dimethyl-formamide / 15 h / 70 °C / Inert atmosphere
3.1: NADH; NADPH; Citrobacter sp. N-ethylmaleimide reductase / dimethyl sulfoxide / 22 h / 30 °C / pH 7 / Enzymatic reaction; Aqueous phosphate buffer
View Scheme
Multi-step reaction with 3 steps
1.1: tetramethyl ammoniumhydroxide / hexane; water / 0.67 h / 5 - 15 °C / Inert atmosphere
1.2: 2.5 h / 5 - 10 °C
2.1: tetrakis(triphenylphosphine) palladium(0) / N,N-dimethyl-formamide / 15 h / 70 °C / Inert atmosphere
3.1: NADH; NADPH; Lycopersicon esculentum 12-oxophytodienoate reductase / dimethyl sulfoxide / 22 h / 30 °C / pH 7 / Enzymatic reaction; Aqueous phosphate buffer
View Scheme
5-methyl-3-oxo-hexanoic acid ethyl ester
34036-16-3

5-methyl-3-oxo-hexanoic acid ethyl ester

A

5-methyl-3-cyanohexanoic acid ethyl ester

5-methyl-3-cyanohexanoic acid ethyl ester

B

(S)-3-cyano-5-methylhexanoic acid ethyl ester
181289-39-4

(S)-3-cyano-5-methylhexanoic acid ethyl ester

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.5 h / 0 - 10 °C / Inert atmosphere
1.2: 1.5 h / 0 - 10 °C
2.1: tetrakis(triphenylphosphine) palladium(0) / N,N-dimethyl-formamide / 15 h / 70 °C / Inert atmosphere
3.1: NADPH; recombinant OPR1 reductase (tomato) / dimethyl sulfoxide / 45 h / 30 °C / pH 7 / Enzymatic reaction; Aqueous phosphate buffer
View Scheme
Multi-step reaction with 3 steps
1.1: tetramethyl ammoniumhydroxide / hexane; water / 0.67 h / 5 - 15 °C / Inert atmosphere
1.2: 2.5 h / 5 - 10 °C
2.1: tetrakis(triphenylphosphine) palladium(0) / N,N-dimethyl-formamide / 15 h / 70 °C / Inert atmosphere
3.1: NADPH; recombinant OPR1 reductase (tomato) / dimethyl sulfoxide / 45 h / 30 °C / pH 7 / Enzymatic reaction; Aqueous phosphate buffer
View Scheme
Multi-step reaction with 3 steps
1.1: tetramethyl ammoniumhydroxide / water; hexane / 0.67 h / 5 - 15 °C / Inert atmosphere
1.2: 2.5 h / 5 - 10 °C / Inert atmosphere
2.1: tetrakis(triphenylphosphine) palladium(0) / N,N-dimethyl-formamide / 15 h / 70 °C / Inert atmosphere
3.1: Saccharomyces pastorianus old yellow enzyme, isoenzyme OYE3; NADH / aq. buffer / 24 h / 30 °C / pH 7.5 / Green chemistry; Enzymatic reaction
View Scheme
3-methylbutanoyl cyanide
66582-16-9

3-methylbutanoyl cyanide

(S)-3-cyano-5-methylhexanoic acid ethyl ester
181289-39-4

(S)-3-cyano-5-methylhexanoic acid ethyl ester

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: n-butyllithium / hexane; tetrahydrofuran / 0.5 h / 0 °C
1.2: 0 - 20 °C
2.1: NADH; NADPH; Citrobacter sp. N-ethylmaleimide reductase / dimethyl sulfoxide / 22 h / 30 °C / pH 7 / Enzymatic reaction; Aqueous phosphate buffer
View Scheme
Multi-step reaction with 2 steps
1.1: n-butyllithium / hexane; tetrahydrofuran / 0.5 h / 0 °C
1.2: 0 - 20 °C
2.1: NADH; NADPH; Lycopersicon esculentum 12-oxophytodienoate reductase / dimethyl sulfoxide / 22 h / 30 °C / pH 7 / Enzymatic reaction; Aqueous phosphate buffer
View Scheme
3-methylbutanoyl cyanide
66582-16-9

3-methylbutanoyl cyanide

A

5-methyl-3-cyanohexanoic acid ethyl ester

5-methyl-3-cyanohexanoic acid ethyl ester

B

(S)-3-cyano-5-methylhexanoic acid ethyl ester
181289-39-4

(S)-3-cyano-5-methylhexanoic acid ethyl ester

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: n-butyllithium / hexane; tetrahydrofuran / 0.5 h / 0 °C
1.2: 0 - 20 °C
2.1: NADPH; recombinant OPR1 reductase (tomato) / dimethyl sulfoxide / 45 h / 30 °C / pH 7 / Enzymatic reaction; Aqueous phosphate buffer
View Scheme
(Z)-ethyl 5-methyl-3-(trifluoromethylsulfonyloxy)hex-2-enoate

(Z)-ethyl 5-methyl-3-(trifluoromethylsulfonyloxy)hex-2-enoate

(S)-3-cyano-5-methylhexanoic acid ethyl ester
181289-39-4

(S)-3-cyano-5-methylhexanoic acid ethyl ester

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: tetrakis(triphenylphosphine) palladium(0) / N,N-dimethyl-formamide / 15 h / 70 °C / Inert atmosphere
2: NADH; NADPH; Lycopersicon esculentum 12-oxophytodienoate reductase / dimethyl sulfoxide / 22 h / 30 °C / pH 7 / Enzymatic reaction; Aqueous phosphate buffer
View Scheme
Multi-step reaction with 2 steps
1: tetrakis(triphenylphosphine) palladium(0) / N,N-dimethyl-formamide / 70 °C
2: NADP / isopropyl alcohol / 96 h / 30 °C / Enzymatic reaction
View Scheme
(Z)-ethyl 5-methyl-3-(trifluoromethylsulfonyloxy)hex-2-enoate

(Z)-ethyl 5-methyl-3-(trifluoromethylsulfonyloxy)hex-2-enoate

A

5-methyl-3-cyanohexanoic acid ethyl ester

5-methyl-3-cyanohexanoic acid ethyl ester

B

(S)-3-cyano-5-methylhexanoic acid ethyl ester
181289-39-4

(S)-3-cyano-5-methylhexanoic acid ethyl ester

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: tetrakis(triphenylphosphine) palladium(0) / N,N-dimethyl-formamide / 15 h / 70 °C / Inert atmosphere
2: NADPH; recombinant OPR1 reductase (tomato) / dimethyl sulfoxide / 45 h / 30 °C / pH 7 / Enzymatic reaction; Aqueous phosphate buffer
View Scheme
(Z)-ethyl 3-cyano-5-methylhex-2-enoate
1334950-50-3

(Z)-ethyl 3-cyano-5-methylhex-2-enoate

(S)-3-cyano-5-methylhexanoic acid ethyl ester
181289-39-4

(S)-3-cyano-5-methylhexanoic acid ethyl ester

Conditions
ConditionsYield
With Lycopersicon esculentum 12-oxophytodienoate reductase; NADPH; NADH In dimethyl sulfoxide at 30℃; for 22h; pH=7; Product distribution / selectivity; Enzymatic reaction; Aqueous phosphate buffer;
With NADP In isopropyl alcohol at 30℃; for 96h; Enzymatic reaction; enantioselective reaction;n/a
(Z)-ethyl 3-cyano-5-methylhex-2-enoate
1334950-50-3

(Z)-ethyl 3-cyano-5-methylhex-2-enoate

A

5-methyl-3-cyanohexanoic acid ethyl ester

5-methyl-3-cyanohexanoic acid ethyl ester

B

(S)-3-cyano-5-methylhexanoic acid ethyl ester
181289-39-4

(S)-3-cyano-5-methylhexanoic acid ethyl ester

Conditions
ConditionsYield
With recombinant OPR1 reductase (tomato); NADPH In dimethyl sulfoxide at 30℃; for 45h; pH=7; Enzymatic reaction; Aqueous phosphate buffer;A n/a
B n/a
propan-1-ol
71-23-8

propan-1-ol

(S)-3-cyano-5-methylhexanoic acid ethyl ester
181289-39-4

(S)-3-cyano-5-methylhexanoic acid ethyl ester

(S)-propyl 3-cyano-5-methylhexanoate
1415320-55-6

(S)-propyl 3-cyano-5-methylhexanoate

Conditions
ConditionsYield
With hydrogenchloride In water for 24h; Reflux;99%
(S)-3-cyano-5-methylhexanoic acid ethyl ester
181289-39-4

(S)-3-cyano-5-methylhexanoic acid ethyl ester

(S)-4-isobutyl-pyrrolidin-2-one
181289-23-6

(S)-4-isobutyl-pyrrolidin-2-one

Conditions
ConditionsYield
With 5%-palladium/activated carbon; hydrogen In ethanol at 25℃; under 37503.8 Torr; for 6h; Reagent/catalyst; Temperature; Autoclave; Green chemistry;97.2%
methanol
67-56-1

methanol

(S)-3-cyano-5-methylhexanoic acid ethyl ester
181289-39-4

(S)-3-cyano-5-methylhexanoic acid ethyl ester

methyl (S)-3-cyano-5-methyl-hexanoate

methyl (S)-3-cyano-5-methyl-hexanoate

Conditions
ConditionsYield
With hydrogenchloride In water for 24h; Reflux;73%
(S)-3-cyano-5-methylhexanoic acid ethyl ester
181289-39-4

(S)-3-cyano-5-methylhexanoic acid ethyl ester

pregabilin
148553-50-8

pregabilin

Conditions
ConditionsYield
Stage #1: (S)-3-cyano-5-methylhexanoic acid ethyl ester With potassium hydroxide; water In ethanol at 20 - 25℃; for 1.5h;
Stage #2: With hydrogen; sponge nickel In ethanol; water under 2585.81 Torr; for 19h;
Stage #3: With acetic acid In ethanol; water at 0 - 75℃;
Multi-step reaction with 3 steps
1: potassium hydroxide; water / 6 h / 25 °C
2: hydrogen / Raney Nickel / water / 30 °C
3: acetic acid / ethanol / 35 °C / pH 7.5
View Scheme
Stage #1: (S)-3-cyano-5-methylhexanoic acid ethyl ester With potassium hydroxide In Isopropyl acetate; water at 20℃; for 1h;
Stage #2: With hydrogen; nickel In Isopropyl acetate; water for 5h;
Multi-step reaction with 2 steps
1: 5%-palladium/activated carbon; hydrogen / ethanol / 6 h / 25 °C / 37503.8 Torr / Autoclave; Green chemistry
2: sodium hydroxide; ethanol / 5 h / 40 °C / Green chemistry
View Scheme
(S)-3-cyano-5-methylhexanoic acid ethyl ester
181289-39-4

(S)-3-cyano-5-methylhexanoic acid ethyl ester

potassium (S)-3-cyano-5-methylhexanoate

potassium (S)-3-cyano-5-methylhexanoate

Conditions
ConditionsYield
With potassium hydroxide; water at 25℃; for 4h;
With water; potassium hydroxide at 25℃; for 6h;
With potassium hydroxide In ethanol at 20 - 25℃; for 5h;4.8 g
(S)-3-cyano-5-methylhexanoic acid ethyl ester
181289-39-4

(S)-3-cyano-5-methylhexanoic acid ethyl ester

pregabalin potassium salt
914254-26-5

pregabalin potassium salt

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: potassium hydroxide; water / 6 h / 25 °C
2: hydrogen / Raney Nickel / water / 30 °C
View Scheme
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