The magnetic susceptibilities of cobaltocene and chromocene have been measured between 83 and 293 K; for cobaltocene the results suggest an appreciable orthorhombic splitting of the 2∏(σ2πδ4 ground state, whilst for chromocene the data provide further support for the 3Δ(σδ3) ground state ...

Four different chromocenes, in which two hydrogen atoms in the 1 and 1' positions have been substituted by ethyl, t-butyl, trimethylsilyl and phenyl groups, have been reacted with silica gel. As in the case with chromocene (IR bands of adsorbed CO at 2047.1, 1972.2, 1917.2, 1824.1 and 1621....

This article reports experimental investigation of flame suppression ability of metallocenes. In this study, chromocene (CrCp2), manganocene (MnCp2), ferrocene (FeCp2), cobaltcene (CoCp2), and nickelocene (NiCp2) are used. The experiments are conducted by combusting a filter paper on which the m...

The average chromium environment on the surface of a chromocene/silica ethylene polymerisation catalyst has been determined by Cr-EXAFS to be [(η5-C5H5)Cr(μ-OSi)(OSi)]2.

The crystal structure of chromocene has been determined by a low-temperature single-crystal X-ray diffraction study. The average chromium-carbon bond length is 2.151(13) Å.

Two equivalents of K[Cp′] (Cp′=C5(i-Pr)3H2, C5(i-Pr)4H, C5(t-Bu)2H3) react with CrCl2 in THF to give the corresponding chromocenes, Cp′2Cr, in good yield. Despite the presence of bulky substituents on the rings that could affect their properties, the complexes are extremely air- and moisture-...

The mechanism for the preparation of Me2Si(C5Me4)2Cr, 1, from CrCl2(THF)x and Me2Si(C5Me4)2Li2 was investigated and – in contrast to earlier claims – no evidence was found for the participation of an auxiliary ligand. The formation and stability of 1 is attributed to the combination of correct...

Ferrocene and chromocene can be adsorbed on silica surfaces by impregnation or by grinding powders of the metallocenes with silica. The vanishing crystal lattice and formation of mobile surface species can in both cases be proven by diminished Chemical Shift Anisotropies and reduced residual lin...

From sodium 2,3-diisopropyl-1,4-dimethyl-cyclopentadienide and MBr2(dme) (M = Fe, Co, Ni) the corresponding ferrocene (1), cobaltocene (2) and nickelocene (3) could be obtained as pure, crystalline solids. From an analogous reaction of sodium 2,3,5-triisopropyl-1,4-dimethyl-cyclopentadienide wit...

Twofold lithiation of 9,9-dimethylxanthene with n-butyllithium and N,N,N′,N′-tetrametylethylenediamine (TMEDA) in boiling n-heptane followed by reaction with chlorodiphenylphosphine (Ph2PCl) yielded the title compound 4. The phosphine ligand was characterised by 1H NMR, 13C NMR, 31P NMR spectr...

ABSTRACTA phase 1 clinical study was performed to assess the pharmacokinetics and safety of intravenous (i.v.) administration of colistin methanesulfonate (CMS) and azidothymidine (AZT) alone and in combination. Seven healthy subjects received three (every 12 h) 1-h i.v. infusions of 4, 2 and 2 ...

ObjectivesDespite of proven LPS neutralizing activity, intravenous polymyxin use was waned due to experience of associated nephrotoxicity. But, increasing resistance to all available antibiotics has necessitated their resurgence and the prodrug of colistin sulfate (CS), known as colistin-methane...

This study evaluated the influence of colistin sulphate on cholinergic, monoaminergic, purinergic and oxidative stress biomarkers in the brain of male rats. Rats were randomized into four (4) groups (A-D) of five rats each. Group A rats received the vehicle of administration for 7 days. Rats in ...

Considering the disadvantageous of first line anti-tuberculosis (TB) drugs, including poor patient adherence, drug side effects, the long treatment duration and rapidly increasing microbe resistance, alternative treatment strategies are needed. Colistin sulfate (CS), a polymyxin antibiotic consi...

Colistin sulfate is widely used in both human and veterinary medicine. However, its effect on the microbial ecologyis unknown. In this study, we determined the effect of colistin sulfate on the diversity of soil microorganisms by amplified rDNA restriction analysis (ARDRA) and high-throughput se...

The sulfonamides and erythromycin ethylsuccinate in combination oral suspensions were determined by high-performance liquid chromatography and automated turbidimetry, respectively. The chromatographic procedure was rapid, specific, and stability-indicating for sulfisoxazole acetyl and the trisul...

A method is described for the determination of erythromycin ethylsuccinate by liquid chromatography. A C18 reversed-phase column (25 cm x 4.6 mm I.D.) was used with acetonitrile-0.2 M tetrabutylammonium sulphate (pH 6.5)-0.2 M phosphate buffer (pH 6.5)-water [x:5:5:(90 - x)] as mobile phase. The...

Universal quantitative models using NIR reflectance spectroscopy were developed for the analysis of API contents (active pharmaceutical ingredient) in roxithromycin and erythromycin ethylsuccinate tablets from different manufacturers in China. The two quantitative models were built from 78 batch...

A sensitive and selective liquid chromatography–electrospray ionization mass spectrometry (LC–ESI-MS) method was developed for simultaneous identification and quantification of erythromycin ethylsuccinate and erythromycin in human plasma, which can be well applied to clinical study. The method...

Erythromycin, a macrolide antibiotic, has similar antimicrobial spectrum to penicillin and it is widely used, especially in the treatment of patients who are allergic to penicillin.In this work, the application of a renewable silver-amalgam film electrode (Hg(Ag)FE) for the characterization and ...