In this work, we describe the synthesis of N doped carbon nanomaterials from mesoporous silica impregnated with iron (10 wt%), using acetonitrile as carbon and nitrogen source by CVD process at 600, 650, 700 and 800 °C. The obtained materials showed a N/C content between 8.3–10.1% and a carbon...

Nitrogen-rich hierarchical porous carbon nanofibers (N-PCNFs) with highly efficient catalytic activity for the oxidation of hydrogen sulfide (H2S) at low temperature has been constructed through a modified electrospinning technology, using polyacrylonitrile (PAN) and zeolitic imidazolate framewo...

Oxidative stress has been implicated in the pathology of the lethal skeletal muscle disease Duchenne muscular dystrophy (DMD), and various antioxidants have been investigated as a potential therapy. Recently, treatment of the mdx mouse model for DMD with the antioxidant and cysteine and glutathi...

Rat liver cells (the C-9 cell line) are stimulated to metabolize arachidonic acid by α-thrombin, its receptor polypeptide, γ-thrombin, and trypsin. Prostaglandin (PG) I2 synthesis stimulated by α-thrombin is inhibited by dansylarginine N-(3-ethyl-1,5-pentanediyl) amide (DAPA), by hirudin, by ...

The central role of thrombosis in the pathogenesis of acute myocardial infarction, unstable angina and complications after angioplasty has led to intense interest in developing more effective antithrombotic agents for these disorders. Hirudin, a direct thrombin inhibitor, has undergone extensive...

Synthetic peptides cyclized via disulfide linkages have been synthesized as conformationally restricted analogs of a novel class of antithrombotic peptides that inhibit fibrinogen cleavage by binding to a non-enzymatic site on thrombin. Several conformational models for these inhibitors have bee...

A sensitive radioimmunoassay (RIA) for the quantitation of recombinant (r) hirudin in biological fluids is described. Taking advantage of the highly specific hirudinthrombin interaction, a monoclonal antibody to human α-thrombin was used to capture hirudin-thrombin complexes in a competitive bi...

To reevaluate the effects of iodination of hirudin on its thrombin-inhibiting activity, we iodinated a recombinant hirudin analog, CX-397, by a chloramine-T method and isolated the eight kinds of iodinated derivatives by reverse-phase HPLC. Their structure were different combinations of non-, mo...

Using diverse arylmethyl groups to replace the benzyl moiety of the lead Hsp90 inhibitor 1 (N-(5-chloro-2,4-dihydroxybenzoyl)-(R)-N-benzyl-1,2,3,4-tetrahydro-3-iso quinolinecarboxamide), thirty four derivatives (10–43) were developed, and exhibited improved Hsp90 inhibitory and antiproliferativ...

Synthesis of lobucavir prodrug, L-valine, [(1S,2R,3R)-3-(2-amino-1,6-dihydro-6-oxo-9H-purin-9-yl)-2-(hydroxymethyl)cyclobutyl]methyl ester monohydrochloride (BMS 233866), requires regioselective coupling of one of the two hydroxyl groups of lobucavir (BMS 180194) with valine. Either hydroxyl gro...

Nucleoside analogues are used in the treatment of viral infections, including those caused by human immunodeficiency virus, cytomegalovirus, and herpes virus. These drugs are beneficial in the treatment of human disease, but are associated with toxicities that often limit their intended therapeu...

The Z/E isomerisations of the synthesized benzyl 3,4,6-tri-O-acetyl-2-deoxy-2-hydroxyimino-d-hexopyranosides during the NMR measurement and during the Zemplén O-deacetylation were observed. In order to study stabilities and tendency of the obtained compounds to isomerise, B3LYP/6-311++G∗∗ level...

In this study, the mononuclear Ni(II), Cu(II) and UO2(VI) complexes of N'-((2Z,3E)-3-(hydroxyimino)butan-2-ylidene)-2-phenylacetohydrazide ligand (LH2) have been synthesized. All compounds have been characterized by using elemental, spectral, X-ray analyses and magnetic moment measurements....

A series of 1-benzylindole-based TRβ agonists were prepared and evaluated. Compounds 11b′ and 11c′ were found to have cholesterol-lowering in a rat model with marginal effects on cardiac function and HPT axis. The present work illustrates the potential use of indoles as inner ring isosteres.

Alkaline degradation of the ascorbigen 2-C-[(indol-3-yl)methyl]-α-l-xylo-hex-3-ulofuranosono-1,4-lactone (1a) led to a mixture of 1-deoxy-1-(indol-3-yl)-l-sorbose (2a) and 1-deoxy-1-(indol-3-yl)-l-tagatose (3a). The mixture of diastereomeric ketoses underwent acetylation and pyranose ring openi...

Changes in the levels of amino-acid enantiomers are associated with some serious diseases; consequently, amino acid monitoring in peripheral blood can be used to diagnose and predict the onset of disease. Herein, we report the design and synthesis of a new chiral derivatization reagent, namely s...

In a search for novel analogues of β3-adrenoceptor (AR) agonists relaxing the bladder for treatment of urinary dysfunction, 2-[4-(2-{[(1S,2R)-2-hydroxy-2-(4-hydroxyphenyl)-1-methylethyl]amino}ethyl)phenoxy]-2-methylpropionic acids (1a–e), into which a fibrate-like structure had been incorporat...

Rcs phosphorelay system is a two-component signal transduction system, which can regulate the transcription of capsule polysaccharide and biofilm related genes in Enterobacteriaceae. In this study, microarray technology was used to investigate the overall genes regulated by RcsA, RcsB, and RcsAB...

Various compositions of vanadium cadmium borate glasses have been prepared using normal melt quench technique. The changes caused by the addition of V2O5 on the structure of these glasses have been studied by recording the FTIR spectra over the range 400–4000 cm−1. The theoretical optical basic...

A new ternary borate, Pb3Cd3(BO3)4, has been synthesized by solid-state reaction at 530 °C. The compound crystallizes in the hexagonal space group P63/m with a = 9.946(4), c = 7.003(5) Å, and Z = 2. The crystal structure consists of one-dimensional (1D) long [PbO5]∞ tubes. The tubes are furthe...