A 2-(4-methoxyphenyl)ethylamine imprinted polymer (MIP) was successfully applied for the selective separation of tyramine. A computational analysis was used to predict the affinity of the polymer matrix towards tyramine and a preliminary experimental evaluation was made for the target analyte. T...

The synthesis of both enantiomers of four new phenylthiazole-based amines by enantiomer-selective acylation of racemic amines and by hydrolysis of the corresponding racemic amides using lipase B from Candida antarctica (Novozyme 435) as chiral catalyst was performed with good yields and excellen...

The rate constant for H-abstraction (kH) from CH2ClCH2Cl and D-abstraction (kD) from CD2ClCD2Cl by chlorine atoms is described by the expressions: kH = (1.99 ± 0.12) × 10−11 exp(−777 ± 23/T) cm3 molecule−1 s−1 and kD = (1.73 ± 0.12) × 10−11 exp(−1148 ± 16/T) cm3 molecule−1 s−1. The experim...

Chiral alcohols are important as bioactive compounds or as precursors to such molecules. On the basis of the different antifungal properties of the enantiopure alcohol derivatives of 4′-chlorophenyl cyclopropyl ketone and benzyl 4′-chlorophenyl ketone, their enantioselective synthesis by chemi...

A series of 1-[(4′-chlorophenyl)carbonyl-4-(aryl)thiosemicarbazide derivatives 1–25 was synthesized and characterized by spectroscopic techniques such as EI-MS and 1H NMR. All compounds were screened for urease inhibitory activity in vitro and demonstrated excellent inhibitory activity in the ...

A series of novel 5-(3-aryl-1H-pyrazol-5-yl)-2-(6-methoxy-3-methylbenzofuran-2-yl)-1,3,4-oxadiazole derivatives has been synthesized from 6-methoxy-3-methylbenzofuran-2-carboxylic acid and ethyl 3-aryl-1H-pyrazole-5-carboxylate. The structures of compounds obtained were determined by IR, 1H NMR ...

The synthetic usefulness of the title compound is demonstrated through its reactivity towards thio and amino nucleophiles as well as tin-centred radicals. The synthesis of a 2-fluoro analogue of a natural fungicide (Sinharine) is reported. We also show that 3-aryl-2-fluoropropenoates could be ob...

A practical procedure is given for the preparation of 2-(phenylthio)cyclobutanone (3) and the use of the latter as a convenient substitute for cyclobutanone is demonstrated.

Double deprotonations of 1,4-dibromo-2,5-difluorobenzene with LDA (2 equiv., T

Phytochemical investigation on Clusia burlemarxii (Clusiaceae) led to isolation and identification of nine compounds. Were isolated from leaves 3-O-α-L- rhamnopyranosylquercetin, 3-O-α-L-rhamnopyranosylkaempferol, 4-hydroxy-5,5-dimethyldihydrofuran-2-one, 2Z-δ-tocotrienoloic acid and friedeli...

In this paper, a series of new bipolar blue host materials has been designed and synthesized by incorporating dimethyl or diphenyl silane core with connection of carbazole di(biphenyl) groups at different linking positions. The triplet energies and charge-transporting properties of these bipolar...

BackgroundSideroxylon obtusifolium (Roem. & Schult.) T.D. Penn., Sapotaceae family, is a medicinal species native to the Brazilian Northeastern region. The plant is popularly used as an anti-inflammatory and hypoglycemic.

The iminosugar 2,5-dideoxy-2,5-imino-d-altritol (DIA, 2) is a powerful competitive inhibitor of α-galactosidase A and has shown much promise as a pharmacological chaperone for the treatment for Fabry disease. Notwithstanding, syntheses of DIA are in want of optimisation. Accordingly, we report ...

Polyimide resins were obtained from the reaction between N-[4-benzoyl-2-(2,5-dioxo-2,5-dihydro-pyrrol-1-yl)-phenyl]-acetamide and the following compounds with terminal amino groups: urea, 4-[(4-aminophenyl)sulfonyl]aniline, thiourea, 2-aminoethylamine, and 4,4′-diaminodiphenylmethane. The therm...

Different polyimide resins were synthesized using N-[3-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)phenyl]acetamide and the following compounds with terminal amino groups: urea, 6-aminohexylamine, 2-aminoethylamine, 3-[4-(3-aminopropyl)piperazin-1-yl]propan-1-amine, 4-[(4-aminocyclohexyl)methyl]cycloh...

Energy transfer in dye-doped organic light-emitting diodes (OLEDs) often occurs by Förster energy transfer processes. In many cases this energy transfer process can be very efficient, leading to fairly large Förster radii. We have recently shown that saturated red emission can be achieved by dop...

The equilibrium constants [K=anti/syn] of a pair of atropisomers due to restricted rotation about Csp3–Csp2 bond for [2-(2-hydroxynaphthalen-1-yl)-3,3-dimethylindolin-1-yl](4-substituted phenyl)methanone were determined in some solvents. The presence of the effective π–π interaction was demo...

A series of 1,2,4-triazole derivatives (1–17) was synthesized and evaluated for its antimicrobial and anticancer potentials. Antimicrobial screening of the synthesized compounds indicated that they were most potent against Aspergillus niger and compound 14 was found to be the most active. Compo...

We have reported DBU as an efficient organocatalyst for one-pot three-component synthesis of annulated pyrido[2,3-d:6,5-d]dipyrimidine derivatives using aromatic aldehyde, thio-barbituric acid and 6-amino-uracil in aqueous ethanol under reflux. The attractive advantages of this process are mild ...

A combinatorial chemical library of fifty-nine novel 3-amino-1′-((1-aryl-1H-1,2,3-triazol-5-yl)methyl)-2′-oxospiro[benzo[a]pyrano[2,3-c]phenazine-1,3′-indoline]-2-carbonitrile, designed as hybrid molecules of phenazine, pyran, indole and 1,2,3-triazole pharmacophores, were constructed in this...