Alkaline metal, calcium and magnesium p-iodobenzoates and alkaline metal nicotinates, as well as sodium and potassium picolinic and isonicotinates were investigated by means of their antimicrobial and chemical properties. The quality estimation of the influence of metal cation coordinated to the...

Giardia lamblia is an intestinal protozoan parasite that causes giardiasis, a disease of high prevalence in Latin America, Asia and Africa. Giardiasis leads to poor absorption of nutrients, severe electrolyte loss and growth retardation. In addition to its clinical importance, this parasite is o...

Vibrational spectra of Li+, Na+, K+, Rb+ and Cs+ nicotinates, benzoates, salicylates and p-halogenobenzoates have been studied. Characteristic changes of spectra within the regions: 1610–1380 cm−1 [ν(C–C)ar, νasym(COO−) and νsym(COO−)], 1360–1000 cm−1 [β (C–H)], and 970–740 cm−1 [γ (C–...

The FT-IR and FT-Raman spectra of lithium, sodium, potassium, rubidium and caesium isonicotinates were registered, assigned, analysed and compared to the vibrational spectra of the same metal nicotinates published earlier. The NMR (1H and 13C) spectra of alkaline metal isonicotinates and nicotin...

Nicotinic acid is a constituent of the coenzymes NAD and NADP. It also serves as an agonist for the G-protein-coupled receptor GPR109A. Nicotinic acid is widely used at high doses as a lipid-lowering drug, which is associated with an ocular side effect known as niacin maculopathy. Here we invest...

Methyl nicotinate (MN), a metabolite of Mycobacterium tuberculosis, is an important biomarker of tuberculosis (TB). An effective measurement of MN can provide an early detection of TB, before it becomes life threatening. In this study, a cobalt (Co) and reduced graphene oxide (rGO) dispersed N-d...

The lithium, sodium, potassium, rubidium and caesium isonicotinates, potassium picolinate and nicotinate (microbiological data) as well as sodium benzoate (as a referee for microbiological tests) were under study. The selected experimental bands occurring in the FT-IR and FT-Raman spectra of stu...

The miscibility and phase behavior of two components of phospholipids and perfluorocarboxylic acids [FCn; perfluorododecanoic acid (FC12), perfluorotetradecanoic acid (FC14), perfluorohexadecanoic acid (FC16), and perfluorooctadecanoic acid (FC18)] have been systematically investigated using Lan...

Animal protein supplement feeds (APFs) are susceptible to perfluoroalkyl acids (PFAAs) and could be the main sources for raised animals, thereafter causing further human exposure through the farm-to-fork pathway. However, the occurrence of PFAAs has been rarely evaluated in various APFs, especia...

Fluorinated surface active molecules have demonstrated potential for applications in pulmonary surfactant replacement therapy. To characterize molecular-level interactions between constituents in model replacement formulations, the mixing thermodynamics, surfactant recovery and morphology of a m...

The miscibility, mechanical and morphological properties of mixed Langmuir and Langmuir–Blodgett monolayers prepared from the phospholipid 1,2-dipalmitoyl-sn-glycero-3-phosphocholine and the perfluorinated fatty acid perfluorooctadecanoic acid have been studied as a function of film composition...

Hydrolysis of bis(2,2,2-trifluoroethyl) 2,2-dimethylcyclopropane-1,1-dicarboxylate with pig liver esterase afforded (1R)-2,2-dimethyl-1-(2,2,2-trifluoroethoxycarbonyl)-cyclopropane-1-carboxylic acid in high enantiomeric excess. This compound was rearranged to (1S)-2,2,2-trifluoroethyl-2,2-dimeth...

The synthesis and dienophilic behaviour of (S,S)-1,1-bis-ethoxycarbonyl-2,2-bis-p-tolysulfinyl ethene with cyclic and acyclic dienes is reported. The stereoselectivity is high with cyclopentadiene and complete with acyclic dienes, but its reactivity is unexpectedly low, requiring high pressures ...

We report our research about the synthesis of functionalized indanes in the pentagonal ring by a formal [3+2] cycloaddition using benzhydrols and styrene derivatives with electron-withdrawing groups joined to C-β, such as carboxyl, carboxymethyl, carbonyl of ketones, and nitro groups. We also r...

A series of 6-methyl-4-[1-(2-substituted-phenylamino-acetyl)-1H-indol-3-yl]-2-oxo/thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylic acid ethyl esters (1–16) were synthesized and evaluated in vitro for their antimicrobial and anticancer potential. 6-Methyl-4-{1-[2-(4-nitro-phenylamino)-acetyl]-1H...

A series of thirty-six novel 5-(2-(4-(benzo[d]isoxazol-3-yl)piperazin-1-yl)acetyl)indolin-2-one and 5-(2-(4-substitutedpiperazin-1-yl)acetyl)indolin-2-one analogues were synthesized, characterized and screened for their in vitro anti-tubercular activity against Mycobacterium tuberculosis H37Rv s...

The intramolecular evolutionary pathways of three phenylhydrazine derivatives are investigated via Density Functional calculations, as a possible convenient synthetic route towards the preparation of 1H-Indazole derivatives. All reaction steps occur via concerted four membered transition states;...

5-Acetyl-6-methyl-4-aryl-3,4-dihydropyrimidin-2(1H)-ones 1–43 were synthesized in a “one-pot” three component reaction and structurally characterized by various spectroscopic techniques such as 1H, 13C NMR, EI-MS, HREI-MS, and IR. All compounds were evaluated for their in vitro urease inhibit...

l-6-Hydroxynorleucine, a key chiral intermediate used for synthesis of a vasopeptidase inhibitor, was prepared in 89% yield and >99% optical purity by reductive amination of 2-keto-6-hydroxyhexanoic acid using glutamate dehydrogenase from beef liver. In an alternate process, racemic 6-hydroxynor...

Hybrid hollow urchin-like cobalt and copper silicate constructed by nanotubes encapsulated in graphene nanosheets composites were successfully prepared using graphene oxide as carrier and silica spheres as template, which were done through a well-known Stȍber process and a hydrothermal method. I...