The superconducting magnet system plays an important role in the framework of the design of the EU DEMO tokamak. In recent years, ENEA developed a prototype of cable-in-conduit conductor (CICC) with two low-impedance central channels to be used in the DEMO Toroidal Field (TF) coils with a graded...

MicroRNAs (miRNAs) and transcription factors (TFs) are the largest families of trans-acting gene regulatory species, which are pivotal players in a complex regulatory network. Recently, extensive research on miRNAs and TFs in agriculture has identified these trans-acting regulatory species, as a...

Background and aimThe non-glycosylated glycoform of transferrin (Tf), known as asialo-Tf, was not selected (in favor of disialo-Tf) as the measurand for the standardization of carbohydrate deficient transferrin (CDT) determination because of a lower diagnostic sensitivity provided with the curre...

Background and aimCDT is a collective biomarker including asialo- and disialo-Tf, but researchers have generally focused attention on disialo-Tf, because of its easier detectability, since asialo-Tf is typically not detectable by the current methods in abstinent individuals, social drinkers and ...

The toroidal field (TF) coil system is one of the most mechanically stressed systems in a tokamak. Structural integrity of the system must be maintained on the global and on the local scale, where the stress state in each conductor jacket as well as in the insulation is to be within structural a...

Considerable studies demonstrate that plant transcription factors (TFs) play key regulatory roles in abiotic/biotic stress conditions, such as drought and pathogen attack. However, there is no effort dedicated to curate experimentally validated stress-TF regulatory relationships from these indiv...

We present a 14-year-old girl with loss of motor functions, tetraplegia, epilepsy and nystagmus, caused by a novel heteroplasmic m.641A>T transition in an evolutionary conserved region of mitochondrial genome, affecting the aminoacyl stem of mitochondrial tRNA-Phe. In silico prediction, respirom...

Prostate cancer is dangerous due to its metastatic property in the advanced stage. Considerable advance has been made in unraveling the tumor-related molecular basis. Traditionally, differentially expressed genes are focused on for biomarker identification. Here, we argued that subtle gene alter...

Antibodies to carbohydrate epitopes are often of the IgM isotype and require multiple binding for sufficient avidity. Therefore clusters of epitopes are preferred antigenic sites in these cases. We have examined the type of clusters recognized by two anti-Thomsen-Friedenreich (TF, core-1, CD176)...

The heteroleptic complexes, [(MePhtpy)RuCl(dpp)](PF6) and [(tpy)RuCl(dpp)](PF6), have been synthesized, characterized, and investigated with respect to their photophysical, redox, and DNA photocleavage properties (where MePhtpy = 4′-(4-methylphenyl)-2,2′:6′,2′′-terpyridine and dpp = 2,3-bis...

The present study describes the pharmacological profile of the putative antipsychotic drug Lu 35-138 ((+)-(S)-3-{1-[2-(1-acetyl-2,3-dihydro-1H-indol-3-yl)ethyl]-3,6-dihydro-2H-pyridin-4-yl}-6-chloro-1H-indole). The in vitro receptor profile of Lu 35-138 revealed high affinity (Ki = 5 nM) and com...

Utilizing the spin-trapping agent phenyl-t-butyl nitrone, a free radical has been detected which is produced from carbon tetrachloride or bromotrichloromethane during the enzymic oxidation of NADPH by rat liver microsomes. The presence of NADPH is obligatory for generation of the radical.The for...

A highly hydrophilic compound with siderophore activity has been isolated from the supernatant of Staphylococcus hyicus DSM 20459 grown under iron-restricted conditions. The metabolite, named staphyloferrin B, is strictly iron-regulated and produced by a large variety of staphylococci strains. I...

Bastadin-6-34-O-sulfate ester (8) was isolated from methanol extracts of Ianthella basta. The structure of 8 was characterized by analysis of MS and NMR data, and conversion through acid hydrolysis, to the parent compound, bastadin-6, which was identical by HPLC, MS and NMR with an authentic sam...

β-3-Furylalanine has been synthesized and has been found to inhibit the growth of Escherichia coli, ATCC strain 9723; Escherichia coli, ATCC strain 9723f; and Lactobacillus arabinosus 17-5. In each strain of E. coli, in the presence of exogenous phenylalanine, β-3-furylalanine was more toxic t...

Two series of novel 5,7-diarylimidazo[1,2-a]pyridine-8-carbonitrile derivatives (3a–3q and 7a–7n) were designed by modification of CA-4 pharmacophore to develop colchicine targeted antitubulin agents. All compounds were efficiently synthesized and evaluated for their cytotoxicity against five ...

Dipeptidyl peptidase IV (DPP-4) inhibition is suitable mechanism for once daily oral dosing regimen because of its low risk of hypoglycemia. We explored linked bicyclic heteroarylpiperazines substituted at the γ-position of the proline structure in the course of the investigation of l-prolylthi...

In this work, a simple approach was used to quantitative preparation of nicotinum methane sulfonate (1-methyl-2-(pyridin-3-yl)pyrrolidin-1-ium methanesulfonate (NMS)) from nicotine and methane sulfonic acid. NMS, as a novel, mild, efficient, economic, and task-specific ionic liquid (TSIL) with d...

The treatment of 2-[(1-alkyl(aryl)-4-cyano-5,6,7,8-tetrahydroisoquinolin-3-yl)oxy]acetamides (5) with sodium ethoxide to induce a cyclization to form 5-alkyl(aryl)-1-amino-6,7,8,9-tetrahydrofuro[2,3-c]isoquinoline-2-carboxamides 4 furnished unexpected results. Compounds 5 gave rise to two differ...

Ca2+ overload in myocardial cells is responsible for arrhythmia. Sodium–calcium exchanger (NCX) inhibitors are more effective than sodium–hydrogen exchanger (NHE) inhibitors with regard to modulation of Ca2+ overload, because NCX inhibitors can directly inhibit the influx of Ca2+ into cells. N...